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BLOOD, ISSN 0006-4971, 10/2006, Volume 108, Issue 7, pp. 2244 - 2247
The capacity of clopidogrel to inhibit ADP-induced platelet aggregation shows wide intersubject variability. To determine whether frequent functional variants... 
VARIABILITY | PERCUTANEOUS CORONARY INTERVENTION | ANTIAGGREGATING ACTIVITY | PRETREATMENT | METABOLISM | ACUTE MYOCARDIAL-INFARCTION | HUMAN PLATELETS | DRUG-RESISTANCE | HEMATOLOGY | ASPIRIN | VASP PHOSPHORYLATION
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
SEMINARS IN THROMBOSIS AND HEMOSTASIS, ISSN 0094-6176, 04/2005, Volume 31, Issue 2, pp. 174 - 183
Ticlopidine and clopidogrel belong to the same chemical family of thienopyridine adenosine diphosphate (ADP)-receptor antagonists. They have shown their... 
clopidogrel | antiplatelet agents | P-SELECTIN EXPRESSION | atherothrombosis | ACUTE CORONARY SYNDROMES | platelets | ANTIPLATELET THERAPY | IMPORTANT MESSENGER | INDUCED PLATELET-AGGREGATION | ANTIAGGREGATING ACTIVITY | ADP-RECEPTOR | ticlopidine | PERIPHERAL VASCULAR DISEASE | IIB-IIIA COMPLEX | ST-SEGMENT ELEVATION | HEMATOLOGY | ACTIVE METABOLITE
Journal Article
American Journal of Cardiology, The, ISSN 0002-9149, 2008, Volume 101, Issue 8, pp. 1088 - 1093
Journal Article
Journal Article
Acta Crystallographica Section E: Structure Reports Online, ISSN 1600-5368, 01/2011, Volume 67, Issue 1, pp. o221 - U3299
In the crystal structure of the title compound, C18H19BrCl-NO2S, weak C-H center dot center dot center dot O interactions help to establish the packing. 
CRYSTALLOGRAPHY | ANTIAGGREGATING ACTIVITY | CLOPIDOGREL
Journal Article
Journal Article
Molecules, ISSN 1420-3049, 06/2016, Volume 21, Issue 6, pp. 704 - 704
Journal Article
THROMBOSIS AND HAEMOSTASIS, ISSN 0340-6245, 12/2004, Volume 92, Issue 6, pp. 1201 - 1206
Clopidogrel is an effective and specific inhibitor of ADP-induced platelet aggregation. After metabolic activation, the active clopidogrel metabolite... 
clopidogrel | ADP RECEPTORS | ACTIVATION | PLATELET-AGGREGATION | HEALTHY-SUBJECTS | PHOSPHORYLATION | antiplatelet therapy | ANTITHROMBOTIC DRUGS | IDENTIFICATION | ANTIAGGREGATING ACTIVITY | RESISTANCE | PERIPHERAL VASCULAR DISEASE | clopidogrel responsiveness | HEMATOLOGY | MOLECULAR-BASIS
Journal Article
Future Medicinal Chemistry, ISSN 1756-8919, 06/2017, Volume 9, Issue 10, pp. 965 - 981
Journal Article
Journal Article
American Journal of Cardiology, The, ISSN 0002-9149, 2011, Volume 108, Issue 6, pp. 760 - 765
Journal Article