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Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, pp. 450 - 454
The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit. Its regulation by... 
E3 LIGASE | SPINDLE CHECKPOINT | ANAPHASE-PROMOTING COMPLEX | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MITOTIC REGULATION | EM STRUCTURE DETERMINATION | CRYO-EM | ELECTRON-MICROSCOPY | CONJUGATING ENZYME | CHAIN ELONGATION | Phosphorylation | Ubiquitin - ultrastructure | Cadherins - metabolism | Humans | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitin - metabolism | Cell Cycle Proteins - ultrastructure | Substrate Specificity | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cell Cycle Proteins - chemistry | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitination | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cadherins - chemistry | Cytoskeletal Proteins - metabolism | Lysine - metabolism | Anaphase-Promoting Complex-Cyclosome - chemistry | Cadherins - ultrastructure | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Catalytic Domain | F-Box Proteins - metabolism | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | F-Box Proteins - chemistry | Cell Cycle Proteins - metabolism | Ubiquitin - chemistry | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cytoskeletal Proteins - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Cryoelectron Microscopy | F-Box Proteins - ultrastructure | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Protein Subunits - chemistry | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Ubiquitin | Physiological aspects | Structure | Ubiquitin-proteasome system | Ligases | Proteins | Peptides | Molecular structure | Cyclin-dependent kinases | Cell division | Kinases | Gene expression
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 10/2013, Volume 203, Issue 1, pp. 35 - 35
Anaphase B spindle elongation contributes to chromosome segregation during Drosophila melanogaster embryo mitosis. We propose that this process is driven by a... 
Anaphase
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 10/2013, Volume 203, Issue 1, pp. 87 - 87
The switch from activation of the anaphase-promoting complex/cyclosome (APC/C) by CDC20 to CDH1 during anaphase is crucial for accurate mitosis. APC/C super(... 
Anaphase
Journal Article
European Journal of Cancer, ISSN 0959-8049, 01/2013, Volume 49, Issue 2, pp. 500 - 510
Pituitary tumour transforming gene (pttg1) encodes Securin, a protein involved in the inhibition of sister chromatid separation binding to Separase until the... 
Anaphase
Journal Article
European Journal of Cell Biology, ISSN 0171-9335, 05/2013, Volume 92, Issue 4-5, pp. 175 - 186
This work deals with the role of myosin phosphorylation in anaphase chromosome movement. Y27632 and ML7 block two different pathways for phosphorylation of the... 
Anaphase
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 07/2011, Volume 22, Issue 13, pp. 2175 - 2184
The anaphase-promoting complex/cyclosome (APC/C) is an essential ubiquitin ligase that targets cell cycle proteins for proteasome-mediated degradation in... 
Anaphase
Journal Article
Genes & Development, ISSN 0890-9369, 11/2010, Volume 24, Issue 22, pp. 2531 - 2542
Although the PR-Set7/Set8/KMT5a histone H4 Lys 20 monomethyltransferase (H4K20me1) plays an essential role in mammalian cell cycle progression, especially... 
Anaphase
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2015, Volume 112, Issue 17, pp. 5272 - 5279
Journal Article
Lab On a Chip, ISSN 1473-0197, 01/2011, Volume 11, Issue 10, pp. 1754 - 1760
Cell cycle synchronization is an important tool for the study of the cell division stages and signalling. It provides homogeneous cell cultures that are of... 
Anaphase
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 533, Issue 7602, pp. 260 - 264
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 11/2013, Volume 425, Issue 22, pp. 4236 - 4248
The anaphase-promoting complex or cyclosome (APC/C) is a large E3 RING-cullin ubiquitin ligase composed of between 14 and 15 individual proteins. A striking... 
anaphase-promoting complex | crystallography | tetratricopeptide repeat (TPR) | single-particle electron microscopy | cell cycle | PROTEIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DESTRUCTION BOX | 26S PROTEASOME | SOFTWARE | SUBSTRATE RECOGNITION | MITOSIS | MITOTIC CHECKPOINT COMPLEX | KEN BOX | Amino Acid Sequence | Protein Subunits | Schizosaccharomyces pombe Proteins - chemistry | Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Schizosaccharomyces - chemistry | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Humans | Protein Multimerization | Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Models, Molecular | Molecular Sequence Data | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Minichromosome Maintenance Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Cell Cycle Proteins - chemistry | Saccharomyces cerevisiae - metabolism | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Schizosaccharomyces - metabolism | Sequence Alignment | Protein Conformation | Protein Interaction Domains and Motifs | Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitin | Ligases | Analysis | Structure | Crystals | Proteins | EM, electron microscopy | PDB, Protein Data Bank | SAD, single-wavelength anomalous dispersion | APC | TPR, tetratricopeptide repeat | FOM, figure of merit | C, anaphase-promoting complex or cyclosome
Journal Article
Brazilian Journal of Biology, ISSN 1519-6984, 08/2012, Volume 72, Issue 3, pp. 471 - 471
Toxicity and genotoxicity tests were performed on root cells of Allium cepa in order to evaluate wastewater quality following an ECF cellulose bleaching... 
Anaphase
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 01/2011, Volume 18, Issue 1, pp. 6 - 13
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7518, pp. 388 - 393
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 01/2009, Volume 545, pp. 271 - 285
Cell cycle transitions are controlled, in part, by ubiquitin-dependent proteolysis. In mitosis, the metaphase to anaphase transition is governed by an E3... 
Anaphase
Journal Article
PLoS ONE, 07/2013, Volume 8, Issue 7
IL-17 is the founding member of a family of cytokines and receptors with unique structures and signaling properties. IL-17 is the signature cytokine of Th17... 
Anaphase
Journal Article
PLoS ONE, 06/2013, Volume 8, Issue 6
The Saccharomyces cerevisiae Slx5/8 complex is the founding member of a recently defined class of SUMO-targeted ubiquitin ligases (STUbLs). Slx5/8 has been... 
Anaphase
Journal Article
PLoS ONE, 05/2013, Volume 8, Issue 5
Integrity of the microtubule spindle apparatus and intact cell division checkpoints are essential to ensure the fidelity of distributing chromosomes into... 
Anaphase
Journal Article
PLoS ONE, 03/2013, Volume 8, Issue 3
Neuroblastomas (NBs) are tumours of the sympathetic nervous system accounting for 8-10% of paediatric cancers. NBs exhibit extensive intertumour genetic... 
Anaphase
Journal Article
PLoS ONE, 03/2013, Volume 8, Issue 3
The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that initiates chromosome segregation and mitotic exit by targeting... 
Anaphase
Journal Article
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