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index medicus (944) 944
humans (797) 797
aml1 (415) 415
acute myeloid-leukemia (413) 413
hematology (406) 406
oncology (406) 406
animals (389) 389
core binding factor alpha 2 subunit (355) 355
transcription factors - genetics (340) 340
female (295) 295
leukemia (294) 294
mice (281) 281
male (278) 278
oncogene proteins, fusion - genetics (264) 264
core binding factor alpha 2 subunit - genetics (257) 257
dna-binding proteins - genetics (253) 253
biochemistry & molecular biology (240) 240
translocation, genetic (225) 225
cell biology (222) 222
aml1 gene (219) 219
child (206) 206
acute lymphoblastic-leukemia (203) 203
genetics & heredity (183) 183
gene (182) 182
precursor cell lymphoblastic leukemia-lymphoma - genetics (181) 181
proto-oncogene proteins (177) 177
expression (173) 173
molecular sequence data (165) 165
acute myelogenous leukemia (163) 163
base sequence (161) 161
t (158) 158
leukemia, myeloid, acute - genetics (156) 156
child, preschool (153) 153
runx1 translocation partner 1 protein (150) 150
transcription factors - metabolism (149) 149
gene expression (135) 135
adult (134) 134
translocation (134) 134
transcription factor (133) 133
adolescent (131) 131
hemic and lymphatic diseases (130) 130
cancer (127) 127
core binding factor alpha 2 subunit - metabolism (127) 127
dna-binding proteins - metabolism (123) 123
chromosomes, human, pair 21 (122) 122
dna-binding (121) 121
hematopoiesis (114) 114
genetic aspects (113) 113
runx1 (111) 111
children (110) 110
middle aged (110) 110
acute myeloid leukemia (108) 108
research (107) 107
reverse transcriptase polymerase chain reaction (107) 107
differentiation (106) 106
mutation (106) 106
prognosis (104) 104
aml1 protein (103) 103
genes (103) 103
proteins (100) 100
transcription factors (98) 98
protein (95) 95
chromosomes, human, pair 21 - genetics (93) 93
neoplasm proteins - genetics (93) 93
cell line (92) 92
amino acid sequence (91) 91
in situ hybridization, fluorescence (90) 90
leukemia, myeloid - genetics (88) 88
analysis (87) 87
infant (87) 87
fetal liver hematopoiesis (85) 85
runt domain (85) 85
proto-oncogene proteins - genetics (82) 82
transcription factors - physiology (82) 82
abridged index medicus (78) 78
acute disease (78) 78
fusion (78) 78
fusion protein (77) 77
polymerase chain reaction (76) 76
cell differentiation (75) 75
point mutations (73) 73
tel-aml1 (73) 73
aged (72) 72
oncogene proteins, fusion - metabolism (72) 72
transcription, genetic (72) 72
aml1/pebp2-alpha-b gene (71) 71
cells (71) 71
identification (70) 70
fusion transcript (67) 67
protein binding (67) 67
chromosomes, human, pair 8 (66) 66
leukemia - genetics (66) 66
minimal residual disease (66) 66
promoter regions, genetic (66) 66
transcription (66) 66
aml1/eto (65) 65
core-binding-factor (64) 64
binding sites (63) 63
cell line, tumor (63) 63
dna-binding proteins - physiology (63) 63
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Nature Cell Biology, ISSN 1465-7392, 07/2017, Volume 19, Issue 7, pp. 844 - 855
Leukaemogenesis requires enhanced self-renewal, which is induced by oncogenes. The underlying molecular mechanisms remain incompletely understood. Here, we... 
