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Nature Chemistry, ISSN 1755-4330, 04/2016, Volume 8, Issue 5, pp. 407 - 418
Journal Article
Synlett, ISSN 0936-5214, 09/2017, Volume 28, Issue 15, pp. 1929 - 1933
Abstract Cyclic hydroxylamines form esters instead of the expected amides as major product upon reaction with α-ketoacids. In this report, we document a... 
cluster | 5-OXAPROLINE | alpha-ketoacids | esters | SERINE | ligation | CHEMISTRY, ORGANIC | peptides | CHEMICAL PROTEIN-SYNTHESIS | mechanism | hydroxylamines | CYCLIZATION
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2015, Volume 137, Issue 11, pp. 3958 - 3966
The recent disclosures of two classes of acylborons, potassium acyltrifluoroborates (ICATs) and N-methyliminodiacetyl (MIDA) acylboronates, demonstrated that... 
ORGANIC-SYNTHESIS | TETRAHEDRAL CHARACTER | MOLECULAR-STRUCTURE | CARBON-MONOXIDE | CARBONYLATION REACTIONS | AMINE COMPLEXES | BORON ATOM | SUBSTITUTION-REACTIONS | PROTEIN-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-KETOACIDS | Chemical synthesis | Research
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 01/2018, Volume 57, Issue 3, pp. 818 - 822
Journal Article
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 4, pp. 2878 - 2884
The chemical synthesis of peptide-based [1]rotaxanes (lasso peptides) was achieved by [2]rotaxane formation followed by two chemoselective ligation reactions.... 
CYCLIC PEPTIDE | PROPEPTIDES | MICROCIN J25 | AFFINITY | LIGATION | BINDING | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-KETOACIDS | Synthesis (chemistry) | Stability | Peptides | Rotaxanes | Chemical reactions | Scaffolds | Grafting | Chromatography
Journal Article
Nature Chemistry, ISSN 1755-4330, 08/2015, Volume 7, Issue 8, pp. 668 - 672
Amide-forming ligation reactions allow the chemical synthesis of proteins by the union of unprotected peptide segments, and enable the preparation of protein... 
REARRANGEMENT | KETOACID-HYDROXYLAMINE LIGATION | 5-OXAPROLINE | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-KETOACIDS | Amino Acids - chemistry | Amino Acid Sequence | Fluorenes - chemistry | Hydroxylamine - chemistry | Proteins - chemical synthesis | Serine - chemistry
Journal Article
Scientific Reports, ISSN 2045-2322, 07/2016, Volume 6, Issue 1, p. 28775
Maple Syrup Urine Disease (MSUD) is an inherited disorder caused by the dysfunction in the branched chain keto-acid dehydrogenase (BCKDH) enzyme. This leads to... 
SYRUP-URINE-DISEASE | RAT-LIVER CELLS | OXIDATIVE STRESS | PROTEIN-TURNOVER | ABNORMALITIES | PATHWAY | MULTIDISCIPLINARY SCIENCES | MICE | ALPHA-KETOACIDS | DEHYDROGENASE | BRAIN
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 09/2016, Volume 57, Issue 39, pp. 4319 - 4324
The total chemical synthesis of proteins is a useful alternative to living systems for accessing small proteins. Significant progresses have been made these... 
Desulfurization | SEA ligation | Chemical protein synthesis | SUMO | KAHA ligation | NCL | HYDRAZIDES | UBIQUITIN | CHEMISTRY, ORGANIC | SELENOCYSTEINE | THIOESTER | ALPHA-KETOACIDS | KETOACID-HYDROXYLAMINE LIGATION | AMINO-ACID | STAUDINGER LIGATION | UBIQUITYLATION | NATIVE PEPTIDE LIGATION | Chemical synthesis
Journal Article
Synlett, ISSN 0936-5214, 11/2015, Volume 26, Issue 18, pp. 2565 - 1569
Abstract An efficient and straightforward approach for the coupling of N α -protected hydroxamic acids with an amino component in the presence of iodine is... 
letter | protected amino hydroxamic acids | oxidative acylation | acyl nitroso intermediate | amino acid esters | iodine | AMIDE-BOND | NATIVE CHEMICAL LIGATION | LOSSEN REARRANGEMENT | CHEMISTRY, ORGANIC | ALPHA-KETOACIDS | THIOACIDS | STAUDINGER LIGATION | SULFONYL AZIDES | ACYL-NITROSO | N-alpha-protected amino hydroxamic acids | DIRECT AMIDATION | CARBOXYLIC-ACIDS
Journal Article
TETRAHEDRON, ISSN 0040-4020, 06/2010, Volume 66, Issue 26, pp. 4841 - 4853
The design and general synthesis of enantiopure isoxazolidinone monomers as precursors for the preparation of enantiopure N-terminal... 
PEPTIDE FOLDAMERS | DESIGN | CHEMISTRY, ORGANIC | ALPHA-KETOACIDS | OLIGOMERS | STRATEGIES | beta-oligopeptides | BETA-AMINO ACIDS | (+)-NEGAMYCIN | 1,3-DIPOLAR CYCLOADDITION | CHEMICAL LIGATION | Amide ligation | PROTEINS | Enantiopure isoxazolidinone monomers
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 11/2012, Volume 18, Issue 45, pp. 14444 - 14453
A chlorophosphite‐modified, Staudinger‐like acylation of azides involving a highly chemoselective, direct nucleophilic acyl substitution of carboxylic acids is... 
amides | acyl substitution | azides | Staudinger ligation | carboxylic acids | ORGANIC-SYNTHESIS | FMOC AMINO-ACID | SOLID-PHASE | COUPLING REAGENTS | PHASE PEPTIDE-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-KETOACIDS | SYNTHETIC TRICKS | WITTIG REACTION | CHEMICAL-SYNTHESIS | AMIDE BOND FORMATION | Substitution reactions | Organic acids | Acylation | Acids | Chemical synthesis
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2009, Volume 131, Issue 11, pp. 3864 - 3865
A new N-sulfonyloxaziridine reagent for the conversion of N-terminal peptide amines to the corresponding hydroxylamines without overoxidation or erosion of... 
OXIDATION | AMINES | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-KETOACIDS | Amines - chemistry | Indicators and Reagents | Aziridines | Peptides - chemical synthesis | Stereoisomerism | Hydroxylamines - chemical synthesis
Journal Article
Cell Biology and Toxicology, ISSN 0742-2091, 4/2013, Volume 29, Issue 2, pp. 75 - 84
Journal Article