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1. Bendamustine: A Review of its Use in the Management of Chronic Lymphocytic Leukaemia, Rituximab-Refractory Indolent Non-Hodgkin's Lymphoma and Multiple Myeloma
by Hoy, Sheridan M
Drugs, ISSN 0012-6667, 10/2012, Volume 72, Issue 14, pp. 1929 - 1950
Bendamustine (Levact registered ) is an alkylating agent consisting of three structural elements: a 2-chloroethylamine alkylating group; a butyric acid side... 
Alkylating agents
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2. Redox Mechanism of S-Nitrosothiol Modulation of Neuronal Ca sub(V)3.2 T-Type Calcium Channels
by Lee, Jeonghan and Nelson, Michael T and Rose, Kirstin E and Todorovic, Slobodan M
Molecular Neurobiology, ISSN 0893-7648, 10/2013, Volume 48, Issue 2, pp. 274 - 280
T-type calcium channels in the dorsal root ganglia (DRG) have a central function in tuning neuronal excitability and are implicated in sensory processing... 
Alkylating agents
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3. Base Excision Repair: Contribution to Tumorigenesis and Target in Anticancer Treatment Paradigms
by L Illuzzi, J and M Wilson III, D
Current Medicinal Chemistry, ISSN 0929-8673, 08/2012, Volume 19, Issue 23, pp. 3922 - 3936
Cancer treatments often lose their effectiveness due to the development of multiple drug resistance. Thus, identification of key proteins involved in the... 
Alkylating agents
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4. MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates and mutant p53
by Vlachostergios, Panagiotis and Hatzidaki, Eleana and Papandreou, Christos
Neurological Research, ISSN 0161-6412, 10/2013, Volume 35, Issue 8, pp. 879 - 882
The DNA repair enzyme O6-methylguanine methyltransferase (MGMT) is a major determinant of glioma resistance to alkylating agents. Several strategies have been... 
Alkylating agents
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5. Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O super(6)-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage
by Groth, Petra and Auslaender, Simon and Majumder, Muntasir Mamun and Schultz, Niklas and Johansson, Fredrik and Petermann, Eva and Helleday, Thomas
Journal of Molecular Biology, ISSN 0022-2836, 09/2010, Volume 402, Issue 1, pp. 70 - 82
Even though DNA alkylating agents have been used for many decades in the treatment of cancer, it remains unclear what happens when replication forks encounter... 
Alkylating agents
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6. Quantitative relationship between guanine O super(6)-alkyl lesions produced by Onrigin[TM] and tumor resistance by O super(6)-alkylguanine-DNA alkyltransferase
by Ishiguro, Kimiko and Zhu, Yong-Lian and Shyam, Krishnamurthy and Penketh, Philip G and Baumann, Raymond P and Sartorelli, Alan C
Biochemical Pharmacology, ISSN 0006-2952, 11/2010, Volume 80, Issue 9, pp. 1317 - 1325
O super(6)-Alkylguanine-DNA alkyltransferase (AGT) mediates tumor resistance to alkylating agents that generate guanine O super(6)-chloroethyl (Onrigin[TM] and... 
Alkylating agents
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7. GABA sub(B) receptors modulate depolarization-stimulated [ super(3)H]glutamate release in slices of the pars reticulata of the rat substantia nigra
by Cortes, Hernan and Paz, Francisco and Erlij, David and Aceves, Jorge and Floran, Benjamin
European Journal of Pharmacology, ISSN 0014-2999, 12/2010, Volume 649, Issue 1-3, pp. 161 - 167
GABA sub(B) receptors decrease the release of GABA from the striatal terminals within the pars reticulata of the substantia nigra by opposing the increase in... 
Alkylating agents
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8. Microwave promoted C6-alkylation of purines through SNAr-based reaction of 6-chloropurines with 3-alkyl-acetylacetone
by Guo, Hai-Ming and Zhang, Yu and Niu, Hong-Ying and Wang, Dong-Chao and Chu, Zhi-Liang and Qu, Gui-Rong
Organic & Biomolecular Chemistry, ISSN 1477-0520, 01/2011, Volume 9, Issue 7, pp. 2065 - 2068
C6-Alkylated purine analogues were obtained in good to excellent isolated yields by SNAr reaction of 6-chloropurine derivatives with 3-alkyl-acetylacetone.... 
Alkylating agents
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9. Mechlorethamine based Drug Structures for Intervention of Central Nervous System Tumors
by Bartzatt, Ronald
Central Nervous System Agents in Medicinal Chemistry, ISSN 1871-5249, 06/2013, Volume 13, Issue 2, pp. 114 - 121
Tumors of the central nervous system are the third most common type of childhood cancers. Brain tumors occur in children and adults; however pediatric patients... 
Alkylating agents
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10. Some aromatic amines, hydrazine and related susbtances, N-nitroso compounds and miscellaneous alkylating agents
International Agency for Research on Cancer . Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man
1974, Volume 4., 286
Alkylating agents -- Carcinogenicity | Amines -- Carcinogenicity | Hydrazines -- Carcinogenicity | Aromatic amines -- Carcinogenicity
Book
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11. Synthesis and biological evaluation of super(11)C-labeled b-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging
by Celen, Sofie and Cleynhens, Jan and Deroose, Christophe and De Groot, Tjibbe and Ibrahimi, Abdelilah and Gijsbers, Rik and Debyser, Zeger and Mortelmans, Luc and Verbruggen, Alfons and Bormans, Guy
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 07/2009, Volume 17, Issue 14, pp. 5117 - 5125
In our aim to develop LacZ reporter probes with a good retention in LacZ expressing cells, we report the synthesis and preliminary evaluation of two carbon-11... 
