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American journal of human genetics, ISSN 0002-9297, 2016, Volume 99, Issue 5, pp. 1190 - 1198
Uveal melanoma (UM) is a rare intraocular tumor that, similar to cutaneous melanoma, originates from melanocytes. To gain insights into its genetics, we... 
OCULAR MELANOMA | CELLS | COLORECTAL-CANCER | PROTEINS DLK1 | METASTASES | GENETICS & HEREDITY | RISK | EXPRESSION | RADIATION | SF3B1 | SOMATIC MUTATIONS | Melanoma - diagnosis | Exons | Humans | Middle Aged | Male | Phosphoproteins - metabolism | Case-Control Studies | RNA Splicing Factors - metabolism | DNA Copy Number Variations | Melanoma - genetics | Melanocytes - pathology | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Ubiquitin Thiolesterase - metabolism | Adult | Female | Membrane Proteins - metabolism | Eukaryotic Initiation Factor-1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Uveal Neoplasms - genetics | Genome-Wide Association Study | Tumor Suppressor Proteins - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Membrane Proteins - genetics | Eukaryotic Initiation Factor-1 - genetics | Ubiquitin-Protein Ligases - metabolism | GTP-Binding Protein alpha Subunits - genetics | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Ubiquitin Thiolesterase - genetics | Skin Neoplasms | Uveal Neoplasms - diagnosis | Aged | Mutation | Ubiquitin-Protein Ligases - genetics | Genetic aspects | Nucleotide sequencing | Methods | Melanoma | DNA sequencing | Report
Journal Article
The FASEB Journal, ISSN 0892-6638, 02/2013, Volume 27, Issue 2, pp. 832 - 842
Pasteurella multocida is the causative agent of a number of epizootic and zoonotic diseases. Its major virulence factor associated with atrophic rhinitis in... 
deamidation | GTPase domain | helical domain | oncogene | PMT | Helical domain | Deamidation | Oncogene | MITOGENIC TOXIN | ACTIVATION | G-ALPHA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | CANCER | RHOA | CELL BIOLOGY | GROWTH | BIOLOGY | GTPASE | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | GTP-Binding Protein alpha Subunits - chemistry | Humans | DNA, Complementary - genetics | Bacterial Toxins - toxicity | Molecular Sequence Data | Substrate Specificity | Recombinant Fusion Proteins - metabolism | GTP-Binding Protein alpha Subunits, Gi-Go - chemistry | Bacterial Proteins - toxicity | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | Pasteurella multocida - metabolism | Base Sequence | HEK293 Cells | Bacterial Toxins - genetics | Glutamine - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Binding Sites | Peptide Fragments - genetics | Amino Acid Sequence | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Peptide Fragments - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Mutagenesis, Site-Directed | Bacterial Proteins - genetics | Cells, Cultured | GTP-Binding Protein alpha Subunits - genetics | Pasteurella multocida - genetics | Recombinant Fusion Proteins - chemistry | Mice, Knockout | Sequence Homology, Amino Acid | Pasteurella multocida - pathogenicity | Bacterial Toxins - metabolism | Peptide Fragments - chemistry | Animals | Signal Transduction - drug effects | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | GTP-Binding Protein alpha Subunits - deficiency | Mice | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Amino Acid Substitution | Research Communications
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 558, Issue 7711, pp. 553 - 558
Journal Article
Nature cell biology, ISSN 1476-4679, 2014, Volume 16, Issue 8, pp. 758 - 769
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 01/2011, Volume 286, Issue 4, pp. 2625 - 2635
Ric-8A and Ric-8B are nonreceptor G protein guanine nucleotide exchange factors that collectively bind the four subfamilies of G protein alpha subunits.... 