RIBOSOMAL-RNA METHYLATION | BREAST-CANCER | BIOGENESIS | HEMATOPOIETIC STEM-CELLS | TRANSCRIPTION | GRANULOCYTIC DIFFERENTIATION | ACUTE MYELOID-LEUKEMIA | PROTEIN-SYNTHESIS | POLYMERASE-I | TRANSLATIONAL CONTROL | CELL BIOLOGY | Myeloid-Lymphoid Leukemia Protein - metabolism | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Leukemia - pathology | Humans | Leukemia - metabolism | RNA, Ribosomal - genetics | Protein Interaction Maps | Cell Self Renewal | RNA, Small Nucleolar - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | U937 Cells | HEK293 Cells | Ribonucleoproteins - genetics | DEAD-box RNA Helicases - metabolism | Leukemia - genetics | Repressor Proteins - metabolism | Genetic Predisposition to Disease | Core Binding Factor Alpha 2 Subunit - metabolism | Signal Transduction | Mice, Inbred C57BL | RNA, Ribosomal - metabolism | Repressor Proteins - genetics | Ribonucleoproteins - metabolism | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | RNA, Small Nucleolar - genetics | Mice, Knockout | RUNX1 Translocation Partner 1 Protein | Transcription Factors - metabolism | DEAD-box RNA Helicases - genetics | Phenotype | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | K562 Cells | HL-60 Cells | Proto-Oncogene Proteins c-myc - genetics | Cell Transformation, Neoplastic - pathology | Methylation | Core Binding Factor Alpha 2 Subunit - genetics | Enhancer-of-split protein | Leukemia | rRNA | Myc protein | snoRNA | DNA helicase | AML1 protein | Molecular modelling | Clonal deletion | Ribonucleic acids | Stem cells | Deletion | In vitro methods and tests | RNA helicase | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e55481 - e55481
AML1-ETO fusion protein (AE) is generated by t(8;21)(q22;q22) chromosomal translocation, which is one of the most frequently observed structural abnormalities... 
AML1-ETO | PATHWAYS | MONOCYTIC LEUKEMIA | MULTIDISCIPLINARY SCIENCES | G1/S TRANSITION | AML1/ETO | TRANSCRIPTION | KINASE | FUSION PROTEIN | CBP/P300 | ACUTE MYELOID-LEUKEMIA | Oncogene Proteins, Fusion - metabolism | p300-CBP Transcription Factors - antagonists & inhibitors | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | p300-CBP Transcription Factors - genetics | Leukemia, Myeloid, Acute - drug therapy | Female | Proto-Oncogene Proteins c-kit - genetics | Hematopoietic Stem Cells - drug effects | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Leukemic - drug effects | Hematopoietic Stem Cells - metabolism | RUNX1 Translocation Partner 1 Protein | Granulocyte Colony-Stimulating Factor - pharmacology | p300-CBP Transcription Factors - metabolism | Acetylation - drug effects | Animals | Histones - genetics | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Oncogene Proteins, Fusion - genetics | Hematopoietic Stem Cells - cytology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Histones - metabolism | Core Binding Factor Alpha 2 Subunit - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Leukemia, Myeloid, Acute - genetics | Physiological aspects | Genetic aspects | Research | Transferases | Cell proliferation | Transcription | Bcl-2 protein | Leukemia | Event-related potentials | Kinases | Proteins | Cell growth | Allografts | Granulocyte colony-stimulating factor | Peripheral blood | Cell cycle | Colony-stimulating factor | Inhibition | Acetylation | Fusion protein | G1 phase | Translocation | Hematology | Colonies | Myeloid leukemia | Abnormalities | Melanoma | Gene expression | Histone acetyltransferase | c-Kit protein | Patients | AML1 protein | Inhibitors | Cell lines | Stem cells | Leukemogenesis | Leukocytes (granulocytic) | Laboratory animals | Acute myeloid leukemia | Prostate cancer | Histone H3 | Apoptosis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e54715 - e54715
DEAF-1 is an important transcriptional regulator that is required for embryonic development and is linked to clinical depression and suicidal behavior in... 
