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Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 728 - 728
The gateway to morphine biosynthesis in opium poppy (Papaver somniferum) is the stereochemical inversion of (S)-reticuline since the enzyme yielding the first... 
SYNTHASE | (S)-TETRAHYDROPROTOBERBERINE OXIDASE | 1,2-DEHYDRORETICULINE | COPTIS-JAPONICA | BIOCHEMISTRY & MOLECULAR BIOLOGY | BENZYLISOQUINOLINE ALKALOID METABOLISM | REDUCTASE | MOLECULAR-CLONING | NOSCAPINE BIOSYNTHESIS | CULTURED-CELLS | MORPHINE ALKALOIDS | Aldehyde Reductase - genetics | Exons | Saccharomyces cerevisiae - genetics | Stereoisomerism | Ligases - genetics | Open Reading Frames | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Morphine - biosynthesis | Carbohydrate Epimerases - antagonists & inhibitors | Papaver - genetics | Opium - chemistry | Benzylisoquinolines - chemistry | Saccharomyces cerevisiae - metabolism | Morphinans - metabolism | Bromoviridae - genetics | Base Sequence | Escherichia coli - metabolism | Gene Expression Regulation, Plant | Aldehyde Reductase - metabolism | Opium - metabolism | Plant Proteins - metabolism | Alkaloids - biosynthesis | Recombinant Proteins - metabolism | Morphinans - chemistry | Oxidation-Reduction | Introns | Morphine - chemistry | Ligases - metabolism | Gene Fusion | Recombinant Proteins - genetics | Aldo-Keto Reductases | Plant Proteins - genetics | Benzylisoquinolines - metabolism | Bromoviridae - metabolism | Escherichia coli - genetics | Cytochrome P-450 Enzyme System - genetics | Papaver - metabolism | Carbohydrate Epimerases - genetics | Alkaloids - chemistry | Carbohydrate Epimerases - metabolism | Plant biology | Enzymes | Biosynthesis | Flowers & plants | Narcotics
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e108789 - e108789
Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of... 
SECONDARY METABOLISM | COPTIS-JAPONICA | MEDICAGO-TRUNCATULA | CATHARANTHUS-ROSEUS | MULTIDISCIPLINARY SCIENCES | PLANT-CELLS | ARABIDOPSIS | BINDING CASSETTE PROTEIN | MEMBRANE-TRANSPORT | ALKALOID METABOLISM | TOBACCO | Plant Cells - microbiology | Saccharomyces cerevisiae - drug effects | Gene Expression Profiling | Phylogeny | RNA, Messenger - metabolism | Nicotine - pharmacology | Saccharomyces cerevisiae - metabolism | Plant Proteins - classification | Alkaloids - metabolism | Cell Membrane - metabolism | Plant Proteins - metabolism | Plant Roots - metabolism | Tobacco - metabolism | Cyclopentanes - pharmacology | Up-Regulation - drug effects | Plant Proteins - genetics | Anabasine - metabolism | Nicotine - metabolism | Pyridines - metabolism | Plant Leaves - metabolism | Flavonoids - metabolism | Oxylipins - pharmacology | Plant Cells - drug effects | Vacuoles - metabolism | Acetates - pharmacology | Flavonoids | Flavones | RNA | Bioflavonoids | Analysis | Physiological aspects | Fluorescence | Nicotine | Yeast | Xylem | Laboratories | Amino acids | Biochemistry | Plants (organisms) | Biosynthesis | Tissues | Proteins | Alkaloids | Leaves | Metabolites | Cell cycle | Jasmonic acid | Pharmaceutical sciences | Translocation | Cloning | Dentistry | Metabolism | Gene expression | Methyl jasmonate | Tobacco | Extrusion | Herbivores | Transport | Transporter | Vacuoles | Index Medicus
Journal Article
PLoS Biology, ISSN 1544-9173, 02/2017, Volume 15, Issue 2, p. e1002597
Obesity develops when caloric intake exceeds metabolic needs. Promoting energy expenditure represents an attractive approach in the prevention of this... 
