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European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2017, Volume 138, pp. 761 - 773
We have designed a series of tacrine-based homo- and heterodimers that incorporate an antioxidant tether (selenoureido, chalcogenide) as new dual compounds:... 
Tacrine dimers | Anti-Alzheimer | Antiproliferative agent | Antioxidant | AChE inhibition | CELLS | DESIGN | CHEMISTRY, MEDICINAL | ANTICANCER-DRUG | POTENT | DISEASE | ACETYLCHOLINESTERASE INHIBITORS | MULTITARGET DRUGS | PHARMACOLOGICAL EVALUATION | DERIVATIVES | HYBRIDS | Antioxidants - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Organoselenium Compounds - chemistry | Organoselenium Compounds - pharmacology | Dose-Response Relationship, Drug | Tacrine - pharmacology | Amyloid beta-Peptides - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | Dimerization | Tacrine - chemistry | Protein Aggregates - drug effects | Peptide Fragments - metabolism | Alzheimer Disease - drug therapy | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Chalcogens - pharmacology | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Chalcogens - chemistry | Acetylcholinesterase - metabolism | Drug Screening Assays, Antitumor | Antioxidants | Chemotherapy | Enzyme inhibitors | Eels | Drug therapy | Derivatives (Financial instruments) | Alzheimer's disease | Cancer | Index Medicus
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 122, pp. 17 - 26
Journal Article
Journal of Neuroimmune Pharmacology, ISSN 1557-1890, 6/2012, Volume 7, Issue 2, pp. 488 - 498
Impaired mitochondrial function accompanied by microglial activation and the release of nitric oxide (NO) and pro-inflammatory cytokines has been reported in... 
Aging rats | Mitogen activated protein kinase | Neurosciences | Biomedicine | Immunology | Cytokines | Nitric oxide | Lipopolysaccharide | Pharmacology/Toxicology | Virology | Cell Biology | Microglia | OXIDATIVE STRESS | RECEPTOR | CHOLINESTERASE-INHIBITORS | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | ANTI-ALZHEIMER DRUG | DISEASE | NITRIC-OXIDE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | ACTIVATED PROTEIN-KINASES | PROGRESSION | Memory - drug effects | Microglia - metabolism | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Rats, Wistar | Anti-Inflammatory Agents - pharmacology | Aging - drug effects | Rats | Male | Maze Learning - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Brain - drug effects | Brain - metabolism | Animals | Signal Transduction - drug effects | Fluorescent Antibody Technique | Electrophoretic Mobility Shift Assay | Oxidative Stress - drug effects | Real-Time Polymerase Chain Reaction | Aging - metabolism | Indans - pharmacology | Nitrogen oxide | Brain | Messenger RNA | RNA | Metabolites | Anti-inflammatory drugs | Gene expression | Mitogens | Alzheimer's disease | Kinases | Alzheimers disease | Rodents | Drugs | Neuroprotection | Phosphorylation | Memory | Cognitive ability | Drug development | Lipopolysaccharides | Interleukin 6 | Mitochondria | c-Jun amino-terminal kinase | Cortex (parietal) | Aging | Microglial cells | Antiinflammatory agents | Neurodegenerative diseases | spatial memory | Oral administration | Extracellular signal-regulated kinase | MAP kinase | Inflammation | Nitric-oxide synthase | Nuclear transport | NF- Kappa B protein
Journal Article
CURRENT NEUROPHARMACOLOGY, ISSN 1570-159X, 2018, Volume 16, Issue 6, pp. 849 - 864
Background: The last decade was characterized by a growing awareness about the severity of dementia in the field of age-related and no age-related diseases and... 
QSAR ANALYSIS | topology | DOCKING | IDENTIFICATION | Alzheimer | NEUROSCIENCES | ANTI-ALZHEIMER | DISCOVERY | drug | QSAR | design | DISEASE | PHARMACOLOGY & PHARMACY | molecular | AGENTS | PHARMACOPHORE | INHIBITORS | INDEXES
Journal Article
Journal of Neuroimmune Pharmacology, ISSN 1557-1890, 3/2013, Volume 8, Issue 1, pp. 345 - 355
Journal Article
Ageing Research Reviews, ISSN 1568-1637, 2012, Volume 12, Issue 1, pp. 116 - 140
Highlights ► We summarized details of 11 commonly employed transgenic mice models, including APP, tau, double-cross transgenic mice and triple- cross... 
Neurology | Internal Medicine | Anti-Alzheimer therapeutics | Alzheimer's disease | Transgenic mice | ACETYL-L-CARNITINE | AMYLOID-PRECURSOR-PROTEIN | ATTENUATES TAU HYPERPHOSPHORYLATION | IMPROVES MEMORY IMPAIRMENT | GAMMA-SECRETASE MODULATOR | TG-APPSWE/PS1DE9 MOUSE MODEL | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | IN-VIVO | LONG-TERM POTENTIATION | REDUCES A-BETA | AGE-RELATED DEFICITS | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Humans | Alzheimer Disease - drug therapy | Mice, Transgenic - genetics | Nootropic Agents - therapeutic use | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - drug therapy | Drug Discovery | Antioxidants - therapeutic use | Amyloid beta-Protein Precursor - genetics | Animals | tau Proteins - genetics | Immunotherapy | Anti-Inflammatory Agents - therapeutic use | Mice, Transgenic - physiology | Presenilins - genetics | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Alzheimer Disease - genetics | Cholinesterase Inhibitors - therapeutic use | Disease Models, Animal | Type 2 diabetes | Drugs | Immunoglobulins | Glycogen | Genes | Amyloid beta-protein | Calpain | Amino acids | Transplantation | Glutamate | Data mining | Antioxidants | Proteins | Unsaturated fatty acids | Colony-stimulating factors (Physiology) | Synthesis | Stem cells | Genetic engineering | Models | Hormones, Sex | Intermediate filament proteins | Protein kinases | Omega-3 fatty acids
Journal Article