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Diabetologia, ISSN 0012-186X, 12/2017, Volume 60, Issue 12, pp. 2399 - 2408
Journal Article
Journal of Theoretical Biology, ISSN 0022-5193, 10/2019, p. 110036
Journal Article
CELL METABOLISM, ISSN 1550-4131, 12/2013, Volume 18, Issue 6, pp. 871 - 882
Glucagon, secreted by pancreatic islet a cells, is the principal hyperglycemic hormone. In diabetes, glucagon secretion is not suppressed at high glucose,... 
INSULIN | DELTA-CELLS | EXOCYTOSIS | BETA-CELLS | MOUSE | ENDOCRINOLOGY & METABOLISM | INTACT ISLETS | HYPOGLYCEMIA | RELEASE | PANCREATIC ALPHA-CELLS | LANGERHANS | CELL BIOLOGY
Journal Article
NATURE REVIEWS ENDOCRINOLOGY, ISSN 1759-5029, 11/2013, Volume 9, Issue 11, pp. 660 - 669
ATP-sensitive potassium channels (K-ATP channels) link cell metabolism to electrical activity by controlling the cell membrane potential. They participate in... 
NEONATAL DIABETES-MELLITUS | SENSITIVE POTASSIUM-CHANNEL | PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA | INSULIN-SECRETION | ENDOCRINOLOGY & METABOLISM | SUBUNITS KIR6.2 KCNJ11 | PANCREATIC BETA-CELLS | GATED ION CHANNELS | MOUSE ALPHA-CELLS | FOCAL CONGENITAL HYPERINSULINISM | STIMULATES GLUCAGON-RELEASE
Journal Article
DIABETOLOGIA, ISSN 0012-186X, 12/2017, Volume 60, Issue 12, pp. 2399 - 2408
Aims/hypothesis The Cre/loxP system, which enables tissue-specific manipulation of genes, is widely used in mice for diabetes research. Our aim was to develop... 
INSULIN | Cre/loxP | GLUCAGON-LIKE PEPTIDE-1 | GLUCOSE | BETA-CELLS | ENDOCRINE | ENDOCRINOLOGY & METABOLISM | RECEPTOR | CreER(T2) | Pancreatic alpha cells | Proglucagon
Journal Article
DIABETES, ISSN 0012-1797, 10/2011, Volume 60, Issue 10, pp. 2533 - 2545
OBJECTIVE-Sarco-endoplasmic reticulum Ca2+-ATPase 2b (SERCA2b) and SERCA3 pump Ca2+ in the endoplasmic reticulum (ER) of pancreatic beta-cells. We studied... 
ALPHA-CELLS | B-CELL | ISLETS | CA2+-ATPASE | INTRACELLULAR CALCIUM | GLUCOSE | ENDOCRINOLOGY & METABOLISM | DISTINCT ROLES | RELEASE | CYTOPLASMIC CA2 | TARGETED CAMELEONS
Journal Article
DEVELOPMENT, ISSN 0950-1991, 06/2019, Volume 146, Issue 12, p. dev173716
During pancreatic development, endocrine cells appear from the pancreatic epithelium when Neurog3-positive cells delaminate and differentiate into alpha-,... 
PROGENITORS | Neurog3 | Endocrine progenitors | ENDOCRINE | MOUSE | PAX4 | DEVELOPMENTAL BIOLOGY | ORGANOGENESIS | Beta cells | Single cell transcriptome sequencing | MORPHOGENESIS | GENE | GENERATION | Pancreas development | Alpha cells | CHARACTERISTIC FEATURES | REVEALS
Journal Article
DEVELOPMENT, ISSN 0950-1991, 07/2019, Volume 146, Issue 14, p. dev172569
An early step in pancreas development is marked by the expression of the transcription factor Pdx1 within the pancreatic endoderm, where it is required for the... 
ZEBRAFISH | MITOCHONDRIAL | REGENERATION | Pdx1 | DEVELOPMENTAL BIOLOGY | PDX-1 | IN-VITRO | GENE | alpha-Cells | Transdifferentiation | Small molecule screen | DIFFERENTIATION | EXPRESSION | beta-Cells
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 6626 - 6640
The physiological role of the TGR5 receptor in the pancreas is not fully understood. We previously showed that activation of TGR5 in pancreatic cells by bile... 
G protein-coupled receptor | ALPHA-TC1-6 CELLS | GASTRIC BYPASS | pancreatic islet | GLP-1 | ALPHA-CELLS | bile acid | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN-SECRETION | BETA-CELLS | INCRETIN HORMONES | NUCLEAR RECEPTOR | metabolic syndrome | reprogramming | SMOOTH-MUSCLE | GLUCAGON-LIKE PEPTIDE-1 | cell signaling
Journal Article
JOURNAL OF GENERAL PHYSIOLOGY, ISSN 0022-1295, 09/2019, Volume 151, Issue 9, pp. 1094 - 1115
Somatostatin secretion from pancreatic islet delta-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been... 
GLUCAGON-SECRETION | CYCLIC-AMP | PHYSIOLOGY | C-EPSILON | ALPHA-CELLS | CA2+ RELEASE | INSULIN GRANULE DYNAMICS | BETA-CELLS | ELECTRICAL-ACTIVITY | CYTOPLASMIC CALCIUM | MOUSE ISLETS
Journal Article
EUROPEAN JOURNAL OF ENDOCRINOLOGY, ISSN 0804-4643, 06/2018, Volume 178, Issue 6, pp. R267 - R280
Hyperglucagonaemia (in the fasting as well as in the postprandial state) is considered a core pathophysiological component of diabetes and is found to... 
INTRAVENOUS GLUCOSE | FASTING HYPERGLUCAGONEMIA | Y GASTRIC BYPASS | ENDOCRINOLOGY & METABOLISM | POSTPRANDIAL HYPERGLYCEMIA | DEPENDENT INSULINOTROPIC POLYPEPTIDE | NONDIABETIC PATIENTS | TYPE-2 DIABETES-MELLITUS | PANCREATIC ALPHA-CELLS | GLUCOSE-TOLERANCE | DEPANCREATIZED DOGS
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2017, Volume 25, Issue 4, pp. 927 - 934.e3
Glucagon-like peptide 1 (GLP-1) is necessary for normal gluco-regulation, and it has been widely presumed that this function reflects the actions of GLP-1... 
glucose homeostasis | incretin | GLP-1 | GLP-1 SECRETION | ACTIVATION | GLUCAGON-LIKE PEPTIDE-1 | ALPHA-CELLS | INSULIN-SECRETION | BLOOD-GLUCOSE | ENDOCRINOLOGY & METABOLISM | HUMANS | RECEPTOR GENE | MOUSE MODELS | BETA-CELL FUNCTION | CELL BIOLOGY | Gene Targeting | Glucose Tolerance Test | Reproducibility of Results |