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HEPATOLOGY, ISSN 0270-9139, 09/2010, Volume 52, Issue 3, pp. 1078 - 1088
Alpha(1)-antitrypsin is the most abundant circulating protease inhibitor. The severe Z deficiency allele (G1u342Lys) causes the protein to undergo a... 
REACTIVE LOOP | DEMENTIA | NEUROSERPIN | FLUORESCENCE | MECHANISM | PIZ-ALPHA-1-ANTITRYPSIN VARIANT | ALPHA-1-ANTITRYPSIN | ACCUMULATION | CONFORMATION | GASTROENTEROLOGY & HEPATOLOGY | SERPIN POLYMERIZATION
Journal Article
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, ISSN 0098-7484, 05/2018, Volume 319, Issue 19, pp. 2034 - 2035
Journal Article
ARTHRITIS & RHEUMATOLOGY, ISSN 2326-5191, 08/2017, Volume 69, Issue 8, pp. 1576 - 1579
Objective. To examine the prevalence of alpha(1)-antitrypsin deficiency (AATD) in rheumatoid arthritis (RA), and to determine whether AATD is associated with... 
ANTIBODIES | DISEASES | PHENOTYPES | SERUM | RHEUMATOLOGY | ALPHA-1-ANTITRYPSIN DEFICIENCY
Journal Article
Medicinskaâ Immunologiâ, ISSN 1563-0625, 12/2016, Volume 18, Issue 6, pp. 537 - 544
Alpha-1-antitrypsin (A1AT) exerts a wide spectrum of protective effects, being focused on reduction of secondary injury in inflammation. Moreover, A1AT... 
cytokine | alpha-1-antitrypsin deficiency | inflammation | alpha-1-antitrypsin | alpha-1-antitrypsin phenotype
Journal Article
EUROPEAN RESPIRATORY JOURNAL, ISSN 0903-1936, 03/2016, Volume 47, Issue 3, pp. 1005 - 1009
Journal Article
Acta Angiologica, ISSN 1234-950X, 04/2018, Volume 24, Issue 1, pp. 30 - 33
Journal Article
Journal of Neurosurgery, ISSN 0022-3085, 05/2008, Volume 108, Issue 5, pp. 1052 - 1060
Object. The authors conducted a study to investigate the long-term natural history of unruptured intracranial aneurysms and the predictive risk factors... 
Cigarette smoking | Unruptured intracranial aneurysm | Subarachnoid hemorrhage | SURGERY | POPULATION | unruptured intracranial aneurysm | CLINICAL NEUROLOGY | CEREBRAL ANEURYSMS | cigarette smoking | CIGARETTE-SMOKING | MULTIPLE ANEURYSMS | subarachnoid hemorrhage | INTRACEREBRAL HEMORRHAGE | ALPHA-1-ANTITRYPSIN | HYPERTENSION | ELECTIVE SURGERY
Journal Article
EUROPEAN RESPIRATORY JOURNAL, ISSN 0903-1936, 01/2017, Volume 49, Issue 1
Journal Article
HUMAN GENE THERAPY, ISSN 1043-0342, 10/2011, Volume 22, Issue 10, pp. 1239 - 1247
Recombinant adeno-associated virus (rAAV) vectors offer promise for the gene therapy of alpha(1)-antitrypsin (AAT) deficiency. in our prior trial, an rAAV... 
MEDICINE, RESEARCH & EXPERIMENTAL | TRANSDUCTION | VIRUS TYPE-1 | DELIVERY | SKELETAL-MUSCLE | AAT VECTOR | THERAPY | SEROTYPE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FACTOR-IX | GENETICS & HEREDITY | GENE-TRANSFER | HUMAN ALPHA-1-ANTITRYPSIN
Journal Article
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, ISSN 1081-1206, 02/2018, Volume 120, Issue 2, pp. 200 - 206
Background: In patients with humoral immunodeficiency, the progression of bronchiectasis has been known to occur despite adequate gammaglobulin therapy and in... 
VARIABLE IMMUNE-DEFICIENCY | VARIANTS | ALLERGY | HYPOGAMMAGLOBULINEMIA | IMMUNOLOGY | ALPHA-1-ANTITRYPSIN DEFICIENCY | MANIFESTATIONS
Journal Article
CHEST, ISSN 0012-3692, 11/2015, Volume 148, Issue 5, pp. E136 - E138
Panniculitis associated with alpha(1)-antitrypsin deficiency (AATD) is well documented but rare. We report the first case, to our knowledge, of successful... 
PANNICULITIS | RESPIRATORY SYSTEM | ALPHA-1-ANTITRYPSIN DEFICIENCY | CRITICAL CARE MEDICINE
Journal Article
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, ISSN 0021-972X, 08/2014, Volume 99, Issue 8, pp. E1418 - E1426
Context: Recent studies have implicated proinflammatory responses in the mechanism of type 1 diabetes (T1D). Objective: Our objective was to evaluate the... 
PATHOGENESIS | INTERLEUKIN-1 | VIRUS | INHIBITION | INFLAMMATION | BETA-CELLS | ENDOCRINOLOGY & METABOLISM | ALPHA-1-ANTITRYPSIN | PROTEINASE-3 | INFECTION | MELLITUS
Journal Article
European Respiratory Journal, ISSN 0903-1936, 06/2016, Volume 47, Issue 6, pp. 1597 - 1599
Respiratory disease can be considered as a species in constant evolution. Due to population growth and ageing only, and apart from the current 1.1 billion... 
RESPIRATORY SYSTEM | DISEASE | OVERLAP | BRONCHIAL HYPERREACTIVITY | ASTHMA | ALPHA-1-ANTITRYPSIN DEFICIENCY | IMMUNODEFICIENCY
Journal Article
CHEST, ISSN 0012-3692, 10/2005, Volume 128, Issue 4, pp. 1989 - 1994
Background and study objectives: alpha(1)-Antitrypsin (AAT) deficiency is common but underrecognized. A 1994 mail survey showed a long delay between the onset... 
RESPIRATORY SYSTEM | diagnosis | survey | alpha-antitrypsin deficiency | ALPHA-1-ANTITRYPSIN DEFICIENCY
Journal Article
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 06/2009, Volume 360, Issue 26, pp. 2749 - 2757
A 60-year-old white man presents for evaluation of progressive dyspnea. He is a former smoker with a 20-pack-year smoking history and a 10-year history of... 
MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | LUNG TRANSPLANTATION | VOLUME-REDUCTION SURGERY | EMPHYSEMA | SEVERE ALPHA-1-ANTITRYPSIN DEFICIENCY | MZ HETEROZYGOTES | LIVER-DISEASE | SINGLE-LUNG | AIR-FLOW OBSTRUCTION | AUGMENTATION THERAPY
Journal Article
Journal of clinical medicine, ISSN 2077-0383, 08/2019, Volume 8, Issue 9, p. 1341
Diffuse alveolar hemorrhage (DAH) is a fatal complication in patients with lupus. DAH can be induced in B6 mice by an intraperitoneal injection of pristane.... 
Lupus | Diffuse alveolar hemorrhage (DAH) | alpha-1-antitrypsin (AAT)
Journal Article
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