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1. Full Text Platelet granules: Surprise packages
by Whiteheart, Sidney W
Blood, ISSN 0006-4971, 08/2011, Volume 118, Issue 5, pp. 1190 - 1191
RELEASE | PROTEINS | HEMATOLOGY | ALPHA-GRANULES
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2. Full Text Arf6 controls platelet spreading and clot retraction via integrin alpha(IIb)beta(3) trafficking
by Huang, YJ and Joshi, S and Xiang, BG and Kanaho, Y and Li, ZY and Bouchard, BA and Moncman, CL and Whiteheart, SW
BLOOD, ISSN 0006-4971, 03/2016, Volume 127, Issue 11, pp. 1459 - 1467
Platelet and megakaryocyte endocytosis is important for loading certain granule cargo (ie, fibrinogen [Fg] and vascular endothelial growth factor); however,... 
ACTIVATION | MULTIVESICULAR BODIES | ALPHA-GRANULES | IN-VIVO | CELL-ADHESION | SECRETION | ENDOCYTOSIS | HEMATOLOGY | IMMUNOGLOBULIN-G | GUINEA-PIG MEGAKARYOCYTE | FIBRINOGEN
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3. Full Text Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-beta 1 secretion and hematopoiesis in mice
by Capitano, M and Zhao, L and Cooper, S and Thorsheim, C and Suzuki, A and Huang, XX and Dent, AL and Marks, MS and Abrams, CS and Broxmeyer, HE
BLOOD, ISSN 0006-4971, 09/2018, Volume 132, Issue 10, pp. 1027 - 1038
We hypothesized that megakaryocyte (MK) phosphoinositide signaling mediated by phosphatidylinositol transfer proteins (PITPs) contributes to hematopoietic stem... 
PROGENITOR CELLS | INTERLEUKIN-4 | COLONY-STIMULATING FACTOR | BONE-MARROW NICHE | QUIESCENCE | PROLIFERATION | PLATELET ALPHA-GRANULES | RECEPTORS | IDENTIFICATION | HEMATOLOGY | STEM
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4. Full Text Nbeal2 interacts with Dock7, Sec16a, and Vac14
by Mayer, Louisa and Jasztal, Maria and Pardo, Mercedes and Aguera de Haro, Salvadora and Collins, Janine and Bariana, Tadbir K and Smethurst, Peter A and Grassi, Luigi and Petersen, Romina and Nurden, Paquita and Favier, Rémi and Yu, Lu and Meacham, Stuart and Astle, William J and Choudhary, Jyoti and Yue, Wyatt W and Ouwehand, Willem H and Guerrero, Jose A
Blood, ISSN 0006-4971, 03/2018, Volume 131, Issue 9, pp. 1000 - 1011
Mutations in NBEAL2, the gene encoding the scaffolding protein Nbeal2, are causal of gray platelet syndrome (GPS), a rare recessive bleeding disorder... 
PROTEIN | GENE | BIOGENESIS | ALPHA-GRANULES | CRYSTAL-STRUCTURE | GRAY PLATELET SYNDROME | DISEASE | MEGAKARYOCYTES | DISORDERS | HEMATOLOGY | BEACH-DOMAIN | Index Medicus | Abridged Index Medicus | Platelets and Thrombopoiesis
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5. Full Text Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice
by Deppermann, Carsten and Cherpokova, Deya and Nurden, Paquita and Schulz, Jan-Niklas and Thielmann, Ina and Kraft, Peter and Vögtle, Timo and Kleinschnitz, Christoph and Dütting, Sebastian and Krohne, Georg and Eming, Sabine A and Nurden, Alan T and Eckes, Beate and Stoll, Guido and Stegner, David and Nieswandt, Bernhard
Journal of Clinical Investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3331 - 3342
Platelets are anuclear organelle-rich cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity. The major platelet... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLYCOPROTEIN-VI | ALPHA-GRANULES | BLEEDING-TIME | INTEGRIN | IN-VIVO | ARTERIAL THROMBOSIS | NBEAL2 | GROWTH-FACTOR | PROTEINS | ISCHEMIC-STROKE | Care and treatment | Genetic aspects | Diagnosis | Research | Gene expression | Blood platelet disorders | Thrombosis | Blood clot | Proteins | Wound healing | Heart attacks | Blood platelets | Microscopy | Colleges & universities | Defects
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6. Full Text NBEAL2 (Neurobeachin-Like 2) Is Required for Retention of Cargo Proteins by -Granules During Their Production by Megakaryocytes
by Lo, RW and Li, L and Leung, R and Pluthero, FG and Kahr, WHA
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 10/2018, Volume 38, Issue 10, pp. 2435 - 2447
Objective Human and mouse megakaryocytes lacking NBEAL2 (neurobeachin-like 2) produce platelets where -granules lack protein cargo. This cargo is mostly... 
