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1. Full Text Anticonvulsant Activity of Phenylmethylenehydantoins:  A Structure−Activity Relationship Study
by Thenmozhiyal, Jeyanthi Chinnappa and Wong, Peter Tsun-Hon and Chui, Wai-Keung
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2004, Volume 47, Issue 6, pp. 1527 - 1535
Phenylmethylenehydantoins (PMHs) and their des-phenyl analogues were synthesized and evaluated for anticonvulsant activity using the maximal electroshock... 
QSAR ANALYSIS | DIPHENYLHYDANTOIN | NMR | CHEMISTRY, MEDICINAL | PHENYTOIN | HYDANTOINS | QUANTITATIVE STRUCTURE-ACTIVITY | DRUGS | DEPENDENT SODIUM-CHANNEL | DERIVATIVES | 5-PHENYLMETHYLENEHYDANTOIN | Multivariate Analysis | Hydantoins - pharmacology | Magnetic Resonance Spectroscopy | Anticonvulsants - chemical synthesis | Seizures - drug therapy | Models, Molecular | Male | Anticonvulsants - pharmacology | Animals | Anticonvulsants - chemistry | Seizures - etiology | Mice | Hydantoins - chemistry | Electroshock | Quantitative Structure-Activity Relationship | Hydantoins - chemical synthesis
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2. Full Text N’-[(5-chloro-3-methyl-1-phenyl-1 H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: Synthesis and anticonvulsant activity
by Kaushik, Darpan and Khan, Suroor Ahmad and Chawla, Gita and Kumar, Suresh
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 9, pp. 3943 - 3949
A series of ’-[(5-chloro-3-methyl-1-phenyl-1 -pyrazol-4-yl)methylene] 2/4-substituted hydrazides were synthesized using appropriate synthetic route and... 
Acid hydrazide-hydrazone | Anticonvulsant activity | Vilsmeir Haack reaction | Behavioural test | 5-Chloro-3-methyl-1-phenyl-1 H-pyrazole-4-carboxaldehyde | 5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4- carboxaldehyde | ARYL SEMICARBAZONES | CHEMISTRY, MEDICINAL | ANTIEPILEPTIC DRUG DEVELOPMENT | NEUROTOXICITY EVALUATION | AGENTS | 5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxaldehyde | Hydrazines - pharmacology | Electroshock - adverse effects | Anticonvulsants - chemical synthesis | Hydrazines - toxicity | Seizures - drug therapy | Male | Anticonvulsants - pharmacology | Anticonvulsants - toxicity | Seizures - chemically induced | Dose-Response Relationship, Drug | Hydrazines - chemistry | Hydrazines - chemical synthesis | Animals | Nervous System - drug effects | Time Factors | Anticonvulsants - chemistry | Behavior, Animal - drug effects | Mice | Pentylenetetrazole - pharmacology | Seizures (Medicine) | Analysis | Depression, Mental | Phenytoin | Index Medicus
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3. Full Text Evaluation of anticonvulsant and analgesic activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and –butanamides
by Rapacz, Anna and Głuch-Lutwin, Monika and Mordyl, Barbara and Filipek, Barbara and Abram, Michał and Kamiński, Krzysztof
Epilepsy Research, ISSN 0920-1211, 07/2018, Volume 143, pp. 11 - 19
Epilepsy is a chronic neurological disorder that is associated with various types of recurrent seizures, which are drug-resistant in about one third of... 
