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British Journal of Pharmacology, ISSN 0007-1188, 07/2013, Volume 169, Issue 6, pp. 1252 - 1262
Background and Purpose The 5‐HT3 receptor antagonist palonosetron is an important treatment for emesis and nausea during cancer therapy. Its clinical efficacy... 
cancer therapy | irreversible antagonism | down‐regulation | receptor trafficking | emesis | endocytosis | 5‐HT3 receptor | palonosetron | allosterism | receptor | down-regulation | 5-HT | 5-HYDROXYTRYPTAMINE TYPE-3 RECEPTORS | PROTEIN-KINASE-C | CHEMOTHERAPY-INDUCED NAUSEA | HUMAN PLASMA | PHASE-III | ONDANSETRON | IN-VITRO | MODERATELY EMETOGENIC CHEMOTHERAPY | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | EXPRESSION | 5-HT3 receptor | Receptors, Serotonin, 5-HT3 - chemistry | Allosteric Regulation | Humans | Serotonin 5-HT3 Receptor Antagonists - metabolism | Protein Transport - drug effects | Isoquinolines - pharmacology | Nystatin - pharmacology | Cell Membrane - metabolism | Radioligand Assay | Granisetron - pharmacology | Cell Membrane - drug effects | Isoquinolines - metabolism | Recombinant Proteins - metabolism | Chlorocebus aethiops | Receptors, Serotonin, 5-HT3 - genetics | Endocytosis - drug effects | Quinuclidines - pharmacology | Recombinant Proteins - chemistry | Down-Regulation - drug effects | Hydrazones - pharmacology | Palonosetron | Animals | Antiemetics - metabolism | Receptors, Serotonin, 5-HT3 - metabolism | Granisetron - metabolism | Kinetics | Serotonin 5-HT3 Receptor Antagonists - pharmacology | COS Cells | Quinuclidines - metabolism | Antiemetics - pharmacology | Health aspects | Nausea | Enzyme-linked immunosorbent assay | Binding sites | Research Papers
Journal Article
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2019, Volume 294, Issue 43, pp. 15593 - 15603
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 8, pp. 6433 - 6448
Phosphoinositide-dependent kinase 1 (PDK1) is a critical activator of multiple prosurvival and oncogenic protein kinases and has garnered considerable interest... 
AGC KINASES | ACTIVATION | STRUCTURAL MECHANISM | PROTEIN | SPECIFICITY | PATHWAY | SMALL-MOLECULE INHIBITORS | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR | MUTATIONS | Allosteric Regulation - drug effects | Allosteric Regulation - genetics | Drug Screening Assays, Antitumor - methods | Humans | Catalytic Domain - genetics | Protein-Serine-Threonine Kinases - genetics | Neoplasms - enzymology | Crystallography, X-Ray | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms - drug therapy | Phosphorylation - genetics | Protein Kinase Inhibitors - chemistry | Animals | Neoplasms - genetics | Dogs | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | BENCHMARKS | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | PHOSPHORYLATION | COLONY FORMATION | TUMOR CELLS | 60 APPLIED LIFE SCIENCES | TISSUE CULTURES | GENETICS | IN VITRO | CONVERGENCE | PHOSPHOTRANSFERASES | PROTEINS | Cancer Therapy | Enzyme Inhibitors | Biomarker | Signal Transduction | Protein Kinases | X-ray Crystallography | Allosteric Regulation | Phosphatidylinositol 3-Kinase | Phosphatidylinositol-dependent Kinase-1 (PDK1) | Protein-Drug Interactions | AKT PKB
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 06/2016, Volume 23, Issue 6, pp. 600 - 607
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2007, Volume 282, Issue 44, pp. 31891 - 31899
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2016, Volume 22, Issue 10, pp. 1108 - 1119
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is... 
PROSTATE | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | PHOSPHORYLATION SITES | CELL BIOLOGY | SYNTHASE | METABOLISM | LIPOGENESIS | AMPK | HEPATIC STEATOSIS | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Allosteric Regulation | Humans | Lung Neoplasms - metabolism | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Acetyltransferases - antagonists & inhibitors | Lipid Metabolism - genetics | Pyrimidinones - pharmacology | Acetyl-CoA Carboxylase - antagonists & inhibitors | Lung Neoplasms - genetics | Cell Proliferation - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Thiophenes - pharmacology | Mice, Knockout | Xenograft Model Antitumor Assays | Animals | Lipid Metabolism - drug effects | Cell Proliferation - drug effects | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Fatty Acids - biosynthesis | Synthesis | Growth | Cancer cells | Genetic aspects | Models | Research | Lung cancer, Non-small cell | Fatty acids | Carboxylases | Enzymes | Genetically modified organisms | Genetic engineering | Tumor proteins | Tumors | Animal models | p53 Protein | Xenotransplantation | Lung cancer | Non-small cell lung carcinoma | Pharmacology | LKB1 protein | Allosteric properties | Liability | Acetyl-CoA carboxylase | Lungs | Xenografts | Carboplatin | Inhibition | Dimerization | Viability | Cancer
Journal Article
Cell, ISSN 0092-8674, 07/2014, Volume 158, Issue 3, pp. 534 - 548
Journal Article