X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (30992) 30992
Book Review (4776) 4776
Publication (3048) 3048
Book Chapter (178) 178
Conference Proceeding (124) 124
Dissertation (38) 38
Magazine Article (22) 22
Book / eBook (20) 20
Web Resource (9) 9
Paper (3) 3
Streaming Video (3) 3
Trade Publication Article (3) 3
Reference (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (27897) 27897
humans (19891) 19891
animals (16227) 16227
amyloid beta-peptides - metabolism (14241) 14241
alzheimer's disease (13233) 13233
neurosciences (10489) 10489
alzheimers-disease (9761) 9761
alzheimer disease - metabolism (8742) 8742
male (7952) 7952
mice (7642) 7642
alzheimer disease - pathology (6079) 6079
female (6046) 6046
biochemistry & molecular biology (5680) 5680
rats (4909) 4909
amyloid beta-peptides - chemistry (4831) 4831
aged (4590) 4590
brain - metabolism (4358) 4358
brain (4173) 4173
peptide fragments - metabolism (3933) 3933
mice, transgenic (3903) 3903
disease models, animal (3891) 3891
a-beta (3889) 3889
alzheimer disease - genetics (3628) 3628
oxidative stress (3235) 3235
alzheimer disease - drug therapy (3168) 3168
cells, cultured (3099) 3099
brain - pathology (3060) 3060
protein (3009) 3009
middle aged (2981) 2981
neurons - metabolism (2891) 2891
clinical neurology (2856) 2856
amyloid beta-peptides - toxicity (2781) 2781
aged, 80 and over (2775) 2775
neurology (2618) 2618
precursor protein (2548) 2548
amyloid beta-peptides - genetics (2539) 2539
dementia (2512) 2512
transgenic mice (2491) 2491
neurons - drug effects (2473) 2473
peptide fragments - chemistry (2464) 2464
alzheimers disease (2455) 2455
alzheimer disease - physiopathology (2396) 2396
amyloid precursor protein (2373) 2373
amyloid beta-protein precursor - metabolism (2336) 2336
peptide (2322) 2322
pathology (2318) 2318
amyloid beta-peptides - pharmacology (2288) 2288
proteins (2271) 2271
amyloid-beta (2220) 2220
peptides (2191) 2191
amyloid (2169) 2169
amyloid-beta-peptide (2164) 2164
mouse model (2108) 2108
amyloid beta-protein precursor - genetics (2107) 2107
cell biology (2091) 2091
alzheimer’s disease (2066) 2066
in-vivo (2050) 2050
amyloid beta-peptides - cerebrospinal fluid (1972) 1972
neurodegenerative diseases (1967) 1967
mice, inbred c57bl (1937) 1937
tau proteins - metabolism (1914) 1914
alzheimer disease (1888) 1888
article (1860) 1860
β-amyloid (1844) 1844
neurons (1795) 1795
pharmacology & pharmacy (1784) 1784
amino acid sequence (1777) 1777
mild cognitive impairment (1770) 1770
neurodegeneration (1761) 1761
amyloid beta-protein (1743) 1743
beta-amyloid (1715) 1715
apoptosis (1689) 1689
hippocampus - metabolism (1683) 1683
amyloid beta-peptides - antagonists & inhibitors (1657) 1657
immunohistochemistry (1653) 1653
analysis (1647) 1647
aggregation (1645) 1645
peptide fragments - pharmacology (1643) 1643
peptide fragments - toxicity (1623) 1623
in-vitro (1608) 1608
phosphorylation (1596) 1596
disease (1570) 1570
neurotoxicity (1558) 1558
neurons - pathology (1534) 1534
molecular sequence data (1508) 1508
rats, sprague-dawley (1506) 1506
neuroprotective agents - pharmacology (1499) 1499
dose-response relationship, drug (1466) 1466
mutation (1443) 1443
multidisciplinary sciences (1439) 1439
protein binding (1399) 1399
expression (1395) 1395
oligomers (1390) 1390
cell line (1371) 1371
tau (1363) 1363
alzheimer disease - diagnosis (1360) 1360
cell line, tumor (1330) 1330
research (1314) 1314
memory (1306) 1306
alzheimer disease - cerebrospinal fluid (1304) 1304
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (10) 10
Online Resources - Online (9) 9
Collection Dvlpm't (Acquisitions) - Vendor file (3) 3
Chemistry (A D Allen) - Stacks (1) 1
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Dentistry (Harry R Abbott) - Stacks (1) 1
UofT at Mississauga - Stacks (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (30125) 30125
Chinese (330) 330
Japanese (314) 314
Russian (103) 103
French (70) 70
German (59) 59
Spanish (55) 55
Polish (12) 12
Hungarian (7) 7
Swedish (7) 7
Dutch (6) 6
Italian (6) 6
Portuguese (6) 6
Czech (4) 4
Danish (4) 4
Finnish (3) 3
Hebrew (2) 2
Korean (2) 2
Norwegian (2) 2
Serbian (2) 2
Slovak (2) 2
Ukrainian (2) 2
Greek (1) 1
Lithuanian (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


11/2012
γ-Secretase plays a pivotal role in the production of neurotoxic amyloid β-peptide (Aβ), the principal component of amyloid plaques present in Alzheimer’s... 
