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Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 12/2013, Volume 23, Issue 23, pp. 6436 - 6441
A series of novel quinolinoneachalcone hybrids and analogues were designed, synthesized and their biological activity against the mammalian stages of... 
Amastigotes
Journal Article
Iranian Journal of Allergy, Asthma and Immunology, ISSN 1735-1502, 12/2013, Volume 12, Issue 4, pp. 361 - 361
It is well accepted that in experimental model of Leishmania major infection, BALB/c mice mount a Th2 response and produce IgG1 predominantly whereas,... 
Amastigotes
Journal Article
SHORT COMMUNICATION - Effect of Thiadiazine Derivatives on Intracellular Amastigotes of Leishmania amazonensis, 12/2004
Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania... 
Leishmania - thiadiazine - amastigotes
Journal
International Journal for Parasitology, ISSN 0020-7519, 08/2007, Volume 37, Issue 10, pp. 1087 - 1096
Journal Article
Molecular & Biochemical Parasitology, ISSN 0166-6851, 06/2019, Volume 230, pp. 8 - 15
[Display omitted] •Farnesyl pyrophosphate synthase (FPPS) is a central enzyme in isoprenoid synthesis.•FPPS is a potential drug target against protozoan... 
Drug | Target | Leishmania | Essentiality | Isoprenoid | Amastigote | Lipid
Journal Article
Production of Amastigotes from Metacyclic Trypomastigotes of Trypanosoma cruzi, 12/2002
Attempts to recreate all the developmental stages of Trypanosoma cruzi   in vitro have thus far been met with partial success. It is possible, for instance, to... 
amastigogenesis - axenic conditions - differentiation - extracelullar amastigotes - morphogenesis
Journal
Analysis of expressed sequence tags from Trypanosoma cruzi amastigotes, 12/2005
A total of 880 expressed sequence tags (EST) originated from clones randomly selected from a Trypanosoma cruzi amastigote cDNA library have been analyzed. Of... 
Trypanosoma cruzi - gene expression - amastigotes - antigens
Journal
by Giri, S and Shaha, C
CELL DEATH & DISEASE, ISSN 2041-4889, 10/2019, Volume 10, Issue 11, pp. 1 - 19
The importance of autophagy in parasites with a digenetic life cycle like Leishmania spp. is significant. The parasite survives as promastigotes in the insect... 
RECRUITMENT | PATHWAY | ROLES | INCREASE | MITOPHAGY | AUTOPHAGY | DIFFERENTIATION | IDENTIFICATION | AXENIC AMASTIGOTES | TEMPORAL ANALYSIS | CELL BIOLOGY | Oxidative stress | Reactive oxygen species | Starvation | Promastigotes | Parasites | Mammals | Amastigotes | Macrophages | Organelles | Autophagy | Proteins | Mitochondria | Cell death | Infectivity | Phagocytosis | Life cycles
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 6919 - 18
Journal Article
Analytical Chemistry, ISSN 0003-2700, 07/2018, Volume 90, Issue 13, pp. 8154 - 8161
We report the direct probing of the molecular composition of Leishmania-infected macrophage cells in vitro by surface-enhanced Raman scattering (SERS). The... 
GOLD NANOPARTICLES | CHEMISTRY, ANALYTICAL | AMASTIGOTES | SPECTROSCOPY | AMINO-ACIDS | MACROPHAGES | SILVER | PARASITOPHOROUS VACUOLES | MEXICANA | SURFACE-ENHANCED RAMAN | LIPIDS
Journal Article
International Journal for Parasitology, ISSN 0020-7519, 05/2019, Volume 49, Issue 6, pp. 423 - 427
[Display omitted] •Macrophage heme depletion (HD) impairs Leishmania intracellular replication.•Ferritin supplementation of the macrophage endocytic pathway... 
Drug target | Cationic ferritin | Amastigotes | Virulence | Heme | Endocytic pathway
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, p. e0187186
Background Arginase is an enzyme that converts L-arginine to urea and L-ornithine, an essential substrate for the polyamine pathway supporting Leishmania... 
MAJOR AMASTIGOTES | COMPLEX I | SYNTHASE | GENE | MULTIDISCIPLINARY SCIENCES | OXIDOREDUCTASE | CONSEQUENCES | MECHANISMS | PARASITE | PROMASTIGOTES | NITRATION | Oxidases | Physiological aspects | Genetic aspects | Research | Nitric oxide | Leishmania
Journal Article
Scientific reports, ISSN 2045-2322, 01/2020, Volume 10, Issue 1, pp. 785 - 16
Present work aims to utilize systems biology and molecular modelling approach to understand the inhibition kinetics of Leishmania major GLO I and identifying... 
Molecular modelling | Free radicals | Cell death | Parasitic diseases | Leishmaniasis | Amastigotes | Apoptosis | G1 phase
Journal Article
Cellular Microbiology, ISSN 1462-5814, 02/2008, Volume 10, Issue 2, pp. 301 - 308
Journal Article
Parasitology Research, ISSN 0932-0113, 03/2019, Volume 118, Issue 3, pp. 977 - 989
Despite many efforts, the currently available treatments for leishmaniasis are not fully effective. To discover new medications, drug repurposing arises as a... 
Oxidative stress | Intracellular amastigotes isolation | Leishmaniasis | Repositioning | Repurposing | Apoptosis | TRYPANOTHIONE REDUCTASE | METABOLISM | TRYPANOSOME | INHIBITORS | AUTOPHAGY | PARASITOLOGY | Dosage and administration | Drug therapy | Clomipramine | Patient outcomes
Journal Article