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Free Radical Biology and Medicine, ISSN 0891-5849, 01/2015, Volume 78, pp. 202 - 212
The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules... 
Brusatol | Free radicals | Hepatocyte | Nrf2 | Toxicity | Keap1 | Chemical stress | Cell defense | OXIDATIVE STRESS | ACTIVATION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-SYNTHESIS INHIBITION | CANCER | TRANSCRIPTION FACTOR NRF2 | DEFENSE PATHWAY | ACETAMINOPHEN | ENDOCRINOLOGY & METABOLISM | DEGRADATION | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Oxidative Stress | Apoptosis - drug effects | Humans | Hepatocytes - metabolism | Autophagy | Quassins - pharmacology | Hepatocytes - cytology | Carcinoma, Hepatocellular - drug therapy | Liver Neoplasms - pathology | NF-E2-Related Factor 2 - genetics | Real-Time Polymerase Chain Reaction | Hepatocytes - drug effects | Oxidation-Reduction | RNA, Messenger - genetics | Cells, Cultured | Liver Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Brucea - chemistry | Blotting, Western | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Proliferation - drug effects | Mice | Carcinoma, Hepatocellular - metabolism | Chemical inhibitors | Metabolites | Proteolysis | Health aspects | Quinone | Cells | Index Medicus | Gclm, glutamate–cysteine ligase regulatory subunit | NEM, N-ethylmaleimide | NAPQI, N-acetyl-p-benzoquinone imine | IAA, iodoacetamide | Nrf2, nuclear factor erythroid 2-related factor 2 | Original Contribution | Keap1, Kelch-like ECH-associated protein 1 | DNCB, 2,4-dinitrochlorobenzene | Nqo1, NAD(P)H dehydrogenase quinone 1 | CDDO-Me, methyl-2-cyano-3,12-dioxooleana-1, 9dien-28-oate | HIF-1α, hypoxia-inducible factor 1α | RT-qPCR, real-time quantitative PCR | AMC, 7-amino-4-methylcoumarin
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 07/2015, Volume 11, Issue 7, pp. 1161 - 1178
Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance... 
proteasome | multiple myeloma | autophagy | proteasome inhibitors | bortezomib | plasma cells | proteostasis | p62 | SQSTM1 | endoplasmic reticulum | ubiquitin | aggregate | Ubiquitin | Bortezomib | Proteostasis | Multiple myeloma | Plasma cells | Aggregate | Autophagy | Endoplasmic reticulum | P62 | Proteasome inhibitors | Proteasome | SURVIVAL | bafilomycin A | phosphate-buffered saline | CANCER | CELL BIOLOGY | gene ontology | hydroxychloroquine | UPR | immunoprecipitation | UPS | plasma cell | PBS | antibody | ERGIC | Rapa | STRESS-RESPONSE | allophycocyanin | pAb | unfolded protein response | EXTENDED FOLLOW-UP | amc | HCQ | DISEASE | Btz | DEFICIENT MICE | Baf A1 | proteasome inhibitor | polyclonal antibody | immunoglobulin | IMMUNOGLOBULIN PRODUCTION | stable isotope labeling in cell culture | SILAC | 7-amino-4-methylcoumarin | bone marrow | PLASMA-CELLS | LC-MS | ubiquitin-proteasome system | APC | liquid chromatography-tandem mass spectrometry | DIFFERENTIATION | ER-Golgi intermediate compartment | rapamycin | Cell Survival - drug effects | Proteasome Inhibitors - pharmacology | Sequestosome-1 Protein | Humans | Endoplasmic Reticulum - metabolism | Multiple Myeloma - metabolism | Autophagy - drug effects | Endoplasmic Reticulum - ultrastructure | Proteolysis - drug effects | Multiple Myeloma - pathology | Protein Binding - drug effects | Cytoprotection - drug effects | Cell Line, Tumor | Homeostasis - drug effects | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitinated Proteins - metabolism | Protein Aggregates - drug effects
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2012, Volume 443, Issue 1, pp. 287 - 295
The paracaspase domain of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a component of a gene translocation fused to the... 
