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Journal of Neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9677 - 9689
Passive immunization against beta-amyloid (A beta) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD).... 
APP TRANSGENIC MICE | NATURAL OLIGOMERS | HUMAN IGG1 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | PASSIVE-IMMUNIZATION | SECRETED OLIGOMERS | P38 MAP KINASE | Microglia - metabolism | Humans | Middle Aged | Male | Green Fluorescent Proteins - genetics | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Neuroprotective Agents - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Alzheimer Disease - immunology | Receptors, Chemokine - genetics | Plaque, Amyloid - immunology | Disease Models, Animal | Animals, Newborn | Rats | Mice, Transgenic | Mutation - genetics | Rats, Sprague-Dawley | Microscopy, Confocal | Plaque, Amyloid - metabolism | Mice | CX3C Chemokine Receptor 1 | Alzheimer Disease - blood | Immunoglobulin G - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dose-Response Relationship, Immunologic | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Immunoglobulin G - pharmacology | Female | Neurons - drug effects | Peptide Fragments - metabolism | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Alzheimer Disease - therapy | Cells, Cultured | Presenilin-1 - genetics | Hippocampus - cytology | Gene Expression Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Aged
Journal Article
EMBO JOURNAL, ISSN 0261-4189, 10/2010, Volume 29, Issue 19, pp. 3408 - 3420
The amyloid peptides A beta(40) and A beta(42) of Alzheimer's disease are thought to contribute differentially to the disease process. Although A beta(42)... 
LONG-TERM | BIOCHEMISTRY & MOLECULAR BIOLOGY | oligomer | TERMINAL FRAGMENT | AMYLOID PRECURSOR PROTEIN | SYNAPTIC PLASTICITY | OLIGOMERS | CELL BIOLOGY | microelectrode array | neurotoxicity | IN-VIVO | MUTATIONS | beta-amyloid peptides | Alzheimer's disease | GAMMA-SECRETASE | MOLECULAR-BASIS | AGGREGATION
Journal Article
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 01/2003, Volume 100, Issue 1, pp. 330 - 335
Amyloid beta-protein (Abeta) is linked to neuronal injury and death in Alzheimer's disease (AD). Of particular relevance for elucidating the role of Abeta in... 
PATHOGENESIS | ATOMIC-FORCE MICROSCOPY | A-BETA(1-42) | FIBRILS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | CROSS-LINKING | FIBRILLOGENESIS | NEUROTOXICITY | AGGREGATION | SENILE PLAQUES
Journal Article
JOURNAL OF ALZHEIMERS DISEASE, ISSN 1387-2877, 2018, Volume 65, Issue 4, pp. 1377 - 1383
Gait disturbances are some of the earliest changes in dementia and their monitoring presents an opportunity for early diagnosis. The exact relationship between... 
DEMENTIA | biomarkers | OLDER-ADULTS | VALIDATION | COGNITIVE IMPAIRMENT | CEREBROSPINAL-FLUID | cerebrospinal fluid proteins | NEUROSCIENCES | DUAL-TASK | amyloid | gait | MOTOR | SCALE | Alzheimer's disease | BRAIN | PARKINSONS-DISEASE
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 02/2018, Volume 140, Issue 8, pp. 2781 - 2784
Cross-seeding of misfolded amyloid proteins is postulated to induce cross-species infection of prion diseases. In sporadic Alzheimer's disease (AD), misfolding... 
FIBRIL FORMATION | RATIOS | A-BETA(1-42) | PROTEIN | ATOMIC-RESOLUTION STRUCTURE | DISEASE | RISK | CONFORMATION | INSIGHT | CHEMISTRY, MULTIDISCIPLINARY | ALZHEIMERS
Journal Article
JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 02/2010, Volume 396, Issue 1, pp. 9 - 18
Aggregation of the amyloid-beta (A beta) peptide is considered a central event in the pathogenesis of Alzheimer's disease (AD). In order to bypass... 
