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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2008, Volume 181, Issue 12, pp. 8633 - 8641
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15561 - 15576
Preferential expression of the low-activity (dimeric) M2 isoform of pyruvate kinase (PK) over its constitutively active splice variant M1 isoform is considered... 
LUNG-CANCER | METABOLISM | TUMOR SUPPRESSION | PKM2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | PREDICTING SUBCELLULAR-LOCALIZATION | HIGH-TITER LENTIVIRUS | ISOFORM | LKB1 | GENE-TRANSCRIPTION | Mitochondrial Dynamics | AMP-Activated Protein Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Pyruvate Kinase - chemistry | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Isoenzymes - chemistry | Neoplasm Proteins - metabolism | Autophagy | Recombinant Fusion Proteins - metabolism | Thyroid Hormones - chemistry | Organelle Biogenesis | RNA Interference | Isoenzymes - metabolism | Adenosine Triphosphate - metabolism | Carcinoma - enzymology | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Carcinoma - pathology | Neoplasm Proteins - genetics | Dimerization | A549 Cells | Lung Neoplasms - enzymology | Pyruvate Kinase - metabolism | Isoenzymes - genetics | Membrane Proteins - genetics | AMP-Activated Protein Kinases - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Thyroid Hormones - genetics | Protein Transport | Carrier Proteins - genetics | Pyruvate Kinase - antagonists & inhibitors | Carrier Proteins - metabolism | Energy Metabolism | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Thyroid Hormones - metabolism | Cell Line, Tumor | Carcinoma - metabolism | Mutation | Pyruvate Kinase - genetics | AMP-Activated Protein Kinases - genetics | Isoenzymes - antagonists & inhibitors | Amino Acid Substitution | Apoptosis | Index Medicus | cancer metabolism | cancer therapy | pyruvate kinase M1 | mitochondria | pyruvate kinase M2 | cancer biology | Metabolism | mitochondrial oxidative phosphorylation | energy metabolism | Warburg effect
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2013, Volume 17, Issue 1, pp. 113 - 124
Journal Article
Hepatology, ISSN 0270-9139, 04/2014, Volume 59, Issue 4, pp. 1543 - 1554
This study examines the role of protein kinase C (PKC) and AMP‐activated kinase (AMPK) in acetaminophen (APAP) hepatotoxicity. Treatment of primary mouse... 
OXIDATIVE STRESS | ACTIVATION | INHIBITION | RAT HEPATOCYTES | PHORBOL 12-MYRISTATE 13-ACETATE | AUTOPHAGY | GASTROENTEROLOGY & HEPATOLOGY | ISOENZYMES | INDUCED LIVER-INJURY | EXTENDED FAMILY | CELL-DEATH | Acetaminophen - adverse effects | Mitochondria, Liver - metabolism | Maleimides - pharmacology | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Necrosis - pathology | AMP-Activated Protein Kinases - drug effects | Indoles - pharmacology | Chemical and Drug Induced Liver Injury - pathology | Hepatocytes - drug effects | Disease Models, Animal | JNK Mitogen-Activated Protein Kinases - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase C - physiology | AMP-Activated Protein Kinases - antagonists & inhibitors | Mice, Inbred C57BL | Protein Kinase C - drug effects | Cells, Cultured | Necrosis - metabolism | Protein Kinase C - antagonists & inhibitors | Chemical and Drug Induced Liver Injury - physiopathology | Mitochondria, Liver - drug effects | AMP-Activated Protein Kinases - physiology | Animals | Chemical and Drug Induced Liver Injury - metabolism | JNK Mitogen-Activated Protein Kinases - physiology | Signal Transduction - physiology | Mice | Protein Kinase Inhibitors - pharmacology | In Vitro Techniques | Cytotoxicity | Mitochondria | Kinases | Autophagy | Liver | Hepatology | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 18465 - 18473
Resistin has been suggested to be involved in the development of diabetes and insulin resistance. We recently reported that resistin is expressed in diabetic... 
