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Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 08/2019, Volume 23, Issue 8, pp. 5246 - 5258
AML1‐ETO, the most common fusion oncoprotein by t (8;21) in acute myeloid leukaemia (AML), enhances hematopoietic self‐renewal and leukemogenesis. However,... 
self‐renewal | AML1‐ETO | miR‐193a | leukaemia stem cell | melatonin | AML1-ETO | miR-193a | self-renewal | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | AML1-ETO FUSION PROTEIN | T(8/21) LEUKEMIA | ACUTE MYELOID-LEUKEMIA | CELL BIOLOGY | IN-VITRO | POLYMERASE-CHAIN-REACTION | RESIDUAL DISEASE DETECTION | LEUKEMOGENESIS | GENE-EXPRESSION | DEGRADATION | Index Medicus | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2019, Volume 116, Issue 3, pp. 890 - 899
Journal Article
LEUKEMIA & LYMPHOMA, ISSN 1042-8194, 2018, Volume 59, Issue 9, pp. 2188 - 2200
The core binding factor (CBF) gene RUNX1 is a target of chromosomal translocations in leukemia, including t(8;21) in acute myeloid leukemia (AML). Normal CBF... 
AML1-ETO | CBFB | Leukemia | PPI | protein-protein interaction inhibitor | RUNX | ACUTE MYELOID-LEUKEMIA | SMALL-MOLECULE INHIBITOR | BETA | ONCOLOGY | TRANSFER DIFFERENCE NMR | ACUTE LYMPHOBLASTIC-LEUKEMIA | LEUKEMOGENESIS | TRANSCRIPTIONAL CONTROL | STEM/PROGENITOR CELLS | TEL-AML1 | HEMATOLOGY | AML1-ETO ACTIVITY | HEMATOPOIETIC STEM
Journal Article
Genes and Development, ISSN 0890-9369, 10/2015, Volume 29, Issue 20, pp. 2123 - 2139
Journal Article
by Gao, XN and Yan, F and Lin, J and Gao, L and Lu, XL and Wei, SC and Shen, N and Pang, JX and Ning, QY and Komeno, Y and Deng, AL and Xu, YH and Shi, JL and Li, YH and Zhang, DE and Nervi, C and Liu, SJ and Yu, L
LEUKEMIA, ISSN 0887-6924, 08/2015, Volume 29, Issue 8, pp. 1730 - 1740
The mechanisms by which AML1/ETO (A/E) fusion protein induces leukemogenesis in acute myeloid leukemia (AML) without mutagenic events remain elusive. Here we... 
AML1-ETO | STEM-CELLS | FACTOR-BINDING | DNA-BINDING | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | KIT MUTATIONS | T(8/21) | FUSION PROTEIN | TUMOR-SUPPRESSOR | ACUTE MYELOID-LEUKEMIA | HEMATOLOGY
Journal Article
Leukemia & lymphoma, ISSN 1042-8194, 9/2018, Volume 59, Issue 9, pp. 2188 - 2200
The core binding factor (CBF) gene RUNX1 is a target of chromosomal translocations in leukemia, including the t(8;21) in acute myeloid leukemia (AML). Normal... 
AML1-ETO | leukemia | CBFB | PPI | TEL-AML1 | protein-protein interaction inhibitor | RUNX
Journal Article
Journal of Sichuan University (Medical Science Edition), ISSN 1672-173X, 11/2016, Volume 47, Issue 6, pp. 931 - 935
Journal Article
LEUKEMIA, ISSN 0887-6924, 07/2014, Volume 28, Issue 7, pp. 1449 - 1458
t(8;21)/RUNX1-RUNX1T1-positive acute myeloid leukemia (AML) is prognostically favorable; however, outcome is heterogeneous. We analyzed 139 patients with... 
