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index medicus (82) 82
humans (67) 67
oncology (43) 43
rapamycin (42) 42
akt (41) 41
animals (41) 41
kinases (38) 38
phosphorylation (36) 36
akt/mammalian target (35) 35
proteins (34) 34
apoptosis (32) 32
mammalian target (32) 32
signal transduction (32) 32
tor serine-threonine kinases - metabolism (32) 32
female (30) 30
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cancer (27) 27
mtor (27) 27
proto-oncogene proteins c-akt - metabolism (24) 24
expression (23) 23
mammalian target of rapamycin (22) 22
activation (21) 21
phosphoinositide 3-kinase-akt-mammalian target (21) 21
signal transduction - drug effects (20) 20
care and treatment (19) 19
cell growth (19) 19
cell line, tumor (19) 19
medicine, research & experimental (19) 19
neurosciences (19) 19
research (19) 19
tor serine-threonine kinases - antagonists & inhibitors (19) 19
studies (18) 18
tor protein (17) 17
genetic aspects (16) 16
middle aged (16) 16
akt protein (15) 15
articles (15) 15
autophagy (15) 15
gene expression (15) 15
sirolimus - pharmacology (15) 15
aged (14) 14
apoptosis - drug effects (14) 14
cell proliferation (14) 14
cell proliferation - drug effects (14) 14
health aspects (14) 14
immunohistochemistry (14) 14
long-term potentiation (14) 14
adult (13) 13
metastasis (13) 13
mice (13) 13
pathway (13) 13
signal transduction - physiology (13) 13
signaling pathway (13) 13
synaptic plasticity (13) 13
tor serine-threonine kinases - genetics (13) 13
tumors (13) 13
antineoplastic agents - pharmacology (12) 12
cell biology (12) 12
growth (12) 12
pharmacology & pharmacy (12) 12
rodents (12) 12
biochemistry & molecular biology (11) 11
cancer therapies (11) 11
cell cycle (11) 11
medical prognosis (11) 11
1-phosphatidylinositol 3-kinase (10) 10
article (10) 10
chemotherapy (10) 10
development and progression (10) 10
phosphatidylinositol 3-kinases - metabolism (10) 10
physiological aspects (10) 10
tor serine-threonine kinases (10) 10
akt/mammalian target of rapamycin pathway (9) 9
analysis (9) 9
inflammation (9) 9
prognosis (9) 9
rats (9) 9
translation (9) 9
breast cancer (8) 8
carcinoma, squamous cell - metabolism (8) 8
carcinoma, squamous cell - pathology (8) 8
cell survival - drug effects (8) 8
inhibition (8) 8
mammalian target of rapamycin pathway (8) 8
protein-synthesis (8) 8
proto-oncogene proteins c-akt - antagonists & inhibitors (8) 8
proto-oncogene proteins c-akt - genetics (8) 8
angiogenesis (7) 7
cellular signal transduction (7) 7
gene expression regulation, neoplastic (7) 7
head and neck neoplasms - genetics (7) 7
in-vitro (7) 7
mtor inhibitors (7) 7
p70 s6 kinase (7) 7
phosphatidylinositol 3-kinase (7) 7
proliferation (7) 7
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Nature Reviews Neurology, ISSN 1759-4758, 07/2016, Volume 12, Issue 7, pp. 379 - 392
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2019, Volume 234, Issue 4, pp. 4068 - 4080
Asthma is characterized by chronic inflammation, and long‐term chronic inflammation leads to airway remodeling. But the potential regulatory mechanism of... 
asthma | phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) | microRNA (miRNA) | airway remodeling | phosphoinositide 3 kinase (PI3K) | FIBROSIS | CELLS | PHYSIOLOGY | protein kinase B (Akt) | mammalian target of rapamycin (mTOR) | RECEPTOR | PROLIFERATION | CELL BIOLOGY | BIOMARKERS | DISEASES | INFLAMMATION | IMPROVES | Receptor, IGF Type 1 - metabolism | Asthma - prevention & control | TOR Serine-Threonine Kinases - metabolism | Actins - metabolism | Myocytes, Smooth Muscle - pathology | MicroRNAs - metabolism | Airway Resistance | Actins - genetics | Lung - enzymology | Female | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Disease Models, Animal | Ovalbumin | Lung - pathology | Asthma - physiopathology | Signal Transduction | Myocytes, Smooth Muscle - enzymology | Asthma - enzymology | Cells, Cultured | Gene Expression Regulation | Lung - physiopathology | Receptor, IGF Type 1 - genetics | Asthma - chemically induced | Airway Remodeling | Animals | Mice, Inbred BALB C | MicroRNAs - genetics | TOR protein | Post-transcription | Animal models | Smooth muscle | Intracellular signalling | AKT protein | mRNA | Insulin-like growth factors | Remodeling | Kinases | Respiratory tract | Proteins | Signal transduction | Actin | Cascades | miRNA | Therapeutic applications | Muscles | Rapamycin | Ribonucleic acid--RNA | Gene expression | Asthma | 1-Phosphatidylinositol 3-kinase | Polymerase chain reaction | Regulatory mechanisms (biology)
Journal Article
Oncology Reports, ISSN 1021-335X, 12/2018, Volume 40, Issue 6, pp. 3235 - 3248
Capsaicin (8-methyl N-vanillyl-6 nonenamide) is a natural plant extract that has antitumor properties and induces apoptosis and autophagy in various types of... 