MAGNETIC-RESONANCE RELAXATION | PROTEIN STRUCTURES | DNA-BINDING | MULTIDISCIPLINARY SCIENCES | NMR STRUCTURE CALCULATION | N-COR | TRANSCRIPTION | METHYLTRANSFERASE SMYD3 | DIPOLAR COUPLINGS | AUTOMATED NOE ASSIGNMENT | MODEL-FREE APPROACH | Amino Acid Sequence | Nuclear Receptor Co-Repressor 2 - chemistry | Peptides - chemistry | Zinc - metabolism | Humans | Models, Molecular | Molecular Sequence Data | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Carrier Proteins - genetics | Sequence Alignment | Carrier Proteins - metabolism | Peptides - metabolism | Nuclear Magnetic Resonance, Biomolecular | Protein Binding | Carrier Proteins - chemistry | Protein Conformation | Protein Interaction Domains and Motifs | Mutation | Nuclear Proteins - genetics | Cellular proteins | Nuclear magnetic resonance spectroscopy | Cysteine | Deaf | Protein binding | Residues | Transcription | Peptides | Gene regulation | Science | Amino acids | Homology | Biology | Mental depression | Cofactors | Magnetic resonance spectroscopy | Proteins | Embryogenesis | Deoxyribonucleic acid--DNA | Automation | Molecular interactions | SMRT protein | Functional analysis | Topology | Zinc | Embryonic growth stage | AML1 protein | ETO protein | NMR spectroscopy | Binding sites | Structure-function relationships | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/1998, Volume 95, Issue 20, pp. 11590 - 11595
The mammalian AML/CBFα runt domain (RD) transcription factors regulate hematopoiesis and osteoblast differentiation. Like their Drosophila counterparts, most... 
Proteins | T lymphocytes | Yeasts | Plasmids | Myeloid leukemia | Genes | Drosophila | Co repressor proteins | Binding sites | T cell antigen receptors | ALPHA ENHANCER FUNCTION | DOMAIN | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | HELIX-LOOP-HELIX | BETA-CATENIN | PROTEINS | GENE AML1 | EXPRESSION | DROSOPHILA | RUNT | Transcription Factors - chemistry | Saccharomyces cerevisiae - genetics | Humans | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 | Saccharomyces cerevisiae - metabolism | Transfection | Armadillo Domain Proteins | Neoplasm Proteins | Core Binding Factor Alpha 2 Subunit | Cytoskeletal Proteins - metabolism | Proto-Oncogene Proteins | Nuclear Proteins - genetics | Binding Sites | Insect Proteins - metabolism | Genes, Reporter | Repressor Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors | Drosophila - genetics | Amino Acid Sequence | Cell Line | Drosophila Proteins | Repressor Proteins - chemistry | beta Catenin | Trans-Activators | Insect Proteins - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Receptors, Antigen, T-Cell, alpha-beta - genetics | Transcription Factors - metabolism | Animals | Protein Binding | Recombinant Fusion Proteins - genetics | Drosophila - metabolism | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Yeast | Genetic transcription | Research | Biochemistry | Index Medicus | Biological Sciences
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 07/2014, Volume 29, Issue 7, pp. 1564 - 1574
Journal Article
Journal Article
Experimental & molecular medicine, ISSN 1226-3613, 04/2018, Volume 50, Issue 4, pp. 44 - 8
The AML1-ETO fusion protein (A/E), which results from the t(8;21) translocation, is considered to be a leukemia-initiating event. Identifying the mechanisms... 
AML1-ETO | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PROTEIN | REPRESSION | WT1 | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-SITES | EXPRESSION | PROMOTE | BRAIN | Chromosomes, Human, Pair 8 - genetics | Translocation, Genetic | Chromosomes, Human, Pair 21 - metabolism | Oncogene Proteins, Fusion - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | DNA Methylation | Cell Transformation, Neoplastic - genetics | U937 Cells | Nerve Tissue Proteins - biosynthesis | RUNX1 Translocation Partner 1 Protein - genetics | RUNX1 Translocation Partner 1 Protein - metabolism | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Membrane Proteins - genetics | Gene Silencing | THP-1 Cells | Repressor Proteins - genetics | Chromosomes, Human, Pair 21 - genetics | Cell Transformation, Neoplastic - metabolism | Nerve Tissue Proteins - genetics | Chromosomes, Human, Pair 8 - metabolism | Membrane Proteins - biosynthesis | Repressor Proteins - biosynthesis | Oncogene Proteins, Fusion - genetics | HL-60 Cells | Cell Transformation, Neoplastic - pathology | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | Nucleotide sequence | Myeloid leukemia | Leukemia | AML1 protein | Cell lines | Cell cycle | DNA methylation | Leukemogenesis | DNA methyltransferase | Fusion protein | Methylation | Acute myeloid leukemia | Binding sites | Apoptosis | 5-aza-2'-deoxycytidine | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e48954 - e48954
There is increasing evidence supporting DNA virus regulation of the cell adhesion and tumour suppressor protein, E-cadherin. We previously reported that loss... 