Binding | Pyrrolidine-2,5-dione | Anticonvulsant activity | Hybrid compounds | Six-herz (6 Hz) test | Pain models | ANTIHYPERALGESIC ACTIVITY | PHARMACOLOGICAL CHARACTERIZATION | VALPROIC ACID | MECHANISMS | CLINICAL NEUROLOGY | NEUROPATHIC PAIN | PRIMARY HUMAN HEPATOCYTES | ANIMAL-MODELS | HEPG2 CELLS | EPILEPSY | ANTIEPILEPTIC DRUGS | Analgesics - pharmacology | Cell Survival - drug effects | Humans | Seizures - drug therapy | Motor Activity - drug effects | Male | Random Allocation | Anticonvulsants - pharmacology | Hep G2 Cells | Dose-Response Relationship, Drug | Neurotransmitter Agents - chemistry | Animals | Anticonvulsants - adverse effects | Analgesics - chemistry | Neurotransmitter Agents - adverse effects | Pain - drug therapy | Anticonvulsants - chemistry | Neurotransmitter Agents - pharmacology | Epilepsy - drug therapy | Mice | Molecular Structure | Drug Evaluation, Preclinical | Analgesics - adverse effects | Disease Models, Animal | Alkaloids | Divalproex | Nervous system diseases | Chemotherapy | Analysis | Seizures (Medicine) | Valproic acid | Formaldehyde | Cancer
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4. Full Text Antioxidant activity and interaction with DNA and albumins of zinc–tolfenamato complexes. Crystal structure of [Zn(tolfenamato)2(2,2′-dipyridylketoneoxime)2]
by Tarushi, Alketa and Totta, Xanthippi and Papadopoulos, Athanasios and Kljun, Jakob and Turel, Iztok and Kessissoglou, Dimitris P and Psomas, George
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2014, Volume 74, pp. 187 - 198
The zinc(II) complex of the non-steroidal anti-inflammatory drug tolfenamic acid (=Htolf) in the presence of 2,2′-dipyridylketone oxime (=Hpko) as a , ′-donor... 
Interaction with calf-thymus DNA | Zinc(II) complexes | Tolfenamic acid | Interaction with serum albumins | Antioxidant activity | MEFENAMIC-ACID | CANCER-CELLS | CHEMISTRY, MEDICINAL | INDUCED APOPTOSIS | ANTICONVULSANT ACTIVITIES | PROTEIN-BINDING | BINDING PROPERTIES | COPPER(II) COMPLEXES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BIOLOGICAL EVALUATION | METAL-COMPLEXES | Animals | Antioxidants - chemistry | Magnetic Resonance Spectroscopy | Albumins - drug effects | Cattle | Crystallography, X-Ray | Antioxidants - pharmacology | Zinc - chemistry | Spectrophotometry, Ultraviolet | DNA - drug effects | Antioxidants | Cytokinins | Zinc compounds | Fluocinolone acetonide | DNA | Crystals | Structure
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5. Research Paper - Evaluation of CNS activity of Bramhi Ghrita
by Achliya, G. S and Wadodkar, S. G and Dorle, A. K
Research Paper - Evaluation of CNS activity of Bramhi Ghrita, 12/2005
OBJECTIVE: To eavaluate the CNS activity of Bramhi Ghrita, a polyherbal formulation containing Bacopa monneri , Evolvulus alsinoids , Acorus calamus ,... 
Anticonvulsant, panchagavya
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6. Full Text Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles
by Almasirad, Ali and Tabatabai, Sayyed A and Faizi, Mehrdad and Kebriaeezadeh, Abbas and Mehrabi, Nazila and Dalvandi, Afshin and Shafiee, Abbas
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2004, Volume 14, Issue 24, pp. 6057 - 6059
1,3,4-Oxadiazole and 1,2,4-triazole derivatives were prepared as anticonvulsant agents. Pharmacological evaluation was performed on the synthesized compounds.... 
Anticonvulsant | MES | Substituted 1,3,4-oxadiazoles | PTZ | CHEMISTRY, MEDICINAL | anticonvulsant | CHEMISTRY, ORGANIC | DERIVATIVES | substituted 1,3,4-oxadiazoles | Triazoles - pharmacology | Oxadiazoles - chemical synthesis | Anticonvulsants - chemical synthesis | Oxadiazoles - pharmacology | Triazoles - chemical synthesis | Molecular Structure | Structure-Activity Relationship | Drug Evaluation, Preclinical | Anticonvulsants - pharmacology
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7. Full Text Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides
by Kamiński, Krzysztof and Rapacz, Anna and Filipek, Barbara and Obniska, Jolanta
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2016, Volume 24, Issue 13, pp. 2938 - 2946
The focused library of 21 new -phenyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide, 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)propanamide, and... 