Epidermal growth factor receptor/phosphoinositide 3 kinase/Akt/mammalian target of rapamycin signaling | Capsaicin | Sorafenib | Hepatocellular carcinoma | Metastasis | Autophagy | Invasion | Apoptosis | ACTIVATION | autophagy | sorafenib | INDUCED APOPTOSIS | PHOSPHORYLATION | epidermal growth factor receptor | apoptosis | CELL-CYCLE ARREST | Akt | mammalian target of rapamycin signaling | MTOR | invasion | ONCOLOGY | metastasis | PATHWAY | capsaicin | PROSTATE-CANCER | hepatocellular carcinoma | phosphoinositide 3 kinase | MOTILITY | Cell Survival - drug effects | Sorafenib - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | ErbB Receptors - metabolism | TOR Serine-Threonine Kinases - metabolism | Capsaicin - pharmacology | Humans | Liver Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - metabolism | Sorafenib - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Capsaicin - administration & dosage | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Carcinoma, Hepatocellular - drug therapy | Signal Transduction - drug effects | Liver Neoplasms - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Hepatocellular - metabolism
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2014, Volume 460, Issue 1, pp. 35 - 47
GDF15 (growth/differentiation factor 15), a novel member of the TGF beta (transforming growth factor beta) superfamily, plays critical roles in the central and... 
Cerebellar granule neuron (CGN) | Akt/mammalian target of rapamycin (mtor) | Kv2.1 | Growth/differentiation factor 15 (GDF15) | delayed-rectifier outward K+ current (I-K) | BIOCHEMISTRY & MOLECULAR BIOLOGY | growth/differentiation factor 15 (GDF15) | TGF-BETA SUPERFAMILY | RECEPTOR | MECHANISMS | cerebellar granule neuron (CGN) | INSULIN | GDF-15/MIC-1 | Akt/mammalian target of rapamycin (mTOR) | NEURONS | CHANNELS | FACTOR-15/MACROPHAGE INHIBITORY CYTOKINE-1 | 2-IODOMELATONIN PREVENTS APOPTOSIS | EXPRESSION | Animals, Newborn | Protein-Serine-Threonine Kinases - physiology | Humans | Oncogene Protein v-akt - physiology | Cells, Cultured | Growth Differentiation Factor 15 - physiology | Rats | Signal Transduction - genetics | Receptors, Transforming Growth Factor beta - physiology | Cerebellum - physiology | Rats, Sprague-Dawley | Shab Potassium Channels - metabolism | Animals | Cerebellum - cytology | TOR Serine-Threonine Kinases - physiology | MEK, MAPK | delayed-rectifier outward K+ current (IK) | IK, delayed-rectifier outward K+ current | PI3K, phosphoinositide 3-kinase | TGFβ, transforming growth factor β | R-Smad, receptor-regulated Smad | CHX, cycloheximide | ERK kinase | MIC-1, macrophage inhibitory cytokine-1 | NP40, Nonidet P40 | DIC, days in culture | TTX, tetrodotoxin | ERK, extracellular-signal-regulated kinase | qPCR, quantitative real-time PCR | CGN, cerebellar granule neuron | mTOR, mammalian target of rapamycin | TGFβR, TGFβ receptor | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | mammalian target of rapamycin (mTOR) | GDF15, growth | Akt | IA, fast-transient outward K+ current | DMEM, Dulbecco’s modified Eagle’s medium | differentiation factor 15 (GDF15) | growth | 4-AP, 4-aminopyridine | differentiation factor 15 | MAPK, mitogen-activated protein kinase | PKA, protein kinase A
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2014, Volume 130, Issue 2, pp. 172 - 184
The mammalian (or mechanistic) target of rapamycin (mTOR) complex 1 (mTORC1) is a serine and threonine kinase that regulates cell growth, survival, and... 
alcohol | drugs of abuse | mTOR | translation | limbic system | addiction | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOINOSITIDE 3-KINASE-AKT-MAMMALIAN TARGET | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | TERM SYNAPTIC PLASTICITY | VENTRAL TEGMENTAL AREA | TRANSLATIONAL CONTROL | RAPAMYCIN SIGNALING PATHWAY | NEUROPSYCHIATRIC DISORDERS | INDUCED PLACE PREFERENCE | DENDRITIC PROTEIN-SYNTHESIS | Immunosuppressive Agents | Sirolimus | Humans | Adaptation, Physiological - drug effects | Multiprotein Complexes - genetics | Substance-Related Disorders - genetics | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | RNA, Messenger - biosynthesis | TOR Serine-Threonine Kinases - genetics | Synaptic Transmission - drug effects | TOR Serine-Threonine Kinases - physiology | Neurons - drug effects | TOR Serine-Threonine Kinases - drug effects | Multiprotein Complexes - drug effects | RNA, Messenger - genetics | Signal Transduction - genetics | Substance-Related Disorders - physiopathology | Multiprotein Complexes - physiology | Behavior - drug effects | Animals | Substance-Related Disorders - psychology | Protein Biosynthesis - drug effects | Signal Transduction - physiology | Street Drugs - pharmacology | Drugs and athletes | Illegal drugs | Drug abuse | Neurochemistry | Medical research | Substance abuse treatment | Pharmacology | Kinases
Journal Article