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Blood, ISSN 0006-4971, 07/2015, Volume 126, Issue 3, pp. 363 - 372
Overexpression of antiapoptotic Bcl-2 proteins such as Bcl-2, Bcl-xL, and Mcl-1 is widely associated with tumor initiation, progression, and chemoresistance.... 
SURVIVAL | ANTI-APOPTOTIC MCL-1 | POTENT | BIM | BAX | ANTITUMOR-ACTIVITY | PROTEINS | CLEAVAGE | HEMATOLOGY | BCL-2 FAMILY | CELL-DEATH | Immunoprecipitation | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Immunoenzyme Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Biphenyl Compounds - pharmacology | Neoplastic Stem Cells - metabolism | Nitrophenols - pharmacology | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Female | Tumor Cells, Cultured | Mesenchymal Stromal Cells - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Leukemia, Myeloid, Acute - pathology | Mesenchymal Stromal Cells - metabolism | Naphthoquinones - pharmacology | Mice, SCID | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Xenograft Model Antitumor Assays | Gossypol - pharmacology | Animals | Gossypol - analogs & derivatives | Stem Cells - drug effects | Mice, Inbred NOD | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Drug Resistance, Neoplasm - drug effects | Myeloid Neoplasia
Journal Article
Blood, ISSN 0006-4971, 02/2008, Volume 111, Issue 4, pp. 2300 - 2309
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 389 - 399
Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs mimicking their natural antagonists, BH3-only proteins, might... 
CELLCYCLE | SURVIVAL | SELICICLIB CYC202 | R-ROSCOVITINE | ONCOLOGY | SMALL-MOLECULE INHIBITORS | DOWN-REGULATION | DEATH | KINASE INHIBITOR | FAMILY PROTEINS | MULTIPLE-MYELOMA CELLS | BH3-ONLY PROTEINS | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Male | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | Nitrophenols - therapeutic use | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | bcl-2-Associated X Protein - genetics | Disease Models, Animal | Fibroblasts - metabolism | Protein Structure, Tertiary | Cytokines - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Mice, Transgenic | Piperazines - therapeutic use | Sulfonamides - pharmacology | Piperazines - pharmacology | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Proteins | Lymphomas | Analysis
Journal Article
Oncogene, ISSN 0950-9232, 06/2007, Volume 26, Issue 27, pp. 3972 - 3979
ABT-737 is a subnanomolar inhibitor of the antiapoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w. Although ABT-737 triggers extensive cell death in many small-cell... 
ABT-737 | Mcl-1 | siRNA | Off-target | Bcl-X | Seed | Niacinamide - analogs & derivatives | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Carcinoma, Small Cell - genetics | Proto-Oncogene Proteins c-bcl-2 - physiology | Receptor, Fibroblast Growth Factor, Type 2 | Humans | Neoplasm Proteins - physiology | 3' Untranslated Regions - genetics | Cell Survival - genetics | Lung Neoplasms - pathology | Phenylurea Compounds | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Benzenesulfonates - pharmacology | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | bcl-X Protein - antagonists & inhibitors | Base Sequence | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Cell Survival - physiology | Lung Neoplasms - genetics | Cell Survival - drug effects | Purines - pharmacology | Carcinoma, Small Cell - drug therapy | DNA-Binding Proteins - genetics | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Transmembrane Activator and CAML Interactor Protein - genetics | Drug Resistance, Neoplasm - genetics | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Zinc Fingers - genetics | Pyridines - pharmacology | Carcinoma, Small Cell - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Drug Resistance, Neoplasm - drug effects | Gene silencing | Genetic aspects | Research | Methods | Cancer | Inhibitor drugs | Ribonucleic acid | Oncology | Drug resistance | Ribonucleic acid--RNA | Apoptosis | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 01/2007, Volume 67, Issue 2, pp. 782 - 791
The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL but not Mcl-1, which may confer resistance to this novel agent. Here, we show that Mcl-1 down-regulation by... 
CANCER-CELLS | BCL-X-L | APOPTOSIS | R-ROSCOVITINE | ONCOLOGY | HUMAN LEUKEMIA-CELLS | MYELOMA CELLS | MITOCHONDRIAL DYSFUNCTION | INHIBITOR | PROTEINS | ANTIAPOPTOTIC BCL-2 | Piperazines - administration & dosage | Apoptosis - drug effects | Humans | Leukemia - metabolism | Purines - administration & dosage | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | U937 Cells | Cyclin-Dependent Kinases - antagonists & inhibitors | Neoplasm Proteins - genetics | Leukemia - genetics | Jurkat Cells | Neoplasm Proteins - biosynthesis | Purines - pharmacology | bcl-2-Associated X Protein - metabolism | Leukemia - drug therapy | Nitrophenols - administration & dosage | Down-Regulation - drug effects | Sulfonamides - pharmacology | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Mice, Knockout | Drug Synergism | Animals | Myeloid Cell Leukemia Sequence 1 Protein | Biphenyl Compounds - administration & dosage | HL-60 Cells | Mice | Protein Kinase Inhibitors - pharmacology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Sulfonamides - administration & dosage
Journal Article
Oncogene, ISSN 0950-9232, 11/2008, Volume 27, Issue 52, pp. 6646 - 6656
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 18, pp. 4403 - 4413
Journal Article
Cancer Cell, ISSN 1535-6108, 2007, Volume 12, Issue 2, pp. 171 - 185
Cancer cells exhibit many abnormal phenotypes that induce apoptotic signaling via the intrinsic, or mitochondrial, pathway. That cancer cells nonetheless... 
CELLCYCLE | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | B-CELL LYMPHOMA | ONCOLOGY | PROTOTYPE CANCER THERAPEUTICS | CHROMOSOMAL BREAKPOINT | FOLLICULAR LYMPHOMA | INDUCE APOPTOSIS | CYTOCHROME-C RELEASE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | ANTIAPOPTOTIC BCL-2 | Vincristine - pharmacology | Immunoprecipitation | Proto-Oncogene Proteins c-bcl-2 - physiology | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Humans | Immunoblotting | Lymphoma, B-Cell - genetics | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Lymphoma, B-Cell - drug therapy | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | Membrane Proteins - genetics | Tumor Cells, Cultured - drug effects | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Lymphoma, B-Cell - pathology | Apoptosis Regulatory Proteins - physiology | Antineoplastic Agents, Phytogenic - pharmacology | Lymphoma, Large B-Cell, Diffuse - genetics | Doxorubicin - pharmacology
Journal Article