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Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2017, Volume 66, Issue 5, pp. 1631 - 1643
Journal Article
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2011, Volume 44, Issue 4, pp. 487 - 496
It has been reported that polymorphisms in the organic anion transporting polypeptide 1B1 (OATP1B1, SLCO1B1) result in decreased hepatic uptake of simvastatin... 
Transporters | Pharmacokinetics | Statins | NTCP | DRUG | BILE-ACID TRANSPORTERS | PITAVASTATIN | RAT | HMG-COA REDUCTASE | HEPATIC-UPTAKE | UPTAKE SYSTEMS | ANION-TRANSPORTING POLYPEPTIDE | PHARMACOLOGY & PHARMACY | INHIBITOR | ROSUVASTATIN | Estradiol - analogs & derivatives | Fatty Acids, Monounsaturated - pharmacology | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Sodium - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Sodium - deficiency | Indoles - metabolism | Organic Anion Transporters - genetics | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Transfection | Fatty Acids, Monounsaturated - metabolism | Inhibitory Concentration 50 | Indoles - pharmacology | Biological Transport - drug effects | Molecular Structure | Hepatocytes - drug effects | CHO Cells | Binding, Competitive | Estradiol - metabolism | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Simvastatin - metabolism | Cells, Cultured | Symporters - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Symporters - genetics | Kinetics | Rifampin - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Organic Anion Transporters, Sodium-Dependent - metabolism | Index Medicus
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2014, Volume 78, Issue 3, pp. 587 - 598
Aims Rosuvastatin and pitavastatin have been proposed as probe substrates for the organic anion‐transporting polypeptide (OATP) 1B, but clinical data on their... 
regulatory guidance | organic anion‐transporting polypeptide 1B | breast cancer resistance protein | pitavastatin | rosuvastatin | drug–drug interactions | drug-drug interactions | organic anion-transporting polypeptide 1B | RIFAMPICIN | DRUG-DRUG INTERACTION | HEPATIC-CLEARANCE | P-GLYCOPROTEIN | ATORVASTATIN | INHIBITION | PHARMACOKINETICS | HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | METABOLIZING-ENZYMES | Fluorobenzenes - pharmacokinetics | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Area Under Curve | Humans | Middle Aged | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Quinolines - pharmacokinetics | Young Adult | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Adult | Female | Rifampin - administration & dosage | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters - antagonists & inhibitors | Administration, Oral | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Cross-Over Studies | Administration, Intravenous | Pyrimidines - pharmacokinetics | Rifampin - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Rosuvastatin | Drug resistance | Investigations | Antilipemic agents | Drug Metabolism
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 10/2011, Volume 8, Issue 5, pp. 1789 - 1798
Telmisartan, a selective angiotensin II receptor antagonist, is primarily excreted via hepatobiliary transport. The predominant contribution of organic anion... 
positron emission tomography (PET) | telmisartan | hepatobiliary transport | OATP/Oatp (organic anion transporting polypeptide) | MEDICINE, RESEARCH & EXPERIMENTAL | HUMANS | II-RECEPTOR ANTAGONIST | RIFAMPICIN | RIFAMYCIN SV | ATORVASTATIN | IN-VITRO | INHIBITION | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Antihypertensive Agents - analysis | Bile - chemistry | Antihypertensive Agents - administration & dosage | Male | Positron-Emission Tomography | Angiotensin II Type 1 Receptor Blockers - pharmacokinetics | Feasibility Studies | Dose-Response Relationship, Drug | Protein Isoforms - metabolism | Benzimidazoles - administration & dosage | Liver - drug effects | Organic Anion Transporters, Sodium-Independent - metabolism | Liver - diagnostic imaging | Biological Transport - drug effects | Benzoates - analysis | Benzimidazoles - blood | Solute Carrier Organic Anion Transporter Family Member 1B3 | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Angiotensin II Type 1 Receptor Blockers - analysis | Liver Circulation | Tissue Distribution - drug effects | Liver - metabolism | Enzyme Inhibitors - pharmacology | Benzimidazoles - pharmacokinetics | Rats | Antihypertensive Agents - pharmacokinetics | Benzimidazoles - analysis | Rats, Sprague-Dawley | Antihypertensive Agents - blood | Benzoates - administration & dosage | Benzoates - blood | Liver - blood supply | Animals | Biotransformation - drug effects | Metabolic Clearance Rate - drug effects | Angiotensin II Type 1 Receptor Blockers - blood | Rifampin - pharmacology | Protein Isoforms - antagonists & inhibitors | Benzoates - pharmacokinetics | Carbon Radioisotopes
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 07/2019, Volume 74-75, pp. 25 - 31
To understand the pathways involved in drug clearance from the body, quantitative evaluations of the hepatobiliary transport of drugs are important. The... 
Positron-emission tomography | Organic anion transporting polypeptide | Pitavastatin | Fluorine-18 | Integration plot method
Journal Article
PARASITES & VECTORS, ISSN 1756-3305, 11/2018, Volume 11, Issue 1, pp. 593 - 12
BackgroundIxodes scapularis organic anion transporting polypeptides (OATPs) play important roles in tick-rickettsial pathogen interactions. In this report, we... 
Borrelia burgdorferi |