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ACCOUNTS OF CHEMICAL RESEARCH, ISSN 0001-4842, 07/2009, Volume 42, Issue 7, pp. 969 - 980
The alpha(v)beta(3)- and alpha(5)beta(1)-integrins play a key role in angiogenesis, the formation of new vessels in tissues that lack them. By serving as... 
BREAST-CANCER | F-18-LABELED RGD | POSITRON-EMISSION-TOMOGRAPHY | BIODISTRIBUTION CHARACTERISTICS | BIOLOGICAL EVALUATION | DRUG DEVELOPMENT | CYCLIC RGDFK DIMER | INTEGRIN ALPHA(V)BETA | TUMOR ANGIOGENESIS | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-V-BETA-3 EXPRESSION
Journal Article
by Niu, J and Li, ZQ
CANCER LETTERS, ISSN 0304-3835, 09/2017, Volume 403, pp. 128 - 137
Journal Article
MATRIX BIOLOGY, ISSN 0945-053X, 07/2017, Volume 60-61, pp. 70 - 85
Integrins mediate cell adhesion to extracellular matrix and transduce signals bidirectionally across the membrane. Integrin alpha(v)beta(3) has been shown to... 
Binding kinetics | ACTIVATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Integrin conformational change | ALPHA | CATCH BONDS | LIGAND BINDING-KINETICS | CELL BIOLOGY | Biomechanics | CELL-SURFACES | ADHESION | Integrin alpha(v)beta | ALPHA-V-BETA-3 | EXTRACELLULAR-MATRIX | VITRONECTIN RECEPTOR | Force regulation
Journal Article
Journal Article
by Chen, HJ and Niu, G and Wu, H and Chen, XY
THERANOSTICS, ISSN 1838-7640, 2016, Volume 6, Issue 1, pp. 78 - 92
Molecular imaging for non-invasive assessment of angiogenesisis is of great interest for clinicians because of the wide-spread application of anti-angiogenic... 
RADIATION-DOSIMETRY | MEDICINE, RESEARCH & EXPERIMENTAL | clinical translation | MOYAMOYA-DISEASE | WHOLE-BODY PET/CT | MYOCARDIAL-INFARCTION | F-18-ALFATIDE II | RGD | ALPHA-V-BETA-3 EXPRESSION | Angiogenesis | POSITRON-EMISSION-TOMOGRAPHY | BREAST-CANCER PATIENTS | IN-VIVO EVALUATION | PET | GA-68-PRGD2 PET/CT
Journal Article
THERANOSTICS, ISSN 1838-7640, 2011, Volume 1, pp. 48 - 57
PET imaging of integrin alpha v beta 3 expression has been studied intensely by the academia and recently also by the industry. Imaging of integrin alpha v... 
MEDICINE, RESEARCH & EXPERIMENTAL | RGD PEPTIDES | angiogenesis | CELL-ADHESION | BIODISTRIBUTION | molecular imaging | CANCER ALPHA(V)-INTEGRIN EXPRESSION | ALPHA(V)BETA EXPRESSION | CARBON NANOTUBES | integrin alpha v beta 3 | BREAST-CANCER | F-18-GALACTO-RGD | POSITRON-EMISSION-TOMOGRAPHY | GLY-ASP PEPTIDE | metastasis | PET
Journal Article
JOURNAL OF NEUROINFLAMMATION, ISSN 1742-2094, 09/2017, Volume 14
Background: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging... 
