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Cancer Cell, ISSN 1535-6108, 09/2014, Volume 26, Issue 3, pp. 414 - 427
MYC proteins are major drivers of cancer yet are considered undruggable because their DNA binding domains are composed of two extended alpha helices with no... 
MECHANISM | ONCOLOGY | HISTONE H3 | PHOSPHORYLATION | N-MYC | DFG FLIP | MLN8237 | THERAPEUTIC TARGETS | A KINASE | NEUROBLASTOMA | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | Phosphorylation | Area Under Curve | Allosteric Regulation | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Aurora Kinase A - antagonists & inhibitors | Aurora Kinase A - metabolism | Pyrimidines - chemistry | Aurora Kinase A - chemistry | Phenylurea Compounds - chemistry | Proteolysis | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | N-Myc Proto-Oncogene Protein | Phenylurea Compounds - pharmacokinetics | Neuroblastoma - pathology | Cell Survival - drug effects | Catalytic Domain | Oncogene Proteins - chemistry | Protein Structure, Secondary | Oncogene Proteins - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Nuclear Proteins - chemistry | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Neuroblastoma - drug therapy | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Mice, Inbred NOD | Mice | Phenylurea Compounds - pharmacology | Protein Processing, Post-Translational | S Phase Cell Cycle Checkpoints - drug effects | Proteins | DNA-ligand interactions | Analysis | Protein binding
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2008, Volume 283, Issue 4, pp. 2042 - 2048
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 2011, Volume 21, Issue 2, pp. 167 - 172
Journal Article
Biochimica et biophysica acta. General subjects, ISSN 0304-4165, 04/2019
Human hemoglobin is an allosteric protein that exerts exquisite control over ligand binding through large-scale conformational changes. The two-state model... 
Journal Article
Nature, ISSN 0028-0836, 11/2018, Volume 563, Issue 7730, pp. 275 - 279
The serotonin 5-HT3 receptor is a pentameric ligand-gated ion channel (pLGIC). It belongs to a large family of receptors that function as allosteric signal... 
ALLOSTERIC MODULATOR | MOLECULAR-DYNAMICS | ACTIVATION | INTERFACE | MECHANISM | 5-HYDROXYTRYPTAMINE | DESENSITIZATION | MULTIDISCIPLINARY SCIENCES | X-RAY-STRUCTURE | NICOTINIC ACETYLCHOLINE-RECEPTOR | AGONIST BINDING | Life Sciences | Biomolecules | Biochemistry, Molecular Biology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 14, pp. 5608 - 5613
Journal Article
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 05/2015, Volume 119, Issue 21, pp. 6389 - 6400
The measured effective torsional rigidities of Single twisted DNAs under Various tensions conflict with theoretical predictions of Motoz and Nelson.(MN) At low... 
ENTROPIC ELASTICITY | ETHIDIUM | TEMPERATURE-DEPENDENCE | ALLOSTERIC TRANSITIONS | FLEXIBILITY | DYNAMICS | CHEMISTRY, PHYSICAL | TORSIONAL RIGIDITY | FREE-ENERGY | DUPLEX DNA | TWIST | Models, Theoretical | Stress, Mechanical | Thermodynamics | DNA - chemistry | Nucleic Acid Conformation
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2014, Volume 136, Issue 13, pp. 5097 - 5105
Journal Article
Biochemistry, ISSN 0006-2960, 01/2013, Volume 52, Issue 2, pp. 310 - 319
It is established that prion protein is the sole causative agent in a number of diseases in humans and animals. However, the nature of conformational changes... 
PATHWAYS | DOMAIN | DISEASES | ALLOSTERIC COMMUNICATION | CONVERSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DYNAMICS | NMR STRUCTURE | MOLECULAR-BASIS | AGGREGATION | HUMAN PRION PROTEIN | Quantitative Biology - Biomolecules
Journal Article