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enantioselective alpha-trifluoromethylation (78) 78
chemistry, multidisciplinary (75) 75
chemistry, organic (71) 71
alpha-trifluoromethylation (68) 68
catalysis (52) 52
trifluoromethylation (41) 41
fluorine (38) 38
aldehydes (36) 36
index medicus (35) 35
photoredox catalysis (28) 28
carbonyl-compounds (27) 27
medicinal chemistry (26) 26
organocatalysis (23) 23
oxidative trifluoromethylation (23) 23
stereoisomerism (22) 22
ketones (21) 21
copper-catalyzed trifluoromethylation (20) 20
electrophilic trifluoromethylation (20) 20
radical trifluoromethylation (20) 20
silyl enol ethers (20) 20
derivatives (19) 19
molecular structure (19) 19
organic chemistry (19) 19
alkenes (18) 18
copper (18) 18
fluorination (18) 18
chemistry (15) 15
reagents (15) 15
asymmetric catalysis (14) 14
copper - chemistry (13) 13
mediated trifluoromethylation (13) 13
methylation (13) 13
radicals (13) 13
room-temperature (13) 13
allylic alkylation (12) 12
c-h trifluoromethylation (12) 12
construction (12) 12
hydrocarbons, fluorinated - chemistry (12) 12
synthesis (12) 12
alkylation (11) 11
nucleophilic trifluoromethylation (11) 11
pd-catalyzed ortho-trifluoromethylation (11) 11
cooperative catalysis (10) 10
cyclization (10) 10
acids (9) 9
bond formation (9) 9
catalyzed trifluoromethylation (9) 9
hydrocarbons, fluorinated - chemical synthesis (9) 9
kupfer (9) 9
light photoredox catalysis (9) 9
michael addition (9) 9
alcohols (8) 8
asymmetric trifluoromethylation (8) 8
catalysts (8) 8
chemistry, applied (8) 8
esters (8) 8
ethers (8) 8
mild electrophilic trifluoromethylation (8) 8
photocatalysis (8) 8
reagent (8) 8
silver-mediated trifluoromethylation (8) 8
terminal alkenes (8) 8
alkenes - chemistry (7) 7
alkynes (7) 7
carbon (7) 7
efficient (7) 7
highly efficient (7) 7
organic-synthesis (7) 7
oxidation-reduction (7) 7
radical reactions (7) 7
trimethylchlorosilan (7) 7
trimethylchlorosilane (7) 7
aldehydes - chemistry (6) 6
alpha,beta-unsaturated carboxylic-acids (6) 6
arenes (6) 6
article (6) 6
aryl (6) 6
asymmetric synthesis (6) 6
boronic acids (6) 6
bronsted acid (6) 6
c-h functionalization (6) 6
homogeneous catalysis (6) 6
perfluoroalkyl iodides (6) 6
perfluoroalkylation (6) 6
photochemistry (6) 6
photoredox organocatalysis (6) 6
propargylic alcohols (6) 6
relay catalysis (6) 6
stereoselective-synthesis (6) 6
titanium ate (6) 6
transformations (6) 6
transition-metal catalysis (6) 6
visible light (6) 6
activated alkenes (5) 5
alkyl-halides (5) 5
analysis (5) 5
aromatic-compounds (5) 5
aryl boronic acids (5) 5
bond-formation (5) 5
bond-forming reactions (5) 5
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Accounts of Chemical Research, ISSN 0001-4842, 09/2016, Volume 49, Issue 9, pp. 1937 - 1945
Trifluoromethyl (CF3) and difluoromethyl (CF2H) groups are versatile structural motifs, especially in the fields of pharmaceuticals and agrochemicals. Thus,... 
