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alpha,alpha-difluoroarylacetic acids (16) 16
chemistry, organic (11) 11
decarboxylative alkynylation (6) 6
fluorine (6) 6
alkynes (5) 5
carboxylic-acids (4) 4
chemistry, multidisciplinary (4) 4
medicinal chemistry (4) 4
palladium (4) 4
room-temperature (4) 4
alkenes (3) 3
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aryl boronic acids (3) 3
arylboronic acids (3) 3
catalysis (3) 3
complexes (3) 3
fluorination (3) 3
ketones (3) 3
light photoredox catalysis (3) 3
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access (2) 2
aliphatic carboxylic-acids (2) 2
alpha-arylation (2) 2
bisaminosulfur trifluoride (2) 2
c-f bond (2) 2
c-h difluoroalkylation (2) 2
carbon center (2) 2
carbonyl-compounds (2) 2
copper (2) 2
coupling (2) 2
cyclization (2) 2
decarboxylation (2) 2
decarboxylierung (2) 2
difluoroalkylation (2) 2
difluoromethylation (2) 2
efficient access (2) 2
electron-deficient alkenes (2) 2
enhanced thermal-stability (2) 2
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funktionelle gruppe (2) 2
gem-difluoromethylenation (2) 2
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hypervalent iodine (2) 2
organic-compounds (2) 2
photoredox (2) 2
photoredox catalysis (2) 2
spectrum deoxofluorinating agent (2) 2
transformation (2) 2
übergangsmetalle (2) 2
1,4-diynes (1) 1
1st (1) 1
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[ chim ] chemical sciences (1) 1
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acid-derivatives (1) 1
acids (1) 1
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aldehyd (1) 1
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alpha,alpha-difluoromethylated alkynes (1) 1
alpha,beta-unsaturated carboxylic-acids (1) 1
amide (1) 1
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arenes (1) 1
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bearing (1) 1
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boronic acids (1) 1
bridge construction (1) 1
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Angewandte Chemie International Edition, ISSN 1433-7851, 02/2017, Volume 56, Issue 7, pp. 1898 - 1902
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 25, pp. 5308 - 5317
A silver-catalyzed oxidative decarboxylative gem-difluoromethylenation of difluoroacetates with activated alkenes under mild reaction conditions has been... 
ROOM-TEMPERATURE | PALLADIUM | EFFICIENT ACCESS | CARBON CENTER | LIGHT PHOTOREDOX CATALYSIS | CHEMISTRY, ORGANIC | ELECTRON-DEFICIENT ALKENES | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | ARYLBORONIC ACIDS | CARBOXYLIC-ACIDS | GEM-DIFLUOROMETHYLENATION
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 06/2017, Volume 15, Issue 25, pp. 5308 - 5317
A silver-catalyzed oxidative decarboxylative gem-difluoromethylenation of difluoroacetates with activated alkenes under mild reaction conditions has been... 
Journal Article
Organic Letters, ISSN 1523-7060, 05/2017, Volume 19, Issue 10, pp. 2610 - 2613
A palladium-catalyzed Negishi cross-coupling reaction of ethyl bromodifluoroacetate with aryl bromides or aryl triflates to construct C(sp(2))-CF2 bonds is... 
MEDICINAL CHEMISTRY | BORONIC ACIDS | ACID-DERIVATIVES | ROOM-TEMPERATURE | ALPHA-ARYLATION | CHEMISTRY, ORGANIC | COPPER | FLUORINATION | OXIDATIVE ADDITION | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | TRANSMETALATION STEP
Journal Article
Organic Chemistry Frontiers, ISSN 2052-4110, 2018, Volume 5, Issue 5, pp. 797 - 800
Visible-light-mediated tandem radical difluoroalkylation and alkynylation of unactivated alkenes is described in this communication. The process comprises a... 
PALLADIUM-CATALYZED DIFLUOROALKYLATION | VISIBLE-LIGHT | HETEROARENES | ARYL BORONIC ACIDS | PHENANTHRIDINE DERIVATIVES | ARENES | CHEMISTRY, ORGANIC | C-H DIFLUOROALKYLATION | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | ACCESS | CARBOXYLIC-ACIDS | Alkenes | Ketones | Access routes | Migration
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 06/2019, Volume 25, Issue 31, pp. 7453 - 7456
Syntheses of substituted pyridines and fluorinated compounds, which are often pharmaceutical targets, are important objectives in organic chemistry. Herein, we... 
