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CLINICAL CANCER RESEARCH, ISSN 1078-0432, 11/2019, Volume 25, Issue 22, pp. 6868 - 6881
Purpose: Long noncoding RNAs (lncRNA) have essential roles in diverse cellular processes, both in normal and diseased cell types, and thus have emerged as... 
SURVIVAL | METASTASIS | MESSENGER-RNA | ONCOLOGY | EXPRESSION | BINDING | ALPHA-ACTININ-4
Journal Article
Nature Reviews Nephrology, ISSN 1759-5061, 01/2012, Volume 8, Issue 1, pp. 14 - 21
Almost all mammalian cell types have morphologies that are uniquely tailored to their physiological functions. This immense variation in cell shape depends on... 
PROTEIN | CELL MOTILITY | SLIT DIAPHRAGM | NEPHRIN | DYNAMICS | UROLOGY & NEPHROLOGY | ACTIN CYTOSKELETON | FILTRATION | NEPHROTIC SYNDROME | DEPENDENT REORGANIZATION | ALPHA-ACTININ-4 | Cell interaction | Actin | Physiological aspects | Cytoskeleton | Development and progression | Research | Proteinuria
Journal Article
by Peng, W and Tong, C and Li, L and Huang, CY and Ran, YX and Chen, XH and Bai, YX and Liu, YM and Zhao, JL and Tan, B and Luo, XF and Wang, H and Wen, L and Zhang, C and Zhang, H and Ding, YB and Qi, HB and Baker, PN
FASEB JOURNAL, ISSN 0892-6638, 05/2019, Volume 33, Issue 5, pp. 6327 - 6338
Successful pregnancy requires normal placentation, which largely depends on the tight regulation of proliferation, invasion, and migration of trophoblast... 
ACTIVATION | COMPLEX | CYTOSKELETON | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | BETA-CATENIN | BINDING-PROTEINS | ALPHA-ACTININ | CELL BIOLOGY | podosome | SCREEN REVEALS | BIOLOGY | migration | placenta | DIFFERENTIATION | ALPHA-ACTININ-4 | MOTILITY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 7, pp. 1517 - 1522
alpha-Actinin-4 (ACTN4) bundles and cross-links actin filaments to confer mechanical resilience to the reconstituted actin network. How this resilience is... 
Podocyte | Cytoskeleton | Α-actinin-4 | Actin | Kidney | cytoskeleton | MULTIDISCIPLINARY SCIENCES | PRESTRESS | VISCOELASTICITY | alpha-actinin-4 | kidney | actin | MECHANICAL-STRESS | podocyte | DYNAMICS | MUTANT ALPHA-ACTININ-4 | FORCES | FOCAL SEGMENTAL GLOMERULOSCLEROSIS | CELL | PROGRESSION | Biological Sciences | α-actinin-4
Journal Article
Cell and Bioscience, ISSN 2045-3701, 08/2015, Volume 5, Issue 1, p. 48
Journal Article
Current Biology, ISSN 0960-9822, 06/2016, Volume 26, Issue 11, pp. 1473 - 1479
Journal Article
Science, ISSN 0036-8075, 6/2005, Volume 308, Issue 5729, pp. 1801 - 1804
Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here... 
Receptors | Kidneys | Messenger RNA | Focal segmental glomerulosclerosis | Calcium | HEK293 cells | Cell lines | Reports | Kidney cells | Kidney diseases | Genetic mutation | INSERTION | PROTEIN | SLIT DIAPHRAGM | NEPHRIN | MULTIDISCIPLINARY SCIENCES | GENETIC-HETEROGENEITY | PODOCIN | NEPHROTIC SYNDROME | EXPRESSION | ALPHA-ACTININ-4 | GLOMERULAR-DISEASE | Haplotypes | Uridine Triphosphate - metabolism | Calcium Channels - metabolism | Calcium - metabolism | Exons | Glomerulosclerosis, Focal Segmental - genetics | Humans | Male | Mutation, Missense | Sodium - metabolism | Kidney - metabolism | Receptor, Angiotensin, Type 1 - genetics | Transfection | Kidney Glomerulus - metabolism | Female | Cell Membrane - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Kidney Tubules - metabolism | Calcium Channels - genetics | Calcium Signaling | Cell Line | Angiotensin II - pharmacology | TRPC6 Cation Channel | Angiotensin II - metabolism | TRPC Cation Channels | Uridine Triphosphate - pharmacology | Chromosomes, Human, Pair 11 - genetics | Sequence Analysis, DNA | Carbachol - pharmacology | Patch-Clamp Techniques | Pedigree | Calcium Channels - chemistry | Receptor, Angiotensin, Type 1 - metabolism | Amino Acid Substitution | Glomerulonephritis | Case studies | Research | Analysis | Heredity | Mutation | Chromosomes | Genes
Journal Article
Journal Article
by He, SJ and Liu, X and Lin, ZM and Liu, YT and Gu, L and Zhou, H and Tang, W and Zuo, JP
ARTHRITIS RESEARCH & THERAPY, ISSN 1478-6354, 01/2019, Volume 21, Issue 1
BackgroundGlomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by... 