megakaryocytes | fibrinogen | ALPHA-GRANULES | THROMBUS FORMATION | GRAY PLATELET SYNDROME | endosomes | ENDOCYTOSIS | IMMUNE CONTINUUM | BIOGENESIS | INFLAMMATION | Von Willebrand factor | DISEASE | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | P-selectin | RAB GTPASES
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7. Full Text Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis
by Claushuis, Theodora A.M and de Stoppelaar, Sacha F and de Vos, Alex F and Grootemaat, Anita E and van der Wel, Nicole N and Roelofs, Joris and Ware, Jerry and van‘t Veer, Cornelis and van der Poll, Tom
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2018, Volume 38, Issue 8, pp. 1772 - 1784
OBJECTIVE—Nbeal2 mice, a model of human gray platelet syndrome, have reduced neutrophil granularity and impaired host defense against systemic Staphylococcus... 
IMMUNITY | LUNG | infection | BACTERIA | ALPHA-GRANULES | endotoxemia | PLATELET SYNDROME | NEUTROPHIL EXTRACELLULAR TRAPS | MYELOPEROXIDASE | INFLAMMATION | gray platelet syndrome | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | neutrophils | CONTRIBUTES | sepsis
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8. Full Text A Dominant-Negative GFI1B Mutation in the Gray Platelet Syndrome
by Monteferrario, Davide and Bolar, Nikhita A and Marneth, Anna E and Hebeda, Konnie M and Bergevoet, Saskia M and Veenstra, Hans and Laros-van Gorkom, Britta A.P and MacKenzie, Marius A and Khandanpour, Cyrus and Botezatu, Lacramiora and Fransen, Erik and Van Camp, Guy and Duijnhouwer, Anthonie L and Salemink, Simone and Willemsen, Brigith and Huls, Gerwin and Preijers, Frank and Van Heerde, Waander and Jansen, Joop H and Kempers, Marlies J.E and Loeys, Bart L and Van Laer, Lut and Van der Reijden, Bert A
The New England Journal of Medicine, ISSN 0028-4793, 01/2014, Volume 370, Issue 3, pp. 245 - 253
A large family is described with gray platelet syndrome due to an autosomal dominant inheritance pattern related to a dominant-negative mutation in GFI1B . The... 
GFI-1B | THROMBOPOIESIS | CELLS | MEDICINE, GENERAL & INTERNAL | PROTEIN | GENE | ALPHA-GRANULES | BONE-MARROW | NBEAL2 | GROWTH-FACTOR | DIFFERENTIATION | Blood Platelets - pathology | Humans | Gray Platelet Syndrome - genetics | Repressor Proteins - genetics | Male | Proto-Oncogene Proteins - genetics | Gray Platelet Syndrome - pathology | Stem Cells | Thrombocytopenia - genetics | Megakaryocytes - pathology | Genes, Dominant | Pedigree | Bone Marrow - pathology | Female | Mutation | Causes of | Transcription factors | Genetic aspects | Research | Gene mutations | Blood platelet disorders | Nonsense mutation | Genes | Bone marrow | Megakaryocytes | Platelets | Blood diseases | Hereditary diseases | Index Medicus | Abridged Index Medicus
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9. Full Text Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow
by Bieback, Karen and Hecker, Andrea and Kocaömer, Asli and Lannert, Heinrich and Schallmoser, Katharina and Strunk, Dirk and Klüter, Harald
Stem Cells, ISSN 1066-5099, 09/2009, Volume 27, Issue 9, pp. 2331 - 2341
Mesenchymal stromal cells (MSCs) are promising candidates for novel cell therapeutic applications. For clinical scale manufacturing, human factors from serum... 
