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Nature Medicine, ISSN 1078-8956, 05/2016, Volume 22, Issue 5, pp. 547 - 556
Doxorubicin is an anthracycline chemotherapy agent effective in treating a wide range of malignancies, but it causes a dose-related cardiotoxicity that can... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | RISK-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEXRAZOXANE | INDUCED CARDIOMYOPATHY | MATURATION | MUSCLE GENE-EXPRESSION | CELL BIOLOGY | CHILDHOOD-CANCER | INHIBITION | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | CONGESTIVE-HEART-FAILURE | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Calcium - metabolism | Humans | Middle Aged | Transcriptome | Antibiotics, Antineoplastic - adverse effects | Mitochondria, Heart - drug effects | Membrane Potential, Mitochondrial - drug effects | Flow Cytometry | Adult | Female | Real-Time Polymerase Chain Reaction | Cardiotoxicity - genetics | DNA Damage - drug effects | Cell Survival - drug effects | Disease Susceptibility | Heart Failure - genetics | Breast Neoplasms - drug therapy | Myocytes, Cardiac - drug effects | Fluorescent Antibody Technique | Myocytes, Cardiac - metabolism | Aged | Polymorphism, Single Nucleotide | Oxidative Stress - drug effects | Induced Pluripotent Stem Cells | Doxorubicin - adverse effects | Doxorubicin - pharmacology | Heart Failure - chemically induced | Complications and side effects | Patient outcomes | Stem cells | Development and progression | Breast cancer | Transplantation | Cardiovascular diseases | Drug therapy | Doxorubicin | Methods | Heart failure | Chemotherapy | Toxicity | Index Medicus
Journal Article
G3 (Bethesda, Md.), ISSN 2160-1836, 07/2019, Volume 9, Issue 8, pp. 2637 - 2646
Anthracyclines cause progressive cardiotoxicity whose ultimate severity is individual to the patient. Genetic determinants contributing to this variation are... 
MATRIX | Anthracyclines | OXIDATIVE STRESS | biomarkers | INJURY | TOXICITY | INDUCED CARDIOMYOPATHY | MODEL | mouse | cardiotoxicity | CANCER-PATIENTS | ADRIAMYCIN NEPHROPATHY | GENETICS & HEREDITY | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | fibrosis | CARDIAC TROPONIN-I | Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 1, pp. 332 - 345
This study aimed to develop a novel and non-invasive approach, low-dose radiation (LDR, 75 mGy X-rays), to prevent doxorubicin (DOX)-induced cardiotoxicity.... 
Oxidative stress | Hormesis | Low dose radiation | Doxorubicin | Adaptive response | low dose radiation | adaptive response | RATS | SUPPRESSION | CELL BIOLOGY | BREAST-CANCER | GAMMA-IRRADIATION | ATTENUATION | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | MITOCHONDRIAL DYSFUNCTION | doxorubicin | hormesis | BCL-2 FAMILY | oxidative stress | TRANSGENIC MICE
Journal Article
CARDIOVASCULAR RESEARCH, ISSN 0008-6363, 02/2018, Volume 114, Issue 2, pp. 282 - 290
Aim Anthracyclines such as doxorubicin are widely used in cancer therapy but their use is limited by cardiotoxicity. Up to date there is no established... 
Heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOMYOCYTES | CHEMOTHERAPY | HEART | HYPERTROPHY | CARVEDILOL | PRESSURE | Doxorubicin cardiotoxicity | Anthracycline | LEFT-VENTRICULAR DYSFUNCTION | Mineralocorticoid receptor | ANTHRACYCLINE-INDUCED CARDIOMYOPATHY | SPIRONOLACTONE | Antagonist | EXPRESSION
Journal Article
Journal Article
Heart Failure Reviews, ISSN 1382-4147, 9/2015, Volume 20, Issue 5, pp. 621 - 631
Journal Article
Journal Article
Reviews in Cardiovascular Medicine, ISSN 1530-6550, 2015, Volume 16, Issue 4, pp. 225 - 234
Journal Article
European Journal of Heart Failure, ISSN 1388-9842, 03/2014, Volume 16, Issue 3, pp. 300 - 308
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e96736 - e96736
Cardiotoxicity is a dose-limiting side-effect of cancer chemotherapeutics such as anthracyclines. The drug-induced cardiac toxicity is currently monitored with... 
CARDIAC-FUNCTION | CHRONIC HEART-FAILURE | BRAIN NATRIURETIC PEPTIDE | NT-PRO-BNP | DOXORUBICIN TREATMENT | BIOCHEMICAL MARKERS | MULTIDISCIPLINARY SCIENCES | BREAST-CANCER PATIENTS | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | DYSFUNCTION | OF-THE-LITERATURE | Anthracyclines - adverse effects | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Young Adult | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Registries | Ventricular Function, Left - physiology | Heart Failure - diagnosis | Child | Heart Failure - etiology | Natriuretic Peptide, Brain - blood | Proportional Hazards Models | Neoplasms - mortality | Neoplasms - drug therapy | Gated Blood-Pool Imaging | Adolescent | Aged | Anthracyclines - therapeutic use | Anthracyclines | Chemotherapy | Analysis | Natriuretic peptides | Cancer | Heart | Nuclear medicine | Transplants & implants | Peptides | Toxicity | Cardiomyopathy | Radioisotopes | Population studies | Congestive heart failure | Medical diagnosis | Cancer therapies | Physiology | Bioindicators | Drug dosages | Monitoring | Heart failure | Brain natriuretic peptide | Echocardiography | Cut-off | Mortality | Breast cancer | Patients | Equilibrium | Studies | Side effects | Hospitals | Anthracycline | Biomarkers | Death | Ventricle | Ejection | Index Medicus
Journal Article