Pyrrolidine-2,5-dione | Anticonvulsant activity | Hybrid compounds | In vitro studies | In vivo studies | PROTECTIVE ACTION | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DILTIAZEM | DISCOVERY | SEIZURES | CALCIUM | EPILEPSY | ANTIEPILEPTIC DRUGS | BINDING | CHANNEL BLOCKERS | VERAPAMIL | Amides - pharmacology | Calcium Channels - drug effects | Amides - chemical synthesis | Anticonvulsants - chemical synthesis | Humans | Injections, Intraperitoneal | Seizures - drug therapy | Anticonvulsants - therapeutic use | Anticonvulsants - administration & dosage | Amides - therapeutic use | Anticonvulsants - pharmacology | Pyrrolidines - chemistry | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Animals | Pyrrolidines - chemical synthesis | Drug Design | Amides - chemistry | Mice | Molecular Structure | Neurons - drug effects | Anticonvulsants | Divalproex | Calcium channels | Analysis | Pharmacy | Drugstores | Seizures (Medicine) | Diltiazem | Valproic acid | Index Medicus
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8. Biological Activities of Quinoline Derivatives
by Kumar, S and Bawa, S and Gupta, H
MINI-REVIEWS IN MEDICINAL CHEMISTRY, ISSN 1389-5575, 12/2009, Volume 9, Issue 14, pp. 1648 - 1654
Quinoline and its fused heterocyclic derivatives tested with diverse pharmacological activity constitute an important class of compounds for new drug... 
antibacterial activity | antimycobacterial | ANTIRHEUMATIC ACTIVITY | DESIGN | CHEMISTRY, MEDICINAL | anticonvulsant | cardiovascular activities | CONVENIENT | anticancer | BAYLIS-HILLMAN ADDUCTS | ANILINES | Quinoline | INHIBITORS | CELL | ANTIMICROBIAL ACTIVITY | Anti-Bacterial Agents - chemistry | Anti-Infective Agents - chemistry | Anti-Infective Agents - pharmacology | Anticonvulsants - chemistry | Molecular Conformation | Quinolines - chemistry | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Antineoplastic Agents - chemistry | Anticonvulsants - pharmacology | Quinolines - pharmacology | Antibacterial activity | Anticonvulsant | Anticancer | Antimycobacterial | Cardiovascular activities
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9. Full Text Effect of N(4)-Phenyl Substitution in 2-Oxo-1,2-dihydroquinoline-3-carbaldehyde Semicarbazones on the Structure, DNA/Protein Interaction, and Antioxidative and Cytotoxic Activity of Cu(II) Complexes
by Senthil Raja, Duraisamy and Bhuvanesh, Nattamai S. P and Natarajan, Karuppannan
Inorganic Chemistry, ISSN 0020-1669, 12/2011, Volume 50, Issue 24, pp. 12852 - 12866
A new ligand, 2-oxo-1,2-dihydroquinoline-3-carbaldehyde semicarbazone (OQsc-H) (1);, its N(4)-phenyl derivative (OQsc-Ph) (2); and their corresponding... 
COPPER(II) COMPLEXES | IN-VITRO | PHOTOCLEAVAGE | DNA CLEAVAGE ACTIVITY | THIOSEMICARBAZONES | INDUCED NUCLEASE ACTIVITY | LIGHT | ANTICONVULSANT | COORDINATION | PROTEIN-BINDING | CHEMISTRY, INORGANIC & NUCLEAR | Antineoplastic Agents - chemical synthesis | Humans | Crystallography, X-Ray | Semicarbazones - chemical synthesis | Structure-Activity Relationship | Cattle | Aldehydes - pharmacology | Coordination Complexes - pharmacology | Serum Albumin, Bovine - chemistry | Antineoplastic Agents - pharmacology | Copper | Cell Survival - drug effects | Aldehydes - chemical synthesis | Models, Molecular | Spectrometry, Fluorescence | Antioxidants - chemical synthesis | Antioxidants - pharmacology | DNA - chemistry | Animals | Cell Line, Tumor | Coordination Complexes - chemical synthesis | Protein Binding | Phenols - chemistry | Semicarbazones - pharmacology | Mice | HeLa Cells | DNA Cleavage | Ligand binding (Biochemistry) | Analysis | Cancer cells | Physiological aspects | Quinoline | Substitution reactions | Research | Chemical properties
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10. Full Text Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures
by Oliveira, Cleide Correia de and Oliveira, Clarissa Vasconcelos de and Grigoletto, Jéssica and Ribeiro, Leandro Rodrigo and Funck, Vinícius Rafael and Grauncke, Ana Cláudia Beck and Souza, Thaíze Lopes de and Souto, Naieli Schiefelbein and Furian, Ana Flávia and Menezes, Irwin Rose Alencar and Oliveira, Mauro Schneider
Epilepsy and Behavior, ISSN 1525-5050, 2015, Volume 56, pp. 26 - 31
Abstract Increasing evidence suggests that plant-derived extracts and their isolated components are useful for treatment of seizures and, hence, constitute a... 