Alkylating agents
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12. Full Text O6-Methylguanine-DNA methyltransferase in glioma therapy: Promise and problems
by Silber, John R and Bobola, Michael S and Blank, A and Chamberlain, Marc C
BBA - Reviews on Cancer, ISSN 0304-419X, 08/2012, Volume 1826, Issue 1, pp. 71 - 82
Gliomas are the most frequent adult primary brain tumor, and are invariably fatal. The most common diagnosis glioblastoma multiforme (GBM) afflicts 12,500 new... 
Biomarker | Chemotherapy resistance | Glioma | MGMT | Alkylating agents | Glioblastoma
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13. Full Text Anticancer agents found in environment affect Daphnia at population, individual and molecular levels
by Grzesiuk, Małgorzata and Grzesiuk, Elżbieta and Bednarska, Anna and Mielecki, Damian and Garbicz, Damian and Marcinkowski, Michał and Pilžys, Tomaš and Malinowska, Agata and Świderska, Bianka
Aquatic Toxicology, ISSN 0166-445X, 10/2019, Volume 215, p. 105288
Pharmaceuticals are used in medical treatment on a large scale and as a waste contaminate freshwater ecosystems. Growing amount of so-called civilization... 
Proteome | Cyclophosphamide | Life history | Alkylating agents | Cisplatin | Pharmaceuticals
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14. Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPAR delta /PGE sub(2) and elevation of PGE sub(3)
by Vanamala, J and Glagolenko, A and Yang, P and Carroll, RJ and Murphy, ME and Newman, RA and Ford, JR and Braby, LA and Chapkin, RS and Turner, ND and Lupton, JR
Carcinogenesis, ISSN 0143-3334, 04/2008, Volume 29, Issue 4, pp. 790 - 796
We have shown that dietary fish oil and pectin (FP) protects against radiation-enhanced colon cancer by upregulating apoptosis in colonic mucosa. To... 
Alkylating agents
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15. Interaction between DNA Polymerase beta and BRCA1. e66801
by Masaoka, Aya and Gassman, Natalie R and Horton, Julie K and Kedar, Padmini S and Witt, Kristine L and Hobbs, Cheryl A and Kissling, Grace E and Tano, Keizo and Asagoshi, Kenjiro and Wilson, Samuel H
PLoS ONE, 06/2013, Volume 8, Issue 6
The breast cancer 1 (BRCA1) protein is a tumor suppressor playing roles in DNA repair and cell cycle regulation. Studies of DNA repair functions of BRCA1 have... 
Alkylating agents
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16. Altered Expression of MGMT in High-Grade Gliomas Results from the Combined Effect of Epigenetic and Genetic Aberrations. e58206
by Ramalho-Carvalho, Joao and Pires, Malini and Lisboa, Susana and Graca, Ines and Rocha, Patricia and Barros-Silva, Joao Diogo and Savva-Bordalo, Joana and Mauricio, Joaquina and Resende, Mario and Teixeira, Manuel R
PLoS ONE, 03/2013, Volume 8, Issue 3
MGMT downregulation in high-grade gliomas (HGG) has been mostly attributed to aberrant promoter methylation and is associated with increased sensitivity to... 
Alkylating agents
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17. Full Text Understanding cancer and the anticancer activities of naphthoquinones - a review
by Wellington, Kevin W
02/2015, Volume 5, Issue 26, pp. 239 - 2338
The non-communicable disease, cancer, is one of the major causes of death across the world and is forecast to increase by 75% to reach close to 25 million... 
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18. Full Text Understanding cancer and the anticancer activities of naphthoquinones-a review
by Wellington, Kevin W
RSC Advances, ISSN 2046-2069, 2015, Volume 5, Issue 26, pp. 20309 - 20338
The non-communicable disease, cancer, is one of the major causes of death across the world and is forecast to increase by 75% to reach close to 25 million... 
BIOREDUCTIVE ALKYLATING-AGENTS | ANTITUMOR ANTIBIOTICS | OXIDOREDUCTASE DT-DIAPHORASE | 1,4-NAPHTHOQUINONE DERIVATIVES | MANSONONE-F | ABC TRANSPORTERS | DNA TOPOISOMERASE-I | MULTIDRUG-RESISTANCE MDR | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | FREE-RADICALS
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19. Full Text Phase II Trial of Temozolomide Plus O-6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma
by Quinn, JA and Jiang, SX and Reardon, DA and Desjardins, A and Vredenburgh, JJ and Rich, JN and Gururangan, S and Friedman, AH and Bigner, DD and Sampson, JH and McLendon, RE and Herndon, JE and Walker, A and Friedman, HS
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 03/2009, Volume 27, Issue 8, pp. 1262 - 1267
Purpose This phase II trial was designed to define the role of O-6- benzylguanine (O-6-BG) in restoring temozolomide sensitivity in patients with recurrent or... 
GLIOBLASTOMA | METHYLTRANSFERASE | POTENTIATION | ONCOLOGY | ALKYLATING-AGENTS | BCNU | SENSITIVITY | MISMATCH REPAIR | O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ACTIVITY | HUMAN TUMOR-CELLS | CARMUSTINE
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20. Biological alkylating agents
: fundamental chemistry and the design of compounds for selective toxicity
by Ross, Walter Charles Joseph, 1918
1962, Cancer monograph series, 232
Alkaloids | Physiological effect
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