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International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 06/2011, Volume 43, Issue 6, pp. 877 - 885
Amyloid-β (Aβ) is believed to play a crucial role in the ethiopathogenesis of Alzheimer's Disease (AD). In particular, its interactions with biologically... 
Oligomers | Tau | Alzheimer's disease | Amyloid precursor protein | Metal ions
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 06/2019, Volume 294, Issue 24, pp. 9366 - 9366
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 13
An early pathological hallmark of Alzheimer’s disease (AD) is amyloid-β (Aβ) deposits in the brain, which largely consist of up to 43 amino acids long Aβ... 
Cerebrospinal fluid | Peptides | Glycopeptides | Alzheimer's disease | Amyloid precursor protein
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 11/2009, Volume 29, Issue 45, pp. 14271 - 14286
M-1 muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment of disorders involving impaired cognitive function. However, a... 
ACTIVATION | MEMORY | CORTEX | XANOMELINE | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | MODULATION | DISCOVERY | AGONIST | BETA
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 08/2019, pp. 1 - 1
The original version of this article unfortunately contained a mistake in the author name. The family name of Dr. Vanessa A. Johannsen should be written as... 
Neurotoxicity | Toxicity | Alzheimer's disease | Amyloid precursor protein | Rotenone
Journal Article
Neuron, ISSN 0896-6273, 03/2005, Volume 45, Issue 5, pp. 675 - 688
Progressive memory loss and cognitive dysfunction are the hallmark clinical features of Alzheimer's disease (AD). Identifying the molecular triggers for the... 
HUMAN NEURONS | MEMORY CONSOLIDATION | DEMENTIA | A-BETA-42 ACCUMULATION | DOWN-SYNDROME | AMYGDALA MODULATION | AMYLOID PRECURSOR PROTEIN | PLAQUES | NEUROSCIENCES | BRAIN | IMPAIRMENT
Journal Article
Respiratory Physiology & Neurobiology, ISSN 1569-9048, 07/2019, Volume 265, pp. 55 - 67
Alzheimer’s disease (AD) is a progressive neurodegenerative condition disturbing major brain networks, including those pivotal to the motor control of... 
Neuroinflammation | Presenilin-1 | Pulmonary chemoreflex | Respiratory behaviour | Amyloid precursor protein
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2007, Volume 26, Issue 6, pp. 1702 - 1712
Processing of the amyloid precursor protein (APP) by β‐ and γ‐secretases leads to the generation of amyloid‐β (Aβ) peptides with varying lengths. Particularly... 
dimerization | secretase | amyloid Aβ | amyloid precursor protein (APP) | GxxxG | Amyloid Aβ | Dimerization | Amyloid precursor protein (APP) | Secretase
Journal Article
Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7513, pp. 166 - 170
The gamma-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important... 
PRESENILIN | COMPLEX | PARTICLE ELECTRON CRYOMICROSCOPY | TRANSMEMBRANE DOMAIN-4 | MEMBRANE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NICASTRIN | CRYO-EM | FAMILY INTRAMEMBRANE PROTEASE | BINDING | Cryoelectron Microscopy | Protein Structure, Tertiary | Models, Molecular | Crystallography, X-Ray | Amyloid Precursor Protein Secretases - chemistry | Humans | Index Medicus
Journal Article
Pharmacological Research, ISSN 1043-6618, 04/2018, Volume 130, pp. 366 - 373
Besides its involvement in Alzheimer's disease (AD) as precursor of the neurotoxic amyloid peptides, the pathophysiological impact of brain accumulation of... 
Alzheimer's disease | Cannabinoid receptor | Amyloid precursor protein | Hippocampus | Transgenic mice
Journal Article
by Lu, KP and Zhou, XZ
NATURE REVIEWS MOLECULAR CELL BIOLOGY, ISSN 1471-0072, 11/2007, Volume 8, Issue 11, pp. 904 - 916
Protein phosphorylation regulates many cellular processes by causing changes in protein conformation. The prolyl isomerase PIN1 has been identified as a... 
TAU-PROTEIN | NEUROFIBRILLARY TANGLES | STRUCTURAL BASIS | CIS-TRANS ISOMERIZATION | ALZHEIMERS-DISEASE | CELL-CYCLE | AMYLOID PRECURSOR PROTEIN | REGULATORY MECHANISM | NF-KAPPA-B | PROLINE ISOMERIZATION | CELL BIOLOGY
Journal Article
Bioscience Reports, ISSN 0144-8463, 05/2019, Volume 39, Issue 5, p. BSR20182485
Journal Article
The FEBS Journal, ISSN 1742-464X, 04/2017, Volume 284, Issue 7, pp. 1040 - 1044
The cloning of APP and genetic analysis of families with Alzheimer's disease were both reported in 1987 and much present work on the disease is based upon the... 
APP | amyloid | genetics | Down syndrome | Alzheimer's disease | Neurodegenerative diseases | Cloning | Genetic analysis | Amyloid | Mutation | Alzheimers disease | Amyloid precursor protein
Journal Article
NATURE, ISSN 0028-0836, 08/2013, Volume 500, Issue 7460, pp. 45 - U62
Late-onset Alzheimer's disease (LOAD) risk is strongly influenced by genetic factors such as the presence of the apolipoprotein E epsilon 4 allele (referred to... 
COMMON VARIANTS | BETA PRODUCTION | MULTIDISCIPLINARY SCIENCES | NETWORKS | AMYLOID PRECURSOR PROTEIN | WIDE ASSOCIATION | PATHOLOGY | LARGE GENE LISTS | EXPRESSION | BRAIN | APOLIPOPROTEIN-E
Journal Article
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