ALKENES | DIASTEREOSELECTIVE SYNTHESIS | CONVERSION | RECENT PROGRESS | FLUORINE | ARYL | ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION | ALKYNES | COMBINING PHOTOREDOX | CHEMISTRY, MULTIDISCIPLINARY | HIGHLY EFFICIENT
Journal Article
Nature, ISSN 0028-0836, 05/2011, Volume 473, Issue 7348, pp. 470 - 477
Recent advances in catalysis have made the incorporation of fluorine into complex organic molecules easier than ever before, but selective, general and... 
PALLADIUM | CARBON | COUPLING REACTIONS | FUNCTIONALIZED ARYL | MULTIDISCIPLINARY SCIENCES | COMPLEXES | REACTIVITY | CHEMISTRY | BOND FORMATION | FORMING REDUCTIVE ELIMINATION | ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION | Tomography | Chemistry | Catalysis | Fluorides | Fluorine | Pharmaceuticals
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 05/2015, Volume 137, Issue 17, pp. 5678 - 5681
The visible-light-driven, phase-transfer-catalyzed, enantioselective perfluoroalkylation and trifluoromethylation of cyclic β-ketoesters is described. The... 
DONOR-ACCEPTOR COMPLEX | ALPHA-TRIFLUOROMETHYLATION | ALKYLATION | FLUORINE | ALDEHYDES | DUAL-CATALYSIS | CHEMISTRY, MULTIDISCIPLINARY | Illumination | Iodides | Perfluoroalkyls | Ambient temperature | Photochemical | Communication
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 1/2013, Volume 42, Issue 3, pp. 1337 - 1378
The combination of transition metal catalysis and organocatalysis as a new and exciting research area has attracted increasing attention as it can enable the... 
LEWIS-BASE CATALYSIS | COOPERATIVE CATALYSIS | RELAY CATALYSIS | DOMINO REACTIONS | GOLD CATALYSIS | ALLYLIC ALCOHOLS | BIOMIMETIC ASYMMETRIC HYDROGENATION | CHIRAL BRONSTED ACID | MERGING ORGANOCATALYSIS | ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 01/2013, Volume 42, Issue 3, pp. 1337 - 1378
The combination of transition metal catalysis and organocatalysis as a new and exciting research area has attracted increasing attention as it can enable the... 
Transition metals | Transformations | Excitation | Catalysis | Catalysts
Journal Article
Chemical Science, ISSN 2041-6520, 2/2012, Volume 3, Issue 3, pp. 633 - 658
Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct... 
ASYMMETRIC CATALYSIS | BRONSTED ACID | DOUBLE-ACTIVATION METHOD | COOPERATIVE CATALYSIS | MILD ELECTROPHILIC TRIFLUOROMETHYLATION | AMINO-ACID DERIVATIVES | TRANSITION-METAL | PHASE-TRANSFER CATALYST | ALLYLIC ALKYLATION | ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Chemical Science, ISSN 2041-6520, 12/2012, Volume 3, Issue 12, pp. 3458 - 3462
Copper-catalyzed olefinic trifluoromethylation and oxytrifluoromethylation of enamides is reported. The direct olefinic C-H trifluoromethylation constitutes an... 
BORONIC ACIDS | HYPERVALENT IODINE | MEDIATED TRIFLUOROMETHYLATION | BOND FORMATION | FLUORINE | ARYL | ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION | OXIDATIVE TRIFLUOROMETHYLATION | ELECTROPHILIC TRIFLUOROMETHYLATION | CHEMISTRY, MULTIDISCIPLINARY | TERMINAL ALKENES | Synthesis
Journal Article
Organic Letters, ISSN 1523-7060, 01/2017, Volume 19, Issue 1, pp. 146 - 149
A practical and straightforward synthetic route to construct a variety of 3-CF2/CF3-containing chromones via photoredox catalysis was developed. This novel... 