Pooled platelet lysate | Bone marrow | Mesenchymal stromal cells | Human serum | Platelet-derived factors | Fetal bovine serum | STEM-CELLS | CALF SERUM | HUMAN AB SERUM | AUTOLOGOUS SERUM | CELL & TISSUE ENGINEERING | CELL BIOLOGY | EX-VIVO EXPANSION | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VITRO EXPANSION | ANIMAL SERUM | UMBILICAL-CORD BLOOD | PLATELET ALPHA-GRANULES | HEMATOLOGY | ADIPOSE-TISSUE | Humans | Stromal Cells - metabolism | Mesenchymal Stromal Cells - metabolism | Mesenchymal Stromal Cells - cytology | Platelet-Derived Growth Factor - metabolism | Animals | Blood Platelets - metabolism | Cattle | Serum | Cell Culture Techniques | Bone Marrow | Cell Differentiation - physiology | Stromal Cells - cytology | Index Medicus
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10. Full Text Platelets and platelet-like particles mediate intercellular RNA transfer
by Risitano, Antonina and Beaulieu, Lea M and Vitseva, Olga and Freedman, Jane E
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 26, pp. 6288 - 6295
The role of platelets in hemostasis and thrombosis is clearly established; however, the mechanisms by which platelets mediate inflammatory and immune pathways... 
HORIZONTAL TRANSFER | IN-VITRO | MESSENGER-RNA | ANGIOGENESIS | ALPHA-GRANULES | LEUKEMIA-CELL LINE | GENE-EXPRESSION | MICROVESICLES | MICROPARTICLES | HEMATOLOGY | MEG-01 | Coculture Techniques | Humans | Mice, Inbred C57BL | Cells, Cultured | Cell Communication - physiology | Blood Platelets - physiology | Cell Communication - genetics | Mice, Knockout | Paracrine Communication - physiology | Human Umbilical Vein Endothelial Cells - physiology | Animals | Gene Transfer, Horizontal - physiology | Blood Platelets - cytology | Blood Platelets - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Cell-Derived Microparticles - physiology | Cell-Derived Microparticles - metabolism | Mice | RNA - metabolism | Index Medicus | Abridged Index Medicus | Platelets and Thrombopoiesis
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11. Full Text Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions
by Coppinger, Judith A and Cagney, Gerard and Toomey, Sinead and Kislinger, Thomas and Belton, Orina and McRedmond, James P and Cahill, Dolores J and Emili, Andrew and Fitzgerald, Desmond J and Maguire, Patricia B
Blood, ISSN 0006-4971, 03/2004, Volume 103, Issue 6, pp. 2096 - 2104
Proteins secreted by activated platelets can adhere to the vessel wall and promote the development of atherosclerosis and thrombosis. Despite this biologic... 
MATRIX GLA PROTEIN | ALPHA-GRANULES | BINDING PROTEINS | IDENTIFICATION TECHNOLOGY | GENE-EXPRESSION | CELL-DERIVED EXOSOMES | PROTEOMIC ANALYSIS | YEAST PROTEOME | HEMATOLOGY | LARGE-SCALE ANALYSIS | MASS-SPECTROMETRY | Calcium-Binding Proteins - metabolism | Cyclophilin A - metabolism | Chromogranins | Proteins - metabolism | Blood Platelets - metabolism | Humans | Arteriosclerosis - physiopathology | Platelet Activation - physiology | Proteomics | Electrophoresis, Gel, Two-Dimensional | Arteriosclerosis - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Index Medicus | Abridged Index Medicus
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12. Full Text Brain-derived neurotrophic factor in megakaryocytes
by Chacón-Fernández, Pedro and Säuberli, Katharina and Colzani, Maria and Moreau, Thomas and Ghevaert, Cedric and Barde, Yves-Alain
Journal of Biological Chemistry, ISSN 0021-9258, 05/2016, Volume 291, Issue 19, pp. 9872 - 9881
The biosynthesis of endogenous brain-derived neurotrophic factor (BDNF) has thus far been examined in neurons where it is expressed at very low levels, in an... 
RAT | ALPHA-GRANULES | VESICLES | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH-FACTORS | RELEASE | FACTOR BDNF | EXPRESSION | EXERCISE | PEPTIDE | Calcium - pharmacology | Rats, Wistar | Species Specificity | Humans | Secretory Vesicles - metabolism | Cercopithecus aethiops | Rats | RNA, Messenger - metabolism | Animals | Blood Platelets - cytology | Blood Platelets - metabolism | Thapsigargin - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Mice | Neurons - metabolism | Blood Coagulation - physiology | Megakaryocytes - cytology | Megakaryocytes - metabolism | COS Cells | Index Medicus | neurochemistry | neurotrophin | blood | Neurobiology | brain-derived neurotrophic factor (BDNF)
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13. Full Text Platelet secretion is kinetically heterogeneous in an agonist-responsive manner
by Jonnalagadda, Deepa and Izu, Leighton T and Whiteheart, Sidney W
Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 26, pp. 5209 - 5216
Platelets release numerous bioactive molecules stored in their granules enabling them to exert a wide range of effects on the vascular microenvironment. Are... 