fluorination | pyridine | difluoromethyl group | decarboxylation | methyl ester | SUBSTITUTION | FLUOROKETONES | MECHANISM | DECOMPOSITION | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | ALKYNYLATION | CHEMISTRY, MULTIDISCIPLINARY | HETEROCYCLES | ALIPHATIC CARBOXYLIC-ACIDS | C-H | DIFLUORINATION | Pyridine | Substitutes | Pyridines | Organic chemistry | Lithium | Transformation | Fluorination
Journal Article
ACS Catalysis, ISSN 2155-5435, 01/2017, Volume 7, Issue 1, pp. 896 - 901
Difluoromethylene (CF2)-skipped 1,4-diynes are a versatile synthon in organic synthesis, but efficient methods to access such a fluorinated structural motif... 
1,4-diynes | cross-coupling | palladium | gem-difluoropropargyl bromide | alkynes | ISOMERIZATION | CHEMISTRY, PHYSICAL | TERMINAL ALKYNES | COPPER | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | DECARBOXYLATIVE ALKYNYLATION | ALKENES | CYCLOADDITION | ARYL BORONIC ACIDS | cross-coupling 1,4-diynes | COUPLING REACTIONS
Journal Article
Synthetic Communications, ISSN 0039-7911, 11/2019, Volume 49, Issue 21, pp. 2961 - 2970
The Ag(I)-catalyzed decarboxylative homocoupling from the difluoroacetate has been developed to the synthesis of symmetric CF 2 -CF 2 containing dimers. This... 
tetrafluoroethylene bridge | difluoroacetate | radical dimerization | Decarboxylative homocoupling | OXIDATIVE DECARBOXYLATION | PHOTOREDOX | COMPLEXES | CHEMISTRY, ORGANIC | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | ALKYNYLATION | DIFLUOROACETATES | ALKENES | DIFLUOROMETHYLATION | FLUORINE | CARBOXYLIC-ACIDS
Journal Article
ORGANIC CHEMISTRY FRONTIERS, ISSN 2052-4129, 04/2019, Volume 6, Issue 7, pp. 1022 - 1026
A visible-light-induced acyldifluoroalkylation of unactivated alkenes with difluoroacetic acids as the difluoroalkylation reagent and PhI(OAc)(2) as the... 
C-H DIFLUOROMETHYLATION | ALPHA,BETA-UNSATURATED CARBOXYLIC-ACIDS | PHOTOREDOX | CATALYZED TRIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | RADICAL-ADDITION | DIFLUOROALKYLATION | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | ACCESS | CYCLIZATION | DECARBOXYLATIVE ALKYNYLATION
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2019, Volume 58, Issue 18, pp. 5956 - 5961
Presented herein is an intriguing effect of fluorine, and it allows difluoroenol silyl ethers to couple with aryliodanes in a redox‐neutral manner to afford... 
hypervalent iodine | difluoromethylation | reduction | rearrangements | fluorine | FUNCTIONALIZATIONS | ALPHA-ARYLATION | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | CHEMISTRY, MULTIDISCIPLINARY | MILD | KETONES | IODONIO-CLAISEN REARRANGEMENT | HYPERVALENT | GENERATION | EFFICIENT | Fluorides | Iodides | Ethers | Fluorine | Aromatic compounds | Substrates
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 11/2017, Volume 15, Issue 46, pp. 9830 - 9836
Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to... 
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 04/2017, Volume 2017, Issue 14, pp. 1911 - 1914
A new fluoroalkylmethanesulfenamide reagent was developed to synthesize various molecules bearing the SCF2CO2Me group. Furthermore, the carboxyl function was... 
C–C coupling | Carbonyl compounds | Aromatic substitution | Sulfur | Fluorine | C-C coupling | 1ST | TRIFLUOROMETHYLTHIOLATION | CHEMISTRY, ORGANIC | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | 2ND-GENERATION | DECARBOXYLATIVE ALKYNYLATION | Chemical tests and reagents
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 46, pp. 9830 - 9836
Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to... 
MEDICINAL CHEMISTRY | ENHANCED THERMAL-STABILITY | COMPLEXES | CHEMISTRY, ORGANIC | SPECTRUM DEOXOFLUORINATING AGENT | FLUORINE | C-F BOND | BIS(2-METHOXYETHYL)AMINOSULFUR TRIFLUORIDE | ALKYNES | ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS | DECARBOXYLATIVE ALKYNYLATION | Gold | Transformation | Hydration | Regioselectivity | Difluorides | Catalysis | Fluorination | Alkynes
Journal Article