MAMMALIAN TARGET | INSULIN-RECEPTOR | OBESITY | PHOSPHORYLATION | GLUCOSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | THERAPEUTIC TARGET | DIABETIC CARDIOMYOPATHY | P70 S6 KINASE | MTOR | AMP-Activated Protein Kinases - metabolism | Resistin - genetics | TOR Serine-Threonine Kinases - metabolism | Ventricular Myosins - biosynthesis | Apoptosis - drug effects | Apoptosis - genetics | Cardiomegaly - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Insulin Receptor Substrate Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Insulin Receptor Substrate Proteins - genetics | Biomarkers - metabolism | Natriuretic Peptide, Brain - genetics | Resistin - metabolism | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Gene Expression Regulation - genetics | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | AMP-Activated Protein Kinases - antagonists & inhibitors | Cells, Cultured | Enzyme Inhibitors - pharmacology | Natriuretic Peptide, Brain - biosynthesis | Rats | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Myocytes, Cardiac - pathology | Animals | Insulin Receptor Substrate Proteins - antagonists & inhibitors | Insulin Resistance - genetics | Myocytes, Cardiac - metabolism | Cardiomegaly - genetics | AMP-Activated Protein Kinases - genetics | Cardiomegaly - metabolism | Ventricular Myosins - genetics | Index Medicus | Molecular Bases of Disease | Cardiomyocyte | Insulin Resistance | AMP-activated Kinase (AMPK) | Gene Transfer | Diabetes | mTOR, JNK Signaling | Cardiac Hypertrophy | Diabetic Cardiomyopathy | Resistin
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2014, Volume 34, Issue 4, pp. 830 - 836
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 09/2014, Volume 54, pp. 1 - 9
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 02/2016, Volume 101, pp. 54 - 70
Pioglitazone (PIO), a PPARγ agonist that improves glycemic control in type 2 diabetes through its insulin-sensitizing action, has been shown to exhibit... 
AMPK | p70S6K | Pioglitazone | Vascular smooth muscle cells | ERK | ACTIVATED PROTEIN-KINASE | RECEPTOR-GAMMA | ANGIOTENSIN-II | NEOINTIMA FORMATION | ANTIDIABETIC DRUGS | AMERICAN-DIABETES-ASSOCIATION | INTIMAL HYPERPLASIA | INSULIN-RESISTANCE | HEART-ASSOCIATION | IN-VIVO | PHARMACOLOGY & PHARMACY | AMP-Activated Protein Kinases - metabolism | Muscle, Smooth, Vascular - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Aorta - metabolism | PPAR gamma - metabolism | Platelet-Derived Growth Factor - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Protein Processing, Post-Translational - drug effects | RNA Interference | Phosphorylation - drug effects | Thiazolidinediones - pharmacology | Muscle, Smooth, Vascular - drug effects | PPAR gamma - genetics | Recombinant Proteins - metabolism | Proto-Oncogene Proteins c-sis - agonists | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | AMP-Activated Protein Kinases - antagonists & inhibitors | Aorta - drug effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Cells, Cultured | Gene Silencing | Recombinant Proteins - chemistry | Enzyme Activation - drug effects | Muscle, Smooth, Vascular - cytology | AMP-Activated Protein Kinases - chemistry | Hypoglycemic Agents - pharmacology | Platelet-Derived Growth Factor - metabolism | MAP Kinase Signaling System - drug effects | PPAR gamma - antagonists & inhibitors | Signal Transduction - drug effects | PPAR gamma - agonists | Cell Proliferation - drug effects | Aorta - cytology | Platelet-Derived Growth Factor - antagonists & inhibitors | AMP-Activated Protein Kinases - genetics | Acetyl-CoA Carboxylase - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Proto-Oncogene Proteins c-sis - antagonists & inhibitors | Index Medicus | pioglitazone | vascular smooth muscle cells
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0152584 - e0152584
Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options. We previously found that PARP is overexpressed in SCLC and that... 
BREAST-CANCER | POLY(ADP-RIBOSE) POLYMERASE | IN-VITRO | MULTIDISCIPLINARY SCIENCES | RESISTANCE | THERAPEUTIC TARGETS | DNA-REPAIR | TUMORS | CARCINOMA | DRUG-DRUG INTERACTIONS | PI3K INHIBITOR | Lung Neoplasms - drug therapy | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Indoles - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | AMP-Activated Protein Kinases - antagonists & inhibitors | Morpholines - pharmacology | Piperazines - pharmacology | Xenograft Model Antitumor Assays | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Small Cell Lung Carcinoma - pathology | Animals | Mice, Nude | Aminopyridines - pharmacology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Poly (ADP-Ribose) Polymerase-1 | Physiological aspects | Lung cancer, Small cell | Development and progression | Genetic aspects | Cellular signal transduction | Research |