REGULATES E-CADHERIN | CANCER-CELLS | BREAST-CANCER | EPIDERMAL LANGERHANS CELLS | PROTEIN | DNA METHYLATION | TUMOR PROGRESSION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | DOWN-REGULATION | EPITHELIAL-MESENCHYMAL TRANSITIONS | Promoter Regions, Genetic | Cadherins - metabolism | DNA Modification Methylases - metabolism | HCT116 Cells | Humans | RNA, Messenger - genetics | Transcriptional Activation | Gene Expression Regulation | Repressor Proteins - genetics | Histone Deacetylases - metabolism | RNA, Messenger - metabolism | Papillomavirus E7 Proteins - genetics | Transcription Factors - metabolism | DNA Methylation | Papillomavirus E7 Proteins - metabolism | Protein Binding | Oncogene Proteins, Viral - genetics | Transcription, Genetic | Enzyme Activation | Cadherins - genetics | Repressor Proteins - metabolism | Oncogene Proteins, Viral - metabolism | Papillomaviruses | Genetic aspects | Genetic transcription | Methyltransferases | Papillomavirus infections | Analysis | Binding | Histone deacetylase | E6 protein | Immune response | Epidermis | Viruses | Sp1 protein | Adhesion | E-cadherin | Cell adhesion & migration | Immune systems | Gene silencing | Human papillomavirus | AML1 protein | Repressors | Rodents | Cell adhesion | DNA methylation | Langerhans cells | DNA methyltransferase | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
STEM CELLS, ISSN 1066-5099, 02/2013, Volume 31, Issue 2, pp. 236 - 247
The initial steps involved in the pathogenesis of acute leukemia are poorly understood. The TEL‐AML1 fusion gene usually arises before birth, producing a... 
Acute lymphocytic leukemia | Self‐renewal | Cancer stem cells | B lymphocytes | Self-renewal | T(12/21) | TEL-AML1 FUSION | CANCER | CELL & TISSUE ENGINEERING | CELL BIOLOGY | RELAPSE | ORIGINS | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | MYELOID-LEUKEMIA | DIFFERENTIATION | HEMATOLOGY | EXPRESSION | HEMATOPOIETIC STEM | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Gene Expression Regulation, Neoplastic | Precursor Cells, B-Lymphoid - immunology | Gene Expression Profiling | Homeodomain Proteins - immunology | HMGB3 Protein - genetics | Oncogene Proteins, Fusion - immunology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology | Cell Cycle Proteins - immunology | Precursor Cells, B-Lymphoid - pathology | Proto-Oncogene Proteins - immunology | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Fetus | Transcription, Genetic | Embryonic Stem Cells - immunology | Trans-Activators - immunology | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | HMGB3 Protein - immunology | Proto-Oncogene Proteins - genetics | Homeodomain Proteins - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Core Binding Factor Alpha 2 Subunit - immunology | Oncogene Proteins, Fusion - genetics | Repressor Proteins - immunology | Embryonic Stem Cells - pathology | Lymphocyte Count | Protein-Serine-Threonine Kinases - immunology | Mice | Mice, Inbred BALB C | Core Binding Factor Alpha 2 Subunit - genetics | Bone marrow | Stem cells | Index Medicus
Journal Article