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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 2, pp. 541 - 548.e9
Background Mast cells express receptors for complement anaphylatoxins C3a and C5a (ie, C3a receptor [C3aR] and C5a receptor [C5aR]), and C3a and C5a are... 
Allergy and Immunology | C3a | inflammation | IgE | anaphylaxis | Anaphylatoxin | complement | mast cells | C5a | HUMAN BASOPHILS | COMPLEMENT ACTIVATION | MOUSE | IMMUNOLOGY | EFFECTOR PHASE | ALLERGY | IN-VIVO | HMC-1 | ASTHMA | HYPERSENSITIVITY REACTIONS | C3A ANAPHYLATOXIN | Receptor, Anaphylatoxin C5a - genetics | Inflammation - pathology | Anaphylatoxins - genetics | Skin - metabolism | Complement C5a - metabolism | Complement C3a - genetics | Receptors, Complement - metabolism | Inflammation - metabolism | Immunoglobulin E - genetics | Receptors, Complement - biosynthesis | Mast Cells - metabolism | Receptors, Complement - genetics | Receptor, Anaphylatoxin C5a - immunology | Female | Complement C3a - metabolism | Skin - pathology | Skin - immunology | Mast Cells - immunology | Immunoglobulin E - metabolism | Mice, Inbred C57BL | Cells, Cultured | Anaphylatoxins - immunology | Inflammation - immunology | Animals | Receptors, Complement - immunology | Inflammation - genetics | Complement C5a - genetics | Mice | Receptor, Anaphylatoxin C5a - biosynthesis | Complement C3a - immunology | Complement C5a - immunology | Albumin | Medical colleges | Respiratory agents | Skin | Immunotherapy | Histamine | Antigens | Flow cytometry | Rodents | Experiments | Allergies | Methods | Index Medicus | Abridged Index Medicus | Complement receptors | Cell activation | Anaphylatoxins | Degranulation | Hypersensitivity (immediate) | Inflammation | Mast cells | Passive cutaneous anaphylaxis | complement component C5a | complement component C3a
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 10, pp. 7633 - 7644
Journal Article
Science, ISSN 0036-8075, 06/2016, Volume 352, Issue 6292, pp. aad1210 - aad1210
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2015, Volume 35, Issue 16, pp. 6517 - 6531
This study investigated the role of the complement activation fragment C5a in secondary pathology following contusive spinal cord injury (SCI). C5ar(-/-) mice,... 
Demyelinating pathology | Anaphylatoxin | Secondary degeneration | CNS trauma | Macrophage | Oligodendrocyte precursor cell | FUNCTIONAL RECOVERY | POLYMORPHONUCLEAR LEUKOCYTES | GLIAL SCAR | macrophage | NEUROSCIENCES | RAT MODEL | oligodendrocyte precursor cell | secondary degeneration | demyelinating pathology | IN-VIVO | REACTIVE ASTROCYTES | LESION DEVELOPMENT | CHOROID-PLEXUS | DUAL ROLE | anaphylatoxin | INTERLEUKIN-8 IL-8 | Receptor, Anaphylatoxin C5a - genetics | Inflammation - pathology | Motor Activity - physiology | Spinal Cord Injuries - drug therapy | Spinal Cord Injuries - complications | Motor Activity - drug effects | Peptides, Cyclic - pharmacology | Gliosis - physiopathology | Complement C5a - biosynthesis | Gliosis - pathology | Inflammation - complications | Inflammation - drug therapy | Recovery of Function - physiology | Female | Complement Activation - drug effects | Complement Activation - physiology | Spinal Cord Injuries - metabolism | Cell Proliferation - physiology | Cells, Cultured | Gliosis - complications | Mice, Knockout | Astrocytes - physiology | Receptor, Anaphylatoxin C5a - physiology | Animals | Peptides, Cyclic - therapeutic use | Cell Proliferation - drug effects | Gliosis - drug therapy | Mice | Receptor, Anaphylatoxin C5a - biosynthesis | Spinal Cord Injuries - physiopathology | Receptor, Anaphylatoxin C5a - antagonists & inhibitors | Inflammation - physiopathology | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 01/2018, Volume 553, Issue 7686, pp. 111 - 114
The complement system is a crucial component of the host response to infection and tissue damage. Activation of the complement cascade generates anaphylatoxins... 
