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alpha-ketoheterocycle inhibitors (53) 53
index medicus (39) 39
chemistry, medicinal (37) 37
amidohydrolases - antagonists & inhibitors (32) 32
humans (32) 32
animals (28) 28
anandamide (26) 26
amidohydrolases - metabolism (24) 24
enzyme (23) 23
fatty acid amide hydrolase (21) 21
acid amide hydrolase (20) 20
enzyme inhibitors - chemistry (20) 20
chemistry, organic (19) 19
discovery (18) 18
enzyme inhibitors - pharmacology (18) 18
faah (18) 18
structure-activity relationship (18) 18
molecular characterization (16) 16
endocannabinoid system (14) 14
enzyme inhibitors - chemical synthesis (14) 14
rats (14) 14
faah inhibitor (13) 13
inactivation (13) 13
molecular structure (13) 13
fatty acids (12) 12
pharmacology & pharmacy (12) 12
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biochemistry & molecular biology (11) 11
enzymes (11) 11
ketooxazole inhibitors (11) 11
lipids (11) 11
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monoacylglycerol lipase (11) 11
article (10) 10
dose-response relationship, drug (10) 10
cannabinoid receptor (9) 9
pain (9) 9
reversible inhibitors (9) 9
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exceptionally potent (8) 8
hydrolases (8) 8
mice (8) 8
design (7) 7
drug discovery (7) 7
models, molecular (7) 7
selective faah inhibitor (7) 7
therapeutic target (7) 7
binding sites (6) 6
drug design (6) 6
enzyme inhibitors - therapeutic use (6) 6
kinetics (6) 6
amidohydrolases - chemistry (5) 5
arachidonic acids - metabolism (5) 5
binding (5) 5
cannabinoid receptors (5) 5
crystal-structure (5) 5
endocannabinoids - metabolism (5) 5
in-vivo (5) 5
pain - drug therapy (5) 5
polyunsaturated alkamides - metabolism (5) 5
psychological phenomena and processes (5) 5
urea (5) 5
analgesia (4) 4
analgesics - chemistry (4) 4
analogs (4) 4
anandamide hydrolysis (4) 4
brain - metabolism (4) 4
cannabinoid (4) 4
catalysis (4) 4
catalytic domain (4) 4
crystallography, x-ray (4) 4
monoacylglycerol lipases - antagonists & inhibitors (4) 4
nervous system (4) 4
pf-04457845 (4) 4
research (4) 4
selectivity (4) 4
spirocyclic inhibitors (4) 4
urea - analogs & derivatives (4) 4
urea - chemistry (4) 4
urea - pharmacology (4) 4
active-site (3) 3
analgesics - pharmacology (3) 3
anti-inflammatory agents, non-steroidal - chemistry (3) 3
biological evaluation (3) 3
cb1 receptor (3) 3
chemical properties (3) 3
complex proteomes (3) 3
computer simulation (3) 3
covalent inhibitors (3) 3
endogenous cannabinoid anandamide (3) 3
enzyme activation (3) 3
faah inhibitors (3) 3
fatty acid amides (3) 3
hydrolysis (3) 3
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letter (3) 3
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Annual Reports in Medicinal Chemistry, ISSN 0065-7743, 2012, Volume 47, pp. 413 - 439
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2011, Volume 338, Issue 1, pp. 114 - 124
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 21, pp. 8484 - 8496
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 3, pp. 1272 - 1277
The rationale behind the discovery and the biological evaluations of this novel class of FAAH inhibitors are presented. Both in vitro and in vivo results of... 
FAAH | Nonprostanoid | Oxime | Inhibition kinetic | Prostacyclin | 1MT5 | Cannabinoid | Pain | Endocannabinoid | Molecular modeling | Signaling lipid | Eicosanoid | Curtius | Antiinflammatory | Biphenyl | Antinociceptive | Essential fatty acid | Tetrahydrocannabinol | Nociception | Reversible | para-Phenoxy | Hargreaves | Fatty acid amide hydrolase | Isoprenoid | Cholesterol | Anandamide | Electrophilic recognition | Urea | Bisarylazole carbamates | 2VYA | Signal termination | Hammond’s Postulate | Marijuana | Inhibitor | Carbamate | Preclinical model | Hammond's Postulate | DESIGN | INACTIVATION | DERIVATIVES | ALPHA-KETOHETEROCYCLE INHIBITORS | CHEMISTRY, MEDICINAL | MECHANISM | CHEMISTRY, ORGANIC | POTENT | ACID AMIDE HYDROLASE | AGENTS | BINDING | Protein Structure, Tertiary | Cell Line | Humans | Rats | Amidohydrolases - antagonists & inhibitors | Crystallography, X-Ray | Drug Discovery - methods | Carbamates - chemistry | Carbamates - metabolism | Oximes - chemistry | Cannabinoid Receptor Modulators - physiology | Animals | Signal Transduction - drug effects | Oximes - metabolism | Amidohydrolases - physiology | Oximes - pharmacology | Signal Transduction - physiology | Carbamates - pharmacology | Protein Binding - physiology | Enzymes | Monounsaturated fatty acids | Analysis | Carbamates | Hydrolases | Essential fatty acids | Prostanoids
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2019, Volume 29, Issue 2, pp. 238 - 243
Conceptual design and modification of urea moiety in chemotype PF-3845/04457845, the bench marking irreversible inhibitor of fatty acid amide hydrolase (FAAH),... 
Diastereomeric resolution | Fatty acid amide hydrolase (FAAH) inhibitors | Chemotherapy-induced peripheral neuropathy | Reversible mechanism of action | ALPHA-KETOHETEROCYCLE INHIBITORS | CHEMISTRY, MEDICINAL | MANAGEMENT | PHARMACOLOGICAL CHARACTERIZATION | ANANDAMIDE | CHEMISTRY, ORGANIC | POTENT | ENZYME | ACID AMIDE HYDROLASE
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 10, pp. 2865 - 2869
Journal Article