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Science, ISSN 0036-8075, 11/2009, Volume 326, Issue 5954, pp. 853 - 858
Virtually all of the 560 human proteases are stored as inactive proenyzmes and are strictly regulated. We report the identification and characterization of the... 
Executioners | T lymphocytes | Molecules | HEK293 cells | B lymphocytes | Cell lines | Cytochromes | Reports | Kidney cells | Viability | Apoptosis | APOPTOSIS | IN-VITRO | CYSTEINE PROTEASE | DOMAIN | INHIBITION | MULTIDISCIPLINARY SCIENCES | MECHANISMS | DEATH | INDUCTION | CASPASE ACTIVATION | ALLOSTERIC SITE | Enzyme Activators - pharmacology | Caspase 6 - metabolism | Pyridines - chemistry | Caspase 3 - chemistry | Granzymes - metabolism | Humans | Caspase 3 - metabolism | Enzyme Precursors - genetics | Imidazoles - chemistry | Benzopyrans - metabolism | Enzyme Activators - metabolism | Small Molecule Libraries - metabolism | Benzopyrans - chemistry | Enzyme Activators - chemistry | Caspase 3 - genetics | Enzyme Precursors - antagonists & inhibitors | Molecular Structure | Benzopyrans - pharmacology | Imidazoles - metabolism | Catalytic Domain | Biocatalysis | Enzyme Inhibitors - metabolism | Enzyme Precursors - chemistry | Signal Transduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Caspase Inhibitors | Small Molecule Libraries - chemistry | Enzyme Precursors - metabolism | Animals | Pyridines - metabolism | Mutagenesis | Caspase 6 - genetics | Cell Line, Tumor | Mice | Pyridines - pharmacology | Enzyme Activation | Kinetics | Caspase 6 - chemistry | Cell Line, Transformed | Chemical properties | Research | Zymogens | Proteases | Identification and classification | Enzymes | Biochemistry | Molecular biology | Index Medicus
Journal Article
Science, ISSN 0036-8075, 3/2013, Volume 339, Issue 6124, pp. 1216 - 1219
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 11, pp. 8340 - 8351
Journal Article
Nature, ISSN 0028-0836, 11/2007, Volume 450, Issue 7170, pp. 712 - 716
Journal Article
Journal Article
Science, ISSN 0036-8075, 7/2003, Volume 301, Issue 5631, pp. 370 - 373
Glucokinase (GK) plays a key role in whole-body glucose homeostasis by catalyzing the phosphorylation of glucose in cells that express this enzyme, such as... 
Circles | Blood glucose | Enzymes | Hepatocytes | Homeostasis | Reports | Glucose tolerance test | Type 2 diabetes mellitus | Diabetes | Insulin | Vehicles | GLUCOSE-HOMEOSTASIS | MUTANTS | MODY-2 | MULTIDISCIPLINARY SCIENCES | LIVER | BETA-CELL | MICE | MUTATIONS | MELLITUS | Enzyme Activators - pharmacology | Islets of Langerhans - drug effects | Rats, Wistar | Stereoisomerism | Allosteric Regulation | Humans | Liver Glycogen - biosynthesis | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Keto Acids - metabolism | Dose-Response Relationship, Drug | Liver - drug effects | Islets of Langerhans - metabolism | Enzyme Activators - chemistry | Drug Evaluation, Preclinical | Insulin Secretion | Carrier Proteins | Recombinant Proteins - metabolism | Glucose Tolerance Test | Liver - metabolism | Mice, Inbred C57BL | Rats | Hypoglycemic Agents - chemistry | Glucokinase - metabolism | Hypoglycemic Agents - pharmacology | Adaptor Proteins, Signal Transducing | Insulin - metabolism | Animals | Proteins - metabolism | Glucose - metabolism | Mice, Obese | Thiazoles - chemistry | Mice | Proteins - pharmacology | Thiazoles - pharmacology | Enzyme Activation | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Glucose metabolism | Care and treatment | Research | Glucose | Drug therapy | Metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2010, Volume 285, Issue 43, pp. 32695 - 32703
Journal Article
Science, ISSN 0036-8075, 08/2017, Volume 357, Issue 6350, pp. 507 - 511
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy homeostasis in eukaryotes. Despite three decades of investigation,... 
HEART | METABOLIC SYNDROME | ENERGY HOMEOSTASIS | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | DISEASE | MECHANISMS | MICE | HEALTH | GLYCOGEN-STORAGE | EXERCISE | Insulin - pharmacology | AMP-Activated Protein Kinases - metabolism | Fasting | Pyridines - chemistry | Imidazoles - adverse effects | Mice, Inbred C57BL | Imidazoles - chemistry | Male | Muscle, Skeletal - metabolism | Imidazoles - pharmacology | Macaca mulatta | Blood Glucose - drug effects | Pyridines - adverse effects | Animals | Glycogen - metabolism | Muscle, Skeletal - drug effects | Cardiomegaly - chemically induced | Glucose - metabolism | Mice | Pyridines - pharmacology | Homeostasis - drug effects | Hypoglycemia - chemically induced | Glucose metabolism | Heart enlargement | Homeostasis | Observations | Protein kinases | Health aspects | Risk factors | Heart | Animal models | Energy levels | Monkeys | Activation | Glucose | Kinases | Eukaryotes | Allosteric properties | Synthesis | Pathways | Energy | Rodents | Heart diseases | Adenosine triphosphate | Enlargement | Adenosine | Adenosine monophosphate | AMP | Complications | Glycogen | Diabetes mellitus | Muscles | Metabolic diseases | Pharmacology | Hypoglycemia | Mammals | Insulin | Skeletal muscle | Energy balance | Protein kinase | Adenosine kinase | Diabetes | ATP | Hypertrophy | Index Medicus
Journal Article
Journal Article