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Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15561 - 15576
.... Interestingly, the PKM1/2 knockdown in H1299 cells activated AMP-activated protein kinase (AMPK) signaling and stimulated mitochondrial biogenesis and autophagy to maintain energy homeostasis... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Mitochondrial Dynamics | AMP-Activated Protein Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Pyruvate Kinase - chemistry | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Isoenzymes - chemistry | Neoplasm Proteins - metabolism | Autophagy | Recombinant Fusion Proteins - metabolism | Thyroid Hormones - chemistry | Organelle Biogenesis | RNA Interference | Isoenzymes - metabolism | Adenosine Triphosphate - metabolism | Carcinoma - enzymology | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Carcinoma - pathology | Neoplasm Proteins - genetics | Dimerization | A549 Cells | Lung Neoplasms - enzymology | Pyruvate Kinase - metabolism | Isoenzymes - genetics | Membrane Proteins - genetics | AMP-Activated Protein Kinases - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Thyroid Hormones - genetics | Protein Transport | Carrier Proteins - genetics | Pyruvate Kinase - antagonists & inhibitors | Carrier Proteins - metabolism | Energy Metabolism | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Thyroid Hormones - metabolism | Cell Line, Tumor | Carcinoma - metabolism | Mutation | Pyruvate Kinase - genetics | AMP-Activated Protein Kinases - genetics | Isoenzymes - antagonists & inhibitors | Amino Acid Substitution | Apoptosis | Index Medicus | cancer metabolism | cancer therapy | pyruvate kinase M1 | mitochondria | pyruvate kinase M2 | cancer biology | Metabolism | mitochondrial oxidative phosphorylation | energy metabolism | Warburg effect
Journal Article
Biochemical journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
... (protein kinase A/protein kinase G/protein kinase Q family kinases such as Akt (protein kinase 13), S6K (p70 ribosomal S6 kinase... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | kinase inhibitor | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | cancer | serum and glucocorticoid protein kinase (SGK) | MAPK, mitogen-activated protein kinase
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 18465 - 18473
.... Overexpression of resistin using adenoviral vector in neonatal rat ventricular myocytes was associated with inhibition of AMP-activated protein kinase (AMPK... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | AMP-Activated Protein Kinases - metabolism | Resistin - genetics | TOR Serine-Threonine Kinases - metabolism | Ventricular Myosins - biosynthesis | Apoptosis - drug effects | Apoptosis - genetics | Cardiomegaly - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Insulin Receptor Substrate Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Insulin Receptor Substrate Proteins - genetics | Biomarkers - metabolism | Natriuretic Peptide, Brain - genetics | Resistin - metabolism | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Gene Expression Regulation - genetics | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | AMP-Activated Protein Kinases - antagonists & inhibitors | Cells, Cultured | Enzyme Inhibitors - pharmacology | Natriuretic Peptide, Brain - biosynthesis | Rats | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Myocytes, Cardiac - pathology | Animals | Insulin Receptor Substrate Proteins - antagonists & inhibitors | Insulin Resistance - genetics | Myocytes, Cardiac - metabolism | Cardiomegaly - genetics | AMP-Activated Protein Kinases - genetics | Cardiomegaly - metabolism | Ventricular Myosins - genetics | Index Medicus | Molecular Bases of Disease | Cardiomyocyte | Insulin Resistance | AMP-activated Kinase (AMPK) | Gene Transfer | Diabetes | mTOR, JNK Signaling | Cardiac Hypertrophy | Diabetic Cardiomyopathy | Resistin
Journal Article
FEBS letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0127885 - e0127885
...) increases macrophage phagocytosis through adenosine monophosphate-activated protein kinase (AMPK... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | AMP-Activated Protein Kinases - metabolism | Apoptosis - drug effects | Apoptosis - genetics | Male | Phagocytosis - genetics | Aminoimidazole Carboxamide - pharmacology | Gene Knockdown Techniques | Ribonucleotides - pharmacology | Phosphorylation - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Phagocytosis - drug effects | MAP Kinase Kinase Kinases - genetics | AMP-Activated Protein Kinases - antagonists & inhibitors | Macrophages, Peritoneal - enzymology | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Animals | Aminoimidazole Carboxamide - analogs & derivatives | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Pyridines - pharmacology | Enzyme Activation - genetics | AMP-Activated Protein Kinases - genetics | Bone morphogenetic proteins | Inflammation | Adenylic acid | Macrophages | Transforming growth factors | Mitogens | Protein kinases | Apoptosis | Phosphorylation | Transforming growth factor-b | Homeostasis | AKT protein | Kinases | AMP-activated protein kinase | Medical schools | Proteins | Phagocytes | Cell activation | Pain | Penicillin | Cell cycle | Inhibition | Growth factors | Adenosine | Adenosine monophosphate | AMP | TAK1 protein | Neutrophils | Dipyridamole | MAP kinase | Leukocytes (neutrophilic) | siRNA | 1-Phosphatidylinositol 3-kinase | Medicine | Studies | Inhibitors | Thymocytes | Lungs | Adenosine kinase | Stem cells | Anesthesiology | Laboratory animals | Transporter | Phagocytosis | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 08/2017, Volume 292, Issue 33, pp. 13795 - 13808
.... Here, we report that phosphorylation of autophagy-associated protein p62 by AMP-activated protein kinase (AMPK... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | AMP-Activated Protein Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Protein Transport - drug effects | Hippocampus - drug effects | Neural Stem Cells - cytology | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Gene Deletion | Phosphorylation - drug effects | Sequestosome-1 Protein - metabolism | Adult Stem Cells - drug effects | Autophagy-Related Protein 7 - antagonists & inhibitors | Cell Survival - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Adult Stem Cells - cytology | AMP-Activated Protein Kinases - antagonists & inhibitors | Sequestosome-1 Protein - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Hippocampus - cytology | Autophagy-Related Protein 7 - genetics | Nerve Tissue Proteins - genetics | AMP-Activated Protein Kinases - chemistry | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Point Mutation | Sequestosome-1 Protein - genetics | Adult Stem Cells - metabolism | Animals | Protein Kinase Inhibitors - pharmacology | Neural Stem Cells - metabolism | AMP-Activated Protein Kinases - genetics | Amino Acid Substitution | Index Medicus | AMP-activated kinase (AMPK) | mitophagy | autophagy | phosphorylation | p62 (sequestosome 1 (SQSTM1)) | Protein Synthesis and Degradation
Journal Article