CYLD | Positional-scanning substrate library | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) | Protease | Substrate specificity | Paracaspase | TRANSLOCATION | ACTIVATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLEAVAGE | positional-scanning substrate library | protease | substrate specificity | CASPASES | LYMPHOMA | mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) | paracaspase | NF-KAPPA-B | ZYMOGEN | KEY | Protein Structure, Tertiary | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | Recombinant Fusion Proteins - isolation & purification | Neoplasm Proteins - biosynthesis | Escherichia coli | Humans | Substrate Specificity | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Caspases - isolation & purification | Citrates - chemistry | Chromatography, Affinity | Neoplasm Proteins - isolation & purification | Proteolysis | Enzyme Activators - chemistry | Caspases - biosynthesis | HEK293 Cells | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Enzyme Activation | Kinetics | Protein Stability | Caspases - chemistry | Oligopeptides - chemistry | PS-SCL, positional-scanning substrate combinatorial library | WT, wild-type | CARD, caspase recruitment domain | MALT1, mucosa-associated lymphoid tissue lymphoma translocation protein 1 | HEK, human embryonic kidney | AFC, 7-amino-4-trifluoromethylcoumarin | JNK, c-Jun N-terminal kinase | DTT, dithiothreitol | IAP, inhibitor of apoptosis protein | z, benzyloxycarbonyl | ACC, 7-amino-4-carbamoylmethylcoumarin | DD, death domain | CARMA1, CARD-containing MAGUK (membrane-associated guanylate kinase) 1 | TCA, trichloroacetic acid | Ac, acetyl | AMC, 7-amino-4-methylcoumarin | FMK, fluoromethylketone | IPTG, isopropyl β-D-thiogalactopyranoside | NF-κB, nuclear factor κB | FKBP, FK506-binding protein | BIR, baculovirus inhibitor of apoptosis protein repeat | Ni-NTA, Ni2+-nitrilotriacetate | NIK, NF-κB-inducing kinase | cIAP2, cellular inhibitor of apoptosis protein 2
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2005, Volume 390, Issue 1, pp. 125 - 136
Hepsin is a membrane-anchored, trypsin-like serine protease with prominent expression in the human liver and tumours of the prostate and ovaries. To better... 
Proteolytic cascade | c-Met receptor activation | Hepsin | Positional scanning-synthetic combinatorial library (PS-SCL) | Substrate specificity | Hepatocyte growth factor (HGF) | BLOOD-COAGULATION | SPECIFICITY | MICE DEFICIENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR HGF | hepatocyte growth factor (HGF) | ACTIVATOR INHIBITOR-1B HAI-1B | IDENTIFICATION | proteolytic cascade | FACTOR-VII | PLASMINOGEN-ACTIVATOR | substrate specificity | positional scanning-synthetic combinatorial library (PS-SCL) | EXPRESSION | hepsin | REVEALS | Prostatic Neoplasms - metabolism | Up-Regulation | Gene Expression | Humans | Substrate Specificity | Male | Hepatocyte Growth Factor - metabolism | Cell Line, Tumor | Female | Protein Conformation | Ovarian Neoplasms - metabolism | Serine Endopeptidases - metabolism | Enzyme Activation | Binding Sites | Ac-, acetyl | HAI, hepatocyte growth factor activator inhibitor | TTSP, type II transmembrane serine protease | TMPRSS, transmembrane serine protease | FBS, fetal bovine serum | MT-SP1, membrane-type serine protease 1 | sc-HGF, single-chain hepatocyte growth factor | cmk, chloromethylketone | ACC, 7-amino-4-carbamoylmethylcoumarin | S, subsite, describing substrate-binding cleft of serine protease | RFU, relative fluorescence units | pNA, p-nitroanilide | PEG, poly(ethylene glycol) | PS-SCL, positional scanning-synthetic combinatorial library | AMC, 7-amino-4-methylcoumarin | HGF, hepatocyte growth factor
Journal Article
Frontiers in Chemistry, ISSN 2296-2646, 08/2018, Volume 6, p. 367
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2006, Volume 398, Issue 2, pp. 197 - 206
Hyperglycaemia, triose phosphate decomposition and oxidation reactions generate reactive aldehydes in vivo. These compounds react non-enzymatically with... 
