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International Journal of Cancer, ISSN 0020-7136, 04/2019, Volume 144, Issue 8, pp. 1775 - 1779
The androgen receptor (AR) plays a central role in the pathogenesis of prostate cancer (PCa). Most PCa cases develop eventually from an androgen‐dependent... 
receptor degradation | castration resistance | androgen receptor | protein stability | therapy resistance | CELLS | AR-V7 | SPLICE VARIANT | OPEN-LABEL | GANETESPIB | MECHANISMS | CONFERS RESISTANCE | GLUCOCORTICOID-RECEPTOR | ONCOLOGY | INHIBITOR | Receptors, Glucocorticoid - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Heat-Shock Proteins - metabolism | Humans | Receptors, Androgen - metabolism | Ubiquitin-Protein Ligases - metabolism | Ubiquitin-Protein Ligases - antagonists & inhibitors | Heat-Shock Proteins - antagonists & inhibitors | Male | Antineoplastic Agents - therapeutic use | Receptors, Glucocorticoid - metabolism | Prostatic Neoplasms, Castration-Resistant - drug therapy | Androgen Receptor Antagonists - pharmacology | Prostatic Neoplasms, Castration-Resistant - pathology | Prostate - pathology | Proteolysis - drug effects | Signal Transduction - drug effects | Protein Stability - drug effects | Treatment Failure | Prostate - drug effects | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Drug Resistance, Neoplasm - drug effects | Proteins | Care and treatment | Prostate cancer | Health aspects | Cancer | Therapy | Stability | Glucocorticoids | Therapeutic applications | Pathogenesis | Heat shock proteins | Chaperones | Carcinogenesis | Signaling | Carcinogens | Androgens | Molecular modelling | Castration | Evolution | Prostate | Heat shock | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2019, Volume 861, p. 172534
Cepharanthine is a biscoclaurine alkaloid extracted from that has a variety of biological activities in multiple diseases. Spinal and bulbar muscular atrophy... 
Degradation | Spinal and bulbar muscular atrophy | Cepharanthine hydrochloride | Polyglutamine | Autophagy | Androgen receptor | SHOCK | DISEASE | PHARMACOLOGY & PHARMACY | CANCER
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2007, Volume 27, Issue 19, pp. 5115 - 5126
Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine tract within the androgen receptor... 
Protein degradation | CHIP | Polyglutamine | SBMA | Androgen receptor | Transgenic mice | LIGASE CHIP | MOLECULAR CHAPERONES | RECESSIVE BULBOSPINAL NEURONOPATHY | QUALITY-CONTROL | polyglutamine | 70-INTERACTING PROTEIN | NEUROSCIENCES | E3 LIGASE | HEAT-SHOCK PROTEINS | androgen receptor | transgenic mice | CO-CHAPERONE CHIP | CARBOXYL-TERMINUS | protein degradation | UBIQUITIN-PROTEASOME PATHWAY | Central Nervous System - metabolism | Humans | Receptors, Androgen - metabolism | Nerve Degeneration - genetics | Male | Motor Neurons - pathology | Nerve Degeneration - metabolism | Muscular Atrophy, Spinal - genetics | Female | Inclusion Bodies - metabolism | Disease Models, Animal | Genetic Predisposition to Disease - genetics | Muscular Atrophy, Spinal - metabolism | Heat-Shock Proteins - metabolism | Intranuclear Inclusion Bodies - genetics | Gene Expression Regulation - physiology | Mice, Transgenic | Mutation - genetics | Down-Regulation - genetics | Protein Folding | Motor Neurons - metabolism | Inclusion Bodies - genetics | Phenotype | Animals | Receptors, Androgen - genetics | Muscular Atrophy, Spinal - therapy | Mice | Central Nervous System - physiopathology | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Intranuclear Inclusion Bodies - metabolism | Genetic Therapy - methods | Nerve Degeneration - therapy
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2003, Volume 23, Issue 6, pp. 2203 - 2211
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 10/2017, Volume 28, Issue 9, pp. 1018 - 1031
Journal Article
Journal Article
Medicina (Lithuania), ISSN 1010-660X, 07/2018, Volume 54, Issue 3, p. 39
Background and Objective: Although triptolide was effective for prostate cancer (PCa), the mechanism is still unclear. Androgen receptor (AR) plays a large... 
Calpain | Protein stability | Triptolide | Androgen receptor | PROSTATE | ACTIVATION | PHOSPHORYLATION | triptolide | protein stability | calpain | MEDICINE, GENERAL & INTERNAL | androgen receptor | AMPLIFICATION | INHIBITION | GENE | DEGRADATION | CANCER STATISTICS | EXPRESSION
Journal Article
Journal Article