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Journal of Neuroscience, ISSN 0270-6474, 12/2005, Volume 25, Issue 49, pp. 11300 - 11312
Journal Article
Journal Article
Journal Article
Journal of Medicinal Food, ISSN 1096-620X, 03/2012, Volume 15, Issue 3, pp. 231 - 241
This study was carried out to evaluate the anticancer effects of guava leaf extracts and its fractions. The chemical compositions of the active extracts were... 
Full Communications | Guava leaves | Prostate cancer | AKT/mammalian target of rapamycin/ribosomal p70 S6 kinase | Apoptosis | MAMMALIAN TARGET | PHOSPHATIDYLINOSITOL 3-KINASE/AKT | ANDROGEN RECEPTOR | AQUEOUS EXTRACT | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | FOOD SCIENCE & TECHNOLOGY | apoptosis | ACTION MECHANISM | prostate cancer | IN-VITRO | NUTRITION & DIETETICS | ANTIMICROBIAL ACTIVITIES | NF-KAPPA-B | guava leaves | LEAF EXTRACT | Plant Extracts - chemistry | Prostatic Neoplasms - metabolism | TOR Serine-Threonine Kinases - metabolism | Antineoplastic Agents, Phytogenic - analysis | Apoptosis - drug effects | Plant Extracts - pharmacology | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Protein Processing, Post-Translational - drug effects | Sesquiterpenes - analysis | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - drug therapy | Plant Leaves - chemistry | Cell Survival - drug effects | Prostatic Neoplasms - pathology | Sesquiterpenes - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - chemistry | Down-Regulation - drug effects | Drug Discovery | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Cell Line, Tumor | Psidium - chemistry | Sesquiterpenes - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Guava | Usage | Care and treatment | Research | Chemical properties | Health aspects | Index Medicus | mammalian target of rapamycin | AKT | ribosomal p70 S6 kinase
Journal Article
Head & Neck, ISSN 1043-3074, 06/2017, Volume 39, Issue 6, pp. 1145 - 1154
Background. Previous genomic studies revealed phosphotidylinositol-3-kinase (PI3K)/Akt pathway mutation in human salivary gland adenoid cystic carcinoma (ACC).... 
prognostic biomarker | salivary gland cancer | adenoid cystic carcinoma | insulin‐like growth factor‐1 receptor (IGF‐1R) | phosphotidylinositol‐3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) | insulin-like growth factor-1 receptor (IGF-1R) | phosphotidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) | SURGERY | HEAD | ACTIVATION | PROTEIN-KINASE B | BREAST-CANCER | PI3K | SIGNALING PATHWAY | CELL-MIGRATION | OTORHINOLARYNGOLOGY | PROGNOSTIC-SIGNIFICANCE | NECK | TRANSCRIPTION FACTOR | Immunohistochemistry | Predictive Value of Tests | Salivary Gland Neoplasms - mortality | Phosphorylation | Salivary Gland Neoplasms - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - genetics | Adult | Female | Retrospective Studies | Intracellular Signaling Peptides and Proteins - genetics | TOR Serine-Threonine Kinases - drug effects | Carcinoma, Adenoid Cystic - drug therapy | Carcinoma, Adenoid Cystic - pathology | Risk Assessment | Signal Transduction | Kaplan-Meier Estimate | Proportional Hazards Models | Sirolimus - pharmacology | Disease-Free Survival | Carcinoma, Adenoid Cystic - mortality | Salivary Gland Neoplasms - drug therapy | Carcinoma, Adenoid Cystic - genetics | Survival Analysis | Aged | Biopsy, Needle | Salivary Gland Neoplasms - pathology | Proto-Oncogene Proteins c-akt - drug effects | Genetic research | Carcinoma | Cancer | TOR protein | Adenoid | Insulin-like growth factor I | Glands | Salivary gland | AKT protein | Insulin-like growth factors | Rapamycin | Nuclei | Insulin | Survival | 1-Phosphatidylinositol 3-kinase | Neck | Cytoplasm | Index Medicus
Journal Article
Journal of Pain, ISSN 1526-5900, 2012, Volume 13, Issue 4, pp. 338 - 349
Journal Article
Journal Article
Cancer Prevention Research, ISSN 1940-6207, 12/2010, Volume 3, Issue 12, pp. 1586 - 1595
Journal Article
Oncology Letters, ISSN 1792-1074, 05/2018, Volume 15, Issue 5, pp. 6257 - 6264
Rapamycin is known to inhibit the mammalian target of rapamycin complex (mTORC)1 signaling pathway, but it is unable to effectively inhibit mTORC2, resulting... 
Rapamycin | MM1.S cells | Multiple myeloma | Resveratrol | CANCER-CELLS | APOPTOSIS | multiple myeloma | KINASE | ONCOLOGY | SIGNALING PATHWAY | THERAPEUTIC TARGET | GROWTH | RICTOR | MTOR INHIBITORS | resveratrol | EXPRESSION | PHOSPHATIDYLINOSITOL 3-KINASE/AKT/MAMMALIAN TARGET | rapamycin
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 02/2015, Volume 14, Issue 2, pp. 395 - 406
The mammalian target of rapamycin (mTOR) is a serine/ threonine protein kinase that exists in two complexes (mTORC1 and mTORC2) and integrates extracellular... 
MAMMALIAN TARGET | SYNOVIAL SARCOMA | MESSENGER-RNA TRANSLATION | ACTIVATION | ONCOLOGY | AKT/MAMMALIAN TARGET | EMBRYONAL RHABDOMYOSARCOMA | CELL-CYCLE | COMPLEX 2 | RAPAMYCIN PATHWAY | P70 S6 KINASE | Osteosarcoma - drug therapy | Benzoxazoles - pharmacology | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Antineoplastic Agents - therapeutic use | Mechanistic Target of Rapamycin Complex 2 | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Adenosine Triphosphate - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Protein Kinase Inhibitors - chemistry | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Disease Models, Animal | Benzoxazoles - therapeutic use | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Down-Regulation - drug effects | Sarcoma - drug therapy | Sirolimus - pharmacology | Xenograft Model Antitumor Assays | Animals | Benzoxazoles - chemistry | Substrate Specificity - drug effects | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Index Medicus | mTOR | Rapamycin | MLN0128
Journal Article
Journal Article