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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6083, pp. 918 - 922
Journal Article
Circulation Research, ISSN 0009-7330, 05/2017, Volume 120, Issue 11, pp. 1825 - 1841
The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever... 
Heart | Phosphates | Cardiovascular system | AMP | Energy charge | Contractility | Blood vessels | Homeostasis | Inflammation | AMP-activated protein kinase | Kinases | Muscle contraction | Energy balance | Mutation | Heart diseases
Journal Article
Journal Article
Science, ISSN 0036-8075, 6/2011, Volume 332, Issue 6036, pp. 1433 - 1435
Journal Article
2019, ISBN 3038976628
Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types... 
n/a | HDACs | transcription | epigenetics | spermatozoa | par complex | A769662 | MDCK | skeletal muscle | AID | phosphorylation | energy metabolism | monocytes | autophagy | CML | liver | hindlimb suspension | pregnancy | preeclampsia | gestational diabetes mellitus | CaMKK2 | assisted reproduction techniques | nutrient-sensing signals | sonic hedgehog | protein acetylation | glycogen storage disease | AMPK | adenosine monophosphate-activated protein kinase | AICAR | indirect calorimetry | IL-1? | MyHC I(?) | HDAC4/5 | endothelial cells | infection | hepatocyte | p70S6K | lipid metabolism | host defense | exercise | kidney disease | heat shock protein | mycobacteria | activation loop | developmental origins of health and disease (DOHaD) | CREB | TAK1 | metabolic-inflammation | phenylephrine | AMP-activated protein kinase (AMPK) | KATs | 2-methoxyestradiol | DNA methylation | NLRP3 | pump | steatosis | AMPK kinase | stress | linker | endothelial nitric-oxide synthase | vasodilation | adherent junctions | epithelial cells | glycogen | Akt | synaptic activation | cellular energy sensing | glucose uptake | transporter | co-expression | atrophy | nutrigenomics | motility | vasoconstriction | fatty acid oxidation | oxidative stress | AS160 | membrane | histone modification | sirtuin 1 (SIRT1) | chromatin remodeling | insulin signalling | dietary fatty acids | ULK | CMML | adaptive thermogenesis | mTOR | MDS | mechanical unloading | AML | catechol-O-methyltransferase | endothelial function | medulloblastoma | PKA | adipose tissue | membranes | nutrition | ZO-1 | TBC1D4 | adipocyte | soluble Adenylyl cyclase | metabolism | renin-angiotensin system | energy utilization | proteasome | differentiation | signaling | peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) | hypertrophy | AMP-activated protein kinase | metabolic disease | LKB1 | soleus muscle | macrophages | Immediate early genes | CBS | beiging | motor endplate remodeling | ionomycin | nectin-afadin | tight junctions | resveratrol | protein kinase B | regrowth | mitochondria | protein synthesis | energy deficiency | fiber-type | microarrays | NAD | carrier | RIM | acetyl-CoA | hypertension | 3T3-L1 | hypothalamus | food intake
eBook
Science, ISSN 0036-8075, 1/2011, Volume 331, Issue 6016, pp. 456 - 461
Adenosine monophosphate—activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and... 
Birds of prey | Medical research | Phosphorylation | Starvation | Mitochondria | Hepatocytes | Complementary DNA | Liver | REPORTS | Cell lines | Vehicles | TARGET | CATALYTIC SUBUNIT | METFORMIN | COMPLEX | METABOLISM | ROLES | MULTIDISCIPLINARY SCIENCES | DISEASE | C-ELEGANS | AUTOPHAGY | DOMAINS | AMP-Activated Protein Kinases - metabolism | Mitochondria, Liver - metabolism | Sequestosome-1 Protein | Humans | Caenorhabditis elegans Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Hepatocytes - metabolism | Autophagy | Autophagy-Related Protein-1 Homolog | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Caenorhabditis elegans - metabolism | Signal Transduction | Cell Survival | Liver - metabolism | Metformin - pharmacology | Protein-Serine-Threonine Kinases - genetics | Phenformin - pharmacology | Transcription Factors - metabolism | Insulin - metabolism | Animals | Energy Metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Mitochondria, Liver - ultrastructure | Cell Line, Tumor | Mice | Protein-Serine-Threonine Kinases - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Caenorhabditis elegans Proteins - genetics | Autophagy (Cytology) | Research | Properties | Protein kinases | Index Medicus | Proteins | Yeast | Adenosines | Homeostasis | Nutrients | Kinases | Survival
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2007, Volume 403, Issue 1, pp. 139 - 148
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 07/2017, Volume 95, Issue 7, pp. 1427 - 1437
Estradiol (E) mitigates acute and postacute adverse effects of 12 hr‐food deprivation (FD) on energy balance. Hindbrain 5′‐monophosphate‐activated protein... 
A2 noradrenergic neurons | glucocorticoid receptor | very‐long‐chain acyl‐CoA synthetase 3 | free fatty acid levels | adenosine 5′‐monophosphate‐activated protein kinase | corticosterone | estradiol | adenosine 5′-monophosphate-activated protein kinase | very-long-chain acyl-CoA synthetase 3 | OVARIECTOMIZED FEMALE RAT | PROGESTERONE | AMPK ACTIVITY | ENERGY STATUS | NEUROSCIENCES | LUTEINIZING-HORMONE | RESPONSES | GLUCOCORTICOID-RECEPTOR | FREE FATTY-ACIDS | HYPOGLYCEMIA | adenosine 5 '-monophosphate-activated protein kinase | BRAIN | AMP-Activated Protein Kinases - metabolism | Adrenergic Neurons - metabolism | Estradiol - administration & dosage | Receptors, Adrenergic, alpha-2 - metabolism | Rats | Drug Implants - administration & dosage | Enzyme Activation - drug effects | Rhombencephalon - drug effects | Rats, Sprague-Dawley | Phosphorylases - metabolism | Gene Expression Regulation, Enzymologic | Fatty Acids, Nonesterified - metabolism | Food Deprivation - physiology | Animals | Adenosine - metabolism | Glucose - metabolism | Rhombencephalon - metabolism | Female | Adrenergic Neurons - drug effects | Enzyme Activation - physiology | Brain | Phosphatases | Glucagon | Corticosterone | Blood sugar | Neurons | Fatty acids | Estradiol | Glucose metabolism | Ligases | Analysis | Leptin | Journalists | Phenols | Protein kinases | Glucocorticoids | Menopause | Stimulation | Activation | Glucose | Hypothalamus | Kinases | Proteins | Dietary restrictions | H protein | Energy | Rodents | Oxidation | Deprivation | Dopamine | AMP | Ovariectomy | Hydroxylase | Discordance | Upstream | Metabolism | Catecholamine | Phosphorylase | Augmentation | Energy balance | Sex hormones | Side effects | Protein kinase | Adenosine kinase | Hindbrain | Norepinephrine | Index Medicus | very long-chain acyl-CoA synthetase 3
Journal Article