Neurology | Natural product | Cannabinoids | Convulsion | EEG | PTZ | Phytomedicine | OXIDATIVE STRESS | ACTIVATION | ILAE | PSYCHIATRY | SENSITIVITY | DISCOVERY | CLINICAL NEUROLOGY | PATHWAY | BEHAVIORAL SCIENCES | MICE | CEREBRAL ISCHEMIC-INJURY | EPILEPSY | AGONIST | Mice, Inbred C57BL | Seizures - drug therapy | Anticonvulsants - therapeutic use | Motor Activity - drug effects | Epilepsies, Myoclonic - chemically induced | Postural Balance - drug effects | Sesquiterpenes - therapeutic use | Seizures - chemically induced | Dose-Response Relationship, Drug | Epilepsies, Myoclonic - psychology | Animals | Electroencephalography - drug effects | Swimming - psychology | Convulsants | Epilepsies, Myoclonic - drug therapy | Mice | Pentylenetetrazole | Oxidative Stress - drug effects | Recognition (Psychology) | Seizures - psychology | Index Medicus
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11. Full Text Epileptic activity in Alzheimer's disease: causes and clinical relevance
by Vossel, Keith A, Dr and Tartaglia, Maria C, MD and Nygaard, Haakon B, MD and Zeman, Adam Z, FRCP and Miller, Bruce L, MD
Lancet Neurology, The, ISSN 1474-4422, 2017, Volume 16, Issue 4, pp. 311 - 322
Summary Epileptic activity is frequently associated with Alzheimer's disease; this association has therapeutic implications, because epileptic activity can... 
Neurology | CHRONIC DIVALPROEX SODIUM | HIPPOCAMPAL SCLEROSIS | AMYLOID-BETA DEPOSITION | MOUSE MODEL | BEHAVIORAL DEFICITS | MILD COGNITIVE IMPAIRMENT | DEEP BRAIN-STIMULATION | SYNAPTIC PLASTICITY | NEURONAL DYSFUNCTION | CLINICAL NEUROLOGY | LATE-ONSET SEIZURES | Anticonvulsants - therapeutic use | Epilepsy - drug therapy | Alzheimer Disease - complications | Animals | Humans | Epilepsy - complications | Alzheimer's disease | Seizures (Medicine) | Neurophysiology | Studies | Phosphorylation | Neural networks | Rodents | Epilepsy | Electroencephalography | Mutation | Kinases | Alzheimers disease | Gene expression | Patients | Dementia
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12. Full Text Antiseizure activity of midazolam in mice lacking δ-Subunit extrasynaptic GABA A receptors
by Reddy, Sandesh D and Younus, Iyan and Clossen, Bryan L and Reddy, Doodipala Samba
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2015, Volume 353, Issue 3, pp. 517 - 528
Midazolam is a benzodiazepine anticonvulsant with rapid onset and short duration of action. Midazolam is the current drug of choice for acute seizures and... 
