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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 06/2016, Volume 55, Issue 25, pp. 7048 - 7067
Journal Article
CANCER AND METASTASIS REVIEWS, ISSN 0167-7659, 12/2008, Volume 27, Issue 4, pp. 631 - 644
The integrin alpha v beta 3 plays an important role in angiogenesis and tumor metastasis. It is expressed on activated endothelial cells as well as some tumor... 
angiogenesis | alpha v beta 3 | molecular imaging | RGD | CANCER ALPHA(V)-INTEGRIN EXPRESSION | CARBON NANOTUBES | ALPHA(V)BETA EXPRESSION | QUANTUM DOTS | BREAST-CANCER | integrins | RGD PEPTIDE | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | ANGIOGENESIS INHIBITORS | IN-VIVO | VX-2 RABBIT TUMORS
Journal Article
ACCOUNTS OF CHEMICAL RESEARCH, ISSN 0001-4842, 07/2009, Volume 42, Issue 7, pp. 969 - 980
The alpha(v)beta(3)- and alpha(5)beta(1)-integrins play a key role in angiogenesis, the formation of new vessels in tissues that lack them. By serving as... 
BREAST-CANCER | F-18-LABELED RGD | POSITRON-EMISSION-TOMOGRAPHY | BIODISTRIBUTION CHARACTERISTICS | BIOLOGICAL EVALUATION | DRUG DEVELOPMENT | CYCLIC RGDFK DIMER | INTEGRIN ALPHA(V)BETA | TUMOR ANGIOGENESIS | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-V-BETA-3 EXPRESSION
Journal Article
by Niu, J and Li, ZQ
CANCER LETTERS, ISSN 0304-3835, 09/2017, Volume 403, pp. 128 - 137
Journal Article
MATRIX BIOLOGY, ISSN 0945-053X, 07/2017, Volume 60-61, pp. 70 - 85
Integrins mediate cell adhesion to extracellular matrix and transduce signals bidirectionally across the membrane. Integrin alpha(v)beta(3) has been shown to... 
Binding kinetics | ACTIVATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Integrin conformational change | ALPHA | CATCH BONDS | LIGAND BINDING-KINETICS | CELL BIOLOGY | Biomechanics | CELL-SURFACES | ADHESION | Integrin alpha(v)beta | ALPHA-V-BETA-3 | EXTRACELLULAR-MATRIX | VITRONECTIN RECEPTOR | Force regulation
Journal Article
JOURNAL OF NEUROINFLAMMATION, ISSN 1742-2094, 09/2017, Volume 14
Background: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging... 
MICROGLIAL ACTIVATION | GLIAL SCAR | Reactive astrocytes | Amyotrophic lateral sclerosis | Inflammation | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | NEUROSCIENCES | TNF-ALPHA | ATP RELEASE | UP-REGULATION | EXPRESSION | Cell migration | BETA INTEGRIN | BRAIN | Integrins | TRIGGER MOTONEURON DEATH
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 06/2004, Volume 165, Issue 5, pp. 723 - 734
Transforming growth factor-betas (TGF-beta) are secreted as inactive complexes containing the TGF-beta, the TGF-beta propeptide, also called the... 
CELLS | CELL BIOLOGY | TGF-beta | GROWTH-FACTOR-BETA | IN-VITRO | 8-CYSTEINE REPEAT | MESSENGER-RNA | LTBP | ALPHA-V-BETA-6 | INFLAMMATION | TRANSFORMING GROWTH-FACTOR-BETA-1 | EXTRACELLULAR-MATRIX | integrin | alpha(v)beta | EXPRESSION | latent TGF-beta
Journal Article
Journal Article
JACC-CARDIOVASCULAR IMAGING, ISSN 1936-878X, 02/2014, Volume 7, Issue 2, pp. 178 - 187
OBJECTIVES The goal of this study was to evaluate the feasibility of [F-18]Galacto-RGD positron emission tomography (PET)/computed tomography (CT) imaging of... 
plaque | PLAQUE INFLAMMATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOGENESIS | biomarker | molecular imaging | imaging | ALPHA(V)BETA EXPRESSION | POSITRON-EMISSION-TOMOGRAPHY | CANCER-PATIENTS | TRACER F-18-GALACTO-RGD | MICE | carotid stenosis | INTRAPLAQUE HEMORRHAGE | NEOVASCULARIZATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PROGRESSION
Journal Article
by Chen, HJ and Niu, G and Wu, H and Chen, XY
THERANOSTICS, ISSN 1838-7640, 2016, Volume 6, Issue 1, pp. 78 - 92
Molecular imaging for non-invasive assessment of angiogenesisis is of great interest for clinicians because of the wide-spread application of anti-angiogenic... 
