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Blood, ISSN 0006-4971, 08/2011, Volume 118, Issue 5, pp. 1190 - 1191
Journal Article
BLOOD, ISSN 0006-4971, 03/2016, Volume 127, Issue 11, pp. 1459 - 1467
Platelet and megakaryocyte endocytosis is important for loading certain granule cargo (ie, fibrinogen [Fg] and vascular endothelial growth factor); however,... 
ACTIVATION | MULTIVESICULAR BODIES | ALPHA-GRANULES | IN-VIVO | CELL-ADHESION | SECRETION | ENDOCYTOSIS | HEMATOLOGY | IMMUNOGLOBULIN-G | GUINEA-PIG MEGAKARYOCYTE | FIBRINOGEN
Journal Article
BLOOD, ISSN 0006-4971, 09/2018, Volume 132, Issue 10, pp. 1027 - 1038
We hypothesized that megakaryocyte (MK) phosphoinositide signaling mediated by phosphatidylinositol transfer proteins (PITPs) contributes to hematopoietic stem... 
PROGENITOR CELLS | INTERLEUKIN-4 | COLONY-STIMULATING FACTOR | BONE-MARROW NICHE | QUIESCENCE | PROLIFERATION | PLATELET ALPHA-GRANULES | RECEPTORS | IDENTIFICATION | HEMATOLOGY | STEM
Journal Article
Blood, ISSN 0006-4971, 03/2018, Volume 131, Issue 9, pp. 1000 - 1011
Mutations in NBEAL2, the gene encoding the scaffolding protein Nbeal2, are causal of gray platelet syndrome (GPS), a rare recessive bleeding disorder... 
PROTEIN | GENE | BIOGENESIS | ALPHA-GRANULES | CRYSTAL-STRUCTURE | GRAY PLATELET SYNDROME | DISEASE | MEGAKARYOCYTES | DISORDERS | HEMATOLOGY | BEACH-DOMAIN | Index Medicus | Abridged Index Medicus | Platelets and Thrombopoiesis
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3331 - 3342
Platelets are anuclear organelle-rich cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity. The major platelet... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLYCOPROTEIN-VI | ALPHA-GRANULES | BLEEDING-TIME | INTEGRIN | IN-VIVO | ARTERIAL THROMBOSIS | NBEAL2 | GROWTH-FACTOR | PROTEINS | ISCHEMIC-STROKE | Care and treatment | Genetic aspects | Diagnosis | Research | Gene expression | Blood platelet disorders | Thrombosis | Blood clot | Proteins | Wound healing | Heart attacks | Blood platelets | Microscopy | Colleges & universities | Defects
Journal Article
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 10/2018, Volume 38, Issue 10, pp. 2435 - 2447
Objective Human and mouse megakaryocytes lacking NBEAL2 (neurobeachin-like 2) produce platelets where -granules lack protein cargo. This cargo is mostly... 
megakaryocytes | fibrinogen | ALPHA-GRANULES | THROMBUS FORMATION | GRAY PLATELET SYNDROME | endosomes | ENDOCYTOSIS | IMMUNE CONTINUUM | BIOGENESIS | INFLAMMATION | Von Willebrand factor | DISEASE | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | P-selectin | RAB GTPASES
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2018, Volume 38, Issue 8, pp. 1772 - 1784
OBJECTIVE—Nbeal2 mice, a model of human gray platelet syndrome, have reduced neutrophil granularity and impaired host defense against systemic Staphylococcus... 
IMMUNITY | LUNG | infection | BACTERIA | ALPHA-GRANULES | endotoxemia | PLATELET SYNDROME | NEUTROPHIL EXTRACELLULAR TRAPS | MYELOPEROXIDASE | INFLAMMATION | gray platelet syndrome | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | neutrophils | CONTRIBUTES | sepsis
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2014, Volume 370, Issue 3, pp. 245 - 253
Journal Article
Journal Article
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, ISSN 1538-7933, 03/2016, Volume 14, Issue 3, pp. 606 - 618
Platelet releasates (PRs) enhance endothelial colony forming cell (ECFC) angiogenesis. The impact of platelet membrane components on ECFC angiogenesis was... 
PROGENITOR CELLS | endothelial cells | ACTIVATION | ALPHA-GRANULES | angiogenesis | CD151 protein | CORD BLOOD | PROLIFERATION | PATHOLOGICAL ANGIOGENESIS | integrin 61 | platelets | ADHESION | IN-VIVO | PERIPHERAL VASCULAR DISEASE | PROTEINS | ALPHA-3-BETA-1 | HEMATOLOGY
Journal Article
THROMBOSIS AND HAEMOSTASIS, ISSN 0340-6245, 03/2017, Volume 117, Issue 3, pp. 556 - 569
Glanzmann thrombasthenia (GT) is one of the best characterised inherited platelet function disorders but global platelet proteome has not been determined in... 
ACTIVATABLE FIBRINOLYSIS INHIBITOR | proteomics | ALPHA-GRANULES | Glanzmann thrombasthenia | haemorrhage | alpha(llb)beta integrin | VON-WILLEBRAND-FACTOR | platelets | VONWILLEBRAND-FACTOR | HUMAN MEGAKARYOCYTES | PLASMINOGEN-ACTIVATOR | FACTOR-XIII | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | BINDING | GLYCOPROTEIN-IIB-IIIA | FIBRINOGEN
Journal Article