OXIDATION | MECHANISM | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | OLIGOMERS | A beta 1-42 | amyloid | neurotoxicity | FIBRILS | ETCH VIRUS PROTEASE | protein misfolding | RELEVANCE | PURIFICATION | Alzheimer's disease | EXPRESSION
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 05/2019, Volume 512, Issue 4, pp. 653 - 658
Alzheimer's disease (AD) is characterized by the formation of extracellular amyloid plaques containing the amyloid beta-protein (A beta) within the parenchyma... 
ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Amyloid beta-protein | Iron | COPPER | COGNITION | NEUROTOXICITY | BIOPHYSICS | HYPOTHESIS | Amyloid deposition | GENERATION | Alzheimer's disease | TRANSGENIC MICE
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 11/2016, Volume 139, Issue 4, pp. 651 - 658
Journal Article
by Yan, YL and Wang, CY
JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 12/2006, Volume 364, Issue 5, pp. 853 - 862
A beta 40 and A beta 42 are the major forms of amyloid beta pepticles (A beta) in the brain. Although A beta 42 differs from A beta 40 by only two residues, A... 
A beta toxicity | A beta aggregation | MAGNETIC-RESONANCE RELAXATION | CHEMICAL-SHIFT INDEX | AMYLOID PROTEIN | PLAQUE-COMPETENCE | PROTEIN SECONDARY STRUCTURE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEPTIDE | OLIGOMERS | MODEL-FREE APPROACH | NMR | dynamics | Alzheimer's disease | BINDING
Journal Article
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ISSN 0003-9861, 05/2016, Volume 597, pp. 1 - 11
Recent findings suggest that the senile plaques in Alzheimer's disease may contain soluble amyloid-beta peptide (A beta) fibril precursors along with insoluble... 
Amyloid-beta protein | Light scattering | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIGHT-SCATTERING | OLIGOMERS | PEPTIDE | Protofibrils | Aggregation | FORMS | BIOPHYSICS | BETA-PROTEIN FIBRILLOGENESIS | AMYLOID-BETA(1-42) PROTOFIBRILS | A-BETA | GAMMA-SECRETASE ACTIVITY | PRESENILIN-1
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 05/2016, Volume 597, p. 1
Recent findings suggest that the senile plaques in Alzheimer's disease may contain soluble amyloid-[beta] peptide (A[beta]) fibril precursors along with... 
Oligomers | Peptides | Alzheimer's disease
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2014, Volume 34, Issue 38, pp. 12893 - 12903
Journal Article
Journal Article
CHEMICAL RESEARCH IN TOXICOLOGY, ISSN 0893-228X, 09/2019, Volume 32, Issue 9, pp. 1824 - 1839
Amyloid beta (A beta) peptide aggregation is considered as one of the key hallmarks of Alzheimer's disease (AD). Moreover, A beta peptide aggregation increases... 
NEUROFIBRILLARY TANGLES | TARGET-DIRECTED LIGANDS | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | COPPER | NEUROPROTECTIVE PROPERTIES | CHEMISTRY, MULTIDISCIPLINARY | AMYLOID-BETA-PEPTIDE | THERAPEUTIC AGENTS | A-BETA | TOXICOLOGY
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 05/2006, Volume 45, Issue 17, pp. 5503 - 5516
Amyloid fibrils associated with Alzheimer's disease and a wide range of other neurodegenerative diseases have a cross beta-sheet structure, where main chain... 
ANGLE-SPINNING NMR | FIBRIL FORMATION | IN-VITRO | ASSISTED ROTATIONAL RESONANCE | EXPERIMENTAL CONSTRAINTS | SOLID-STATE NMR | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SECONDARY STRUCTURE | HELIX ASSOCIATION | MEMBRANE-PROTEINS
Journal Article
NEUROBIOLOGY OF DISEASE, ISSN 0969-9961, 04/2016, Volume 88, pp. 75 - 84
One attractive pharmacological strategy for Alzheimer's disease (AD) is to design small peptides to interact with amyloid-beta (A beta) protein reducing its... 
DRUG | C. elegans | ASSAY | ALZHEIMERS-DISEASE | MODEL | Oligomer | NEUROSCIENCES | A beta(A2V) | Amyloid beta | CAENORHABDITIS-ELEGANS | A-BETA(1-42) | GENE | IMMUNOTHERAPY | MUTATION | HYPOTHESIS | Alzheimer's disease
Journal Article
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