MEDICINAL CHEMISTRY | ASYMMETRIC FLUORINATION | ALKENES | HETEROARENES | ALPHA-TRIFLUOROMETHYLATION | ACIDS | COMPLEXES | ORGANOCATALYSIS | CHEMISTRY, ORGANIC | FLUOROALKYLATION REACTIONS | PHOTOREDOX CATALYSIS
Journal Article
ACS Catalysis, ISSN 2155-5435, 08/2014, Volume 4, Issue 8, pp. 2530 - 2535
The use of organofluorine compounds, especially those with an incorporated trifluoromethyl moiety, has increased dramatically in both the pharmaceutical and... 
methylene blue | photoredox catalysis | trifluoromethylation | metal-free | laser flash photolysis | ARENES | CHEMISTRY, PHYSICAL | OXIDATIVE TRIFLUOROMETHYLATION | ALKENES | HETEROARENES | HYDROTRIFLUOROMETHYLATION | ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION | EFFICIENT
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2012, Volume 134, Issue 26, pp. 10769 - 10772
Enantioselective Cu-catalyzed trifluoromethylation of β-ketoesters using commercially available trifluoromethylating reagents is reported. A number of α-CF3... 
MEDICINAL CHEMISTRY | ORGANIC-CHEMISTRY | QUATERNARY AMMONIUM PHENOXIDES | ALPHA-TRIFLUOROMETHYLATION | ASYMMETRIC TRIFLUOROMETHYLATION | RADICAL TRIFLUOROMETHYLATION | CARBONYL-COMPOUNDS | ARYL KETONES | CHEMISTRY, MULTIDISCIPLINARY | DIASTEREOSELECTIVE TRIFLUOROMETHYLATION | PHOTOREDOX CATALYSIS
Journal Article
by Liu, XW and Xiong, F and Huang, XP and Xu, L and Li, PF and Wu, XX
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 2013, Volume 52, Issue 27, pp. 6962 - 6966
Journal Article
Organic Letters, ISSN 1523-7060, 01/2017, Volume 19, Issue 2, pp. 376 - 379
Cheap and commercially available trichloroisocyanuric acid has been used to promote trifluoromethylation by using TMSCF3 as the trifluoromethyl source. The... 
ALCOHOLS | REAGENT | ALPHA-TRIFLUOROMETHYLATION | CATALYZED SYNTHESIS | NITRILE OXIDES | SILVER | DIRECT CONVERSION | CHEMISTRY, ORGANIC | ARYL IODIDES | INHIBITORS | DERIVATIVES
Journal Article
Chemical Communications, ISSN 1359-7345, 04/2014, Volume 50, Issue 33, pp. 4272 - 4284
Synergistic-cooperative combination of enamine catalysis with transition metal catalysis is an emerging and exciting field aiming to achieve organic... 
BIFUNCTIONAL ASYMMETRIC CATALYSIS | GOLD CATALYSIS | AMINE CATALYSIS | DIELS-ALDER REACTION | PROPARGYLIC ALCOHOLS | ALLYLIC ALKYLATION | CARBONYL-COMPOUNDS | BOND ACTIVATION | MERGING ORGANOCATALYSIS | ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
by Liu, H and Gu, ZH and Jiang, XF
ADVANCED SYNTHESIS & CATALYSIS, ISSN 1615-4150, 03/2013, Volume 355, Issue 4, pp. 617 - 626
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 07/2015, Volume 13, Issue 32, pp. 8740 - 8749
A visible light-induced selective hydrobromodifluoromethylation of alkenes using CF2Br2 was developed. This transformation proceeded smoothly in the presence... 
ETHYL 3-BROMO-3,3-DIFLUOROPROPIONATE | CATALYTIC HYDROTRIFLUOROMETHYLATION | ALPHA-TRIFLUOROMETHYLATION | BROMODIFLUOROMETHYLATION | PHOTOREDOX | CHEMISTRY, ORGANIC | FLUORINE | TRANSFER RADICAL-ADDITION | TRIFLUOROMETHYLATION REACTIONS | STEREOSELECTIVE-SYNTHESIS | EFFICIENT
Journal Article