AML1-ETO | COMPLETE REMISSION | T(8/21) | ASXL1 mutation | C-KIT | secondary mutations | PATIENTS YOUNGER | prognosis | KIT mutation | acute myeloid leukemia | ONCOLOGY | CORE-BINDING-FACTOR | MUTATIONS | t(8;21)/RUNX1-RUNX1T1 | STEM-CELL TRANSPLANTATION | HEMATOLOGY | MINIMAL RESIDUAL DISEASE | FRENCH AML INTERGROUP
Journal Article
STRUCTURE, ISSN 0969-2126, 05/2018, Volume 26, Issue 5, pp. 734 - 734
Communication within cells relies on a few protein nodes called hubs, which organize vast interactomes with many partners. Frequently, hub proteins are... 
COMPLEX | COACTIVATOR BINDING DOMAIN | NMR-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | T-ALPHA | PAH2 DOMAIN | MOTIF | CELL BIOLOGY | SIN3 COREPRESSOR | BIOPHYSICS | PROTEIN INTRINSIC DISORDER | TRANSACTIVATION DOMAIN | AML1-ETO ACTIVITY
Journal Article
Cell Reports, ISSN 2211-1247, 11/2016, Volume 17, Issue 8, pp. 2087 - 2100
Journal Article
Blood, ISSN 0006-4971, 05/2013, Volume 121, Issue 20, pp. 4056 - 4062
Journal Article
Leukemia Research, ISSN 0145-2126, 01/2019, Volume 76, pp. 15 - 23
Acute myeloid leukemia is an aggressive disease that arises from clonal expansion of malignant hematopoietic precursor cells of the bone marrow. Deletions on... 
AML | CEBPA | del(9q) | HNRNPK | AML1-ETO | NUCLEAR-RIBONUCLEOPROTEIN-K | HNRNP-K | C/EBP-ALPHA | MESSENGER-RNA | ONCOLOGY | TUMOR-SUPPRESSOR | MUTATIONS | HEMATOLOGY | EXPRESSION | Index Medicus
Journal Article
Journal Article
AUTOPHAGY, ISSN 1554-8627, 12/2013, Volume 9, Issue 12, pp. 2175 - 2177
Both radiation and chemotherapeutic drugs induce autophagy in tumor cells, and whether this contributes to cell death or survival is debated. Although a... 
AML | AML1-ETO | chloroquine | leukemia | PML-RARA | autophagy | vorinostat | BCR-ABL | valproic acid | CELL BIOLOGY
Journal Article
by Zhou, B and Li, HY and Xing, CY and Ye, HG and Feng, JH and Wu, JB and Lu, ZQ and Fang, J and Gao, SM
BIOCHEMICAL PHARMACOLOGY, ISSN 0006-2952, 03/2017, Volume 128, pp. 12 - 25
AMLI-ETO is the most common oncoprotein leading to acute myeloid leukemia (AML), in which 5-year survival rate is only about 30%. However, currently there are... 
APOPTOSIS | AML1-ETO FUSION PROTEIN | CANCER PROGRAM | Honokiol | AMLI-ETO | CELL-CYCLE ARREST | ACUTE MYELOID-LEUKEMIA | POLYMERASE-CHAIN-REACTION | EPITHELIAL-CELLS | RESIDUAL DISEASE DETECTION | PHARMACOLOGY & PHARMACY | HISTONE DEACETYLASE INHIBITORS | UbcH8 | DEPENDENT DEGRADATION
Journal Article
BLOOD, ISSN 0006-4971, 09/2011, Volume 118, Issue 9, pp. 2541 - 2550
Dysfunction of AML1/Runx1, a transcription factor, plays a crucial role in the development of many types of leukemia. Additional events are often required for... 
AML1-ETO | MURINE MODEL | ADULT HEMATOPOIESIS | GENE | HEMATOPOIETIC STEM-CELLS | LEUKEMOGENESIS | FUSION PROTEIN | TUMOR-SUPPRESSOR | SELF-RENEWAL | ACUTE MYELOID-LEUKEMIA | HEMATOLOGY
Journal Article