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JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 03/2019, Volume 132, Issue 6, p. jcs222315
We describe a method, termed cryoAPEX, which couples chemical fixation and high-pressure freezing of cells with peroxidase tagging (APEX) to allow precise... 
Membrane protein | FIC AMPylation | Electron tomography | HORSERADISH-PEROXIDASE | MICROSCOPY | CryoAPEX | MOLECULES | CELL BIOLOGY | PRESERVATION | REPORTER | AMPYLATION | ADENYLYLATION/AMPYLATION | Cryofixation | FIC-DOMAIN | ULTRASTRUCTURE | TANNIC-ACID
Journal Article
PROTEOMICS, ISSN 1615-9853, 03/2013, Volume 13, Issue 6, pp. 955 - 963
Although the addition of a 5′‐adenosine phosphodiester group to proteins, called adenylylation, has been known for decades, the possibility that adenylylation... 
Adenylation | Technology | AMPylation | Adenylylation
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 03/2019, Volume 10, Issue 1, pp. 1 - 10
FIC proteins regulate molecular processes from bacteria to humans by catalyzing posttranslational modifications (PTM), the most frequent being the addition of... 
AMPYLATION | DOMAIN | ADENYLYLATION/AMPYLATION | HOMEOSTASIS | MECHANISM | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CALCIUM | ENDOPLASMIC-RETICULUM STRESS | REVEALS | Proteins | X-ray crystallography | Calcium | AMP | Protein folding | Metals | Post-translation | Magnesium | Crystallography | Calcium ions | Metal ions | Life Sciences | Biomolecules | Biochemistry, Molecular Biology
Journal Article
Pathogens and disease, ISSN 2049-632X, 03/2018, Volume 76, Issue 2
During the last decade, FIC proteins have emerged as a large family comprised of a variety of bacterial enzymes and a single member in animals. The air de... 
AMPYLATION TARGETS | INFECTIOUS DISEASES | DOMAIN | MECHANISM | FIC proteins | CRYSTAL-STRUCTURE | PHOSPHOCHOLINATION | cellular biology | MICROBIOLOGY | IMMUNOLOGY | IDENTIFICATION | CYCLIC-AMP | ADENYLYLATION/AMPYLATION | pathogens | biochemistry | toxins | DOC | structural biology | REVEALS
Journal Article
Chemical Science, ISSN 2041-6520, 2018, Volume 9, Issue 40, pp. 7797 - 7801
Lysine 3-hydroxyl-3-methylglutarylation (HMG-K) is a newly identified PTM that can occur non-enzymatically in mitochondria. However, the substrate scope of... 
AMPYLATION | CELLS | SUCCINYLATION | PROTEIN ACYLATION | MALONYLATION | SIRT5 | CHEMISTRY, MULTIDISCIPLINARY | GLUTARYLATION
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 12/2013, Volume 9, Issue 12, pp. 811 - 817
Fic proteins are ubiquitous in all of the domains of life and have critical roles in multiple cellular processes through AMPylation of (transfer of AMP to)... 
SYSTEM | AMPYLATION | SMALL-ANGLE SCATTERING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | PROPHAGE P1 | INHIBITS TRANSLATION | TRANSFER-RNA | ELONGATION-FACTOR-TU | PHD | Proteins | Enzymes | Phosphorylation | Substrates
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7396, pp. 114 - 118
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 05/2019, Volume 431, Issue 12, pp. 2266 - 2282
During disease, cells experience various stresses that manifest as an accumulation of misfolded proteins and eventually lead to cell death. To combat this... 
Fic | Parkinson's disease | AMPylation | adenylylation | α-synuclein | VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IBPA | BIP | alpha-synuclein | NEUROTOXICITY | PATHOGENESIS | UNFOLDED PROTEIN RESPONSE | DISRUPTION | STRUCTURAL BASIS | BINDING | AGGREGATION | Proteins | Post-translational modification | Cell death | Analysis | Adenylic acid | Mass spectrometry | Protein binding
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 27, pp. 10435 - 10437
My winding path toward a career in science was awkward, like an adolescent finding an identity. It did not follow a classic course; it had many interruptions,... 
post-translational modification (PTM) | acetylation | type III secretion system (T3SS) | signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | microbiology | YopJ | enzyme mechanism | AMPylation | ASBMB Award
Journal Article
eLife, ISSN 2050-084X, 10/2017, Volume 6
The endoplasmic reticulum (ER)-localized Hsp70 chaperone BiP contributes to protein folding homeostasis by engaging unfolded client proteins in a process that... 
Hydrolysis | Proteins | Enzymes | Peptides | Protein folding | Homeostasis | Post-translation | Hsp70 protein | Endoplasmic reticulum | Adenosine triphosphatase | J protein
Journal Article
Bio-protocol, ISSN 2331-8325, 07/2017, Volume 7, Issue 14
Post-translational protein modifications (PTMs) orchestrate the activity of individual proteins and ensure their proper function. While modifications such as... 
Journal Article