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Journal of Immunology, ISSN 0022-1767, 06/2019, Volume 202, Issue 11, pp. 3246 - 3255
To evade the immune system, the lethal human pathogen Streptococcus pyogenes produces SpyCEP, an enzyme that cleaves the C-terminal alpha-helix of CXCL8,... 
AMINO-TERMINUS | MIGRATION | CHONDROITIN SULFATE | INTERLEUKIN-8 RECEPTOR | INVASIVE DISEASE | PYOGENES | SURFACE | HEPARAN-SULFATE | HIGH-AFFINITY BINDING | CXC CHEMOKINES | IMMUNOLOGY | Infectious Disease and Host Response
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2019, Volume 378, p. 114642
Organic anion transporting polypeptides (OATPs) are key players of drug absorption, distribution and excretion due to their broad substrate specificity, wide... 
Uptake function | Protein stability | Transmembrane domains | Organic anion transporting polypeptides | Amino-terminus | ACID-RESIDUES | DISPOSITION | OATP1B1 | KINETICS | ESTRONE-3-SULFATE | SUPERFAMILY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | BINDING | DRUG-DRUG INTERACTIONS
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 02/2019, Volume 54, pp. 78 - 85
Gap junction family proteins form conduits connecting the cytoplasm of adjacent cells, thereby enabling electrical and chemical coupling to maintain... 
3-DIMENSIONAL STRUCTURE | AMINO-TERMINUS | RECTIFICATION | TRANSMISSION | CONFORMATIONAL-CHANGES | DETERMINANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATING POLARITY | N-TERMINUS | PROTEINS | CONFIGURATIONS | CELL BIOLOGY | Proteins | Physiological aspects | Analysis
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2010, Volume 13, Issue 3, pp. 310 - 318
Journal Article
Journal of Virology, ISSN 0022-538X, 11/2017, Volume 91, Issue 21
Mammalian orthoreovirus (MRV) infection induces phosphorylation of translation initiation factor eIF2 alpha, which promotes the formation of discrete... 
Mammalian orthoreovirus | Viral factories | Stress granules | G3BP1 | Translational shutoff | AMINO-TERMINUS | REOVIRUS SIGMA-NS | DOUBLE-STRANDED-RNA | INCLUSIONS | EIF2-ALPHA PHOSPHORYLATION | VIRAL REPLICATION | MU-NS | ENDORIBONUCLEASE G3BP | translational shutoff | mammalian orthoreovirus | VIROLOGY | MESSENGER-RNA | VIRUS-REPLICATION | stress granules | viral factories
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2018, Volume 475, Issue 15, pp. 2435 - 2455
Protein tyrosine sulfation is a post-translational modification best known for regulating extracellular protein-protein interactions. Tyrosine sulfation is... 
AMINO-TERMINUS | O-SULFATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-VIII | POSTTRANSLATIONAL MODIFICATIONS | MOLECULAR-CLONING | N-TERMINUS | RESISTANT AURORA | MASS-SPECTROMETRY | DISCOVERY | PEPTIDE | kinase inhibitor | PAPS | tyrosine sulfotransferase | sulfation | sulfotransferase | RAF
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 10/2016, Volume 473, pp. 3667 - 3682
Imported sucrose is cleaved by sucrose synthase (SUS) as a critical initial reaction in the biosynthesis of storage end-products by developing seeds. Although... 
AMINO-TERMINUS | LEAF NITRATE REDUCTASE | NADPH OXIDASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | PHOSPHOENOLPYRUVATE CARBOXYLASE | SUBCELLULAR-LOCALIZATION | VIVO REGULATORY PHOSPHORYLATION | PARTIAL-PURIFICATION | MEMBRANE ASSOCIATION | SUBSTRATE RECOGNITION
Journal Article
PLOS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3
Androgen receptor (AR) is a member of the steroid receptor family and a therapeutic target for all stages of prostate cancer. AR is activated by ligand binding... 
AMINO-TERMINUS | CELLS | RECRUITMENT | AR SUPPRESSES TRANSCRIPTION | MULTIDISCIPLINARY SCIENCES | N-TERMINAL DOMAIN | GENE-EXPRESSION | INCREASED SURVIVAL | IDENTIFICATION | SPLICE VARIANTS | PSA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 6, pp. 1767 - 1772
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 8, pp. 2642 - 2650
The cellular prion protein (PrPC) is a glycoprotein that is processed through several proteolytic pathways. Modulators of PrPC proteolysis are of interest... 
AMINO-TERMINUS | ALPHA-CLEAVAGE | capillary Western | DOMAIN | prion disease | BIOCHEMISTRY & MOLECULAR BIOLOGY | neurodegeneration | IMPAIRMENT | simple Western | PEPTIDE APTAMERS | high-throughput screening (HTS) | PrPC | protein misfolding | glycoprotein | proteolysis | Index Medicus
Journal Article
JOURNAL OF VIROLOGY, ISSN 0022-538X, 03/2019, Volume 93, Issue 5
Broadly neutralizing antibodies (bNAbs) target five major epitopes on the HIV-1 envelope glycoprotein (Env). The most potent bNAbs have median half-maximal... 
AMINO-TERMINUS | antibody | CRYSTAL-STRUCTURE | FUSION INHIBITOR T-20 | N-TERMINUS | envelope glycoprotein | V3-glycan | VIROLOGY | tyrosine sulfation | BROADLY NEUTRALIZING ANTIBODIES | human immunodeficiency virus | IMMUNODEFICIENCY-VIRUS TYPE-1 | HIV-1 ENVELOPE GLYCOPROTEIN | CCR5 | CRYO-EM STRUCTURE
Journal Article