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Neurosurgery, ISSN 0148-396X, 11/2017, Volume 81, Issue 5, pp. E56 - E57
Journal Article
CANCER CELL, ISSN 1535-6108, 12/2015, Volume 28, Issue 6, pp. 773 - 784
Heterozygous mutation of IDH1 in cancers modifies IDH1 enzymatic activity, reprogramming metabolite flux and markedly elevating 2-hydroxyglutarate (2-HG).... 
ISOCITRATE DEHYDROGENASE 1 | GLIOMA-CELLS | ONCOLOGY | PROMOTES DIFFERENTIATION | PATHWAY MUTATIONS | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | ALPHA-KETOGLUTARATE | ACUTE MYELOID-LEUKEMIA | ONCOMETABOLITE 2-HYDROXYGLUTARATE | GLUTAMINE-METABOLISM | REDUCTIVE CARBOXYLATION | CELL BIOLOGY
Journal Article
CURRENT OPINION IN BIOTECHNOLOGY, ISSN 0958-1669, 08/2015, Volume 34, pp. 189 - 201
Measuring intracellular metabolism has increasingly led to important insights in biomedical research. C-13 tracer analysis, although less information-rich than... 
NUCLEOTIDE SYNTHESIS | REDUCTIVE GLUTAMINE-METABOLISM | PENTOSE-PHOSPHATE PATHWAY | FATTY-ACID SYNTHESIS | FLUX RATIO ANALYSIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMICAL RESEARCH METHODS | ALPHA-KETOGLUTARATE | MASS ISOTOPOMER DISTRIBUTIONS | MAMMALIAN-CELLS | CORYNEBACTERIUM-GLUTAMICUM | CELLULAR-METABOLISM
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2015, Volume 373, Issue 10, pp. 895 - 907
Journal Article
Journal of Physical Chemistry A, ISSN 1089-5639, 03/2016, Volume 120, Issue 8, p. 1261
Journal Article
Coordination Chemistry Reviews, ISSN 0010-8545, 01/2013, Volume 257, Issue 2, pp. 414 - 428
Journal Article
Drug and Chemical Toxicology, ISSN 0148-0545, 2019, pp. 1 - 6
Alcohol is the most abused psychoactive substance and known hepatotoxicant. Present study elucidates possible therapeutic effect of oral alpha-ketoglutarate... 
Tc-mebrofenin hepatobiliary scintigraphy | alcohol | Alpha-ketoglutarate | functional imaging | hepatotoxicity
Journal Article
RADIOLOGY, ISSN 0033-8419, 05/2018, Volume 287, Issue 2, pp. 667 - 675
Purpose: To assess the clinical safety, pharmacokinetics, and tumor imaging characteristics of fluorine 18-(2S,4R)-4-fluoroglutamine (FGln), a glutamine analog... 
CELLS | ACTIVATION | PROTEIN | ACID | GROWTH | ALPHA-KETOGLUTARATE | MAINTAINS | CARBOXYLATION | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ATF4
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2018, Volume 24, Issue 24, pp. 6433 - 6446
Purpose: Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC) is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH).... 
IDH2 MUTATIONS | GENE | ONCOLOGY | ACIDURIA | ALPHA-KETOGLUTARATE | ACUTE MYELOID-LEUKEMIA | ONCOMETABOLITE 2-HYDROXYGLUTARATE | PUTATIVE ONCOMETABOLITE | CELL CARCINOMA | DEHYDROGENASE | HISTONE
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7492, pp. 371 - 375
Journal Article
Oncotarget, 2017, Volume 8, Issue 48, pp. 83962 - 83974
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 03/2019, Volume 20, Issue 3, pp. 252 - 260
Activated p53 can promote apoptosis or cell cycle arrest. Differences in energy metabolism can influence cell fate in response to activated p53. Nutlin-3a is a... 
apoptosis | Alpha-ketoglutarate | autophagy | Nutlin-3a | p53 | GLYCOLYSIS | INHIBITION | METABOLISM | ONCOLOGY | CANCER | LIFE
Journal Article