ACTIVATED PROTEIN-KINASE | FATTY-ACID OXIDATION | MITOCHONDRIAL BIOGENESIS | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | COACTIVATOR PGC-1 | BIOLOGY | FIBER-TYPE | AMPK | ENERGY-METABOLISM | INSULIN SENSITIVITY | AMARYLLIDACEAE ISOCARBOSTYRILS | AMP-Activated Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Obesity - drug therapy | Diet - adverse effects | Humans | Male | Muscle, Skeletal - metabolism | Muscle Fibers, Slow-Twitch - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Muscle Fibers, Slow-Twitch - drug effects | Protective Agents - therapeutic use | Membrane Potential, Mitochondrial - drug effects | Phenanthridines - pharmacology | Protective Agents - pharmacology | Adenosine Triphosphate - metabolism | Diet, High-Fat | Muscle, Skeletal - drug effects | Cell Respiration - drug effects | Oxidation-Reduction - drug effects | Cyclic AMP - metabolism | Fatty Acids - metabolism | Physical Conditioning, Animal | Biomarkers - metabolism | Phenanthridines - therapeutic use | Mice, Inbred C57BL | Cells, Cultured | Amaryllidaceae Alkaloids - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Obesity - metabolism | Animals | Signal Transduction - drug effects | Amaryllidaceae Alkaloids - therapeutic use | Mice | Adenosine Diphosphate - metabolism | Energy Metabolism - drug effects | Obesity | Statistical analysis | Laboratories | Colleges & universities | Biology | Kinases | Metabolism | Fatty acids | Proteins | Medicine | Consortia | Musculoskeletal system | Weight control | Rodents | Spectrum analysis | Stem cells | Expenditures | Life sciences | Respiration | Bioinformatics
Journal Article
Nature Reviews Microbiology, ISSN 1740-1526, 12/2005, Volume 3, Issue 12, pp. 937 - 947
Journal Article
Nature, ISSN 0028-0836, 11/2010, Volume 468, Issue 7322, pp. 461 - 467
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e25436
Aims: Berberine, a botanical alkaloid purified from Coptidis rhizoma, is reported to activate the AMP-activated protein kinase (AMPK). Whether AMPK is required... 
SKELETAL-MUSCLE | OXYGEN SPECIES PRODUCTION | MITOCHONDRIAL BIOGENESIS | ENDOTHELIAL-CELLS | IN-VIVO | BIOLOGY | TRADITIONAL CHINESE MEDICINE | SMOOTH-MUSCLE-CELLS | HYDROGEN-PEROXIDE | GLUCOSE-UPTAKE | INSULIN SENSITIVITY | Transcription, Genetic - drug effects | AMP-Activated Protein Kinases - metabolism | Berberine - administration & dosage | Apolipoproteins E - deficiency | Cholesterol - blood | Humans | Ion Channels - genetics | Mitochondrial Proteins - genetics | Protein Transport - drug effects | Aorta - metabolism | Aldehydes - metabolism | Threonine - metabolism | Tyrosine - analogs & derivatives | Mitochondrial Proteins - metabolism | Phosphorylation - drug effects | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Plaque, Atherosclerotic - metabolism | Aorta - drug effects | Mitochondrial Proteins - biosynthesis | Enzyme Activation - drug effects | Serine - metabolism | AMP-Activated Protein Kinases - chemistry | Atherosclerosis - metabolism | Aorta - pathology | Atherosclerosis - blood | Up-Regulation - drug effects | Berberine - pharmacology | Intercellular Adhesion Molecule-1 - metabolism | Tyrosine - metabolism | Animals | Ion Channels - metabolism | Triglycerides - blood | Mice | Uncoupling Protein 2 | Berberine - therapeutic use | Blood Glucose - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Acetyl-CoA Carboxylase - metabolism | Acetyl-CoA Carboxylase - chemistry | Alkaloids | RNA | Atherosclerosis | Biosynthesis | Cardiovascular diseases | Protein kinases | Endothelium | Health sciences | Oxidative stress | Mitochondrial uncoupling protein 2 | Atherogenesis | Homeostasis | mRNA | Kinases | AMP-activated protein kinase | Cell adhesion & migration | Proteins | Mitochondria | Reduction | Hyperglycemia | Chinese medicine | Transfection | Apolipoprotein E | Rodents | Aorta | Physiology | Lesions | Heart diseases | Berberine | Immunoglobulins | AMP | siRNA | Metabolism | Gene expression | Endothelial cells | Studies | Diet | Arteriosclerosis | Nitric oxide | In vivo methods and tests | Diabetes | Umbilical vein | Veins & arteries
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 14, pp. 5891 - 5896
Journal Article
12.