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Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 03/2011, Volume 18, Issue 3, pp. 439 - 451
Cytosolic inhibitor of Nrf2 (INrf2) is an adaptor protein that mediates ubiquitination/degradation of NF-E2-related factor 2 (Nrf2), a master regulator of... 
Bcl-2 | Anti-apoptotic | Nrf2 | INrf2 (Keap1) | Apoptosis | SURVIVAL | DOMAIN | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTHYMOSIN-ALPHA | CELL BIOLOGY | LUNG-CANCER | UBIQUITIN LIGASE COMPLEX | CUL3-BASED E3 LIGASE | ADAPTER | STRESS | Gamma Rays | Apoptosis - drug effects | Apoptosis - radiation effects | Antioxidants - metabolism | Humans | Lung Neoplasms - metabolism | Up-Regulation - radiation effects | Lung Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Hydroquinones - pharmacology | DNA Fragmentation - radiation effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Ubiquitination - drug effects | Ultraviolet Rays | Protein Processing, Post-Translational - drug effects | Protein Binding - drug effects | Protein Binding - radiation effects | Cullin Proteins - metabolism | Cytoskeletal Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - chemistry | Lysine - metabolism | DNA Fragmentation - drug effects | Phosphorylation - drug effects | Protein Stability - radiation effects | Kelch-Like ECH-Associated Protein 1 | Protein Structure, Tertiary | Cell Survival - drug effects | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Protein Processing, Post-Translational - radiation effects | Phosphoserine - metabolism | Cell Survival - radiation effects | Up-Regulation - drug effects | Phosphorylation - radiation effects | Animals | Carrier Proteins - metabolism | Protein Stability - drug effects | Cell Line, Tumor | Ubiquitination - radiation effects | Mice | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Original Paper
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 03/2014, Volume 83, Issue 3, pp. 317 - 323
Overexpression of Bcl‐2 has been recognized in various malignancies. Recently, HA 14‐1, a Bcl‐2 antagonist, has been identified for its anti‐apoptotic effect.... 
anti‐apoptotic proteins | apoptosis‐regulating proteins | pro‐apoptotic proteins | cervical cancer | anti-apoptotic proteins | apoptosis-regulating proteins | pro-apoptotic proteins | CANCER-CELLS | MOLECULE BCL-2 INHIBITOR | MITOCHONDRIAL APOPTOSIS | CHEMISTRY, MEDICINAL | ANTAGONIST | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | BH3 DOMAIN | BAX | ORGANIC-COMPOUND | LEUKEMIA | EXPRESSION | bcl-2-Associated X Protein - chemistry | Nitriles - pharmacology | Apoptosis - drug effects | Humans | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | Nitriles - chemical synthesis | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Benzopyrans - chemistry | bcl-X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - metabolism | Benzopyrans - chemical synthesis | Proto-Oncogene Proteins c-bcl-2 - chemistry | Benzopyrans - pharmacology | Binding Sites | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Nitriles - chemistry | Molecular Docking Simulation | HeLa Cells | bcl-X Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Tumor proteins | Analysis | Cervical cancer | Protein binding | Apoptosis | Index Medicus
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 05/2015, Volume 33, Issue 5, pp. 1067 - 1081
Mcl-1 has emerged as a potential therapeutic target in the treatment of several malignancies. Peptides representing BH3 region of pro-apoptotic proteins have... 
hydrophobic residues | Mcl-1 BH3 domain | anti-apoptotic Mcl-1 protein | free energy | molecular dynamics simulation | apoptosis regulating proteins | BCL-X-L | ANTAGONIZES MCL-1 | BINDING AFFINITIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | MEDIATED APOPTOSIS | CELL-SURVIVAL | FREE-ENERGY DECOMPOSITION | COMPUTATIONAL ANALYSIS | BREAST-CANCER | BIOPHYSICS | LIQUID WATER | bcl-2-Associated X Protein - chemistry | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Peptides - genetics | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | Thermodynamics | Peptides - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Peptides - chemistry | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Molecular Dynamics Simulation | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Hydrogen Bonding | Membrane Proteins - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Mutation | Index Medicus
Journal Article
Protein Science, ISSN 0961-8368, 09/2017, Volume 26, Issue 9, pp. 1749 - 1758
Voltage‐dependent anion channel 1 (VDAC1), which is located in the outer mitochondrial membrane, plays important roles in various cellular processes. For... 