MOLECULAR-DYNAMICS | ACTIVATION | PROTEIN-COUPLED RECEPTOR | OPIOID RECEPTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | BINDING-SITE | OLIGOMERIZATION | IDENTIFICATION | DISCOVERY | Receptor, Anaphylatoxin C5a - chemistry | Receptor, Anaphylatoxin C5a - genetics | Protein Structure, Secondary | Receptors, G-Protein-Coupled - metabolism | Humans | Imidazoles - chemistry | Benzodioxoles - metabolism | Models, Molecular | Crystallography, X-Ray | Imidazoles - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Receptors, Adrenergic, beta-2 - chemistry | Animals | Drug Inverse Agonism | HEK293 Cells | Benzodioxoles - chemistry | Mutation | Protein Stability | Receptor, Anaphylatoxin C5a - antagonists & inhibitors | Binding Sites | Benzodioxoles - pharmacology | Receptors, G-Protein-Coupled - chemistry | Imidazoles - metabolism | Receptor, Anaphylatoxin C5a - metabolism | Drugs | Inflammatory bowel diseases | G protein-coupled receptors | Peptides | Complement component C5a | Manufacturing engineering | Complement | Antagonists | Helices | Arthritis | Production costs | Receptors | Reperfusion | Ischemia | Anaphylatoxins | Alzheimer's disease | Neurodegenerative diseases | Psoriasis | Medical treatment | Crystallization | Inflammation | Crohn's disease | Bioavailability | Mode of action | Complement activation | Immunogenicity | Rheumatoid arthritis | Sepsis | Ligands | Index Medicus
Journal Article
Molecular Immunology, ISSN 0161-5890, 2008, Volume 45, Issue 14, pp. 3767 - 3774
There is now strong evidence for non-immune or inflammatory functions of complement, notably in the central nervous system. In particular, it has been recently... 
Cerebellum | Development | Complement | Anaphylatoxin | MIGRATION | CYCLASE-ACTIVATING POLYPEPTIDE | development | MESSENGER-RNA EXPRESSION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURODEGENERATION | IMMUNOLOGY | cerebellum | CELL-DEATH | HUMAN ASTROCYTES | LIVER-REGENERATION | NEURONS | COMPONENT | complement | anaphylatoxin | Immunohistochemistry | Receptor, Anaphylatoxin C5a - agonists | Rats, Wistar | Apoptosis - drug effects | Cells, Cultured | Neurons - immunology | Rats | Receptors, Complement - agonists | Receptors, Complement - metabolism | Receptors, G-Protein-Coupled - immunology | Cell Movement - drug effects | Neurons - classification | Animals | Receptors, Complement - immunology | Anaphylatoxins - metabolism | Cerebellum - cytology | Receptor, Anaphylatoxin C5a - immunology | Cerebellum - growth & development | Cell Proliferation - drug effects | Neurons - metabolism | Anaphylatoxins - pharmacology | Receptor, Anaphylatoxin C5a - metabolism | Brain | Index Medicus | Complement receptors | Neonates | Histogenesis | Granule cells | Central nervous system | Anaphylatoxins | Antagonists | Inflammation | complement component C3a | Cell migration | Cell Proliferation | Neurons | Neurons and Cognition | Receptors, G-Protein-Coupled | Neurobiology | Pharmacology | Cellular Biology | Chemical Sciences | Receptors, Complement | Medicinal Chemistry | Life Sciences | Receptor, Anaphylatoxin C5a | Pharmaceutical sciences | Apoptosis | Cell Movement | Cell Behavior
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 06/2018, Volume 25, Issue 6, pp. 472 - 481
Journal Article
FASEB journal, ISSN 0892-6638, 2017, Volume 31, Issue 7, pp. 3193 - 3204
Journal Article
Oncology Reports, ISSN 1021-335X, 4/2015, Volume 33, Issue 4, pp. 1844 - 1850
The anaphylatoxin C5a is a chemoattractant for leukocyte migration via the C5a receptor (C5aR). We recently reported that C5aR was aberrantly expressed in a... 
renal cell carcinoma | C5a receptor | signal transduction | neoplasm invasiveness | Neoplasm invasiveness | Signal transduction | Renal cell carcinoma | SIGNALING PATHWAYS | ACTIVATION | ACTIN | PHOSPHORYLATION | INVOLVEMENT | CHEMOTACTIC MIGRATION | RECEPTOR | ANAPHYLATOXIN C5A | C3A | ONCOLOGY | RESISTANCE | Receptor, Anaphylatoxin C5a - genetics | Humans | Middle Aged | Neoplasm Proteins - physiology | Actins - metabolism | Male | Complement C5a - physiology | Kidney Neoplasms - metabolism | Recombinant Fusion Proteins - metabolism | MAP Kinase Signaling System | Female | Signal Transduction | Carcinoma, Renal Cell - pathology | Neoplasm Invasiveness | Receptor, Anaphylatoxin C5a - analysis | Cytoskeleton - ultrastructure | Recombinant Proteins - pharmacology | Carcinoma, Renal Cell - metabolism | Receptor, Anaphylatoxin C5a - physiology | Complement C5a - pharmacology | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Recombinant Fusion Proteins - genetics | Anoikis | Kidney Neoplasms - pathology | Neoplasm Proteins - analysis | Aged | Cytoskeleton - drug effects | Receptor, Anaphylatoxin C5a - metabolism | Cell receptors | Development and progression | Carcinoma, Renal cell | Metastasis | Health aspects | Phosphotransferases | Membrane proteins | Immunoglobulins | Life sciences | Kinases | Vascular endothelial growth factor | Kidney cancer | Index Medicus
Journal Article