Gamma-secretase | Alzheimer's Disease | Proteomics | Amyloid beta peptide | 0317
Dissertation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2014, Volume 111, Issue 26, pp. 9384 - 9389
The two major forms of the amyloid-beta (A beta) peptide found in plaques in patients suffering from Alzheimer's disease, A beta 40 and A beta 42, only differ... 
aggregation mechanism | MECHANISM | protein aggregation | rate law | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | AMYLOID-BETA-PEPTIDE | neurodegeneration | OCCURS
Journal Article
Neuroscience, ISSN 0306-4522, 2016, Volume 344, pp. 39 - 47
Highlights • Resveratrol pretreatment significantly inhibited the spatial learning memory impairment induced by Aβ1–42 in a rat model. • Resveratrol... 
Neurology | amyloid beta peptide | LTP | CREB | learning and memory | resveratrol | SIRT1 | Index Medicus
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 01/2017, Volume 114, Issue 2, pp. E200 - E208
The aggregation of the 42-residue form of the amyloid-beta peptide (A beta 42) is a pivotal event in Alzheimer's disease (AD). The use of chemical kinetics has... 
DESIGN | MULTIDISCIPLINARY SCIENCES | NEURODEGENERATION | AMYLOID HYPOTHESIS | MECHANISMS | amyloid-beta peptide | PHASE | drug discovery | protein misfolding | protein aggregation | OCCURS | Alzheimer's disease | MODULATION
Journal Article
NEUROLOGY, ISSN 0028-3878, 07/2003, Volume 61, Issue 1, pp. 46 - 54
Background: AD is characterized by cerebral deposition of beta-amyloid plaques with amyloid beta-peptide (Abeta) 42 as the major peptide constituent, along... 
ANTIBODIES | MRI FINDINGS | MEMORY | ACUTE DISSEMINATED ENCEPHALOMYELITIS | ALZHEIMERS-DISEASE | AMYLOID-BETA-PEPTIDE | VACCINATION | MODEL | PATHOLOGY | CLINICAL NEUROLOGY | TRANSGENIC MICE
Journal Article
by Yin, ZZ and Wang, SH and Shen, BC and Deng, CY and Tu, QY and Jin, Y and Shen, L and Jiao, B and Xiang, J
ANALYTICAL CHEMISTRY, ISSN 0003-2700, 03/2019, Volume 91, Issue 5, pp. 3539 - 3545
Phosphorylated proteins play important roles in the pathogenesis of Alzheimer's disease (AD). The most abundant constituent in AD's brain deposit is the... 
CHEMISTRY, ANALYTICAL | DEMENTIA | ALZHEIMERS-DISEASE | AMYLOID-BETA-PEPTIDE | LIGHT | MASS | ASSOCIATION | BINDING | AGGREGATION
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 2019, Volume 123, Issue 25, pp. 5206 - 5215
Aggregation of amyloid beta peptide (A beta) and inflammatory processes associated with the generation of superoxide, hydrogen peroxide, and hydroxyl radicals... 
