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Frontiers in Immunology, ISSN 1664-3224, 10/2019, Volume 10
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with... 
CD1d | beta-mannosylceramide | alpha-galactosylceramide | natural killer T cells | L363
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/2019, Volume 203, Issue 4, pp. 825 - 834
Extracellular vesicles (EV) are candidates for cancer immunotherapy because of their capacity to stimulate tumor-specific activity in vivo. However, clinical... 
CO-DELIVERY | ANTITUMOR IMMUNITY | IMMUNOLOGY | CELL-DERIVED EXOSOMES | ALPHA-GALACTOSYLCERAMIDE | IMMUNOTHERAPY
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 06/2019, Volume 565, pp. 123 - 132
The recognition of α-galactosylceramide (αGC), a high-affinity CD1d antigen, by the invariant Natural Killer T (iNKT) lymphocytes results in potent... 
Nanoparticles | Invariant Natural Killer T lymphocytes | IFN-γ | Nano spray dryer | Alpha-galactosylceramide | NKT
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 06/2009, Volume 119, Issue 6, pp. 1524 - 1536
Tumor infiltration with V alpha 24-invariant NKT cells (NKTs) associates with favorable outcome in neuroblastoma and other cancers. Although NKTs can be... 
MEDICINE, RESEARCH & EXPERIMENTAL | CD1D EXPRESSION | CANCER-PATIENTS | DENDRITIC CELLS | ALPHA-GALACTOSYLCERAMIDE | RECEPTOR EXPRESSION | BONE-MARROW METASTASES | IMMUNOSUPPRESSIVE ACTIVITY | KILLER-T-CELLS | PHASE-I | INNATE IMMUNITY
Journal Article
NATURE, ISSN 0028-0836, 10/2001, Volume 413, Issue 6855, pp. 531 - 534
Experimental autoimmune encephalomyelitis (EAE) is a prototype autoimmune disease mediated by type 1 helper T (T(H)1) cells and under the control of regulatory... 
NKT CELLS | TCR | ACTIVATION | MULTIPLE-SCLEROSIS | RECOGNITION | ALPHA-GALACTOSYLCERAMIDE | MULTIDISCIPLINARY SCIENCES | DISEASE | ALTERED PEPTIDE LIGAND | SELECTIVE REDUCTION | ANTIGENS
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 10/2005, Volume 11, Issue 20, pp. 7322 - 7327
Purpose: Human invariant natural killer T (NKT) cells are novel, distinct lymphocyte populations with a restricted T-cell receptor repertoire (V alpha 24-V... 
TCR | RECOGNITION | ONCOLOGY | ALPHA-GALACTOSYLCERAMIDE | ULCERATIVE-COLITIS | V-ALPHA-14 NKT CELLS | RECEPTOR | IMMUNOSURVEILLANCE | MICE | IL-13 | REQUIREMENT
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 03/2007, Volume 178, Issue 5, pp. 2706 - 2713
NKT cells are thought of as a bridge between innate and adaptive immunity. In this study, we demonstrate that mouse NKT cells are activated in response to... 
ACTIVATION | INTERFERON-GAMMA | MESSENGER-RNA | LIVER-INJURY | ALPHA-GALACTOSYLCERAMIDE | IFN-GAMMA | IN-VIVO | KILLER T-CELLS | SEPTIC SHOCK | IMMUNOLOGY | SHWARTZMAN REACTION
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 02/2011, Volume 11, Issue 2, pp. 131 - 142
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 11/2006, Volume 203, Issue 12, pp. 2639 - 2648
Ischemia reperfusion injury results from tissue damage during ischemia and ongoing inflammation and injury during reperfusion. Liver reperfusion injury is... 
MEDICINE, RESEARCH & EXPERIMENTAL | KAPPA-B ACTIVATION | TISSUE PROTECTION | LIVER-INJURY | RECOGNITION | ALPHA-GALACTOSYLCERAMIDE | IFN-GAMMA | KILLER T-CELLS | INDUCTION | IMMUNOLOGY | CUTTING EDGE | CYCLOSPORINE
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 10/2010, Volume 207, Issue 11, pp. 2383 - 2393
Invariant natural killer T cells (iNKT cells) rapidly produce effector cytokines. In this study, we report the first crystal structures of the iNKT cell T cell... 
MEDICINE, RESEARCH & EXPERIMENTAL | NKT CELLS | ACTIVATION | GLYCOSPHINGOLIPIDS | RECOGNITION | SPECIFICITY | ALPHA-GALACTOSYLCERAMIDE | DIVERSE GLYCOLIPIDS | HIGH-AFFINITY | RECEPTOR | ANTIGENS | IMMUNOLOGY
Journal Article
IMMUNOLOGY AND CELL BIOLOGY, ISSN 0818-9641, 02/2015, Volume 93, Issue 2, pp. 198 - 212
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has an important role at mucosal sites in a wide range of immune responses including infection,... 
PROTECTIVE IMMUNITY | INTERFERON-GAMMA | DENDRITIC CELLS | ALPHA-GALACTOSYLCERAMIDE | IFN-GAMMA | INFECTION | DIFFERENTIATION | IMMUNOLOGY | IL-17 PRODUCTION | SKIN INFLAMMATION | LYMPHOCYTES | CELL BIOLOGY
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 05/2007, Volume 204, Issue 5, pp. 1131 - 1144
CD1d-restricted lymphocytes recognize a broad lipid range. However, how CD1d-restricted lymphocytes translate T cell receptor (TCR) recognition of lipids with... 
RECEPTOR-LIGAND INTERACTIONS | MOUSE CD1D | MEDICINE, RESEARCH & EXPERIMENTAL | ALPHA-GALACTOSYLCERAMIDE | ANTIGEN RECOGNITION | STRUCTURAL REQUIREMENTS | CRYSTAL-STRUCTURE | IN-VIVO | KILLER T-CELLS | MATURE DENDRITIC CELLS | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 08/2007, Volume 117, Issue 8, pp. 2302 - 2312
Because of the paucity of known self lipid-reactive ligands for NKT cells, interactions among distinct NKT cell subsets as well as immune consequences... 
MEDICINE, RESEARCH & EXPERIMENTAL | CONCANAVALIN-A | ACTIVATION | A-INDUCED HEPATITIS | DENDRITIC CELLS | RECOGNITION | ALPHA-GALACTOSYLCERAMIDE | GLYCOLIPID ANTIGENS | KILLER T-CELLS | MICE | SELF-GLYCOLIPIDS
Journal Article