RADIATION-DOSIMETRY | MEDICINE, RESEARCH & EXPERIMENTAL | clinical translation | MOYAMOYA-DISEASE | WHOLE-BODY PET/CT | MYOCARDIAL-INFARCTION | F-18-ALFATIDE II | RGD | ALPHA-V-BETA-3 EXPRESSION | Angiogenesis | POSITRON-EMISSION-TOMOGRAPHY | BREAST-CANCER PATIENTS | IN-VIVO EVALUATION | PET | GA-68-PRGD2 PET/CT
Journal Article
THERANOSTICS, ISSN 1838-7640, 2011, Volume 1, pp. 48 - 57
PET imaging of integrin alpha v beta 3 expression has been studied intensely by the academia and recently also by the industry. Imaging of integrin alpha v... 
MEDICINE, RESEARCH & EXPERIMENTAL | RGD PEPTIDES | angiogenesis | CELL-ADHESION | BIODISTRIBUTION | molecular imaging | CANCER ALPHA(V)-INTEGRIN EXPRESSION | ALPHA(V)BETA EXPRESSION | CARBON NANOTUBES | integrin alpha v beta 3 | BREAST-CANCER | F-18-GALACTO-RGD | POSITRON-EMISSION-TOMOGRAPHY | GLY-ASP PEPTIDE | metastasis | PET
Journal Article
DEVELOPMENT, ISSN 0950-1991, 12/2014, Volume 141, Issue 23, pp. 4489 - 4499
Vascular development of the central nervous system and blood-brain barrier (BBB) induction are closely linked processes. The role of factors that promote... 
Integrin alpha V beta 8 | INTEGRIN ALPHA-V-BETA-8-MEDIATED ACTIVATION | Brain | Sprouting | PREMATURE-INFANTS | VESSEL FORMATION | CNS | DEVELOPMENTAL BIOLOGY | Hemorrhage | ALPHA-V INTEGRINS | Angiogenesis | GROWTH-FACTOR-BETA | Mouse | PROTEIN-COUPLED RECEPTOR | ENDOTHELIAL-CELLS | BLOOD-VESSELS | GERMINAL MATRIX | CENTRAL-NERVOUS-SYSTEM | TGF beta
Journal Article
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, ISSN 0887-3585, 11/2009, Volume 77, Issue 2, pp. 359 - 369
There is a critical need for compounds that target cell surface integrin receptors for applications in cancer therapy and diagnosis. We used directed evolution... 
alternative scaffolds | III DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHAGE DISPLAY | CELL-ADHESION | RGD | integrin binding peptides | protein engineering | HUMAN-ANTIBODIES | BIOPHYSICS | ALPHA(V)BETA | IN-VIVO | tumor targeting agents | yeast surface display | STRUCTURAL SCAFFOLD | EXPRESSION | RGD LOOP | directed evolution
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. E10161 - E10168
Human regulatory T cells (Tregs) suppress other T cells by converting the latent, inactive form of TGF-beta 1 into active TGF-beta 1. In Tregs, TGF-beta 1... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | DENDRITIC CELLS | human regulatory T cells | MULTIDISCIPLINARY SCIENCES | LATENT TGF-BETA | integrin alpha V beta 8 | ACTIVE TGF-BETA-1 | TGF-beta | GROWTH-FACTOR-BETA | IMMUNE-SYSTEM | INFLAMMATION | cancer immunotherapy | REGULATORY T-CELLS | MICE | GARP (LRRC32)
Journal Article
by Zhang, JJ and Niu, G and Lang, LX and Li, F and Fan, XR and Yang, XF and Yao, SB and Yan, WG and Huo, L and Chen, LB and Li, ZY and Zhu, ZH and Chen, XY
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 02/2017, Volume 58, Issue 2, pp. 228 - 234
This study aimed to document the first-in-human application of a Ga-68-labeled heterodimeric peptide BBN-RGD (bombesin-RGD) that targets both integrin... 
ANTAGONIST | first-in-human | GUIDELINES | BBN-RGD | MODEL | GRPR | (99M)TECHNETIUM-HYNIC(TRICINE/TPPTS)-ACA-BOMBESIN(7-14) | TUMORS | prostate cancer | integrin alpha(v)beta | PROSTATE-CANCER | LYMPH-NODE | HETERODIMER | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 03/2011, Volume 52, Issue 3, pp. 424 - 430
Arginine-glycine-aspartate (RGD)-binding alpha(v)beta(3)-integrin and alpha(v)beta(5)-integrin play key roles in tumor angiogenesis. We examined an... 
sunitinib | ANGIOGENESIS | RGD peptide | BREAST-CANCER | POSITRON-EMISSION-TOMOGRAPHY | alpha(v)beta-integrin | ALPHA-V-BETA-3 | IN-VIVO | 18F-fluciclatide | TYROSINE KINASE INHIBITOR | INTEGRIN ALPHA(V)BETA | CYCLIC RGD PEPTIDES | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | ENDOTHELIAL GROWTH-FACTOR
Journal Article
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