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Journal Article
Pharmacological Research, ISSN 1043-6618, 2011, Volume 64, Issue 1, pp. 36 - 43
The present study aimed to investigate the effects of separate and simultaneous dietary intake of atorvastatin (ATO) and the soluble fiber oat bran on serum... 
Lipids | Nutrition | Genetically altered mice | Statins | Cholesterol | Oat bran | LOVASTATIN | DENSITY-LIPOPROTEIN CHOLESTEROL | SERUM-LIPIDS | THERAPY | PLASMA | METABOLISM | DIETARY FIBER | BARLEY | PHARMACOLOGY & PHARMACY | SIMVASTATIN | Cholesterol - blood | Heptanoic Acids - therapeutic use | Dietary Fiber - analysis | Intestinal Absorption - drug effects | Body Weight - drug effects | Avena - chemistry | Dietary Fiber - therapeutic use | Liver - drug effects | Lipids - blood | Cholesterol, LDL - blood | Female | Plaque, Atherosclerotic - pathology | Pyrroles - therapeutic use | Heptanoic Acids - pharmacology | Dietary Fiber - pharmacology | Receptors, LDL - genetics | beta-Glucans - analysis | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Aorta - drug effects | Liver - metabolism | Plaque, Atherosclerotic - diet therapy | Blood - drug effects | Treatment Outcome | Cholesterol - metabolism | Mice, Inbred Strains | Atherosclerosis - metabolism | Atherosclerosis - diet therapy | Mice, Knockout | Triglycerides - metabolism | Aorta - pathology | Atherosclerosis - blood | Atorvastatin Calcium | Eating - drug effects | Pyrroles - pharmacology | Animals | Anticholesteremic Agents - therapeutic use | Triglycerides - blood | Cholesterol, HDL - blood | Combined Modality Therapy - methods | Mice | Plaque, Atherosclerotic - drug therapy | Adipose Tissue - drug effects | Anticholesteremic Agents - pharmacology | Triglycerides | Fatty acids | Public health | Atherosclerosis | Basic Medicine | Oat | Medical and Health Sciences | Medicin och hälsovetenskap | bran | Medicinska och farmaceutiska grundvetenskaper | Farmakologi och toxikologi | Pharmacology and Toxicology
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 04/2015, Volume 29, Issue 4, pp. 1540 - 1550
Journal Article
Environmental Pollution, ISSN 0269-7491, 04/2019, Volume 247, pp. 775 - 782
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2007, Volume 92, Issue 6, pp. 2292 - 2299
Aim/Hypothesis: Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is... 
3T3-L1 ADIPOCYTES | SUBCUTANEOUS FAT-CELLS | BETA-ADRENERGIC STIMULATION | WEIGHT-REDUCTION | TISSUE | ENDOCRINOLOGY & METABOLISM | UPPER-BODY OBESITY | PPAR-GAMMA | SKELETAL-MUSCLE METABOLISM | TNF-ALPHA | LIPOPROTEIN-LIPASE | Hyperinsulinism - metabolism | Obesity - diet therapy | Humans | Middle Aged | Sterol Esterase - metabolism | Adipose Tissue - pathology | Male | Lipase - metabolism | RNA, Messenger - metabolism | Diet, Reducing | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation, Enzymologic | Hyperinsulinism - pathology | Regression Analysis | Sterol Esterase - genetics | Biopsy | Insulin Resistance - physiology | Weight Loss - physiology | Adult | Female | Adipose Tissue - enzymology | Hyperinsulinism - diet therapy | Lipase - genetics | Obesity | Sterol Esterase | Biochemistry, Molecular Biology | Insulin Resistance | Lipase | Life Sciences | Weight Loss | Adipose Tissue | RNA, Messenger | Hyperinsulinism | Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions. In addition | gender | indicating a tight coregulation and transcriptional control. CONCLUSIONS: In obese subjects | Medical and Health Sciences | Medicin och hälsovetenskap | before and just after a 10-wk hypocaloric diet. ATGL and HSL protein and mRNA expression was determined by Western blot and quantitative RT-PCR | and body composition. Both mRNA and protein levels of ATGL and HSL were reduced in insulin-resistant compared with insulin-sensitive subjects (P < 0.05). Weight reduction significantly decreased ATGL and HSL mRNA and protein expression. A positive correlation between the decrease in leptin and the decrease in ATGL protein level after weight reduction was observed. Finally | we investigated whether a possible impaired expression could be reversed by a period of weight reduction. METHODS: Adipose tissue biopsies were taken from obese subjects (n = 44) with a wide range of insulin resistance | respectively. RESULTS: Fasting insulin levels and the degree of insulin resistance (using the homeostasis model assessment index for insulin resistance) were negatively correlated with ATGL and HSL protein expression | Klinisk medicin | independent of fat mass. Data on weight reduction indicated that also other factors (e.g. leptin) relate to ATGL and HSL protein expression | Clinical Medicine | Endokrinologi och diabetes | ATGL and HSL mRNA and protein levels seem to be highly correlated | independent of age | insulin resistance and hyperinsulinemia are strongly associated with ATGL and HSL mRNA and protein expression | fat cell size | Endocrinology and Diabetes
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2010, Volume 30, Issue 7, pp. 1333 - 1339
Journal Article