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The Journal of biological chemistry, ISSN 1083-351X, 05/2016, Volume 291, Issue 21, pp. 11083 - 11093
The AlkB repair enzymes, including Escherichia coli AlkB and two human homologues, ALKBH2 and ALKBH3, are iron(II)- and 2-oxoglutarate-dependent dioxygenases... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | DNA Repair Enzymes - genetics | Crystallography, X-Ray | Mixed Function Oxygenases - metabolism | DNA Methylation | RNA Interference | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - metabolism | DNA Repair Enzymes - metabolism | DNA Repair Enzymes - antagonists & inhibitors | Escherichia coli Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cell Line | Catalytic Domain | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Mixed Function Oxygenases - antagonists & inhibitors | Recombinant Proteins - genetics | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | Escherichia coli Proteins - genetics | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - metabolism | Anthraquinones - pharmacology | DNA Damage | Anthraquinones - chemistry | Mixed Function Oxygenases - genetics | Methyl Methanesulfonate - pharmacology | Index Medicus | cancer therapy | DNA and Chromosomes | bacteria | chemical biology | enzyme inhibitor | DNA-protein interaction | DNA repair | enzyme structure
Journal Article
Chemistry, an Asian journal, ISSN 1861-4728, 10/2018, Volume 13, Issue 19, pp. 2854 - 2867
Dynamic combinatorial chemistry (DCC) is a powerful supramolecular approach for discovering ligands for biomolecules. To date, most, if not all, biologically... 
inhibitors | dynamic combinatorial chemistry | drug discovery | proteins | epigenetics | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Oxidoreductases, O-Demethylating - chemistry | Humans | Peptides - genetics | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - chemistry | Fluorometry - methods | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - antagonists & inhibitors | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics | AlkB Homolog 5, RNA Demethylase - genetics | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Protein Denaturation | Protein Engineering | Oxidoreductases, O-Demethylating - antagonists & inhibitors | AlkB Homolog 5, RNA Demethylase - chemistry | Molecular Structure | AlkB Homolog 5, RNA Demethylase - antagonists & inhibitors | Catalysis | Oxidoreductases, O-Demethylating - genetics | Combinatorial Chemistry Techniques - methods | Peptides - chemistry | Protein Structure, Secondary | Recombinant Fusion Proteins - chemistry | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - chemistry | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - genetics | Hydrazones - chemistry | Recombinant Fusion Proteins - genetics | Ligands | Kinetics | Transition Temperature | Proteins | Combinatorial chemistry | Epigenetic inheritance | Drug discovery | Nucleic acids | Surface active agents | Index Medicus
Journal Article
Journal Article
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 11/2007, Volume 318, Issue 5855, pp. 1469 - 1472
Journal Article
Cancer cell, ISSN 1535-6108, 04/2019, Volume 35, Issue 4, pp. 677 - 691.e10
FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis. Using structure-based rational design, we have developed two... 
cancer therapy | acute myeloid leukemia | target validation | FTO inhibitor | structure-based design | RNA epitranscriptomics | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Apoptosis - drug effects | Humans | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - antagonists & inhibitors | Structure-Activity Relationship | Molecular Targeted Therapy | RNA, Messenger - metabolism | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics | Dose-Response Relationship, Drug | Leukemia, Myeloid, Acute - enzymology | Enzyme Inhibitors - pharmacokinetics | U937 Cells | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Signal Transduction | Leukemia, Myeloid, Acute - pathology | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - chemistry | Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism | Antineoplastic Agents - chemistry | Rats, Sprague-Dawley | Xenograft Model Antitumor Assays | Animals | Cell Cycle Checkpoints - drug effects | Cell Differentiation - drug effects | Mice, Inbred NOD | Protein Conformation | Cell Proliferation - drug effects | Mice, Inbred BALB C | Methylation | Leukemia, Myeloid, Acute - genetics | Medical colleges | RNA | Analysis | Index Medicus
Journal Article
Journal Article
The New England journal of medicine, ISSN 1533-4406, 09/2015, Volume 373, Issue 10, pp. 895 - 907
Journal Article