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NATURE CELL BIOLOGY, ISSN 1465-7392, 11/2013, Volume 15, Issue 11, pp. 1340 - U182
The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally... 
RAPTOR | ACTIVATION | AKT/PKB | PATHWAY | SUBSTRATE | GROWTH | PHOSPHOPROTEOME REVEALS | RICTOR | CELL-SURVIVAL | CANCER | CELL BIOLOGY
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 03/2009, Volume 69, Issue 5, pp. 1821 - 1827
The mammalian target of rapamycin (mTOR) serine/threonine kinase is the catalytic component of two evolutionarily conserved signaling complexes. mTOR signaling... 
RAPTOR | BINDING PARTNER | ACTIVATION | AKT/PKB | ONCOLOGY | PATHWAY | KINASE | RICTOR | AKT | COMPONENT | IDENTIFICATION
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2019, Volume 164, pp. 23 - 33
Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. They are generally well tolerated, but can cause insulin resistance in... 
Insulin receptor signaling | GLUT4 | Glucose transport | Insulin | Simvastatin | Akt/PKB
Journal Article
Nature Communications, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, pp. 13267 - 13267
Obesity-related insulin resistance represents the core component of the metabolic syndrome, promoting glucose intolerance, pancreatic beta cell failure and... 
AKT/PKB | GENE | MULTIDISCIPLINARY SCIENCES | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 2011, Volume 44, Issue 2, pp. 290 - 303
The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR. As such, the abundance of DEPTOR is a critical... 
DESTRUCTION | AKT/PKB | UBIQUITIN LIGASE | PHOSPHORYLATION | PROTEIN-KINASE | DOWNSTREAM | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEX 1 | CELL-CYCLE | AUTOPHAGY | CANCER | CELL BIOLOGY
Journal Article
02/2013
Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function. The events linking these signals to regulation of β-cell... 
Cell proliferation | Islets of Langer- hans | type 2 | Signal Transductions | Cell cycle | Diabetes Mellitus | AKT/PKB/mTORC1signaling pathway
Web Resource
MOLECULAR & CELLULAR PROTEOMICS, ISSN 1535-9476, 07/2019, Volume 18, Issue 7, pp. 1307 - 1319
The PI3K/AKT signaling pathway is known to regulate a broad range of cellular processes, and it is often altered in several types of cancers. Recently, somatic... 
SYNTHASE | INSULIN | MTORC1 | PROTEIN | AKT/PKB | PHOSPHORYLATION | FOLLICULAR DEVELOPMENT | KINASE | BIOCHEMICAL RESEARCH METHODS | MUTATIONS | EXPRESSION
Journal Article
Cellular Signalling, ISSN 0898-6568, 08/2004, Volume 16, Issue 8, pp. 951 - 957
Protein kinase Bα (PKBα/Akt-1) is a key mediator of multiple signaling pathways involved in angiogenesis, cell proliferation and apoptosis among others. The... 
siRNA | PKCα | Akt/PKB | Endothelial cells
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2017, Volume 7
Although we have shown that avian reovirus (ARV) p17-mediated inhibition of Akt leads to induction of autophagy, the precise mechanisms remain largely unknown.... 
APOPTOSIS | ACTIVATION | PROTEIN | AKT/PKB | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | RICTOR | CELL-GROWTH | AUTOPHAGY | P53
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 8855 - 8855
The discovery of mutations within genes associated with autosomal recessive Parkinson's disease allowed for the identification of PINK1/Parkin regulated... 
OUTER-MEMBRANE | PARKIN | STEM-CELLS | MTORC2 | AKT/PKB | PHOSPHORYLATION | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL DYSFUNCTION | AUTOPHAGY | DROSOPHILA-PINK1
Journal Article
Cellular Signalling, ISSN 0898-6568, 06/2019, Volume 58, pp. 131 - 136
The inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP ), is thought to negatively regulate the critical insulin signaling protein Akt/PKB.... 
Inositol hexakisphosphate kinase 1 | Diphosphoinositol pentakisphosphate/IP7 | Akt/PKB | Pancreatic beta cell | Insulin signaling | Diphosphoinositol pentakisphosphate/IP
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 23, pp. 9126 - 9136
Circadian locomotor output cycles kaput (CLOCK) is a transcription factor that activates transcription of clock-controlled genes by heterodimerizing with BMAL1... 
PROTEIN | DBP | RHYTHMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | MOUSE CLOCK | RECEPTOR | CELL-SURVIVAL | Index Medicus | Editors' Picks | mouse genetics | Akt PKB | phosphorylation | circadian rhythm | substrate specificity
Journal Article
GLIA, ISSN 0894-1491, 04/2007, Volume 55, Issue 6, pp. 604 - 616
We previously reported that extracellular ATP induces membrane ruffling and chernotaxis of microglia and suggested that their induction is mediated by the... 
EXTRACELLULAR ATP | NERVOUS-SYSTEM | CELLS | PROTEIN-KINASE-B | BRAIN-INJURY | RAT MICROGLIA | P2Y12 | AKT/PKB ACTIVATION | NEUROSCIENCES | P2Y RECEPTORS | CULTURED MICROGLIA | IN-VIVO | P2X4 | microglia | ATP | chemotaxis
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7497, pp. 541 - 545
Journal Article
Circulation Research, ISSN 0009-7330, 06/2006, Volume 98, Issue 11, pp. 1390 - 1397
Journal Article