single‐channel gating | β‐barrel structure | voltage‐dependent anion channel 1 | cell‐free protein synthesis | X‐ray crystallography | crystallization | oligomerization state | X-ray crystallography | β-barrel structure | cell-free protein synthesis | single-channel gating | voltage-dependent anion channel 1 | MITOCHONDRIAL APOPTOSIS | beta-barrel structure | ANTI-APOPTOTIC PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELECTIVE CHANNEL | CANCER-THERAPY | CELL-DEATH | CYTOCHROME-C | VDAC OLIGOMERIZATION | MEMBRANE-PROTEINS | EXPRESSION | N-TERMINAL REGION | Recombinant Proteins - metabolism | Humans | Protein Multimerization | Voltage-Dependent Anion Channel 1 - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Crystallography, X-Ray | Recombinant Proteins - genetics | Protein Subunits - metabolism | Escherichia coli - genetics | Surface Properties | Hydrophobic and Hydrophilic Interactions | Protein Subunits - chemistry | Voltage-Dependent Anion Channel 1 - chemistry | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Voltage-Dependent Anion Channel 1 - genetics | Protein Subunits - genetics | Proteins | Oligomers | Analysis | Escherichia coli | Denaturation | Crystals | Protein biosynthesis | Structure | Cytochrome | Electric potential | High resolution | Bcl-2 protein | Strands | Hydrophobicity | Mitochondria | Anions | Protein folding | Voltage | Crystal structure | Oligomerization | Crystallization | Cytochrome c | Diffraction | Protein synthesis | Cytoplasm | Structural analysis | Apoptosis | Index Medicus
Journal Article
STEM CELLS, ISSN 1066-5099, 07/2017, Volume 35, Issue 7, pp. 1760 - 1772
Bre is a conserved cellular protein expressed in various tissues. Its major function includes DNA damage repair and anti‐apoptosis. Recent studies indicate... 
Mdm2 | Ubiquitination | Bre | Osteogenesis | Mesenchymal stem cells | p53 | ANTI-APOPTOTIC PROTEIN | Ubiqu nation | OSTEOGENIC DIFFERENTIATION | MESENCHYMAL STEM-CELLS | NEGATIVE REGULATOR | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BONE-FORMATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TRANSCRIPTION FACTOR OSTERIX | IN-VIVO | HUMAN HEPATOCELLULAR-CARCINOMA | HEMATOLOGY | SKELETAL DEVELOPMENT | ORPHAN RECEPTOR NUR77 | Bone and Bones - pathology | RNA, Small Interfering - genetics | Proto-Oncogene Proteins c-mdm2 - genetics | Osteoporosis - therapy | Tumor Suppressor Protein p53 - antagonists & inhibitors | Tumor Suppressor Protein p53 - genetics | Tissue Scaffolds | Toluene - analogs & derivatives | Mesenchymal Stromal Cells - cytology | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Osteoporosis - metabolism | Bone and Bones - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Bone Marrow Cells - drug effects | Female | Osteoporosis - genetics | Cell Differentiation | Nuclear Proteins - genetics | Toluene - pharmacology | Proto-Oncogene Proteins c-mdm2 - metabolism | Osteogenesis - genetics | Disease Models, Animal | Tissue Engineering | Mesenchymal Stromal Cells - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Signal Transduction | Benzothiazoles - pharmacology | Bone Marrow Cells - cytology | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Mesenchymal Stromal Cells - metabolism | Nuclear Proteins - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Osteoporosis - pathology | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Protein Stability - drug effects | Mice | Mice, Inbred BALB C | Primary Cell Culture | Bone Marrow Cells - metabolism | RNA, Small Interfering - metabolism | Proteins | Osteoporosis | Phosphatases | Analysis | Stem cells | Cell differentiation | Gene expression | GTP-binding protein | Alkaline phosphatase | Transcription | Mesenchyme | p53 Protein | DNA damage | Differentiation (biology) | Stem cell transplantation | Activation | Tissues | Osteoblasts | DNA repair | Degradation | Biomedical materials | Pathways | Mineralization | Bone marrow | Bones | Biocompatibility | Inhibition | Damage | Deoxyribonucleic acid--DNA | MDM2 protein | siRNA | Molecular modelling | Osteoblastogenesis | In vivo methods and tests | In vitro methods and tests | Apoptosis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 12, pp. e15636 - e15636
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2016, Volume 472, Issue 1, pp. 108 - 113
Journal Article
The Protein Journal, ISSN 1572-3887, 10/2018, Volume 37, Issue 5, pp. 428 - 443
Journal Article
FEBS Journal, ISSN 1742-464X, 05/2014, Volume 281, Issue 10, pp. 2456 - 2470
Journal Article