RELEASE REACTION | HUMAN MEGAKARYOCYTES | DENSE GRANULES | EXOCYTOSIS | ALPHA-GRANULES | SYNTAXIN 2 | PROTEINS | SNAP-23 | HEMATOLOGY | FIBRINOGEN | MOLECULAR-MECHANISMS | Enzyme-Linked Immunosorbent Assay - methods | Crotalid Venoms - pharmacology | beta-N-Acetylhexosaminidases - metabolism | Humans | Lectins, C-Type | Receptor, PAR-1 - agonists | Secretory Vesicles - metabolism | Male | Blood Platelets - secretion | Protein Array Analysis - methods | beta-N-Acetylhexosaminidases - secretion | Secretory Pathway - drug effects | Receptors, Thrombin - agonists | Thrombin - pharmacology | Blood Platelets - metabolism | Platelet Factor 4 - secretion | Secretory Vesicles - drug effects | Serotonin - metabolism | Serotonin - secretion | Platelet Factor 4 - metabolism | Kinetics | Blood Platelets - drug effects | Index Medicus | Abridged Index Medicus | Platelets and Thrombopoiesis
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14. Full Text Cytoskeletal mechanics of proplatelet maturation and platelet release
by Jonathan N. Thon and Alejandro Montalvo and Sunita Patel-Hett and Matthew T. Devine and Jennifer L. Richardson and Allen Ehrlicher and Mark K. Larson and Karin Hoffmeister and John H. Hartwig and Joseph E. Italiano
The Journal of Cell Biology, ISSN 0021-9525, 11/2010, Volume 191, Issue 4, pp. 861 - 874
Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production.... 
Cytometry | Microscopy | Microtubules | Fluorescent antibody techniques | Cytoskeleton | Megakaryocytes | Barbells | Platelets | Blood transfusion | Blood | BLOOD-PLATELETS | BETA-1 TUBULIN | HUMAN MEGAKARYOCYTES | MARROW | PLASMA | MULTIVESICULAR BODIES | ALPHA-GRANULES | INVITRO | TRANSCRIPTION FACTOR NF-E2 | MODEL | CELL BIOLOGY | Platelet Transfusion | Fluoresceins - metabolism | Humans | Cells, Cultured | Fluorescent Dyes - metabolism | Stress, Mechanical | Tubulin - genetics | Megakaryocytes - physiology | Blood Platelets - physiology | Recombinant Fusion Proteins - metabolism | Microtubules - metabolism | Tubulin - metabolism | Animals | Blood Platelets - cytology | Microtubules - ultrastructure | Cytoskeleton - metabolism | Recombinant Fusion Proteins - genetics | Mice | Megakaryocytes - cytology | Blood platelets | Cytoplasm | Research | Proteins | Maturation | Cells | Index Medicus
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15. Full Text Respective contributions of single and compound granule fusion to secretion by activated platelets
by Eckly, Anita and Rinckel, Jean-Yves and Proamer, Fabienne and Ulas, Neslihan and Joshi, Smita and Whiteheart, Sidney W and Gachet, Christian
Blood, ISSN 0006-4971, 11/2016, Volume 128, Issue 21, pp. 2538 - 2549
Although granule secretion is pivotal in many platelet responses, the fusion routes of alpha and delta granule release remain uncertain. We used a 3D... 
BLOOD-PLATELETS | RELEASE REACTION | HUMAN MEGAKARYOCYTES | EXOCYTOSIS | ANGIOGENESIS | ALPHA-GRANULES | CANALICULAR SYSTEM | PROTEINS | HEMATOLOGY | FIBRINOGEN | REVEALS | Secretory Vesicles - genetics | Animals | Blood Platelets - metabolism | Mice, Mutant Strains | Platelet Activation | R-SNARE Proteins - genetics | R-SNARE Proteins - metabolism | Secretory Vesicles - metabolism | Mice | Exocytosis | Index Medicus | Abridged Index Medicus | Platelets and Thrombopoiesis
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16. Full Text Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response
by Battinelli, Elisabeth M and Markens, Beth A and Kulenthirarajan, Rajesh A and Machlus, Kellie R and Flaumenhaft, Robert and Italiano Jr, Joseph E
Blood, ISSN 0006-4971, 01/2014, Volume 123, Issue 1, pp. 101 - 112
Platelets are a reservoir for angiogenic proteins that are secreted in a differentially regulated process. Because of the propensity for clotting, patients... 
