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ISSN 0306-0012, 12/2014, Volume 44, Issue 1, pp. 91 - 12
Peptide stapling is a strategy for constraining short peptides typically in an alpha-helical conformation. Stapling is carried out by covalently linking the... 
Journal Article
ACCOUNTS OF CHEMICAL RESEARCH, ISSN 0001-4842, 08/2017, Volume 50, Issue 8, pp. 1838 - 1846
The carbonyl group holds a prominent position in chemistry and biology not only because it allows diverse transformations but also because it supports key... 
PRO AMIDE BONDS | SIDE-CHAINS | PI-ASTERISK INTERACTION | CRYSTAL-STRUCTURE | COLLAGEN TRIPLE-HELIX | CARBONYL-CARBONYL INTERACTIONS | PEPTIDE-BOND ISOSTERES | CONFORMATIONAL STABILITY | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-HELICES | HYDROGEN-BONDS
Journal Article
11/2013
The fundamental process by which an alpha-helical membrane protein attains its ultimate structure has previously been depicted as two energetically distinct... 
Membrane protein | Detergent | PLP | 0487 | TM alpha helices | Proteolipid protein | Helix interactions | Membrane | 0307 | Bilayer | 0317
Dissertation
Chemical Society Reviews, ISSN 0306-0012, 01/2015, Volume 44, Issue 1, pp. 91 - 102
Peptide stapling is a strategy for constraining short peptides typically in an alpha-helical conformation. Stapling is carried out by covalently linking the... 
ANALOGS | SIDE-CHAIN | STABILIZATION | STABILITY | CROSS-LINKING | EFFICIENT SYNTHESIS | HELICAL STRUCTURES | INHIBITOR | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-HELICES | Cyclization | Peptides - chemistry | Click Chemistry | Cycloaddition Reaction | Lactams - chemistry | Photochemical Processes
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2013, Volume 110, Issue 11, pp. E986 - E995
Proapoptotic B-cell lymphoma 2 (BCL-2) antagonist/killer (BAK) and BCL-2-associated X (BAX) form toxic mitochondrial pores in response to cellular stress.... 
photocrosslinking | BCL-2 family | BCL-2 HOMOLOG | PROTEIN | MULTIDISCIPLINARY SCIENCES | apoptosis | STABILIZED ALPHA-HELICES | SAHB | BH3 DOMAIN | CYTOCHROME-C | X-RAY | stapled peptide | INHIBITOR | BINDING | MEMBRANE PERMEABILIZATION
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2011, Volume 133, Issue 36, pp. 14220 - 14223
Structure-based design of synthetic inhibitors of protein–protein interactions (PPIs) requires adept molecular design and synthesis strategies as well as... 
PEPTIDOMIMETICS | PEPTIDES | FOLDAMERS | HOT-SPOTS | TARGETS | BINDING-ENERGY | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-HELICES | Molecular Sequence Data | Amino Acid Sequence | Protein Structure, Secondary | Databases, Protein | Drug Design | Proteins | Enzyme inhibitors | Research | Structure | Protein-protein interactions
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 7, pp. 2962 - 2972
A 26-residue peptide BimBH3 binds indiscriminately to multiple oncogenic Bcl2 proteins that regulate apoptosis of cancer cells. Specific inhibition of the... 
APOPTOSIS | CHEMISTRY, MEDICINAL | MELANOMA | BIM | BACTERIAL | PROTEASE INHIBITORS | CONFERS RESISTANCE | ALPHA-HELICES | FAMILY | BFL-1 | WATER
Journal Article
Journal of Proteomics, ISSN 1874-3919, 07/2019, Volume 204, p. 103411
Integral membrane proteins are under-represented in standard proteomic analyses, mostly because of their low expression and absence of trypsin-cleavage sites... 
Integral membrane proteins | Alpha-helices | Membrane proteomics | Glycopeptides | Lymphoma | Missing proteins
Journal Article
by Tian, Y and Li, JX and Zhao, H and Zeng, XZ and Wang, DY and Liu, QS and Niu, XG and Huang, XH and Xu, NH and Li, ZG
CHEMICAL SCIENCE, ISSN 2041-6520, 2016, Volume 7, Issue 5, pp. 3325 - 3330
Peptide stapling emerged as a versatile strategy to recapitulate the bioactive helical conformation of unstructured short peptides in water to improve their... 
ESTROGEN-RECEPTORS | DESIGN | ACTIVATION | AMINO-ACIDS | SIDE-CHAIN | IN-VIVO | PROTEIN-PROTEIN INTERACTIONS | CHEMISTRY, MULTIDISCIPLINARY | CYCLIC-PEPTIDES | ALPHA-HELICES | MACROCYCLIZATION
Journal Article
BIOPHYSICAL JOURNAL, ISSN 0006-3495, 05/2016, Volume 110, Issue 9, pp. 1967 - 1979
Contrary to DNA double-helical structures, hydrogen bonds (H-bonds) involving nitrogen as the acceptor are not common in protein structures. We systematically... 
CONTACTS | NMR DETECTION | TRANSMEMBRANE HELICES | BIOPHYSICS | PI INTERACTIONS | AB-INITIO | COMPLEXES | BASIS-SETS | ALPHA-HELICES | CD-HIT | INSIGHTS
Journal Article
Chemical Science, ISSN 2041-6520, 2016, Volume 7, Issue 6, pp. 3694 - 3702
The development of constrained peptides represents an emerging strategy to generate peptide based probes and hits for drug-discovery that address challenging... 
APOPTOSIS | BH3 HELIX | SMALL-MOLECULE INHIBITORS | AMINO-ACIDS | IN-VIVO | CROSS-LINKING | PROTEIN-PROTEIN INTERACTIONS | STAPLED PEPTIDES | DISORDERED PROTEIN | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-HELICES
Journal Article
JOURNAL OF PROTEOMICS, ISSN 1874-3919, 07/2019, Volume 204
Integral membrane proteins are under-represented in standard proteomic analyses, mostly because of their low expression and absence of trypsin-cleavage sites... 
Integral membrane proteins | DIGESTION | EXTRACTION | Membrane proteomics | Missing proteins | BIOCHEMICAL RESEARCH METHODS | ENRICHMENT | Alpha-helices | Glycopeptides | Lymphoma
Journal Article
Chemical Science, ISSN 2041-6520, 2016, Volume 7, Issue 8, pp. 4842 - 4847
The precise control over the organization of photoactive components at the nanoscale is one of the main challenges for the generation of new and sophisticated... 
DYE | CHARGE-CARRIER | DESIGN | CIRCULAR-DICHROISM | SOLAR-CELLS | FILMS | DNA | TPR PROTEINS | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-HELICES | ARRAYS
Journal Article
Journal Article