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PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0182407 - e0182407
Retinal ischemia is common in eye disorders, like diabetic retinopathy or retinal vascular occlusion. The goal of this study was to evaluate the potential... 
OPTIC-NERVE | AUTOIMMUNE GLAUCOMA MODEL | PROLIFERATIVE DIABETIC-RETINOPATHY | PRESSURE-INDUCED ISCHEMIA | MULTIDISCIPLINARY SCIENCES | REPERFUSION INJURY | RAT RETINA | GANGLION-CELLS | MACULAR DEGENERATION | GLIAL-CELLS | ENDOTHELIAL GROWTH-FACTOR | Amacrine Cells - drug effects | Microglia - metabolism | Cell Count | Humans | Photoreceptor Cells, Vertebrate - drug effects | Amacrine Cells - metabolism | Retina | Ranibizumab - therapeutic use | Vascular Endothelial Growth Factor A - metabolism | Protective Agents - therapeutic use | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Retinal Ganglion Cells - metabolism | Rhodopsin - metabolism | Aqueous Humor - metabolism | Synapses - metabolism | Protective Agents - pharmacology | Protein Binding - drug effects | Microfilament Proteins - metabolism | Ischemia - pathology | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Synapses - drug effects | Microglia - drug effects | Reperfusion Injury - pathology | Cholinergic Neurons - metabolism | RNA, Messenger - genetics | Rats | Cholinergic Neurons - drug effects | Ranibizumab - pharmacology | Animals | Ischemia - drug therapy | Mice | Photoreceptor Cells, Vertebrate - metabolism | Retinal Ganglion Cells - drug effects | Retinal diseases | Care and treatment | Occlusion | Immunohistochemistry | Intervention | Diabetic retinopathy | Neurosciences | Retinopathy | Disorders | Neurobiology | Activation | Eye | Macular degeneration | Proteins | Cell growth | Ischemia | Rodents | Eye (anatomy) | Vascular endothelial growth factor | Retinal cells | Glial fibrillary acidic protein | Diabetes mellitus | Brn-3 protein | Microglia | Vascular endothelial growth factor receptors | Studies | Polymerase chain reaction | Retinal ganglion cells | Pathology | Hospitals | Cell number | Morphology | Eye disorders | Amacrine cells | Photoreceptors | Diabetes | Glia | Apoptosis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2014, Volume 111, Issue 39, pp. E4086 - E4095
Previously, we have shown that Onecut1 (Oc1) and Onecut2 (Oc2) are expressed in retinal progenitor cells, developing retinal ganglion cells (RGCs), and... 
Retinal development | Transcription factors | Cell fate determination | Gene regulation | Neural development | HOMEODOMAIN | HORIZONTAL CELLS | transcription factors | MULTIDISCIPLINARY SCIENCES | neural development | retinal development | MAMMALIAN RETINA | AMACRINE | CONE PHOTORECEPTORS | GENE | gene regulation | GANGLION-CELLS | cell fate determination | MOUSE RETINA | EXPRESSION | Embryonic Stem Cells - metabolism | Retina - metabolism | Embryonic Stem Cells - cytology | Homeodomain Proteins - metabolism | Transcription Factors - deficiency | Retinal Horizontal Cells - cytology | Amacrine Cells - metabolism | Amacrine Cells - cytology | Male | Mice, 129 Strain | Retina - embryology | Neural Stem Cells - cytology | Retinal Ganglion Cells - metabolism | Retinal Ganglion Cells - cytology | Retina - cytology | Gene Expression Regulation, Developmental | Female | Hepatocyte Nuclear Factor 6 - metabolism | Mice, Inbred C57BL | Transcription Factors - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Pregnancy | Transcription Factors - metabolism | Animals | Hepatocyte Nuclear Factor 6 - genetics | Retinal Cone Photoreceptor Cells - cytology | Mice | Retinal Horizontal Cells - metabolism | Neural Stem Cells - metabolism | Retinal Cone Photoreceptor Cells - metabolism | Hepatocyte Nuclear Factor 6 - deficiency | Retina | Nervous system | Ribonucleic acid--RNA | Genes | Cells | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. 290 - 305
The P2X7 receptor (P2X7-R) is expressed in the retina and brain and has been implicated in neurodegenerative diseases. However, whether it is expressed by... 