SURVIVAL | ACTIVATION | PROGNOSTIC-FACTOR | METASTASIS | ALPHA-GRANULES | MOLECULAR-WEIGHT HEPARIN | THROMBOCYTOSIS | SECRETION | HEMATOLOGY | CANCER | ENDOSTATIN | Human Umbilical Vein Endothelial Cells | Receptor, PAR-1 - antagonists & inhibitors | Anticoagulants - metabolism | Receptor, PAR-1 - metabolism | Humans | Receptor, PAR-1 - agonists | Anticoagulants - therapeutic use | Vascular Endothelial Growth Factor A - metabolism | Polysaccharides - pharmacology | Blood Coagulation - drug effects | MCF-7 Cells | Blood Platelets - cytology | Blood Platelets - metabolism | Neovascularization, Pathologic - metabolism | Platelet Aggregation Inhibitors - metabolism | Angiogenic Proteins - metabolism | Microscopy, Fluorescence | Index Medicus | Abridged Index Medicus | 37 | 35 | Platelets and Thrombopoiesis
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17. Full Text Tetraspanin CD151 and integrin 61 mediate platelet-enhanced endothelial colony forming cell angiogenesis
by Huang, Z and Miao, X and Patarroyo, M and Nilsson, GP and Pernow, J and Li, N
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, ISSN 1538-7933, 03/2016, Volume 14, Issue 3, pp. 606 - 618
Platelet releasates (PRs) enhance endothelial colony forming cell (ECFC) angiogenesis. The impact of platelet membrane components on ECFC angiogenesis was... 
PROGENITOR CELLS | endothelial cells | ACTIVATION | ALPHA-GRANULES | angiogenesis | CD151 protein | CORD BLOOD | PROLIFERATION | PATHOLOGICAL ANGIOGENESIS | integrin 61 | platelets | ADHESION | IN-VIVO | PERIPHERAL VASCULAR DISEASE | PROTEINS | ALPHA-3-BETA-1 | HEMATOLOGY
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18. Full Text Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous deIG frameshift mutations in ITGA2B
by Loroch, S and Trabold, K and Gambaryan, S and Reiss, C and Schwierczek, K and Fleming, I and Sickmann, A and Behnisch, W and Zieger, B and Zahedi, RP and Walter, U and Jurk, K
THROMBOSIS AND HAEMOSTASIS, ISSN 0340-6245, 03/2017, Volume 117, Issue 3, pp. 556 - 569
Glanzmann thrombasthenia (GT) is one of the best characterised inherited platelet function disorders but global platelet proteome has not been determined in... 
ACTIVATABLE FIBRINOLYSIS INHIBITOR | proteomics | ALPHA-GRANULES | Glanzmann thrombasthenia | haemorrhage | alpha(llb)beta integrin | VON-WILLEBRAND-FACTOR | platelets | VONWILLEBRAND-FACTOR | HUMAN MEGAKARYOCYTES | PLASMINOGEN-ACTIVATOR | FACTOR-XIII | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | BINDING | GLYCOPROTEIN-IIB-IIIA | FIBRINOGEN
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19. Full Text Platelets actively sequester angiogenesis regulators
by Klement, Giannoula Lakka and Yip, Tai-Tung and Cassiola, Flavia and Kikuchi, Lena and Cervi, David and Podust, Vladimir and Italiano, Joseph E and Wheatley, Erin and Abou-Slaybi, Abdo and Bender, Elise and Almog, Nava and Kieran, Mark W and Folkman, Judah
Blood, ISSN 0006-4971, 03/2009, Volume 113, Issue 12, pp. 2835 - 2842
Clinical trials with antiangiogenic agents have not been able to validate plasma or serum levels of angiogenesis regulators as reliable markers of cancer... 
FACTOR VEGF | HUMAN MEGAKARYOCYTES | PROTEIN | ALPHA-GRANULES | PROSTATE-CANCER | TUMOR ANGIOGENESIS | HUMAN LIPOSARCOMA | RELEASE | HEMATOLOGY | ENDOTHELIAL GROWTH-FACTOR | ENDOSTATIN | Neoplasm Transplantation | Humans | Liposarcoma - blood supply | Fibroblast Growth Factor 2 - pharmacology | Drug Implants | Male | Cell Line, Tumor - transplantation | Liposarcoma - secretion | Neovascularization, Pathologic - blood | Vascular Endothelial Growth Factor A - secretion | Fibroblast Growth Factor 2 - secretion | Laminin | Thrombin - pharmacology | Neoplasm Proteins - secretion | Platelet-Derived Growth Factor - analysis | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Vascular Endothelial Gr