KIDNEY-DISEASE | FOOT PROCESS EFFACEMENT | Integrin-linked kinase | LINKED KINASE | POTENTIAL BIOMARKERS | Focal adhesion | ILK | Lupus nephritis | RHEUMATOLOGY | ALPHA-ACTININ | Actinin-4 | ADHESION | Integrin | SAHH inhibitor | PROTEOMIC ANALYSIS | BINDING | ALPHA-ACTININ-4 | Glomerulonephritis | Prevention | Immunohistochemistry | Usage | Western immunoblotting | Patient outcomes | Risk factors
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, ISSN 1931-857X, 05/2018, Volume 314, Issue 5, pp. F921 - F925
Focal segmental glomerulosclerosis (FSGS) is a histologically defined form of kidney injury typically mediated by podocyte dysfunction. Podocytes rely on their... 
FOOT PROCESS EFFACEMENT | PHYSIOLOGY | HUMAN PODOCYTES | STRETCH | STRESS IN-VITRO | alpha-actinin-4 | mechanical challenges | GENE | cytoskeleton protein | podocyte | SHEAR-STRESS | FSGS | UROLOGY & NEPHROLOGY | MUTATIONS | NEPHROTIC SYNDROME | EXPRESSION | Podocyte | Cytoskeleton protein | Mechanical challenges | Alpha-actinin-4 | Cytoskeleton | Health aspects | Review
Journal Article
Veterinary Pathology, ISSN 0300-9858, 3/2018, Volume 55, Issue 2, pp. 277 - 285
Focal segmental glomerulosclerosis (FSGS) recently has been recognized as a common cause of proteinuria in dogs in general, and in Miniature Schnauzer dogs in... 
dogs | kidney | Miniature Schnauzer | primary focal segmental glomerulosclerosis | proteinuria | podocyte | GLOMERULONEPHRITIDES | PODOCYTES RESPONSE | INJURY | ACTN4 | PATHOLOGY | FEATURES | VETERINARY SCIENCES | MUTATIONS | RENAL BIOPSIES | ALPHA-ACTININ-4 | GLOMERULAR-DISEASE
Journal Article
by Fang, C and Li, JJ and Deng, T and Li, BH and Geng, PL and Zeng, XT
MEDICAL SCIENCE MONITOR, ISSN 1643-3750, 05/2019, Volume 25, pp. 3298 - 3302
Background: a-actinin-4 (Actinin-4 or ACTN4), originally identified as an actin-binding protein associated with the biological function of cancer cells,... 
MEDICINE, RESEARCH & EXPERIMENTAL | METASTASIS | PROTEIN | Actinin | EFFICACY | PROGNOSIS | Breast Neoplasms | CHINESE WOMEN | CELL-MIGRATION | RELEVANCE | Diagnosis | EXPRESSION | ALPHA-ACTININ-4 | STRATIFICATION
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 10/2019, Volume 9, Issue 1, pp. 1 - 12
Natural mutations such as lysine 255 to glutamic acid (K to E), threonine 259 to isoleucine (T to I) and serine 262 to proline (S to P) that occur within the... 
DOMAIN | MECHANISM | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | DYNAMICS | BETA-CATENIN | EXPRESSION | ALPHA-ACTININ-4 | ALPHA-ACTININ | PHOSPHOINOSITIDE BINDING | Tyrosine | Glutamic acid | Phosphorylation | Phenotypes | Actinin | Threonine | Serine | Melanoma | Proline | Epidermal growth factor | Filaments | Actin | Lysine | Fibroblasts | Cytoskeleton | Mutation | Protein-tyrosine kinase | Isoleucine
Journal Article