AMYLOID-BETA PEPTIDE | MOLECULAR-DYNAMICS | BINDS | EXPERIMENTAL CONSTRAINTS | RELEVANCE | COMPLEXES | CHEMISTRY, PHYSICAL | TOXICITY | MODEL | AGGREGATION
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 07/2019, Volume 431, Issue 15, pp. 2687 - 2699
Within the amyloid hypothesis in Alzheimer's disease, current focus has shifted to earlier stages of amyloid beta (Aβ) peptide assembly, involving soluble... 
amyloid beta peptide | high-speed atomic force microscopy | oligomerization | Alzheimer's disease | single molecule kinetics
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 08/2016, Volume 22, Issue 34, pp. 11874 - 11874
Learning by looking into a mirror , using a variant of the Alzheimer′s amyloid beta 42 peptide (E22e variant) with a d ‐amino acid introduced at the glutamate... 
amyloid beta peptide | Alzheimer′s disease | aggregation | neurotoxicity | chirality
Journal Article
Chemical Communications, ISSN 1359-7345, 2019, Volume 55, Issue 42, pp. 5847 - 5850
We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(II)bound... 
SYSTEM | SPECTROSCOPY | AMYLOID-BETA-PEPTIDE | DISEASE | A-BETA | MECHANISMS | CHEMISTRY, MULTIDISCIPLINARY | ALZHEIMERS | ZINC
Journal Article
NEUROLOGY, ISSN 0028-3878, 01/2005, Volume 64, Issue 1, pp. 94 - 101
Background: Abeta42-immunization reduces plaque burden and improves cognition in transgenic mouse models of Alzheimer disease (AD). This phase 1 study... 
IMMUNIZATION | PROTEIN | ALZHEIMERS-DISEASE | AMYLOID-BETA-PEPTIDE | MOUSE | TAU | PATHOLOGY | MODEL | CLINICAL NEUROLOGY | TRANSGENIC MICE
Journal Article
Food Chemistry, ISSN 0308-8146, 05/2016, Volume 199, pp. 185 - 194
Various food constituents have been proposed as disease-modifying agents for Alzheimer’s disease (AD), due to epidemiological evidence of their beneficial... 
Antioxidants | Polyphenols | Vitamins | Metal chelators | Amyloid-beta peptide
Journal Article
Cell Calcium, ISSN 0143-4160, 2011, Volume 50, Issue 3, pp. 222 - 233
Abstract A variety of stimuli utilize an increase of cytosolic free Ca2+ concentration as a second messenger to transmit signals, through Ca2+ release from the... 
Advanced Basic Science | Mitochondria | Permeability transition pore | Apoptosis | Necrosis | AMYOTROPHIC-LATERAL-SCLEROSIS | WOLF-HIRSCHHORN-SYNDROME | CELL-DEATH | CELL BIOLOGY | HEXOKINASE-II | CYCLOPHILIN-D | AMYLOID BETA-PEPTIDE | CYCLOSPORINE-A | Ca2 | BCL-2 PROTEIN FAMILY | ENDOPLASMIC-RETICULUM | PARKINSONS-DISEASE
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 10/2018, Volume 70, pp. 160 - 169
Alzheimer's disease (AD) is characterized by progressive cognitive impairment and by extensive neuronal loss associated with extracellular amyloid β-peptide... 
Tau | Functional MRI | Amyloid beta peptide | Alzheimer's disease | Hippocampus | Hyperexcitability | Alzheimer’s disease
Journal Article
TRENDS IN NEUROSCIENCES, ISSN 0166-2236, 09/2016, Volume 39, Issue 9, pp. 581 - 586
The many interactions between the nervous and the immune systems, which are active in both physiological and pathological states, have recently become more... 
IMMUNOLOGICAL SIGNIFICANCE | CLEARANCE | ALZHEIMERS-DISEASE | AMYLOID-BETA-PEPTIDE | INTERSTITIAL FLUID | CENTRAL-NERVOUS-SYSTEM | CEREBROSPINAL-FLUID | BASEMENT-MEMBRANES | BLOOD-BRAIN-BARRIER | DEEP CERVICAL LYMPH | NEUROSCIENCES
Journal Article
Antioxidants and Redox Signaling, ISSN 1523-0864, 10/2009, Volume 11, Issue 10, pp. 2481 - 2504
Journal Article