MICROGLIAL ACTIVATION | GLIAL SCAR | Reactive astrocytes | Amyotrophic lateral sclerosis | Inflammation | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | NEUROSCIENCES | TNF-ALPHA | ATP RELEASE | UP-REGULATION | EXPRESSION | Cell migration | BETA INTEGRIN | BRAIN | Integrins | TRIGGER MOTONEURON DEATH
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 03/2011, Volume 52, Issue 3, pp. 424 - 430
Arginine-glycine-aspartate (RGD)-binding alpha(v)beta(3)-integrin and alpha(v)beta(5)-integrin play key roles in tumor angiogenesis. We examined an... 
sunitinib | ANGIOGENESIS | RGD peptide | BREAST-CANCER | POSITRON-EMISSION-TOMOGRAPHY | alpha(v)beta-integrin | ALPHA-V-BETA-3 | IN-VIVO | 18F-fluciclatide | TYROSINE KINASE INHIBITOR | INTEGRIN ALPHA(V)BETA | CYCLIC RGD PEPTIDES | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | ENDOTHELIAL GROWTH-FACTOR
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 10/2005, Volume 46, Issue 10, pp. 1707 - 1718
Integrin alpha(v)beta(3) plays a critical role in tumor-induced angiogenesis and metastasis and has become a promising diagnostic indicator and therapeutic... 
microPET | RGD peptide | TRACERS | CANCER ALPHA(V)-INTEGRIN EXPRESSION | BRAIN-TUMORS | PHARMACOKINETICS | ALPHA-V-BETA-3 | tumor angiogenesis | IN-VIVO | multimeric peptide | INTEGRIN ALPHA(V)BETA | integrin | DOSIMETRY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | VITRONECTIN RECEPTOR | Cu-64
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. E10161 - E10168
Human regulatory T cells (Tregs) suppress other T cells by converting the latent, inactive form of TGF-beta 1 into active TGF-beta 1. In Tregs, TGF-beta 1... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | DENDRITIC CELLS | human regulatory T cells | MULTIDISCIPLINARY SCIENCES | LATENT TGF-BETA | integrin alpha V beta 8 | ACTIVE TGF-BETA-1 | TGF-beta | GROWTH-FACTOR-BETA | IMMUNE-SYSTEM | INFLAMMATION | cancer immunotherapy | REGULATORY T-CELLS | MICE | GARP (LRRC32)
Journal Article
JACC-CARDIOVASCULAR IMAGING, ISSN 1936-878X, 02/2014, Volume 7, Issue 2, pp. 178 - 187
OBJECTIVES The goal of this study was to evaluate the feasibility of [F-18]Galacto-RGD positron emission tomography (PET)/computed tomography (CT) imaging of... 
plaque | PLAQUE INFLAMMATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOGENESIS | biomarker | molecular imaging | imaging | ALPHA(V)BETA EXPRESSION | POSITRON-EMISSION-TOMOGRAPHY | CANCER-PATIENTS | TRACER F-18-GALACTO-RGD | MICE | carotid stenosis | INTRAPLAQUE HEMORRHAGE | NEOVASCULARIZATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PROGRESSION
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 01/2006, Volume 47, Issue 1, pp. 113 - 121
The development of noninvasive methods to visualize and quantify integrin alpha(v)beta(3) expression in vivo appears to be crucial for the success of... 
dynamic microPET | ANGIOGENESIS | MICROPET | TRACERS | Logan plot | molecular imaging | CANCER ALPHA(V)-INTEGRIN EXPRESSION | RGD-PEPTIDE | POSITRON-EMISSION-TOMOGRAPHY | integrin alpha(v)beta | ULTRASOUND | ALPHA-V-BETA-3 | IN-VIVO | GROWTH | dimeric RGD peptide | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
CURRENT OPINION IN CELL BIOLOGY, ISSN 0955-0674, 10/2008, Volume 20, Issue 5, pp. 514 - 519
In the adult, angiogenesis, the formation of new blood vessels from pre-existing vasculature contributes to the pathogenesis of many disorders including... 
