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Gut, ISSN 0017-5749, 11/2004, Volume 53, Issue 11, pp. 1646 - 1651
Objective: To evaluate the safety and efficacy of an enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule, after 1, 3,... 
INTERCELLULAR-ADHESION MOLECULE-1 | INFLAMMATORY-BOWEL-DISEASE | THERAPY | CROHNS-DISEASE | LFA-1 | TRANSENDOTHELIAL MIGRATION | OLIGODEOXYNUCLEOTIDE | PLACEBO-CONTROLLED TRIAL | GASTROENTEROLOGY & HEPATOLOGY | 5-AMINOSALICYLIC ACID | ICAM-1 ANTISENSE OLIGONUCLEOTIDE | Severity of Illness Index | Double-Blind Method | Oligodeoxyribonucleotides, Antisense - administration & dosage | Thionucleotides - therapeutic use | Intercellular Adhesion Molecule-1 - immunology | Humans | Middle Aged | Gastrointestinal Agents - administration & dosage | Oligodeoxyribonucleotides, Antisense - therapeutic use | Male | Treatment Outcome | Phosphorothioate Oligonucleotides | Enema | Dose-Response Relationship, Drug | Thionucleotides - administration & dosage | Gastrointestinal Agents - therapeutic use | Oligodeoxyribonucleotides, Antisense - adverse effects | Adult | Female | Thionucleotides - adverse effects | Gastrointestinal Agents - adverse effects | Colitis, Ulcerative - drug therapy | Care and treatment | Research | Gastroenterology | Ulcerative colitis | Inflammatory bowel disease | Rodents | Neutrophils | Clinical trials | Colon | Bioavailability | Endoscopy | Retention | Drug dosages | Chemokines | Pharmaceuticals | enema | alicaforsen | ulcerative colitis | Inflammatory Bowel Disease | intercellular adhesion molecule 1 | antisense oligonucleotide
Journal Article
Inflammatory Bowel Diseases, ISSN 1078-0998, 05/2015, Volume 21, Issue 7, pp. 1719 - 1736
Journal Article
Journal Article
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 05/2019, Volume 2019, Issue 5, p. CD001176
Journal Article
Inflammatory Bowel Diseases, ISSN 1078-0998, 01/2019, Volume 25, Issue 2, pp. 270 - 282
Abstract After 20 years of successful targeting of pro-inflammatory cytokines for the treatment of IBD, an alternative therapeutic strategy has emerged, based... 
MAdCAM-1 | Crohns | colitis | INTERCELLULAR-ADHESION MOLECULE-1 | CROHNS-DISEASE | ULCERATIVE-COLITIS | MAINTENANCE THERAPY | ALICAFORSEN ENEMA | INDUCTION THERAPY | ANTISENSE INHIBITOR | VEDOLIZUMAB INDUCTION | DOUBLE-BLIND | sphingosine-1-phosphate | ulcerative colitis | gut homing | GASTROENTEROLOGY & HEPATOLOGY | 47 Integrin | MEMORY T-CELLS
Journal Article
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 05/2018, Volume 16, Issue 5, pp. 637 - 647.e13
Advances in development of therapeutic agents for ulcerative colitis (UC) have been paralleled by innovations in trial design. It would be useful to identify a... 
RCT | IBD | UCDAI | MCS | COS | CROHNS-DISEASE | MONOCLONAL-ANTIBODY | RANDOMIZED CONTROLLED-TRIAL | ORAL TACROLIMUS FK506 | MAINTENANCE THERAPY | ALICAFORSEN ENEMA | INDUCTION THERAPY | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | JAPANESE PATIENTS | GASTROENTEROLOGY & HEPATOLOGY | Clinical trials | Medicine, Experimental | Medical research | Immunosuppressive agents | Ulcerative colitis
Journal Article
CURRENT PHARMACEUTICAL DESIGN, ISSN 1381-6128, 2019, Volume 25, Issue 1, pp. 19 - 24
Inflammatory Bowel Disease is lifetime chronic progressive inflammatory disease. A considerable portion of patients, do not respond or lose response or... 
CROHNS-DISEASE | ULCERATIVE-COLITIS | Crohn's disease | NATALIZUMAB | PHASE-2 | VEDOLIZUMAB | MAINTENANCE THERAPY | ALICAFORSEN ENEMA | INDUCTION THERAPY | INTEGRINS | gut selectivity | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | ulcerative colitis | Inflammatory Bowel Disease | integrin | Anti-adhesion
Journal Article
Inflammatory Bowel Diseases, ISSN 1078-0998, 03/2015, Volume 21, Issue 5, pp. 1160 - 1165
Journal Article