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alpha-a-crystallin (336) 336
biochemistry & molecular biology (223) 223
humans (169) 169
animals (164) 164
index medicus (159) 159
proteins (111) 111
b-crystallin (104) 104
lens (95) 95
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alpha a-crystallin (86) 86
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αa-crystallin (76) 76
lens, crystalline - metabolism (69) 69
amino acid sequence (66) 66
molecular chaperone (62) 62
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crystallins - metabolism (53) 53
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deamidation (43) 43
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heat-shock-protein (39) 39
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crystallins - chemistry (37) 37
crystallins - genetics (37) 37
protein binding (37) 37
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lens, crystalline - chemistry (36) 36
cataract - genetics (35) 35
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subunit exchange (35) 35
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developmental biology (33) 33
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eye (32) 32
life sciences (31) 31
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gene (30) 30
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temperature (30) 30
gene expression (29) 29
heat-shock proteins (29) 29
mass spectrometry (29) 29
stereoisomerism (29) 29
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crystallin (27) 27
mass-spectrometry (27) 27
aspartic acid - chemistry (26) 26
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physiological aspects (26) 26
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cattle (22) 22
d-aspartic acid (22) 22
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phosphorylation (22) 22
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biochemistry, general (21) 21
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chromatography, high pressure liquid (21) 21
evolution (21) 21
eye proteins - metabolism (21) 21
fluorescence (21) 21
heat shock proteins (21) 21
molecular biology (21) 21
posttranslational modifications (21) 21
protein conformation (21) 21
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NATURE REVIEWS MOLECULAR CELL BIOLOGY, ISSN 1471-0072, 01/2013, Volume 14, Issue 1, pp. 55 - 61
Protein turnover is an effective way of maintaining a functional proteome, as old and potentially damaged polypeptides are destroyed and replaced by newly... 
HUMAN LENS | SKELETAL-MUSCLE | MESSENGER-RNA | NUCLEAR-PORE COMPLEX | IN-VIVO | POSTTRANSLATIONAL MODIFICATIONS | PROTEOMIC ANALYSIS | ALPHA-A-CRYSTALLIN | GLYCATION END-PRODUCTS | ASPARTIC-ACID RACEMIZATION | CELL BIOLOGY
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2019, Volume 294, Issue 32, pp. 12203 - 12219
Transparency in the lens is accomplished by the dense packing and short-range order interactions of the crystallin proteins in fiber cells lacking organelles.... 
post-translational modification (PTM) | GAMMA-S-CRYSTALLIN | ALPHA-A CRYSTALLIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | L-isoaspartate | POSTTRANSLATIONAL MODIFICATIONS | lens | IDENTIFICATION | EYE LENS | ASPARTYL RESIDUES | protein aggregation | AGE-RELATED-CHANGES | aging | MOLECULAR-WEIGHT PROTEIN | DEAMIDATION | protein degradation | CATARACT
Journal Article
Annual Review of Genetics, ISSN 0066-4197, 12/2009, Volume 43, pp. 25 - 47
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 08/2017, Volume 58, Issue 10, pp. 3896 - 3922
PURPOSE. Previous research showed that the absence of beta 1-integrin from the mouse lens after embryonic day (E) 13.5 (beta 1MLR10) leads to the perinatal... 
development | TGF-BETA | TISSUE-PLASMINOGEN ACTIVATOR | ENDOPLASMIC-RETICULUM STRESS | lens | EPITHELIAL-MESENCHYMAL TRANSITION | TUMOR-NECROSIS-FACTOR | cell stress | GENE-EXPRESSION | OPHTHALMOLOGY | SMOOTH-MUSCLE-CELLS | FOCAL ADHESION KINASE | ALPHA-A-CRYSTALLIN | TRANSCRIPTION FACTOR
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 09/2019, Volume 1867, Issue 9, pp. 831 - 839
With age, long-lived proteins in the human body deteriorate, which can have consequences both for aging and disease. The aging process is often associated with... 
Aging | Racemisation | Cataract | Lens | Long-lived proteins | HUMAN LENS | SUCCINIMIDE FORMATION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ASPARAGINYL | IDENTIFICATION | ASPARTYL RESIDUES | BIOPHYSICS | DEGRADATION | ALPHA-A-CRYSTALLIN | GLYCATION END-PRODUCTS | Proteins | Medical colleges | Crosslinked polymers | Amines | Proteases | Analysis
Journal Article
Experimental Eye Research, ISSN 0014-4835, 02/2019, Volume 179, pp. 32 - 46
Epithelial cells and differentiated fiber cells represent distinct compartments in the ocular lens. While previous studies have revealed proteins that are... 
Transcription factors | RNA-Seq | Transcriptome | Proteome | Lens | Differentiation | Mass spectrometry | LENTOID BODIES | MAJOR INTRINSIC PROTEIN | TRANSLATION INITIATION | EYE LENS | DEVELOPING MURINE LENS | BEADED FILAMENT | GAP-JUNCTIONS | OPHTHALMOLOGY | CELL-DIFFERENTIATION | ALPHA-A-CRYSTALLIN | GENE REGULATORY NETWORKS
Journal Article
FEBS JOURNAL, ISSN 1742-464X, 03/2016, Volume 283, Issue 5, pp. 850 - 859
Aged cataract formation is caused by the accumulative precipitation of lens proteins incorporating diverse post-translational modifications. -Crystallin, a... 
HUMAN LENS | SIMULTANEOUS STEREOINVERSION | BETA-CRYSTALLINS | d-Asp | cataract | ASPARTIC-ACID RESIDUES | isomerization | DEAMIDATION ALTERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-B-CRYSTALLIN | MASS-SPECTROMETRY | HEAT-SHOCK-PROTEIN | AGE-RELATED-CHANGES | alpha A-crystallin | aging | BACKBONE CLEAVAGE | Isomerization | Cataracts | Chromatography
Journal Article
Experimental Eye Research, ISSN 0014-4835, 01/2019, Volume 178, pp. 247 - 254
Oxidative modification of proteins can perturb their structure and function, often compromising cellular viability. Such modifications include lipid-derived... 
Smith-Lemli-Opitz | Oxidative stress | Retina | Oxidation | Cholesterol | Protein modification | ADDUCTS | PEROXIDATION | DEGENERATION | INHIBITION | 7-DEHYDROCHOLESTEROL-DERIVED OXYSTEROLS | BETA-A3/A1-CRYSTALLIN | TRANSALDOLASE | OPHTHALMOLOGY | ALPHA-A-CRYSTALLIN | AGGREGATION | Albumin | Physiological aspects
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 46, pp. 17997 - 18009
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2019, Volume 20, Issue 10, p. 2410
Journal Article