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Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6091, pp. 232 - 236
Pharmacological responses of G protein-coupled receptors (GPCRs) can be fine-tuned by allosteric modulators. Structural studies of such effects have been... 
Molecules | Receptors | Sodium | Molecular structure | REPORTS | Lipids | Ligands | Cell membranes | Cholesterols | Water channels | Crystal structure | ANGSTROM CRYSTAL-STRUCTURE | COMPLEX | ANTAGONIST | OPIOID RECEPTOR | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | PROTEIN-COUPLED RECEPTORS | ADENOSINE A(2A) RECEPTOR | ALPHA-2-ADRENERGIC RECEPTORS | MODULATION | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Allosteric Regulation | Humans | Crystallography, X-Ray | Adenosine A2 Receptor Agonists - metabolism | Recombinant Fusion Proteins - metabolism | Cholesterol - chemistry | Adenosine A2 Receptor Antagonists - metabolism | Lipids - chemistry | Lipid Bilayers | Sodium - analysis | HEK293 Cells | Protein Engineering | Water - chemistry | Triazines - metabolism | Protein Structure, Secondary | Models, Molecular | Receptor, Adenosine A2A - metabolism | Recombinant Fusion Proteins - chemistry | Triazoles - metabolism | Hydrogen Bonding | Receptor, Adenosine A2A - chemistry | Protein Conformation | Cytochrome b Group - chemistry | Escherichia coli Proteins - chemistry | Chemistry | G proteins | Chemical properties | Research | Receptor-mediated endocytosis | Proteins | Ions | Adenosine | Pharmacology | Binding | Control | Stabilization | Strategy | Channels | BASIC BIOLOGICAL SCIENCES | STABILIZATION | CLATHRATES | RESOLUTION | ADENOSINE | REGULATIONS | 60 APPLIED LIFE SCIENCES | RESIDUES | SODIUM IONS | LIPIDS | WATER
Journal Article
Journal Article
Journal Article
Neurobiology of Learning and Memory, ISSN 1074-7427, 2010, Volume 93, Issue 4, pp. 455 - 462
The present study evaluated the possible role of α-adrenergic receptors of the dorsal hippocampus on scopolamine-induced amnesia and scopolamine... 
Prazosin | Clonidine | Scopolamine | Yohimbine | Phenylephrine | Dorsal hippocampus | ALZHEIMERS-DISEASE | BASOLATERAL AMYGDALA | RADIAL MAZE PERFORMANCE | ACETYLCHOLINE-RELEASE | NEUROSCIENCES | PSYCHOLOGY | CHOLINERGIC HYPOTHESIS | PSYCHOLOGY, MULTIDISCIPLINARY | LOCUS-COERULEUS | SPATIAL WORKING-MEMORY | BEHAVIORAL SCIENCES | PASSIVE-AVOIDANCE | STATE-DEPENDENT MEMORY | ALPHA-2-ADRENERGIC AGONIST | Receptors, Adrenergic, alpha-1 - metabolism | Rats, Wistar | Receptors, Adrenergic, alpha-2 - metabolism | Adrenergic alpha-1 Receptor Agonists | Adrenergic alpha-Antagonists - pharmacology | Hippocampus - drug effects | Adrenergic alpha-Antagonists - administration & dosage | CA1 Region, Hippocampal - drug effects | Dose-Response Relationship, Drug | Scopolamine Hydrobromide - pharmacology | Adrenergic alpha-2 Receptor Agonists | Adrenergic alpha-Agonists - administration & dosage | Time Factors | Adrenergic alpha-1 Receptor Antagonists | Receptors, Adrenergic, alpha - metabolism | CA1 Region, Hippocampal - physiology | Rats | Avoidance Learning - physiology | Mental Recall - drug effects | Neuropsychological Tests | Animals | Nootropic Agents - administration & dosage | Mental Recall - physiology | Adrenergic alpha-Agonists - pharmacology | Avoidance Learning - drug effects | Scopolamine Hydrobromide - administration & dosage | Adrenergic alpha-2 Receptor Antagonists | Hippocampus - physiology | Nootropic Agents - pharmacology
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 06/2018, Volume 59, Issue 7, pp. 2778 - 2791
PURPOSE. Myopia is a refractive disorder that degrades vision. It can be treated with atropine, a muscarinic acetylcholine receptor (mAChR) antagonist, but the... 
REFRACTIVE ERROR | off-target | PHARMACOLOGICAL CHARACTERIZATION | alpha(2a)-adrenoceptor | OCULAR GROWTH | LENS-INDUCED MYOPIA | EYE GROWTH | INTRAOCULAR-PRESSURE | ALPHA-2-ADRENERGIC RECEPTORS | nonspecific binding | ACETYLCHOLINE-RECEPTOR | PIRENZEPINE OPHTHALMIC GEL | muscarinic antagonist | form-deprivation myopia | OPHTHALMOLOGY | atropine
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2006, Volume 26, Issue 2, pp. 467 - 478
In Alzheimer's disease ( AD), there is a significant loss of locus ceruleus (LC) noradrenergic neurons. However, functional and anatomical evidence indicates... 
Norepinephrine | In situ hybridization | Alzheimer's disease | Hippocampus | Adrenoreceptors | Locus ceruleus | norepinephrine | SENILE DEMENTIA | HUMAN ALPHA-2-ADRENERGIC RECEPTOR | locus ceruleus | hippocampus | adrenoreceptors | TYROSINE-HYDROXYLASE | CEREBROSPINAL-FLUID | NEURONAL LOSS | NEUROSCIENCES | DUAL-PROBE MICRODIALYSIS | ADRENERGIC PROJECTION | TRANSPORTER MESSENGER-RNA | HUMAN-BRAIN | RAT-BRAIN | in situ hybridization | Receptors, Adrenergic, alpha-1 - metabolism | Receptors, Adrenergic, alpha-2 - genetics | Locus Coeruleus - chemistry | Hippocampus - chemistry | Norepinephrine - physiology | Humans | Middle Aged | Nerve Tissue Proteins - analysis | Receptors, Adrenergic, alpha-2 - metabolism | Prazosin - metabolism | RNA, Messenger - analysis | Male | Dendrites - ultrastructure | Alzheimer Disease - pathology | RNA, Messenger - biosynthesis | Receptors, Adrenergic, alpha-1 - analysis | In Situ Hybridization | Fluoxetine - analogs & derivatives | Aged, 80 and over | Adult | Female | Idazoxan - analogs & derivatives | Locus Coeruleus - pathology | Lewy Body Disease - pathology | Hippocampus - pathology | Tyrosine 3-Monooxygenase - analysis | Receptors, Adrenergic, alpha-2 - analysis | Nerve Tissue Proteins - genetics | Adrenergic alpha-Antagonists - metabolism | Lewy Body Disease - metabolism | Nerve Tissue Proteins - metabolism | Tyrosine 3-Monooxygenase - biosynthesis | Tyrosine 3-Monooxygenase - genetics | Idazoxan - metabolism | Norepinephrine - chemistry | Receptors, Adrenergic, alpha-1 - genetics | Alzheimer Disease - metabolism | Fluoxetine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - analysis | Aged | Tetralones - metabolism | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Neurobiology of Disease
Journal Article