EXTRACELLULAR ATP | RETINAL GANGLION-CELLS | MULLER GLIAL-CELLS | P2X RECEPTORS | MULTIDISCIPLINARY SCIENCES | RAT RETINA | SPINAL-CORD | VESICULAR NUCLEOTIDE TRANSPORTER | PURINERGIC RECEPTORS | RELEASE | EXPRESSION | Immunohistochemistry | Microglia - metabolism | Retinal Rod Photoreceptor Cells - ultrastructure | Retinal Bipolar Cells - radiation effects | Amacrine Cells - metabolism | RNA Splicing - radiation effects | Microglia - radiation effects | Retinal Rod Photoreceptor Cells - metabolism | Amacrine Cells - radiation effects | RNA, Messenger - metabolism | Retinal Cone Photoreceptor Cells - ultrastructure | Astrocytes - radiation effects | Transport Vesicles - radiation effects | Adenosine Triphosphate - metabolism | Light | RNA Splicing - genetics | Retinal Cone Photoreceptor Cells - pathology | Polymerase Chain Reaction | Signal Transduction - radiation effects | Electroretinography | Retinal Cone Photoreceptor Cells - radiation effects | Retinal Bipolar Cells - metabolism | Retinal Rod Photoreceptor Cells - radiation effects | Mice, Inbred C57BL | RNA, Messenger - genetics | Blotting, Western | Mice, Knockout | Receptors, Purinergic P2X7 - deficiency | Animals | Antibody Specificity - radiation effects | Transport Vesicles - metabolism | Receptors, Purinergic P2X7 - metabolism | Mice | Retinal Cone Photoreceptor Cells - metabolism | Retinal Rod Photoreceptor Cells - pathology | Astrocytes - metabolism | RNA | Nervous system diseases | Neurophysiology | Molecular machines | Brain | Spinal cord | Retina | Nervous system | mRNA | Horizontal cells | Machinery | Experiments | Visual perception | Proteins | Signal transduction | Mouse devices | Rodents | Synaptic ribbons | Localization | Ganglion cells | Polypeptides | Neurodegenerative diseases | Neurons | Cortex (visual) | Neurological diseases | Retinal ganglion cells | Signaling | Amacrine cells | Photoreceptors | Transport buildings, stations and terminals | ATP | Transporter | Synapses | Apoptosis | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2015, Volume 5, Issue 1, pp. 16595 - 16595
Journal Article
Nature Neuroscience, ISSN 1097-6256, 09/2009, Volume 12, Issue 9, pp. 1197 - 1204
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, pp. e114186 - e114186
Retinal ischemia-reperfusion (I/R) injury induces oxidative stress, leukocyte infiltration, and neuronal cell death. Sulforaphane (SF), which can be obtained... 
RESPONSE ELEMENT | CELLS | OXIDATIVE STRESS | ISCHEMIA/REPERFUSION INJURY | GENE | MULTIDISCIPLINARY SCIENCES | PHARMACOLOGICAL INDUCTION | NRF2-DEPENDENT PHASE-2 ENZYME | HEME OXYGENASE-1 | CALCIUM DOBESILATE | KAPPA-B | Amacrine Cells - drug effects | Retina - drug effects | Heme Oxygenase-1 - metabolism | Intraocular Pressure - drug effects | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Antioxidants - metabolism | Amacrine Cells - metabolism | Amacrine Cells - cytology | Male | Retinal Ganglion Cells - metabolism | Retinal Ganglion Cells - cytology | Protective Agents - pharmacology | Reperfusion Injury - metabolism | Isothiocyanates - pharmacology | Disease Models, Animal | Reperfusion Injury - pathology | Injections, Intraperitoneal | Rats | Rats, Sprague-Dawley | Retina - physiology | Up-Regulation - drug effects | Animals | NF-E2-Related Factor 2 - metabolism | Inflammation - prevention & control | Retinal Ganglion Cells - drug effects | Antioxidants | Ischemia | Analysis | Neuroprotection | Oxidative stress | Reactive oxygen species | Neurosciences | Retina | Activation | Kinases | Western blotting | Reperfusion | Corn oil | Protoporphyrin | Rodents | Heme | Pretreatment | Sulforafan | Heme oxygenase (decyclizing) | Inflammation | Zinc | White blood cells | Oxygenase | Retinal ganglion cells | Broccoli | Cell death | Morphology | Amacrine cells | Infiltration | Protoporphyrin IX | Immunofluorescence | Apoptosis | Intraocular pressure | Index Medicus
Journal Article