LIMITED PROTEOLYSIS | CONFORMATIONAL-CHANGES | ADENYLYL-CYCLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOTIDE EXCHANGE FACTOR | PHOSPHOLIPASE-C-BETA | CORTICAL LOCALIZATION | ASYMMETRIC CELL-DIVISION | PLASMA-MEMBRANE | GUANINE-NUCLEOTIDES | BINDING REGULATORY PROTEINS | Recombinant Fusion Proteins - isolation & purification | GTP-Binding Protein alpha Subunits, Gs - chemistry | GTP-Binding Protein alpha Subunits - chemistry | Glutathione Transferase - isolation & purification | Humans | Baculoviridae - genetics | GTP-Binding Protein alpha Subunits - biosynthesis | Isoenzymes - chemistry | Spodoptera | GTP-Binding Protein alpha Subunits, Gs - genetics | GTP-Binding Protein alpha Subunits - isolation & purification | Glutathione Transferase - genetics | Isoenzymes - metabolism | HEK293 Cells | Recombinant Fusion Proteins - biosynthesis | GTP-Binding Protein alpha Subunits, Gs - biosynthesis | Gene Expression | GTP-Binding Protein alpha Subunits - genetics | Adenylyl Cyclases - metabolism | Recombinant Fusion Proteins - chemistry | Glutathione Transferase - chemistry | Glutathione Transferase - biosynthesis | Animals | Adenylyl Cyclases - chemistry | GTP-Binding Protein alpha Subunits, Gs - isolation & purification | Recombinant Fusion Proteins - genetics | Enzyme Activation | Ric-8 | Signal Transduction | G Proteins | Protein Purification | Myristoylation | Adenylate Cyclase (Adenylyl Cyclase) | Phospholipase C | Guanine Nucleotide Exchange Factor
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 05/2016, Volume 107, pp. 59 - 66
[Display omitted] Gαq inhibitor UBO-QIC (FR900359) is becoming an important pharmacological tool, but its selectivity against other G proteins and their... 
UBO-QIC | Gαq inhibitor | GPCR | FR900359 | Gβγ subunits | G protein | inhibitor | GTP-Binding Protein alpha Subunits, Gi-Go - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Receptor, Muscarinic M2 - agonists | Receptor, Muscarinic M2 - genetics | Cricetulus | Humans | GTP-Binding Protein beta Subunits - antagonists & inhibitors | GTP-Binding Protein gamma Subunits - antagonists & inhibitors | Depsipeptides - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | GTP-Binding Protein gamma Subunits - agonists | HEK293 Cells | Platelet Aggregation Inhibitors - pharmacology | Receptor, Muscarinic M2 - antagonists & inhibitors | GTP-Binding Protein beta Subunits - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Adenosine A1 - genetics | CHO Cells | Pertussis Toxin - pharmacology | Recombinant Proteins - metabolism | GTP-Binding Protein gamma Subunits - metabolism | Receptor, Muscarinic M2 - metabolism | Enzyme Inhibitors - pharmacology | GTP-Binding Protein beta Subunits - agonists | Recombinant Proteins - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Receptor, Adenosine A1 - chemistry | Receptor, Adenosine A1 - metabolism | Animals | MAP Kinase Signaling System - drug effects | GTP-Binding Protein alpha Subunits, Gi-Go - antagonists & inhibitors | Signal Transduction - drug effects | Models, Biological | Proto-Oncogene Proteins c-akt - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Gβγsubunits
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 36, pp. 18915 - 18931
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2018, Volume 115, Issue 15, pp. E3549 - E3558
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2009, Volume 119, Issue 10, pp. 3011 - 3023
Cytokines orchestrate the tumor-promoting interplay between malignant cells and the immune system. In many experimental and human cancers, the cytokine... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | INTERLEUKIN-17 FAMILY | IN-VIVO | GROWTH | IL-17-PRODUCING T-CELLS | FACTOR RECEPTOR P55 | PHASE-II | NECROSIS-FACTOR-ALPHA | NF-KAPPA-B | Humans | Tumor Necrosis Factor-alpha - genetics | Interleukin-17 - immunology | Antibodies, Monoclonal - therapeutic use | Gene Expression Profiling | Chimera - genetics | CD4-Positive T-Lymphocytes - immunology | Interleukin-23 - genetics | Ovarian Neoplasms - genetics | Chimera - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Infliximab | Microarray Analysis | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - therapeutic use | Female | Ovarian Neoplasms - drug therapy | Disease Models, Animal | Interleukin-2 Receptor alpha Subunit - immunology | Receptors, Interleukin - immunology | Mice, Inbred C57BL | Receptors, Tumor Necrosis Factor, Type I | Interleukin-17 - genetics | Clinical Trials as Topic | Receptors, Interleukin - genetics | Interleukin-23 - immunology | Mice, Knockout | Animals | Signal Transduction - physiology | Mice | Ovarian Neoplasms - immunology | Interleukin-2 Receptor alpha Subunit | Signal Transduction | Anti-Inflammatory Agents | Interleukin-23 | Receptors, Interleukin | Antibodies, Monoclonal | Tumor Necrosis Factor-alpha | Life Sciences | Immunology | CD4-Positive T-Lymphocytes | Interleukin-17 | Ovarian Neoplasms | Chimera
Journal Article