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Drugs, ISSN 0012-6667, 10/2012, Volume 72, Issue 14, pp. 1929 - 1950
Bendamustine (Levact registered ) is an alkylating agent consisting of three structural elements: a 2-chloroethylamine alkylating group; a butyric acid side... 
Alkylating agents
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 10/2013, Volume 48, Issue 2, pp. 274 - 280
T-type calcium channels in the dorsal root ganglia (DRG) have a central function in tuning neuronal excitability and are implicated in sensory processing... 
Alkylating agents
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 08/2012, Volume 19, Issue 23, pp. 3922 - 3936
Cancer treatments often lose their effectiveness due to the development of multiple drug resistance. Thus, identification of key proteins involved in the... 
Alkylating agents
Journal Article
Neurological Research, ISSN 0161-6412, 10/2013, Volume 35, Issue 8, pp. 879 - 882
The DNA repair enzyme O6-methylguanine methyltransferase (MGMT) is a major determinant of glioma resistance to alkylating agents. Several strategies have been... 
Alkylating agents
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 09/2010, Volume 402, Issue 1, pp. 70 - 82
Even though DNA alkylating agents have been used for many decades in the treatment of cancer, it remains unclear what happens when replication forks encounter... 
Alkylating agents
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2010, Volume 80, Issue 9, pp. 1317 - 1325
O super(6)-Alkylguanine-DNA alkyltransferase (AGT) mediates tumor resistance to alkylating agents that generate guanine O super(6)-chloroethyl (Onrigin[TM] and... 
Alkylating agents
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 12/2010, Volume 649, Issue 1-3, pp. 161 - 167
GABA sub(B) receptors decrease the release of GABA from the striatal terminals within the pars reticulata of the substantia nigra by opposing the increase in... 
Alkylating agents
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 01/2011, Volume 9, Issue 7, pp. 2065 - 2068
C6-Alkylated purine analogues were obtained in good to excellent isolated yields by SNAr reaction of 6-chloropurine derivatives with 3-alkyl-acetylacetone.... 
Alkylating agents
Journal Article
Central Nervous System Agents in Medicinal Chemistry, ISSN 1871-5249, 06/2013, Volume 13, Issue 2, pp. 114 - 121
Tumors of the central nervous system are the third most common type of childhood cancers. Brain tumors occur in children and adults; however pediatric patients... 
Alkylating agents
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 07/2009, Volume 17, Issue 14, pp. 5117 - 5125
In our aim to develop LacZ reporter probes with a good retention in LacZ expressing cells, we report the synthesis and preliminary evaluation of two carbon-11... 
Alkylating agents
Journal Article
BBA - Reviews on Cancer, ISSN 0304-419X, 08/2012, Volume 1826, Issue 1, pp. 71 - 82
Gliomas are the most frequent adult primary brain tumor, and are invariably fatal. The most common diagnosis glioblastoma multiforme (GBM) afflicts 12,500 new... 
Biomarker | Chemotherapy resistance | Glioma | MGMT | Alkylating agents | Glioblastoma
Journal Article
Aquatic Toxicology, ISSN 0166-445X, 10/2019, Volume 215, p. 105288
Pharmaceuticals are used in medical treatment on a large scale and as a waste contaminate freshwater ecosystems. Growing amount of so-called civilization... 
Proteome | Cyclophosphamide | Life history | Alkylating agents | Cisplatin | Pharmaceuticals
Journal Article
Carcinogenesis, ISSN 0143-3334, 04/2008, Volume 29, Issue 4, pp. 790 - 796
We have shown that dietary fish oil and pectin (FP) protects against radiation-enhanced colon cancer by upregulating apoptosis in colonic mucosa. To... 
Alkylating agents
Journal Article
PLoS ONE, 06/2013, Volume 8, Issue 6
The breast cancer 1 (BRCA1) protein is a tumor suppressor playing roles in DNA repair and cell cycle regulation. Studies of DNA repair functions of BRCA1 have... 
Alkylating agents
Journal Article
PLoS ONE, 03/2013, Volume 8, Issue 3
MGMT downregulation in high-grade gliomas (HGG) has been mostly attributed to aberrant promoter methylation and is associated with increased sensitivity to... 
Alkylating agents
Journal Article
02/2015, Volume 5, Issue 26, pp. 239 - 2338
The non-communicable disease, cancer, is one of the major causes of death across the world and is forecast to increase by 75% to reach close to 25 million... 
Journal Article
RSC Advances, ISSN 2046-2069, 2015, Volume 5, Issue 26, pp. 20309 - 20338
The non-communicable disease, cancer, is one of the major causes of death across the world and is forecast to increase by 75% to reach close to 25 million... 
BIOREDUCTIVE ALKYLATING-AGENTS | ANTITUMOR ANTIBIOTICS | OXIDOREDUCTASE DT-DIAPHORASE | 1,4-NAPHTHOQUINONE DERIVATIVES | MANSONONE-F | ABC TRANSPORTERS | DNA TOPOISOMERASE-I | MULTIDRUG-RESISTANCE MDR | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | FREE-RADICALS
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 03/2009, Volume 27, Issue 8, pp. 1262 - 1267
Purpose This phase II trial was designed to define the role of O-6- benzylguanine (O-6-BG) in restoring temozolomide sensitivity in patients with recurrent or... 
GLIOBLASTOMA | METHYLTRANSFERASE | POTENTIATION | ONCOLOGY | ALKYLATING-AGENTS | BCNU | SENSITIVITY | MISMATCH REPAIR | O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ACTIVITY | HUMAN TUMOR-CELLS | CARMUSTINE
Journal Article
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