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American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 11/2010, Volume 182, Issue 10, pp. 1292 - 1304
Rationale We identified a 6 year old girl with pulmonary alveolar proteinosis (PAP), impaired granulocyte macrophage colony stimulating factor (GM CSF)... 
Surfactant | Gm-csf receptor | Alveolar macrophage | Whole lung lavage | Genetic disease | alveolar macrophage | INTERLEUKIN-3 | COLONY-STIMULATING FACTOR | GM CSF | DISORDERS | COMMON BETA-SUBUNIT | DEFICIENT MICE | GM-CSF AUTOANTIBODIES | receptor | whole lung lavage | LUNG LAVAGE | GENE | RESPIRATORY SYSTEM | genetic disease | MACROPHAGE DIFFERENTIATION | surfactant | CRITICAL CARE MEDICINE | Humans | Genetic Diseases, Inborn - genetics | Child, Preschool | Infant | Male | Dyspnea - etiology | Receptors, Granulocyte Colony-Stimulating Factor - genetics | Genetic Diseases, Inborn - therapy | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Pulmonary Alveolar Proteinosis - genetics | Receptors, Granulocyte Colony-Stimulating Factor - blood | Female | Genetic Diseases, Inborn - etiology | Child | Genetic Diseases, Inborn - diagnosis | Granulocyte-Macrophage Colony-Stimulating Factor - blood | Lung - pathology | Pulmonary Alveolar Proteinosis - therapy | Genotype | Disease Progression | Pulmonary Alveolar Proteinosis - pathology | Receptors, Granulocyte Colony-Stimulating Factor - physiology | Autoantibodies - physiology | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - physiology | Pedigree | Genetic Markers - genetics | Age of Onset | Mutation | Pulmonary Alveolar Proteinosis - diagnosis | F. Pediatrics and Lung Development | GM-CSF receptor
Journal Article
Postgraduate Medical Journal, ISSN 0032-5473, 11/2019, Volume 95, Issue 1129, pp. 623 - 623
Journal Article
Journal Article
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ISSN 1073-449X, 10/2019, Volume 200, Issue 7, pp. 881 - 887
Rationale: Pulmonary alveolar proteinosis (PAP) is characterized by filling of the alveolar spaces by lipoprotein-rich material of ill-defined composition, and... 
BRONCHOALVEOLAR LAVAGE FLUID | lipids | PHOSPHOLIPIDS | TANDEM MASS-SPECTROMETRY | BAL | pulmonary alveolar proteinosis | CHILDREN | SURFACTANT PROTEINS | EXTRACTION | CHOLESTERYL ESTER | RESPIRATORY SYSTEM | HIGH-THROUGHPUT QUANTIFICATION | LUNG-DISEASE | MUTATIONS | CRITICAL CARE MEDICINE
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2020, Volume 382, Issue 2, pp. 197 - 198
To the Editor: In reporting the results of the Pulmonary Alveolar Proteinosis GM-CSF Inhalation Efficacy (PAGE) trial, Tazawa and coworkers (Sept. 5 issue) 1... 
Administration, Inhalation | Autoantibodies | Granulocyte-Macrophage Colony-Stimulating Factor | Humans | Pulmonary Alveolar Proteinosis
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2019, Volume 381, Issue 10, pp. 923 - 932
In patients with autoimmune pulmonary alveolar proteinosis, the use of inhaled recombinant granulocyte–macrophage colony-stimulating factor resulted in a... 
ANTIBODIES | AUTOANTIBODIES | MEDICINE, GENERAL & INTERNAL | THERAPY | COLONY-STIMULATING FACTOR | EFFICACY | MICE | Recombinant Proteins - therapeutic use | Smoking - adverse effects | Autoimmune Diseases - diagnostic imaging | Autoantibodies - blood | Humans | Middle Aged | Pulmonary Alveolar Proteinosis - diagnostic imaging | Male | Tomography, X-Ray Computed | Lung - diagnostic imaging | Recombinant Proteins - adverse effects | Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use | Adult | Female | Autoimmune Diseases - drug therapy | Pulmonary Alveolar Proteinosis - drug therapy | Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage | Lung - pathology | Double-Blind Method | Drug Administration Schedule | Immunologic Factors - administration & dosage | Administration, Inhalation | Oxygen - blood | Recombinant Proteins - administration & dosage | Granulocyte-Macrophage Colony-Stimulating Factor - adverse effects | Pulmonary Diffusing Capacity | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Pulmonary Alveolar Proteinosis - immunology | Aged | Immunologic Factors - adverse effects | Walk Test | Immunologic Factors - therapeutic use | Treatment outcome | Usage | Safety and security measures | Pulmonary alveolar proteinosis | Analysis | Drug therapy | Granulocyte-macrophage colony stimulating factor
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 10/2017, Volume 57, Issue 4, pp. 448 - 458
Maintenance of tissue-specific organ lipid compositions characterizes mammalian lipid homeostasis. The lungs and liver synthesize mixed phosphatidylcholine... 
Lipidomics | Fibrotic damage | Hepatic steatosis | Pulmonary alveolar proteinosis | Lipotoxicity | COLONY-STIMULATING FACTOR | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | fibrotic damage | pulmonary alveolar proteinosis | hepatic steatosis | CELL BIOLOGY | LIPID-ACCUMULATION | PHOSPHATIDYLCHOLINE BIOSYNTHESIS | RESPIRATORY SYSTEM | lipotoxicity | CHOLESTEROL EFFLUX | PATHWAY ENZYMES | II CELLS | CSF KNOCKOUT MICE | lipidomics | MOLECULAR-MECHANISMS | TRANSGENIC MICE | Fatty Liver - genetics | Fatty Liver - metabolism | Liver - metabolism | Fatty Liver - complications | Male | Phosphatidylcholines - metabolism | Mice, Knockout | Organ Specificity - genetics | Phosphatidylcholines - genetics | Animals | Pulmonary Alveolar Proteinosis - genetics | Pulmonary Alveoli - metabolism | Pulmonary Alveolar Proteinosis - metabolism | Female | Mice | Pulmonary Alveolar Proteinosis - etiology | Macrophages, Alveolar - metabolism | Liver diseases | Lecithin | Granulocyte-macrophage colony-stimulating factor | Colonies | Secretion | Homeostasis | Bronchus | Lipids | Surfactants | Electron microscopy | Metabolism | Apolipoproteins | Macrophages | Fatty acids | Cholesterol | Steatosis | Signal transduction | Fatty liver | Transmission electron microscopy | Granulocytes | Lungs | Rodents | Colony-stimulating factor | Alveoli
Journal Article