Cathepsin | Thiol | Hyperglycaemia | Cysteine protease | Aldehyde | Protein glycation | thiol | KETO-BETA-ALDEHYDES | ENZYME INACTIVATION | MAILLARD REACTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | aldehyde | protein glycation | OXIDIZED LDL | cathepsin | TISSUE PROTEINS | cysteine protease | LYSOSOMAL-ENZYMES | hyperglycaemia | MODIFIED PROTEINS | END-PRODUCTS | CATHEPSIN-B | Cell Line | o-Phthalaldehyde - pharmacology | Molecular Weight | Papain - isolation & purification | Carbocysteine - pharmacology | Humans | Glycosylation | Enzyme Activation - drug effects | Cathepsins - isolation & purification | Glyoxal - pharmacology | Sulfhydryl Compounds - metabolism | Animals | Cysteine Endopeptidases - metabolism | Cathepsins - metabolism | Cattle | Cysteine Endopeptidases - genetics | Protein Binding | Mice | Binding Sites | Papain - metabolism | catB | CMC, S-carboxymethylcysteine | THF, tetrahydrofuran | GA, glycolaldehyde | DTT, dithiothreitol | DMEM, Dulbecco's modified Eagle's medium | catL | AMC, 7-amino-4-methylcoumarin | LDL, low-density lipoprotein | MGX, methylglyoxal | NEM, N-ethylmaleimide | GO, glyoxal | HA, hydroxyacetone | 4-HNE, 4-hydroxynonenal | catS, cathepsin B | Z, benzyloxycarbonyl | OPA, o-phthalaldehyde | DTNB, 5,5′-dithiobis-(2-nitrobenzoic acid) | AGE, advanced glycation end-product | FCS, fetal calf serum
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2006, Volume 393, Issue 2, pp. 503 - 511
Mosquito-borne WNV (West Nile virus) is an emerging global threat. The NS3 protemase, which is essential for the proteolytic processing of the viral... 
Furin | Peptide inhibitor | Dengue virus | Flavivirus | Proteinase | West Nile virus | NS2B-NS3 PROTEASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | dengue virus | SUBTILISIN BPN | NONSTRUCTURAL PROTEINS | BORNE ENCEPHALITIS-VIRUS | MYELIN BASIC-PROTEIN | IN-VITRO | COMPLEX-FORMATION | proteinase | DELETION ANALYSIS | SERINE-PROTEASE | furin | flavivirus | peptide inhibitor | RNA Helicases - metabolism | Molecular Sequence Data | Substrate Specificity | Arginine - analysis | Myelin Sheath - metabolism | Protease Inhibitors - pharmacology | West Nile virus - genetics | Serine Endopeptidases - genetics | Conserved Sequence | RNA Helicases - genetics | Neurons - metabolism | RNA Helicases - isolation & purification | Furin - metabolism | Amino Acid Sequence | Peptides - chemistry | Cells, Cultured | Furin - chemistry | Protease Inhibitors - chemistry | Viral Nonstructural Proteins - genetics | Serpins - pharmacology | RNA Helicases - antagonists & inhibitors | Viral Nonstructural Proteins - isolation & purification | Arginine - chemistry | Peptides - pharmacology | Sequence Homology, Amino Acid | Animals | Viral Nonstructural Proteins - metabolism | West Nile virus - enzymology | Mice | Serine Endopeptidases - metabolism | Serine Endopeptidases - isolation & purification | Viral Nonstructural Proteins - antagonists & inhibitors | WNV, West Nile virus | PA63, 63 kDa protective antigen | NS2B and NS3, non-structural viral proteins 2b and 3 respectively | PA83, 83 kDa protective antigen | Pyr, pyroglutamic acid | Boc, t-butoxycarbonyl | MBP, myelin basic protein | R.M.S.D., root mean square deviation | SCG, superior cervical ganglia | IPTG, isopropyl β-D-thiogalactoside | Z, benzyloxycarbonyl | AMC, 7-amino-4-methylcoumarin | MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2005, Volume 388, Issue 3, pp. 967 - 972
TMPRSS2 is a type II transmembrane-bound serine protease that has gained interest owing to its highly localized expression in the prostate and its... 