ADVANCED SOLID TUMORS | CELL-MIGRATION | GROWTH-FACTOR RECEPTOR-2 | PATHOLOGICAL ANGIOGENESIS | INHIBITOR | PHASE-I | ALPHA-V INTEGRINS | ALPHA(V)BETA INTEGRIN | CILENGITIDE EMD-121974 | MICE LACKING | CELL BIOLOGY
Journal Article
BIOCONJUGATE CHEMISTRY, ISSN 1043-1802, 02/2014, Volume 25, Issue 2, pp. 393 - 405
Journal Article
by Liu, S
MOLECULAR PHARMACEUTICS, ISSN 1543-8384, 09/2006, Volume 3, Issue 5, pp. 472 - 487
Journal Article
by Zhang, JJ and Niu, G and Lang, LX and Li, F and Fan, XR and Yang, XF and Yao, SB and Yan, WG and Huo, L and Chen, LB and Li, ZY and Zhu, ZH and Chen, XY
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 02/2017, Volume 58, Issue 2, pp. 228 - 234
This study aimed to document the first-in-human application of a Ga-68-labeled heterodimeric peptide BBN-RGD (bombesin-RGD) that targets both integrin... 
ANTAGONIST | first-in-human | GUIDELINES | BBN-RGD | MODEL | GRPR | (99M)TECHNETIUM-HYNIC(TRICINE/TPPTS)-ACA-BOMBESIN(7-14) | TUMORS | prostate cancer | integrin alpha(v)beta | PROSTATE-CANCER | LYMPH-NODE | HETERODIMER | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
DEVELOPMENT, ISSN 0950-1991, 02/2014, Volume 141, Issue 4, pp. 795 - 806
Neocortex expansion during evolution is associated with the enlargement of the embryonic subventricular zone, which reflects an increased self-renewal and... 
ALPHA-V-BETA-3 INTEGRIN | DEVELOPMENTAL BIOLOGY | CEREBROSPINAL-FLUID | RADIAL GLIA | PRIMARY CILIUM | NEURAL STEM-CELLS | CEREBRAL-CORTEX DEVELOPMENT | Mouse | OUTER SUBVENTRICULAR ZONE | Cortical neurogenesis | EXTRACELLULAR-MATRIX | Thyroid hormones | FETAL NEOCORTICOGENESIS | Integrins
Journal Article
HEPATOLOGY, ISSN 0270-9139, 11/2009, Volume 50, Issue 5, pp. 1501 - 1511
The vitronectin receptor integrin alpha v beta 3 promotes angiogenesis by mediating migration and proliferation of endothelial cells, but also drives... 
RAT-LIVER | MATRIX METALLOPROTEINASES | ADVANCED SOLID TUMORS | IMPAIRED ANGIOGENESIS | REMNANT KIDNEY MODEL | STELLATE CELLS | BILIARY FIBROSIS | GASTROENTEROLOGY & HEPATOLOGY | ALPHA(V)BETA INTEGRIN | CILENGITIDE EMD-121974 | ENDOTHELIAL GROWTH-FACTOR
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 01/2016, Volume 55, Issue 4, pp. 1535 - 1539
The alpha v beta 6 integrin binds the RGD-containing peptide of the foot and mouth disease virus with high selectivity. In this study, the long binding helix... 
subtype selectivity | ALPHA-HELIX | BETA-HAIRPIN | TGF-BETA | PROTEIN-PROTEIN INTERACTION | CONFORMATIONAL CONTROL | alpha v beta 6 integrin | molecular imaging | MULTIPLE N-METHYLATION | CHEMISTRY, MULTIDISCIPLINARY | CYCLIC-PEPTIDES | cyclic peptides | integrin inhibitors | PHAGE-DISPLAY | AMINO-ACIDS | THERAPEUTIC TARGETS
Journal Article
by Li, ZB and Chen, K and Chen, X
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1619-7070, 06/2008, Volume 35, Issue 6, pp. 1100 - 1108
Purpose We and others have reported that F-18- and Cu-64-labeled arginine-glycine-aspartate (RGD) peptides allow positron emission tomography (PET)... 
Ga-68 | DESIGN | microPET | ANGIOGENESIS | TUMOR | NOTA | RADIOTRACERS | MELANOMA | integrin alpha(v)beta | TRACER | ALPHA-V-BETA-3 | STABILITIES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | multimeric RGD peptides | VITRONECTIN RECEPTOR | PET
Journal Article
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