LIMBIC EPILEPTOGENESIS | ELECTRICAL-STIMULATION | ANTICONVULSANT ACTIVITY | 5-ALPHA-REDUCTASE INHIBITOR | PERIPHERAL BENZODIAZEPINE-RECEPTOR | NEUROACTIVE STEROIDS | STATUS EPILEPTICUS | PREGNENOLONE SYNTHESIS | PHARMACOLOGY & PHARMACY | BINDING INHIBITOR RECEPTORS | TONIC INHIBITION | Brain Chemistry - drug effects | Seizures - prevention & control | Mice, Inbred C57BL | Neurotransmitter Agents - metabolism | Male | Hippocampus - drug effects | Anticonvulsants - pharmacology | Mice, Knockout | Kindling, Neurologic - drug effects | Flumazenil - pharmacology | Hippocampus - metabolism | Animals | Neurotransmitter Agents - pharmacology | Receptors, GABA-A - genetics | GABA Modulators - pharmacology | Receptors, GABA-A - drug effects | Female | Hypnotics and Sedatives - pharmacology | Mice | Midazolam - pharmacology
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13. Full Text Anticonvulsant Activity of Dimephosphonum
by Abakumova, T R and Karpenko, A I and Khaziakhmetova, V N and Ziganshina, L E
BioNanoScience, ISSN 2191-1630, 6/2019, Volume 9, Issue 2, pp. 235 - 237
A novel Russian medicine dimephosphonum at its therapeutic doses of 50 mg/kg and 100 mg/kg showed anti-seizure activity on models of primary generalized... 
Engineering | Dimephosphonum | Anticonvulsant activity | Rats | Maximal electroshock test | Circuits and Systems | Mice | Biological and Medical Physics, Biophysics | Corazolum antagonism test | Anticonvulsant drugs | Nanotechnology | Biomaterials
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14. Full Text Cinnamamide Derivatives for Central and Peripheral Nervous System Disorders—A Review of Structure–Activity Relationships
by Gunia‐Krzyżak, Agnieszka and Pańczyk, Katarzyna and Waszkielewicz, Anna M and Marona, Henryk
ChemMedChem, ISSN 1860-7179, 08/2015, Volume 10, Issue 8, pp. 1302 - 1325
The cinnamamide scaffold has been incorporated in to the structure of numerous organic compounds with therapeutic potential. The scaffold enables multiple... 
anti‐inflammatory agents | cinnamamides | neuroprotective agents | structure–activity relationships | antidepressants | anticonvulsants | medicinal chemistry | structure-activity relationships | anti-inflammatory agents | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Receptors, Dopamine - metabolism | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Anticonvulsants - therapeutic use | Structure-Activity Relationship | Receptors, GABA-A - chemistry | Histone Deacetylase Inhibitors - chemistry | Receptors, Dopamine - chemistry | Antidepressive Agents - therapeutic use | Animals | Anticonvulsants - chemistry | Antidepressive Agents - chemistry | Histone Deacetylase Inhibitors - therapeutic use | Receptors, GABA-A - metabolism | Cinnamates - chemistry | Cinnamates - therapeutic use | Peripheral Nervous System Diseases - drug therapy | Nervous system | Rodents
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15. Full Text Contrasting effects of Na+ , K+ -ATPase activation on seizure activity in acute versus chronic models
by Funck, V.R and Ribeiro, L.R and Pereira, L.M and de Oliveira, C.V and Grigoletto, J and Della-Pace, I.D and Fighera, M.R and Royes, L.F.F and Furian, A.F and Larrick, J.W and Oliveira, M.S
Neuroscience, ISSN 0306-4522, 2015, Volume 298, pp. 171 - 179
Highlights • DRRSAb antibody increases Na+ , K+ -ATPase activity in mice hippocampi. • A direct Na+ , K+ -ATPase activator delays PTZ-induced seizures in post... 
Neurology | epilepsy | pilocarpine | seizure | sodium pump | EEG | Pilocarpine | Seizure | Sodium pump | Epilepsy | RATS | DECREASE | ISOFORM | ATP1A2 | NEUROSCIENCES | NA+,K+-ATPASE ACTIVITY | HYPEREXCITABILITY | INHIBITION | SODIUM-PUMP | NEURONS | Antibodies - therapeutic use | Gene Expression Regulation, Enzymologic - drug effects | Mice, Inbred C57BL | Status Epilepticus - chemically induced | Status Epilepticus - pathology | Anticonvulsants - therapeutic use | Rats | Status Epilepticus - drug therapy | Male | Electroencephalography | Pilocarpine - toxicity | Hippocampus - drug effects | Sodium-Potassium-Exchanging ATPase - metabolism | Pentylenetetrazole - toxicity | Animals | Time Factors | Convulsants - toxicity | Statistics, Nonparametric | Brain Waves - drug effects | Hippocampus - enzymology | Sodium-Potassium-Exchanging ATPase - immunology | Hippocampus - physiopathology | Disease Models, Animal
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