Type II transmembrane serine protease | TMPRSS2 | Metastasis | Protease-activated receptor-2 (PAR-2) | Prostate cancer | SURFACE PROTEOLYTIC-ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | type II transmembrane serine protease | TRANSMEMBRANE | RECEPTOR-2 ACTIVATION | IDENTIFICATION | LINES | protease-activated receptor-2 (PAR-2) | prostate cancer | INVASION | PEPTIDES | metastasis | TRYPTASE | EXPRESSION | PROGRESSION | Prostatic Neoplasms - metabolism | Suramin | Calcium - metabolism | Humans | Receptor, PAR-2 - metabolism | Substrate Specificity | Male | RNA, Messenger - metabolism | Recombinant Proteins - isolation & purification | Prostatic Neoplasms - genetics | Serine Endopeptidases - genetics | Serine Proteinase Inhibitors - pharmacology | Recombinant Proteins - metabolism | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Recombinant Proteins - chemistry | Serine Endopeptidases - chemistry | Recombinant Proteins - genetics | Catalysis - drug effects | Signal Transduction - drug effects | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Serine Endopeptidases - metabolism | Serine Endopeptidases - isolation & purification | Boron Compounds | HAT, human airway trypsin | TTSP, type II transmembrane serine protease | MMP, matrix metalloprotease | Fmoc, fluoren-9-ylmethoxycarbonyl | MT-SP1, membrane-type serine protease 1 | BCA, bicinchoninic acid | Cbz-Lys(OPh)2, benzyloxycarbonyl lysine diphenylphosphonate | MAP, multiple antigenic peptide | TBS, Tris-buffered saline | 2-APB, 2-aminoethoxydiphenyl borate | FCS, foetal calf serum | PAR, protease-activated receptor | RT, reverse transcriptase | AMC, 7-amino-4-methylcoumarin | Cbz, benzyloxycarbonyl
Journal Article
Molecular & Biochemical Parasitology, ISSN 0166-6851, 2004, Volume 136, Issue 2, pp. 227 - 242
Cysteine proteinases are involved in a variety of important biological processes and have been implicated in molting and tissue remodeling in free living and... 
Cysteine proteases | Nematodes | Function | Cathepsin L | Filariae | Brugia malayi | benzyloxycarbonyl | cathepsin Z-like cysteine protease | expressed sequence tag | FMK | EST | excretory/secretory | CPZ | 7-amino-4-methylcoumarin | fluoromethyl ketone | third-stage larvae | AMC | CPF | fourth-stage larvae | cathepsin L-like cysteine protease | CPL | TRYPANOSOMA-CRUZI | BIOCHEMISTRY & MOLECULAR BIOLOGY | ONCHOCERCA-VOLVULUS | CYSTEINE-PROTEASE | cysteine proteases | BRUGIA-MALAYI | filariae | nematodes | PARASITIC NEMATODE | HAEMONCHUS-CONTORTUS | CAENORHABDITIS-ELEGANS | function | DIROFILARIA-IMMITIS | INFECTIVE LARVAE | MOLECULAR-CLONING | cathepsin L | PARASITOLOGY | DNA, Helminth - genetics | Multigene Family | Species Specificity | Genes, Helminth | Molecular Sequence Data | Phylogeny | Brugia pahangi - drug effects | Microscopy, Immunoelectron | Larva - drug effects | Base Sequence | Larva - growth & development | Cloning, Molecular | Larva - enzymology | Brugia malayi - enzymology | Expressed Sequence Tags | Brugia pahangi - enzymology | Molting - drug effects | Brugia malayi - genetics | Molting - physiology | Brugia pahangi - genetics | Brugia malayi - growth & development | Egg Shell - growth & development | Animals | Cathepsins - genetics | Cysteine Endopeptidases - genetics | Cysteine Proteinase Inhibitors - pharmacology | Brugia pahangi - growth & development
Journal Article