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Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1419 - 1432
The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an... 
GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN-KINASE-C | ADENOSINE-DIPHOSPHATE | ALPHA-IIB-BETA-3 ACTIVATION | MICE | CALDAG-GEFI | PLASMA-MEMBRANE | ADENYLATE-CYCLASE | ADP | MOUSE MODELS | Thrombopoiesis | Ticlopidine - pharmacology | rap1 GTP-Binding Proteins - antagonists & inhibitors | Platelet Activation - physiology | Thrombocytopenia - surgery | Splenectomy | Thrombocytopenia - genetics | Cellular Senescence | Hemostasis | Platelet Aggregation Inhibitors - pharmacology | GTPase-Activating Proteins - physiology | Guanine Nucleotide Exchange Factors - deficiency | Mice, Inbred C57BL | Receptors, Purinergic P2Y12 - physiology | Proto-Oncogene Proteins c-akt - physiology | Ticlopidine - analogs & derivatives | Mice, Knockout | Platelet Activation - genetics | Animals | rap1 GTP-Binding Proteins - physiology | Saphenous Vein - injuries | Clopidogrel | Mice | Mice, Inbred BALB C | Platelet Activation - drug effects | GTPase-Activating Proteins - genetics | Lymphopenia - genetics | Cell receptors | Development and progression | Cellular signal transduction | Genetic aspects | Properties | Health aspects | Blood platelet disorders | Heart attacks | Laboratories | Cloning | Thrombosis | Embryos | Proteins | Studies | Blood platelets | Rodents | Technological change | Protein expression | Mutation | Infrared imaging systems | Veins & arteries
Journal Article
Journal Article
Life Sciences, ISSN 0024-3205, 11/2018, Volume 213, pp. 74 - 81
Increasing evidence displays that deposition of aggregated β-amyloid (Aβ) leads to neuronal cell apoptosis, thus aggravates the pathological progression of... 
ERK1/2 | D3T | PC12 cells | Apoptosis | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | IMPAIRMENT | STRATEGIES | PATHOGENESIS | A beta | HONOKIOL | HYPOTHESIS | PHARMACOLOGY & PHARMACY | MICE | INDUCED NEUROTOXICITY | CYTOTOXICITY | Cell Survival - drug effects | Peptide Fragments - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Calcium - metabolism | Amyloid beta-Peptides - drug effects | Rats | Thiophenes - pharmacology | Thiones - metabolism | Thiophenes - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Antioxidants - pharmacology | L-Lactate Dehydrogenase - drug effects | PC12 Cells - drug effects | Animals | MAP Kinase Signaling System - drug effects | Neuroprotective Agents - pharmacology | Signal Transduction - drug effects | Peptide Fragments - drug effects | Oxidative Stress - drug effects | Thiones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proteins | Development and progression | Alzheimer's disease | Protein kinases | Neuroprotection | Flow cytometry | Bax protein | Calcium | AKT protein | Activation | Kinases | Assaying | Caspase-3 | Pretreatment | Calcium (intracellular) | Neurodegenerative diseases | Neurons | Extracellular signal-regulated kinase | Caspase | Lactate dehydrogenase | Cells | L-Lactate dehydrogenase | 1-Phosphatidylinositol 3-kinase | Pathology | Inhibitors | Protein kinase | Pheochromocytoma cells | β-Amyloid | Lactic acid | Intracellular | Alzheimers disease | Fluo-3 | Viability | Calcium ions
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2015, Volume 125, Issue 11, pp. 4223 - 4238
A high intake of dietary salt (NaCl) has been implicated in the development of hypertension, chronic inflammation, and autoimmune diseases. We have recently... 
MEDICINE, RESEARCH & EXPERIMENTAL | M2 MACROPHAGES | NA+ STORAGE | TISSUE | GENE-EXPRESSION | URINARY SODIUM | TRANSCRIPTION FACTOR | POTASSIUM EXCRETION | ALTERNATIVE ACTIVATION | BLOOD-PRESSURE | T-CELLS | Sodium Chloride, Dietary - pharmacology | Sodium Chloride - pharmacology | Male | Glycolysis - drug effects | Proto-Oncogene Proteins c-akt - genetics | Oxidative Phosphorylation - drug effects | Interleukin-4 - pharmacology | Histone Code - drug effects | Bone Marrow Cells - drug effects | TOR Serine-Threonine Kinases - physiology | Wound Healing - drug effects | Macrophages - immunology | Macrophages - classification | Immunity, Innate - drug effects | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Inflammation | Proto-Oncogene Proteins c-akt - physiology | Mitochondria - drug effects | Random Allocation | Interleukin-13 - pharmacology | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Sodium Chloride, Dietary - toxicity | Chitin - toxicity | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Salt | Medical research | Immune response | Medicine, Experimental | Research | Macrophages | Properties | Observations | Biological control systems | Health aspects | Hypertension | Wound healing | Sodium | Cytokines | Kinases | Metabolism | Gene expression | Experiments | Acquisitions & mergers
Journal Article
Molecular Cell, ISSN 1097-2765, 2011, Volume 44, Issue 2, pp. 290 - 303
The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR. As such, the abundance of DEPTOR is a critical... 
DESTRUCTION | AKT/PKB | UBIQUITIN LIGASE | PHOSPHORYLATION | PROTEIN-KINASE | DOWNSTREAM | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEX 1 | CELL-CYCLE | AUTOPHAGY | CANCER | CELL BIOLOGY
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 01/2017, Volume 8, p. 61
Journal Article
European Journal of Immunology, ISSN 0014-2980, 08/2015, Volume 45, Issue 8, pp. 2389 - 2395
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2014, Volume 124, Issue 2, pp. 592 - 603
Journal Article
Journal Article